KEGG   PATHWAY: mbez04062
Entry
mbez04062                   Pathway                                
Name
Chemokine signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
mbez04062  Chemokine signaling pathway
mbez04062

Other DBs
GO: 0070098
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129535020  [KO:K08291] [EC:2.7.11.16]
129535859  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129536555  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
129536585  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129536645  [KO:K05408]
129536678  [KO:K12964]
129536689  [KO:K05408]
129536697  [KO:K05408]
129536712  CCL5; C-C motif chemokine 5 [KO:K12499]
129536749  [KO:K16596]
129536758  [KO:K16597]
129536764  [KO:K14624]
129536787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129537127  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129537257  RAP1B; ras-related protein Rap-1b [KO:K07836]
129537499  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
129537915  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
129538140  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
129538314  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
129538394  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
129538396  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
129538412  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
129539229  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129539448  [KO:K04513]
129539650  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
129539810  [KO:K04392]
129539827  [KO:K05511]
129539837  [KO:K21092]
129539842  CCL16; C-C motif chemokine 16 isoform X1 [KO:K21093]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129539945  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129540024  CCL1; C-C motif chemokine 1 [KO:K05514]
129540618  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129541258  CRK; adapter molecule crk isoform X1 [KO:K04438]
129541434  [KO:K04353]
129541489  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
129541702  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129541808  NRAS; GTPase NRas [KO:K07828]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129542147  [KO:K21092]
129542185  PXN; paxillin isoform X1 [KO:K05760]
129542379  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
129542477  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
129542481  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129542494  CRKL; crk-like protein [KO:K04438]
129543633  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
129543654  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129544423  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
129544425  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
129544441  CCR10; C-C chemokine receptor type 10 [KO:K04185]
129544591  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
129544725  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129545136  CCL26; C-C motif chemokine 26 [KO:K21096]
129545325  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129545605  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
129545634  CCL24; C-C motif chemokine 24 [KO:K21097]
129545675  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129546252  CCL17; C-C motif chemokine 17 [KO:K21083]
129546253  CCL22; C-C motif chemokine 22 [KO:K21095]
129546768  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129546849  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
129547076  CX3CL1; fractalkine isoform X1 [KO:K05508]
129547117  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547229  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129547261  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129547752  CCR9; C-C chemokine receptor type 9 [KO:K04184]
129547755  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
129547758  CCR1; C-C chemokine receptor type 1 [KO:K04176]
129547759  XCR1; chemokine XC receptor 1 [KO:K04193]
129547760  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
129547762  CCR2; C-C chemokine receptor type 2 [KO:K04177]
129547764  [KO:K04180]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129547858  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129547928  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
129548123  CCR8; C-C chemokine receptor type 8 [KO:K04183]
129548129  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
129548173  CCR4; C-C chemokine receptor type 4 [KO:K04179]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129548707  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
129548767  RELA; transcription factor p65 [KO:K04735]
129548806  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
129548814  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129548858  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129549029  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129549745  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
129549901  [KO:K04692]
129550521  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129550982  XCL1; lymphotactin [KO:K05507]
129551250  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
129551433  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129551440  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129552025  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
129552085  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129552346  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129552393  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
129552454  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129552725  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
129553133  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129553283  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
129553378  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129554397  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
129554677  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
129554914  [KO:K04392]
129555099  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129555304  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129555606  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
129556526  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556560  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556649  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
129556766  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129556920  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
129556961  [KO:K16598]
129557166  CCL27; C-C motif chemokine 27 [KO:K16598]
129557186  SHC3; SHC-transforming protein 3 [KO:K17448]
129557372  CCL19; C-C motif chemokine 19 [KO:K05512]
129557373  CCL21; C-C motif chemokine 21 [KO:K16062]
129557434  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
129557601  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129558306  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
129558379  SHC2; SHC-transforming protein 2 [KO:K17447]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129558601  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
129559031  VAV1; proto-oncogene vav [KO:K05730]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129559327  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
129559389  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
129559391  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
129559856  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
129559901  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129560440  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129561025  FOXO3; forkhead box protein O3 [KO:K09408]
129561215  CCR6; C-C chemokine receptor type 6 isoform X1 [KO:K04181]
129561737  [KO:K05505]
129561756  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
129561847  PPBP; platelet basic protein [KO:K10029]
129561849  [KO:K05407]
129561928  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129561973  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
129561974  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
129561975  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
129562028  [KO:K05505]
129562043  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
129562061  [KO:K05505]
129562064  CXCL8; interleukin-8 [KO:K10030]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129562253  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129562435  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129562463  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129562932  SHC4; SHC-transforming protein 4 [KO:K17449]
129563187  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129563552  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
129563919  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129564332  WAS; actin nucleation-promoting factor WAS [KO:K05747]
129564579  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
mbez04010  MAPK signaling pathway
mbez04060  Cytokine-cytokine receptor interaction
mbez04120  Ubiquitin mediated proteolysis
mbez04630  JAK-STAT signaling pathway
mbez04670  Leukocyte transendothelial migration
mbez04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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