KEGG   PATHWAY: mcep04510
Entry
mcep04510                   Pathway                                
Name
Focal adhesion - Mugil cephalus (flathead mullet)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcep04510  Focal adhesion
mcep04510

Other DBs
GO: 0005925
Organism
Mugil cephalus (flathead mullet) [GN:mcep]
Gene
124995489  lama1; laminin subunit alpha-1 [KO:K05637]
124995534  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
124995595  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
124995643  [KO:K05730]
124995988  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
124996006  col9a3; collagen alpha-3(IX) chain [KO:K08131]
124996387  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
124996400  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
124996477  thbs4b; thrombospondin-4-B [KO:K04659]
124996488  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124996554  tln1; talin-1 isoform X1 [KO:K06271]
124996562  [KO:K12753]
124996666  crkL; crk-like protein [KO:K04438]
124996736  itga1; integrin alpha-1 [KO:K06480]
124996788  tncA; tenascin isoform X1 [KO:K06252]
124996826  junE; JunE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124997018  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124997044  flnA; filamin-A isoform X1 [KO:K04437]
124997088  lamc3; laminin subunit gamma-3 [KO:K06247]
124997093  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta A [KO:K00889] [EC:2.7.1.68]
124997099  shc3; SHC-transforming protein 3 [KO:K17448]
124997320  itgb3a; integrin beta-3a [KO:K06493]
124997457  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
124997478  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124997521  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124997545  emp2; epithelial membrane protein 2 [KO:K26256]
124997688  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme A [KO:K06269] [EC:3.1.3.16]
124997961  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124998073  [KO:K04392]
124998080  actb2; actin, cytoplasmic 2 [KO:K05692]
124998126  col1a1a; collagen, type I, alpha 1a isoform X1 [KO:K06236]
124998162  [KO:K04364]
124998171  ccndx; cyclin Dx [KO:K10151]
124998181  igf3; insulin-like growth factor 3 [KO:K05459]
124998196  [KO:K06482]
124998222  pdgfab; platelet-derived growth factor alpha polypeptide B [KO:K04359]
124998258  itga2b; integrin alpha-IIb [KO:K06476]
124998313  [KO:K26255]
124998363  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124998754  [KO:K06269] [EC:3.1.3.16]
124998801  fynB; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
124998813  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
124998818  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
124998847  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
124998882  [KO:K05735] [EC:2.7.11.1]
124999037  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
124999107  raf1a; raf-1 proto-oncogene, serine/threonine kinase A isoform X1 [KO:K04366] [EC:2.7.11.1]
124999124  [KO:K17388] [EC:2.7.11.39]
124999177  [KO:K16859]
124999255  lama4; laminin subunit alpha-4 [KO:K06241]
124999725  hgfA; hepatocyte growth factor a isoform X1 [KO:K05460]
124999895  [KO:K07836]
124999912  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
124999936  [KO:K04359]
125000036  braF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125000184  [KO:K10151]
125000266  lamb1b; laminin subunit beta-1b [KO:K05636]
125000330  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125001275  [KO:K05449]
125003616  [KO:K19662] [EC:2.7.11.13]
125003653  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
125003676  [KO:K03099]
125003733  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
125003850  [KO:K17386]
125003914  [KO:K05692]
125004183  [KO:K05730]
125004218  emp1; epithelial membrane protein 1 [KO:K26255]
125004243  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125004257  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125004579  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
125004580  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
125004581  capn2b; calpain 2, (m/II) large subunit B [KO:K03853] [EC:3.4.22.53]
125004613  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125004646  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
125005026  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
125005127  fn1b; fibronectin 1b isoform X1 [KO:K05717]
125005167  tln2a; talin-2a isoform X1 [KO:K06271]
125005205  [KO:K17449]
125005277  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
125005336  itgb6; integrin beta-6 [KO:K06589]
125005425  itga5; integrin alpha-5 [KO:K06484]
125005499  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
125005752  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125005756  [KO:K04349]
125005935  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
125006068  [KO:K06244]
125006238  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
125006269  [KO:K04353]
125006588  [KO:K04393]
125006645  [KO:K04513]
125006662  [KO:K05760]
125006668  [KO:K05704] [EC:2.7.10.2]
125006718  [KO:K04353]
125006768  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
125006795  cav3; caveolin-3 [KO:K12959]
125006804  myl2a; myosin regulatory light chain 2a [KO:K10351]
125006809  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125006891  [KO:K06484]
125006892  itga7; integrin alpha-7 isoform X1 [KO:K06583]
125007027  [KO:K12958]
125007179  cav4a; caveolin-2 [KO:K12958]
125007211  [KO:K27392]
125007216  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
125007385  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
125007620  pdgfc; platelet-derived growth factor C [KO:K05450]
125007867  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125007942  kdrL; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
125007958  [KO:K04725] [EC:2.3.2.27]
125008212  egf; pro-epidermal growth factor [KO:K04357]
125008222  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125008365  vegfba; vascular endothelial growth factor B [KO:K05448]
125008712  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
125009089  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
125009234  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125009281  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
125009331  [KO:K04659]
125009338  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
125009346  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
125009384  [KO:K00922] [EC:2.7.1.153]
125009413  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
125009453  jun; transcription factor AP-1 [KO:K04448]
125009744  [KO:K02649]
125009757  mylk4b; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
125009776  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
125010100  [KO:K05730]
125010227  [KO:K06237]
125010340  [KO:K04448]
125010405  [KO:K06240]
125010408  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
125010445  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125010468  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125010479  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
125010593  [KO:K06485]
125010651  [KO:K06237]
125010703  [KO:K05719]
125010704  [KO:K05719]
125010730  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125010771  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
125010793  [KO:K00922] [EC:2.7.1.153]
125010798  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
125010883  lamc1; laminin subunit gamma-1 [KO:K05635]
125010892  lamc2; laminin subunit gamma-2 [KO:K06246]
125011146  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125011170  tnr; tenascin-R isoform X1 [KO:K06252]
125011177  tnn; tenascin-N isoform X1 [KO:K06252]
125011199  [KO:K02649]
125011241  [KO:K00889] [EC:2.7.1.68]
125011331  col6a1; collagen alpha-1(VI) chain [KO:K06238]
125011494  [KO:K12329]
125011684  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
125011690  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
125011727  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
125011786  pxnB; uncharacterized protein pxnb [KO:K05760]
125011901  thbs4a; thrombospondin-4a [KO:K04659]
125011903  [KO:K04513]
125011912  [KO:K04513]
125012012  [KO:K05692]
125012106  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125012107  tncB; tenascin isoform X1 [KO:K06252]
125012108  itga2.2; integrin alpha-2 [KO:K06481]
125012308  [KO:K06277]
125012477  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
125012779  [KO:K02649]
125012801  [KO:K05692]
125012829  [KO:K05692]
125012876  badB; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
125012970  col4a3; collagen alpha-5(IV) chain [KO:K06237]
125012989  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
125013002  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125013133  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
125013277  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
125013288  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
125013336  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125013339  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125013379  crk; adapter molecule crk [KO:K04438]
125013436  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
125013445  pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
125013711  vtnA; vitronectin A [KO:K06251]
125013895  [KO:K06272] [EC:2.7.11.1]
125014171  col4a4; collagen alpha-4(IV) chain [KO:K06237]
125014367  [KO:K04503]
125014371  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
125014422  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
125014500  parvb; beta-parvin isoform X1 [KO:K06275]
125014501  parvg; gamma-parvin [KO:K06275]
125014678  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
125014692  tln2b; talin-2 isoform X1 [KO:K06271]
125014766  relN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
125014887  parvaa; parvin, alpha A [KO:K06275]
125014911  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
125014929  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125014964  cav1; caveolin-1 [KO:K06278]
125015016  [KO:K02833]
125015031  [KO:K06587]
125015133  vwf; von Willebrand factor [KO:K03900]
125015157  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
125015166  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125015268  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125015324  lamb1a; laminin subunit beta-1a [KO:K05636]
125015428  cav2; caveolin-2 [KO:K12958]
125015538  [KO:K05460]
125015539  lamb4; laminin subunit beta-4 isoform X1 [KO:K06245]
125015714  [KO:K06269] [EC:3.1.3.16]
125015808  tnxba; tenascin [KO:K06252]
125015947  itga8; integrin alpha-8 [KO:K06584]
125015974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125016060  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
125016070  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
125016194  zyx; zyxin [KO:K06273]
125016280  cdc42l; cell division cycle 42, like [KO:K04393]
125016611  [KO:K00889] [EC:2.7.1.68]
125016724  [KO:K05725] [EC:2.7.10.2]
125016781  thbs3a; thrombospondin-3a [KO:K04659]
125016815  [KO:K06238]
125017062  itga10; integrin alpha-10 [KO:K06586]
125017096  [KO:K06238]
125017427  itgav; integrin alpha-V [KO:K06487]
125017432  itgb5; integrin beta-5 [KO:K06588]
125017544  itga4; integrin alpha-4 [KO:K06483]
125017546  [KO:K06238]
125017564  fn1a; fibronectin 1a [KO:K05717]
125017569  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
125017570  col4a1; collagen alpha-1(IV) chain [KO:K06237]
125017729  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125018021  col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
125018242  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
125018547  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125018710  cav4b; caveolin-2 [KO:K12958]
125018749  [KO:K05700]
125018803  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125018829  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
125018901  lamb2l; laminin subunit beta-2 isoform X1 [KO:K06243]
125018917  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
125018974  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
125019018  itga9; integrin alpha-9 [KO:K06585]
125019146  [KO:K03853] [EC:3.4.22.53]
125019147  [KO:K03853] [EC:3.4.22.53]
125019343  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125019641  [KO:K08131]
125019908  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
125019954  [KO:K02105]
125020027  [KO:K04393]
125020056  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
125020069  col9a2; collagen alpha-2(IX) chain [KO:K08131]
125020356  [KO:K00889] [EC:2.7.1.68]
125020401  itgb8; integrin beta-8 [KO:K06591]
125020729  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
125020875  [KO:K04456] [EC:2.7.11.1]
125020877  [KO:K06274]
125020984  [KO:K05733] [EC:2.7.11.1]
125021012  [KO:K04393]
125021087  [KO:K04438]
125021100  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
125021342  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
125021590  [KO:K05089] [EC:2.7.10.1]
125021727  vtnB; vitronectin B [KO:K06251]
125021750  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
125022058  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
125022104  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125022122  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125022160  [KO:K12758]
125022245  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
125022253  erbb2; receptor tyrosine-protein kinase ErbB-2 [KO:K05083] [EC:2.7.10.1]
125022267  itga3b; integrin alpha-3b isoform X1 [KO:K06482]
125022308  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
125022322  [KO:K04659]
125022542  itgb4; integrin beta-4 isoform X1 [KO:K06525]
125022560  chaD; chondroadherin [KO:K06248]
125022708  [KO:K00907] [EC:2.7.11.18]
125022881  [KO:K06493]
125022899  [KO:K05700]
125023006  [KO:K04392]
125023025  col1a1b; collagen, type I, alpha 1b [KO:K06236]
125023273  [KO:K16857]
125023286  [KO:K05735] [EC:2.7.11.1]
125023380  fynA; tyrosine-protein kinase fyna isoform X1 [KO:K05703] [EC:2.7.10.2]
125023444  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
125023452  sos2; son of sevenless homolog 2 [KO:K03099]
125023457  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
125023506  pgfB; placenta growth factor [KO:K16859]
125023675  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125023685  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
125023722  [KO:K06269] [EC:3.1.3.16]
125024123  [KO:K04410] [EC:2.7.11.1]
125024403  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
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Fibronectin, integrins, and growth control.
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J Cell Sci 115:3729-38 (2002)
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J Cell Sci 116:1409-16 (2003)
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Nat Rev Mol Cell Biol 6:56-68 (2005)
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Curr Opin Cell Biol 15:565-71 (2003)
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Curr Opin Genet Dev 14:92-101 (2004)
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Cell 116:167-79 (2004)
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Biochem J 346 Pt 3:561-76 (2000)
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The protein kinase B/Akt signalling pathway in human malignancy.
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Cell Signal 14:381-95 (2002)
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Nat Cell Biol 2:E231-6 (2000)
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Related
pathway
mcep04010  MAPK signaling pathway
mcep04060  Cytokine-cytokine receptor interaction
mcep04070  Phosphatidylinositol signaling system
mcep04110  Cell cycle
mcep04310  Wnt signaling pathway
mcep04512  ECM-receptor interaction
mcep04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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