KEGG   PATHWAY: mlk04510
Entry
mlk04510                    Pathway                                
Name
Focal adhesion - Mustela lutreola (European mink)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mlk04510  Focal adhesion
mlk04510

Other DBs
GO: 0005925
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807367  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
131807495  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131807732  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
131808024  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
131808081  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
131808591  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
131808688  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
131808792  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131808865  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131809015  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131809019  JUN; transcription factor Jun [KO:K04448]
131809399  PARVA; alpha-parvin isoform X1 [KO:K06275]
131810003  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
131810028  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
131810066  [KO:K04393]
131810068  RAP1A; ras-related protein Rap-1A [KO:K04353]
131810162  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
131810837  [KO:K12757]
131810838  [KO:K12757]
131810869  PXN; paxillin isoform X1 [KO:K05760]
131811098  CRKL; crk-like protein [KO:K04438]
131811171  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
131811428  LAMA1; laminin subunit alpha-1 [KO:K05637]
131811594  [KO:K04393]
131811641  [KO:K04513]
131811666  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
131811692  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131811845  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
131811851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
131812389  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
131812433  TNC; tenascin isoform X1 [KO:K06252]
131812476  SHC3; SHC-transforming protein 3 [KO:K17448]
131812504  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
131812612  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
131812737  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
131812767  TLN1; talin-1 isoform X1 [KO:K06271]
131813524  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
131813526  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
131814136  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131814353  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
131814364  LAMC2; laminin subunit gamma-2 [KO:K06246]
131814601  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
131814653  BAD; bcl2-associated agonist of cell death [KO:K02158]
131814739  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
131814757  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
131814899  TNR; tenascin-R [KO:K06252]
131814941  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
131815028  TNN; tenascin-N [KO:K06252]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131815290  LAMC1; laminin subunit gamma-1 [KO:K05635]
131815308  LAMB3; laminin subunit beta-3 [KO:K06244]
131815726  VTN; vitronectin [KO:K06251]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131815932  CHAD; chondroadherin [KO:K06248]
131815964  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
131816001  ITGB3; integrin beta-3 [KO:K06493]
131816057  CRK; adapter molecule crk isoform X1 [KO:K04438]
131816144  ACTG1; actin, cytoplasmic 2 [KO:K05692]
131816171  COL1A1; collagen alpha-1(I) chain [KO:K06236]
131816316  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
131816419  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
131816536  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
131816784  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
131816825  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
131816967  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
131817001  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
131817477  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817944  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
131817960  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131818622  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
131818796  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
131818799  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
131818802  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
131818861  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
131819264  MYL11; myosin regulatory light chain 11 isoform X1 [KO:K12758]
131819467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
131819566  MYL10; myosin regulatory light chain 10 [KO:K12756]
131819600  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131819701  IBSP; bone sialoprotein 2 [KO:K06253]
131819729  MYL5; myosin light chain 5 [KO:K12753]
131819765  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819887  EMP2; epithelial membrane protein 2 [KO:K26256]
131820100  ACTB; actin, cytoplasmic 1 [KO:K05692]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131820340  VEGFC; vascular endothelial growth factor C [KO:K05449]
131820782  FLNA; filamin-A isoform X1 [KO:K04437]
131820789  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
131820861  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
131821335  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
131821520  VEGFD; vascular endothelial growth factor D [KO:K05449]
131822161  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
131822235  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
131823143  SHC2; SHC-transforming protein 2 [KO:K17447]
131823296  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
131823393  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
131823754  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131823781  COMP; cartilage oligomeric matrix protein [KO:K04659]
131823907  LAMB2; laminin subunit beta-2 [KO:K06243]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131824009  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131824065  FLNB; filamin-B isoform X1 [KO:K27392]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131824375  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
131824424  CTNNB1; catenin beta-1 [KO:K02105]
131824425  [KO:K12757]
131824529  [KO:K06238]
131824531  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
131824532  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
131824589  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824634  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
131824645  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
131824683  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
131824847  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131825080  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131825485  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
131825488  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
131825800  CAV3; caveolin-3 [KO:K12959]
131826363  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
131826998  ITGAV; integrin alpha-V [KO:K06487]
131827022  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
131827091  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
131827176  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
131827294  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
131827372  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
131827373  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
131827486  FN1; fibronectin isoform X1 [KO:K05717]
131828723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131828809  VCL; vinculin isoform X1 [KO:K05700]
131828969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828977  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828978  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131829020  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131829232  LAMB1; laminin subunit beta-1 [KO:K05636]
131829234  LAMB4; laminin subunit beta-4 [KO:K06245]
131829275  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
131829310  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131829390  COL1A2; collagen alpha-2(I) chain [KO:K06236]
131829482  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
131829655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131829656  CAV1; caveolin-1 isoform X1 [KO:K06278]
131829657  CAV2; caveolin-2 isoform X1 [KO:K12958]
131829849  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
131829888  ZYX; zyxin isoform X1 [KO:K06273]
131830370  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
131830547  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
131830732  SPP1; osteopontin [KO:K06250]
131831160  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131831691  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
131831727  ITGA2; integrin alpha-2 [KO:K06481]
131831728  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
131831763  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131832182  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
131832309  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131832403  THBS4; thrombospondin-4 [KO:K04659]
131832665  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131832669  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131833155  [KO:K04393]
131833342  THBS2; thrombospondin-2 [KO:K04659]
131833489  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
131833494  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
131833812  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
131833967  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
131834157  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
131834319  TNXB; tenascin-X isoform X1 [KO:K06252]
131834448  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
131834540  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
131834551  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
131834629  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
131834784  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
131835485  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
131835676  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
131835890  TLN2; talin-2 isoform X1 [KO:K06271]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131835979  ITGA11; integrin alpha-11 [KO:K06587]
131836095  THBS1; thrombospondin-1 [KO:K16857]
131836104  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
131836254  SHC4; SHC-transforming protein 4 [KO:K17449]
131836447  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131836725  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
131836866  PGF; placenta growth factor isoform X1 [KO:K16859]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131838241  ITGA8; integrin alpha-8 [KO:K06584]
131838306  ITGB1; integrin beta-1 [KO:K05719]
131838412  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
131838428  VWF; von Willebrand factor [KO:K03900]
131838635  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
131838659  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
131838703  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
131839015  EMP1; epithelial membrane protein 1 [KO:K26255]
131839131  RAP1B; ras-related protein Rap-1b [KO:K07836]
131839209  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
131839335  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
131839444  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
131839489  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
131839595  PARVB; beta-parvin isoform X1 [KO:K06275]
131839597  PARVG; gamma-parvin isoform X1 [KO:K06275]
131839774  COL2A1; collagen alpha-1(II) chain [KO:K19719]
131840354  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131840593  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mlk04010  MAPK signaling pathway
mlk04060  Cytokine-cytokine receptor interaction
mlk04070  Phosphatidylinositol signaling system
mlk04110  Cell cycle
mlk04151  PI3K-Akt signaling pathway
mlk04310  Wnt signaling pathway
mlk04512  ECM-receptor interaction
mlk04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

DBGET integrated database retrieval system