KEGG   PATHWAY: mlk04010
Entry
mlk04010                    Pathway                                
Name
MAPK signaling pathway - Mustela lutreola (European mink)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlk04010  MAPK signaling pathway
mlk04010

Other DBs
GO: 0000165
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807582  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
131807915  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
131807994  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
131808468  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
131808471  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
131808527  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
131808844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131808925  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
131809019  JUN; transcription factor Jun [KO:K04448]
131809073  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
131809352  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
131809364  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
131809395  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
131809574  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
131809657  ARTN; artemin [KO:K25415]
131809793  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
131809802  STMN1; stathmin [KO:K04381]
131810037  NGF; beta-nerve growth factor [KO:K02582]
131810066  [KO:K04393]
131810068  RAP1A; ras-related protein Rap-1A [KO:K04353]
131810284  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
131810307  NRAS; GTPase NRas isoform X1 [KO:K07828]
131810524  [KO:K07828]
131810728  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
131810821  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
131811098  CRKL; crk-like protein [KO:K04438]
131811444  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
131811582  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
131811594  [KO:K04393]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131811785  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
131811881  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
131812377  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
131812441  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
131812571  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
131812685  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
131812695  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
131812894  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
131813238  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
131813814  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
131813822  FGF9; fibroblast growth factor 9 [KO:K04358]
131814136  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131814320  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
131814347  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
131814357  EFNA4; ephrin-A4 [KO:K05462]
131814358  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
131814368  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
131814383  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
131814601  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
131814647  EFNA1; ephrin-A1 [KO:K05462]
131814724  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
131814827  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
131814875  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
131814908  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
131814910  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
131814928  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
131814933  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131815106  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
131815252  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
131815534  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
131815578  RELA; transcription factor p65 [KO:K04735]
131815673  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
131815763  ARRB2; beta-arrestin-2 [KO:K04439]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131815809  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131815906  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
131815913  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
131815964  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
131815968  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
131816040  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
131816057  CRK; adapter molecule crk isoform X1 [KO:K04438]
131816095  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
131816125  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
131816173  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
131816348  NF1; neurofibromin isoform X1 [KO:K08052]
131816414  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
131816506  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
131816647  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
131816664  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
131816784  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
131816825  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
131816846  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
131816910  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
131817095  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
131817097  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
131817465  RRAS; ras-related protein R-Ras [KO:K07829]
131817468  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
131817494  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
131817505  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817663  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
131817733  INS; insulin isoform X1 [KO:K04526]
131817764  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
131817821  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131817859  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
131817910  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
131818105  RELB; transcription factor RelB isoform X1 [KO:K09253]
131818296  [KO:K04374]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131818352  FGF21; fibroblast growth factor 21 [KO:K22429]
131818355  NTF4; neurotrophin-4 [KO:K12457]
131818512  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
131818861  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
131818890  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
131818893  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
131818897  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
131818936  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
131819299  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
131819432  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
131819467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
131819600  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131819699  HSPB1; heat shock protein beta-1 [KO:K04455]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819909  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
131819954  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
131819956  FGF5; fibroblast growth factor 5 [KO:K04358]
131820068  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131820333  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
131820340  VEGFC; vascular endothelial growth factor C [KO:K05449]
131820342  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
131820467  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
131820545  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131820615  FGF20; fibroblast growth factor 20 [KO:K04358]
131820646  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
131820782  FLNA; filamin-A isoform X1 [KO:K04437]
131820794  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
131820861  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
131821118  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
131821130  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
131821223  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
131821509  FGF16; fibroblast growth factor 16 [KO:K04358]
131821520  VEGFD; vascular endothelial growth factor D [KO:K05449]
131821842  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
131822182  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
131822216  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
131822739  FGF19; fibroblast growth factor 19 [KO:K22603]
131822740  FGF4; fibroblast growth factor 4 [KO:K04358]
131822741  FGF3; fibroblast growth factor 3 [KO:K04358]
131823103  AREG; amphiregulin [KO:K09782]
131823121  EREG; proepiregulin [KO:K09784]
131823154  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
131823190  EFNA2; ephrin-A2 [KO:K05462]
131823229  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
131823251  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
131823312  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
131823361  NRTN; neurturin [KO:K25414]
131823388  PSPN; persephin [KO:K25416]
131823426  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
131823456  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
131823562  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
131823580  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
131823608  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
131823635  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131823762  JUND; transcription factor JunD [KO:K04449]
131823959  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
131823979  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
131823995  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131824009  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131824017  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131824037  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131824046  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131824370  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
131824456  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
131824584  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
131824683  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
131824725  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
131824772  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
131824888  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
131825063  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
131826401  MYC; myc proto-oncogene protein [KO:K04377]
131826503  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
131826559  STK3; serine/threonine-protein kinase 3 [KO:K04412]
131826895  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
131827068  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
131827086  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
131827098  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131827214  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
131827495  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
131828225  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
131828505  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
131828549  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
131828679  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
131828723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131828824  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131829075  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131829310  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
131829312  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131829655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131829849  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
131829855  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
131829901  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
131829990  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
131830067  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
131830281  FGF8; fibroblast growth factor 8 [KO:K04358]
131830605  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
131830702  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131831160  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131831673  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
131831691  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
131831722  FGF10; fibroblast growth factor 10 [KO:K04358]
131831759  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
131831763  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131831843  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
131831909  FGF18; fibroblast growth factor 18 [KO:K04358]
131831918  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
131831964  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
131832001  [KO:K03283]
131832147  CD14; monocyte differentiation antigen CD14 [KO:K04391]
131832196  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
131832249  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
131832412  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
131832433  RASA1; ras GTPase-activating protein 1 [KO:K04352]
131832443  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
131832511  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
131832665  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131832669  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131833155  [KO:K04393]
131833369  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
131833393  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
131833596  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
131833695  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
131833762  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
131833881  [KO:K03283]
131833998  SRF; serum response factor [KO:K04378]
131834170  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131834189  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
131834191  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
131834240  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
131834291  FGF17; fibroblast growth factor 17 [KO:K04358]
131834338  [KO:K03283]
131834339  [KO:K03283]
131834340  [KO:K03283]
131834372  TNF; tumor necrosis factor isoform X1 [KO:K03156]
131834629  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
131834784  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
131835485  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
131835676  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131835971  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
131836093  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
131836152  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
131836157  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
131836158  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
131836160  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
131836265  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131836639  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
131836691  MAX; protein max isoform X1 [KO:K04453]
131836765  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
131836852  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
131836857  FOS; protein c-Fos [KO:K04379]
131836866  PGF; placenta growth factor isoform X1 [KO:K16859]
131836919  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131837691  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
131838003  [KO:K04347]
131838106  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
131838211  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
131838359  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
131838416  FGF23; fibroblast growth factor 23 [KO:K22428]
131838426  NTF3; neurotrophin-3 [KO:K04356]
131838434  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
131838557  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
131838613  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
131838686  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
131838743  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
131838819  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
131838863  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
131838926  KRAS; GTPase KRas isoform X1 [KO:K07827]
131838931  [KO:K17333]
131839029  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131839131  RAP1B; ras-related protein Rap-1b [KO:K07836]
131839161  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
131839236  KITLG; kit ligand isoform X1 [KO:K05461]
131839239  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
131839335  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
131839423  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
131839444  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
131839489  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
131839494  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
131839499  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
131839502  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
131839655  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
131839656  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
131839672  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
131839695  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131839915  FGF6; fibroblast growth factor 6 [KO:K04358]
131840269  TGFA; protransforming growth factor alpha [KO:K08774]
131840354  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131840429  IL1B; interleukin-1 beta [KO:K04519]
131840430  IL1A; interleukin-1 alpha [KO:K04383]
131840467  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131840495  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131840530  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
131840630  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mlk04070  Phosphatidylinositol signaling system
mlk04110  Cell cycle
mlk04115  p53 signaling pathway
mlk04210  Apoptosis
mlk04310  Wnt signaling pathway
mlk04668  TNF signaling pathway
KO pathway
ko04010   

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