KEGG   PATHWAY: mlk04151
Entry
mlk04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Mustela lutreola (European mink)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlk04151  PI3K-Akt signaling pathway
mlk04151

Other DBs
GO: 0043491
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131807395  YWHAQ; 14-3-3 protein theta [KO:K16197]
131807495  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
131807584  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
131807602  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
131807889  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
131807915  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
131807952  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
131808591  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
131808792  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131808851  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
131808872  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
131808931  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
131808970  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
131809015  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131809060  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
131809364  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
131809395  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
131809520  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
131809657  ARTN; artemin [KO:K25415]
131809675  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
131809752  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
131809984  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
131810003  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
131810037  NGF; beta-nerve growth factor [KO:K02582]
131810162  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
131810292  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
131810307  NRAS; GTPase NRas isoform X1 [KO:K07828]
131810411  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
131810524  [KO:K07828]
131810728  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
131811308  OSM; oncostatin-M [KO:K05418]
131811329  YWHAH; 14-3-3 protein eta [KO:K16198]
131811428  LAMA1; laminin subunit alpha-1 [KO:K05637]
131811551  [KO:K16197]
131811552  [KO:K16197]
131811553  [KO:K16197]
131811573  [KO:K16197]
131811666  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131811825  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
131811845  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
131811907  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
131812092  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
131812130  [KO:K05414]
131812183  TSC1; hamartin isoform X1 [KO:K07206]
131812225  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
131812314  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
131812433  TNC; tenascin isoform X1 [KO:K06252]
131812441  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
131812466  [KO:K05414]
131812513  [KO:K05414]
131812526  [KO:K05414]
131812530  [KO:K05414]
131812531  [KO:K05414]
131812533  [KO:K05414]
131812535  [KO:K05414]
131812554  [KO:K05414]
131812572  [KO:K05414]
131812581  [KO:K05414]
131812595  [KO:K05414]
131812598  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
131812613  [KO:K05414]
131812617  [KO:K05414]
131812618  [KO:K05414]
131812658  [KO:K05414]
131812659  [KO:K05414]
131812737  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
131812775  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
131812838  [KO:K05414]
131813038  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
131813137  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
131813182  IFNB1; interferon beta [KO:K05415]
131813238  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
131813239  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
131813243  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
131813524  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
131813526  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
131813814  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
131813822  FGF9; fibroblast growth factor 9 [KO:K04358]
131813846  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
131814104  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
131814136  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131814284  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
131814287  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
131814357  EFNA4; ephrin-A4 [KO:K05462]
131814358  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
131814364  LAMC2; laminin subunit gamma-2 [KO:K06246]
131814406  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
131814601  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
131814619  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
131814622  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
131814647  EFNA1; ephrin-A1 [KO:K05462]
131814653  BAD; bcl2-associated agonist of cell death [KO:K02158]
131814899  TNR; tenascin-R [KO:K06252]
131814908  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
131814928  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
131814941  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
131815027  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
131815028  TNN; tenascin-N [KO:K06252]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131815290  LAMC1; laminin subunit gamma-1 [KO:K05635]
131815308  LAMB3; laminin subunit beta-3 [KO:K06244]
131815578  RELA; transcription factor p65 [KO:K04735]
131815697  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
131815726  VTN; vitronectin [KO:K06251]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131815809  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131815847  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
131815902  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
131815932  CHAD; chondroadherin [KO:K06248]
131815964  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
131816001  ITGB3; integrin beta-3 [KO:K06493]
131816042  [KO:K05438]
131816060  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
131816081  CSF3; granulocyte colony-stimulating factor [KO:K05423]
131816171  COL1A1; collagen alpha-1(I) chain [KO:K06236]
131816196  [KO:K02991]
131816256  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
131816268  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
131816419  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
131816468  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
131816506  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
131816533  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
131816536  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
131816784  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
131816810  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
131816894  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
131816967  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
131817001  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
131817379  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817663  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
131817733  INS; insulin isoform X1 [KO:K04526]
131817768  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
131818017  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
131818272  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
131818296  [KO:K04374]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131818352  FGF21; fibroblast growth factor 21 [KO:K22429]
131818355  NTF4; neurotrophin-4 [KO:K12457]
131818745  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
131818845  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
131818936  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
131819135  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
131819170  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
131819330  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
131819373  TSC2; tuberin isoform X1 [KO:K07207]
131819466  YWHAG; 14-3-3 protein gamma [KO:K16198]
131819467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
131819528  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
131819701  IBSP; bone sialoprotein 2 [KO:K06253]
131819711  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
131819765  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
131819826  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131819956  FGF5; fibroblast growth factor 5 [KO:K04358]
131820002  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131820306  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
131820333  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
131820340  VEGFC; vascular endothelial growth factor C [KO:K05449]
131820342  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
131820528  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
131820615  FGF20; fibroblast growth factor 20 [KO:K04358]
131820646  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
131820789  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
131820880  MTCP1; protein p13 MTCP-1 [KO:K16837]
131821315  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
131821366  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
131821377  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
131821509  FGF16; fibroblast growth factor 16 [KO:K04358]
131821520  VEGFD; vascular endothelial growth factor D [KO:K05449]
131821562  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
131821676  [KO:K13304] [EC:2.7.11.1]
131822113  [KO:K03259]
131822161  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
131822182  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
131822739  FGF19; fibroblast growth factor 19 [KO:K22603]
131822740  FGF4; fibroblast growth factor 4 [KO:K04358]
131822741  FGF3; fibroblast growth factor 3 [KO:K04358]
131823103  AREG; amphiregulin [KO:K09782]
131823121  EREG; proepiregulin [KO:K09784]
131823154  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
131823185  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
131823190  EFNA2; ephrin-A2 [KO:K05462]
131823267  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
131823312  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
131823313  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
131823361  NRTN; neurturin [KO:K25414]
131823388  PSPN; persephin [KO:K25416]
131823400  [KO:K02991]
131823456  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
131823519  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
131823558  EPOR; erythropoietin receptor [KO:K05079]
131823580  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
131823645  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
131823743  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
131823754  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131823781  COMP; cartilage oligomeric matrix protein [KO:K04659]
131823817  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
131823907  LAMB2; laminin subunit beta-2 [KO:K06243]
131824009  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131824017  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131824103  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131824375  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
131824390  [KO:K02991]
131824529  [KO:K06238]
131824531  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
131824532  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
131824568  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
131824589  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824645  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
131824844  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
131824847  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131825080  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131825176  [KO:K02991]
131825224  [KO:K02991]
131825324  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
131825485  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
131825488  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
131826363  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
131826401  MYC; myc proto-oncogene protein [KO:K04377]
131826440  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
131826503  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
131826540  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
131826589  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
131826682  IL7; interleukin-7 [KO:K05431]
131826753  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
131826998  ITGAV; integrin alpha-V [KO:K06487]
131827022  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
131827068  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
131827091  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
131827098  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131827176  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
131827294  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
131827330  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
131827372  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
131827373  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
131827381  IRS1; insulin receptor substrate 1 [KO:K16172]
131827404  [KO:K04079]
131827486  FN1; fibronectin isoform X1 [KO:K05717]
131827495  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
131827517  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
131828124  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
131828138  [KO:K04542]
131828225  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
131828386  IL2; interleukin-2 [KO:K05429]
131828549  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
131828599  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
131828679  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
131828848  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
131828969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828977  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828978  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131829020  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131829051  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131829232  LAMB1; laminin subunit beta-1 [KO:K05636]
131829234  LAMB4; laminin subunit beta-4 [KO:K06245]
131829247  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
131829275  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
131829300  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
131829310  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131829369  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
131829387  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
131829388  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
131829390  COL1A2; collagen alpha-2(I) chain [KO:K06236]
131829482  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
131829493  IL6; interleukin-6 [KO:K05405]
131829554  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
131829655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131829812  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
131829815  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
131829855  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
131829935  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
131829961  RHEB; GTP-binding protein Rheb [KO:K07208]
131830096  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
131830281  FGF8; fibroblast growth factor 8 [KO:K04358]
131830528  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
131830605  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
131830732  SPP1; osteopontin [KO:K06250]
131831136  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
131831140  [KO:K04736]
131831369  IL4; interleukin-4 [KO:K05430]
131831467  TLR2; toll-like receptor 2 [KO:K10159]
131831649  PRLR; prolactin receptor isoform X1 [KO:K05081]
131831653  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
131831673  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
131831680  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
131831691  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
131831692  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
131831705  GHR; growth hormone receptor isoform X1 [KO:K05080]
131831722  FGF10; fibroblast growth factor 10 [KO:K04358]
131831727  ITGA2; integrin alpha-2 [KO:K06481]
131831728  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
131831759  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
131831763  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131831909  FGF18; fibroblast growth factor 18 [KO:K04358]
131831964  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
131832196  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
131832215  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
131832309  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131832374  F2R; proteinase-activated receptor 1 [KO:K03914]
131832403  THBS4; thrombospondin-4 [KO:K04659]
131832511  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
131832553  [KO:K04079]
131832669  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131833342  THBS2; thrombospondin-2 [KO:K04659]
131833489  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
131833528  [KO:K03259]
131833536  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
131833772  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
131833777  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
131833812  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
131833891  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
131833907  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
131833967  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
131833991  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
131834029  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
131834157  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
131834291  FGF17; fibroblast growth factor 17 [KO:K04358]
131834319  TNXB; tenascin-X isoform X1 [KO:K06252]
131834326  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
131834629  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
131834784  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
131834809  PRL; prolactin isoform X1 [KO:K05439]
131835676  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
131835761  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131835979  ITGA11; integrin alpha-11 [KO:K06587]
131836095  THBS1; thrombospondin-1 [KO:K16857]
131836265  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131836300  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
131836383  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
131836465  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131836560  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
131836664  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
131836866  PGF; placenta growth factor isoform X1 [KO:K16859]
131836998  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
131837003  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131837268  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
131838003  [KO:K04347]
131838068  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
131838241  ITGA8; integrin alpha-8 [KO:K06584]
131838304  [KO:K03258]
131838306  ITGB1; integrin beta-1 [KO:K05719]
131838412  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
131838416  FGF23; fibroblast growth factor 23 [KO:K22428]
131838426  NTF3; neurotrophin-3 [KO:K04356]
131838428  VWF; von Willebrand factor [KO:K03900]
131838449  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
131838470  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
131838541  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
131838613  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
131838622  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
131838635  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
131838659  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
131838703  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
131838711  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
131838743  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
131838903  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
131838926  KRAS; GTPase KRas isoform X1 [KO:K07827]
131839026  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
131839136  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
131839236  KITLG; kit ligand isoform X1 [KO:K05461]
131839335  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
131839347  HSP90B1; endoplasmin [KO:K09487]
131839436  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
131839489  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
131839499  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
131839774  COL2A1; collagen alpha-1(II) chain [KO:K19719]
131839915  FGF6; fibroblast growth factor 6 [KO:K04358]
131840269  TGFA; protransforming growth factor alpha [KO:K08774]
131840447  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mlk00010  Glycolysis / Gluconeogenesis
mlk04010  MAPK signaling pathway
mlk04012  ErbB signaling pathway
mlk04062  Chemokine signaling pathway
mlk04064  NF-kappa B signaling pathway
mlk04068  FoxO signaling pathway
mlk04110  Cell cycle
mlk04115  p53 signaling pathway
mlk04150  mTOR signaling pathway
mlk04210  Apoptosis
mlk04370  VEGF signaling pathway
mlk04510  Focal adhesion
mlk04620  Toll-like receptor signaling pathway
mlk04630  JAK-STAT signaling pathway
mlk04662  B cell receptor signaling pathway
mlk04910  Insulin signaling pathway
KO pathway
ko04151   

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