KEGG   PATHWAY: mpuf04020
Entry
mpuf04020                   Pathway                                
Name
Calcium signaling pathway - Mustela putorius furo (domestic ferret)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mpuf04020  Calcium signaling pathway
mpuf04020

Other DBs
GO: 0019722
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101669870  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101670093  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101670334  EDNRB; endothelin B receptor [KO:K04198]
101670617  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101670625  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
101670702  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101670723  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101671182  TACR2; substance-K receptor isoform X1 [KO:K04223]
101671191  TBXA2R; thromboxane A2 receptor [KO:K04264]
101671296  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101671328  VEGFC; vascular endothelial growth factor C [KO:K05449]
101671344  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
101671348  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101671349  FGF19; fibroblast growth factor 19 [KO:K22603]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101671736  FGF20; fibroblast growth factor 20 [KO:K04358]
101671799  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
101671853  [KO:K04143]
101672107  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101672150  P2RX2; P2X purinoceptor 2 [KO:K05216]
101672160  FIGF; vascular endothelial growth factor D [KO:K05449]
101672634  FGF18; fibroblast growth factor 18 [KO:K04358]
101672676  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101672689  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
101672764  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101672769  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101672983  RYR1; ryanodine receptor 1 [KO:K04961]
101673044  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101673047  [KO:K04282]
101673094  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [KO:K04849]
101673258  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101673442  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101673513  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101673532  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101673644  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101673753  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101673873  P2RX1; P2X purinoceptor 1 [KO:K05215]
101673953  FGF16; fibroblast growth factor 16 [KO:K04358]
101674042  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
101674061  FLT4; vascular endothelial growth factor receptor 3 isoform X8 [KO:K05097] [EC:2.7.10.1]
101674115  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101674156  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101674211  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101674296  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101674583  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101674676  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101674678  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101674771  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
101674862  CALM3; calmodulin [KO:K02183]
101674868  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101674924  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101675037  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101675184  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
101675302  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101675380  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101675381  TACR3; neuromedin-K receptor [KO:K04224]
101675530  FGF4; fibroblast growth factor 4 [KO:K04358]
101675655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101675686  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
101675748  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
101675828  AVPR1B; vasopressin V1b receptor [KO:K04227]
101675837  FGF3; fibroblast growth factor 3 [KO:K04358]
101675854  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675945  VEGFA; vascular endothelial growth factor A [KO:K05448]
101675984  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675997  FGF9; fibroblast growth factor 9 [KO:K04358]
101676150  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101676197  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101676211  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101676243  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
101676370  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101676745  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101676758  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101676816  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101676827  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101676834  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101676981  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
101677051  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
101677543  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101677570  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101677610  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101677799  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101677801  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101678250  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101678347  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101678402  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101678612  ADORA2A; adenosine receptor A2a [KO:K04266]
101678852  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
101678938  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101679131  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101679345  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101679422  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101679448  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101679505  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
101679745  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
101679746  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X10 [KO:K04850]
101679757  CASQ1; calsequestrin-1 [KO:K23468]
101680042  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101680162  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101680196  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101680379  ADORA2B; adenosine receptor A2b [KO:K04267]
101680621  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
101680809  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101680871  FGF5; fibroblast growth factor 5 [KO:K04358]
101680940  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101680942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101681080  FGF10; fibroblast growth factor 10 [KO:K04358]
101681123  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101681131  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101681170  [KO:K02183]
101681283  CCKAR; cholecystokinin receptor type A [KO:K04194]
101681312  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101681327  ORAI3; protein orai-3 [KO:K16058]
101681381  P2RX6; P2X purinoceptor 6 isoform X2 [KO:K05221]
101681427  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101681443  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101681446  [KO:K02183]
101681667  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101681756  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101681986  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101682307  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
101682416  PLN; cardiac phospholamban [KO:K05852]
101682419  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101682554  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101682563  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101682776  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101682911  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101682951  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101682961  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101683071  ASPH; LOW QUALITY PROTEIN: aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
101683074  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101683134  TNNC2; troponin C, skeletal muscle [KO:K12042]
101683168  FGF6; fibroblast growth factor 6 [KO:K04358]
101683196  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101683208  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101683248  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101683393  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
101683475  FGF23; fibroblast growth factor 23 [KO:K22428]
101683487  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101683659  CALM2; calmodulin [KO:K02183]
101683729  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101683760  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101683966  [KO:K04161]
101684065  NTSR1; neurotensin receptor type 1 [KO:K04211]
101684131  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101684190  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101684232  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101684239  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101684361  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101684479  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101684734  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
101684741  TRDN; triadin [KO:K23449]
101685126  OXTR; oxytocin receptor [KO:K04229]
101685175  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101685193  P2RX3; P2X purinoceptor 3 [KO:K05217]
101685230  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
101685356  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101685390  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
101685495  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101685627  DRD1; D(1A) dopamine receptor [KO:K04144]
101685824  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101685981  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101686008  [KO:K10785]
101686107  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
101686129  PTAFR; platelet-activating factor receptor [KO:K04279]
101686132  TACR1; substance-P receptor isoform X1 [KO:K04222]
101686157  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101686929  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101686980  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101687077  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
101687245  EDNRA; endothelin-1 receptor [KO:K04197]
101687308  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101687530  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101687768  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101687790  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101687861  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
101688102  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101688195  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101688476  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101688541  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101688546  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101688646  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101688732  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
101688800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101688912  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101688977  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101689099  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101689134  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101689208  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
101689297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101689486  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
101689541  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
101689701  P2RX7; P2X purinoceptor 7 [KO:K05220]
101689712  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101689839  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101689861  FGF1; fibroblast growth factor 1 [KO:K18496]
101689903  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
101689936  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101690038  TGFA; protransforming growth factor alpha [KO:K08774]
101690321  F2R; proteinase-activated receptor 1 [KO:K03914]
101690442  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101690444  P2RX4; P2X purinoceptor 4 [KO:K05218]
101690739  [KO:K10784]
101690825  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101690957  TPCN2; two pore calcium channel protein 2 isoform X9 [KO:K14077]
101691149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101691254  CALM1; calmodulin [KO:K02183]
101691391  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
101691459  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101691562  [KO:K26467]
101691659  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
101691743  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101691917  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101692081  ORAI2; protein orai-2 [KO:K16057]
101692150  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101692386  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101692436  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101692439  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101692447  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03915]
101692498  CASQ2; calsequestrin-2 [KO:K23445]
101692508  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101692518  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101692594  DRD5; D(1B) dopamine receptor [KO:K05840]
101692668  AVPR1A; vasopressin V1a receptor [KO:K04226]
101692722  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101692938  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101693029  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101693248  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101693327  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
101693424  FGF21; fibroblast growth factor 21 [KO:K22429]
101693787  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101693795  TFEB; transcription factor EB [KO:K15590]
101693846  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
101693907  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101693911  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101693913  FGF8; fibroblast growth factor 8 [KO:K04358]
101693988  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101694006  NGF; beta-nerve growth factor [KO:K02582]
101694142  [KO:K04632]
101694145  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101694209  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101694421  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
101694448  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101694615  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
106003427  [KO:K04632]
106003971  CYSLTR2; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2 [KO:K04323]
106005450  SMIM6; small integral membrane protein 6 [KO:K26468]
106007147  MRLN; myoregulin [KO:K22643]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mpuf04010  MAPK signaling pathway
mpuf04070  Phosphatidylinositol signaling system
mpuf04210  Apoptosis
mpuf04720  Long-term potentiation
mpuf04730  Long-term depression
KO pathway
ko04020   

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