KEGG   PATHWAY: nni04820
Entry
nni04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Nipponia nippon (crested ibis)
Class
Cellular Processes; Cell motility
Pathway map
nni04820  Cytoskeleton in muscle cells
nni04820

Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104008507  ITGA1; integrin alpha-1 [KO:K06480]
104008633  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
104008698  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
104008864  [KO:K19326]
104008903  LAMA2; laminin subunit alpha-2 [KO:K05637]
104008971  AGRN; agrin [KO:K06254]
104008973  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
104009105  TPM2; tropomyosin beta chain [KO:K10374]
104009111  THBS4; thrombospondin-4 [KO:K04659]
104009120  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
104009122  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104009151  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
104009401  [KO:K12314]
104009412  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
104009454  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
104009458  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
104009556  ZYX; zyxin [KO:K06273]
104009563  SDC4; syndecan-4 [KO:K16338]
104009611  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104009676  DAAM1; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1 [KO:K04512]
104009730  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
104009797  [KO:K18267]
104009892  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
104009899  ITGB3; integrin beta-3 [KO:K06493]
104009913  JUP; junction plakoglobin [KO:K10056]
104009985  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
104010032  ITGA6; integrin alpha-6 [KO:K06485]
104010043  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104010052  DES; desmin [KO:K07610]
104010133  SYNE2; LOW QUALITY PROTEIN: nesprin-2 [KO:K19346]
104010144  FN1; fibronectin [KO:K05717]
104010282  ITGA4; integrin alpha-4 [KO:K06483]
104010285  TTN; titin [KO:K12567] [EC:2.7.11.1]
104010331  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
104010355  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
104010371  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
104010779  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
104010981  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
104011027  MYH10; myosin-10 isoform X1 [KO:K10352]
104011080  CSRP1; cysteine and glycine-rich protein 1 isoform X1 [KO:K09377]
104011081  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
104011082  TNNT2; LOW QUALITY PROTEIN: troponin T, cardiac muscle [KO:K12045]
104011110  MYBPH; myosin-binding protein H [KO:K24494]
104011178  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
104011390  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
104011570  FMN2; LOW QUALITY PROTEIN: formin-2 [KO:K02184]
104011646  DCN; decorin [KO:K04660]
104011820  LMOD2; leiomodin-2 [KO:K22030]
104011915  LMNA; lamin [KO:K12641]
104011981  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
104011992  [KO:K23957]
104012011  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
104012250  COL1A1; collagen alpha-1(I) chain [KO:K06236]
104012258  MYL4; myosin light chain 4 [KO:K12750]
104012301  ITGA3; integrin alpha-3 [KO:K06482]
104012305  SGCA; alpha-sarcoglycan [KO:K12565]
104012345  FMNL2; formin-like protein 2 [KO:K23957]
104012361  [KO:K18267]
104012454  ELN; LOW QUALITY PROTEIN: elastin [KO:K14211]
104012504  ITGA2; integrin alpha-2 [KO:K06481]
104012564  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104012565  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
104012600  ATP1A2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
104012665  FBLN1; fibulin-1 [KO:K17307]
104012695  SSPN; LOW QUALITY PROTEIN: sarcospan [KO:K22194]
104012762  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
104012799  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
104012875  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
104012943  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
104013030  NEBL; nebulette [KO:K25865]
104013200  [KO:K28413]
104013311  VIM; vimentin [KO:K07606]
104013324  ITGA8; integrin alpha-8 [KO:K06584]
104013381  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
104013449  [KO:K19867]
104013450  [KO:K19867]
104013477  MYPN; myopalladin [KO:K22028]
104013534  ANK3; ankyrin-3 [KO:K09259]
104013587  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
104013690  COMP; cartilage oligomeric matrix protein [KO:K04659]
104013792  [KO:K19326]
104013832  MYOM2; myomesin-2 [KO:K24495]
104013937  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
104013946  ITGB8; integrin beta-8 [KO:K06591]
104014017  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104014039  SGCE; epsilon-sarcoglycan [KO:K27061]
104014119  MYH15; myosin-15 [KO:K24220]
104014143  [KO:K23932]
104014150  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
104014204  MYOZ3; myozenin-3 [KO:K26050]
104014223  SGCD; delta-sarcoglycan [KO:K12563]
104014277  ACTG1; actin, cytoplasmic 2 isoform X1 [KO:K05692]
104014399  COL5A2; collagen alpha-2(V) chain [KO:K19721]
104014405  COL3A1; collagen alpha-1(III) chain [KO:K19720]
104014456  TMOD4; LOW QUALITY PROTEIN: tropomodulin-4 [KO:K10370]
104014465  ITGA10; integrin alpha-10 [KO:K06586]
104014559  MYH3; myosin-3 [KO:K24220]
104014723  SDC1; syndecan-1 [KO:K06257]
104014744  [KO:K24220]
104014804  SYNE3; nesprin-3 [KO:K21761]
104014909  LMOD1; leiomodin-1 [KO:K22030]
104015029  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
104015071  SUN1; SUN domain-containing protein 1 [KO:K19347]
104015100  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104015304  ITGAV; integrin alpha-V [KO:K06487]
104015311  [KO:K27393]
104015314  [KO:K10374]
104015316  [KO:K06271]
104015333  [KO:K12044]
104015524  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
104015578  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
104015767  MYOM1; LOW QUALITY PROTEIN: myomesin-1 [KO:K24495]
104015865  SDC3; syndecan-3 [KO:K16337]
104015900  ACTC1; actin, alpha cardiac muscle 1 isoform X1 [KO:K12314]
104016486  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
104016493  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104016495  COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
104016510  SDC2; syndecan-2 [KO:K16336]
104016716  [KO:K05692]
104016752  TLN2; talin-2 [KO:K06271]
104016883  TMEM43; transmembrane protein 43 [KO:K27488]
104016927  LMOD3; leiomodin-3 [KO:K22030]
104017039  ITGA11; integrin alpha-11 [KO:K06587]
104017131  FBN1; fibrillin-1 [KO:K06825]
104017146  TMOD2; tropomodulin-2 [KO:K10370]
104017147  TMOD3; tropomodulin-3 [KO:K10370]
104017250  [KO:K07611]
104017515  ANK2; ankyrin-2 [KO:K09255]
104017649  COL11A2; LOW QUALITY PROTEIN: collagen alpha-2(XI) chain [KO:K19721]
104017673  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
104017684  TCAP; telethonin [KO:K19879]
104017736  ACTA1; actin, alpha skeletal muscle [KO:K10354]
104017738  MYOM3; myomesin-3 [KO:K24495]
104017772  MYOZ1; myozenin-1 [KO:K26050]
104017777  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
104017805  FHL3; four and a half LIM domains protein 3 [KO:K24414]
104017845  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
104017909  THBS2; thrombospondin-2 [KO:K04659]
104017965  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
104018014  SNTB1; beta-1-syntrophin [KO:K24064]
104018163  [KO:K07601]
104018338  TNNC2; troponin C, skeletal muscle [KO:K12042]
104018407  COL5A3; collagen alpha-3(V) chain [KO:K19721]
104018455  MYOT; myotilin [KO:K19875]
104018465  [KO:K06271]
104018487  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
104018488  [KO:K06238]
104018497  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
104018573  PLEC; LOW QUALITY PROTEIN: plectin [KO:K10388]
104018578  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
104018657  ITGA9; integrin alpha-9 [KO:K06585]
104018733  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
104018754  FBN3; fibrillin-3 [KO:K23342]
104018787  ITGB5; integrin beta-5 [KO:K06588]
104018848  [KO:K24220]
104018915  FMNL1; formin-like protein 1 [KO:K23957]
104018919  ITGA2B; integrin alpha-IIb [KO:K06476]
104018950  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
104019090  ATP1B4; protein ATP1B4 [KO:K01540]
104019131  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
104019132  SYNPO2; synaptopodin-2 [KO:K24066]
104019261  LMNB1; lamin-B1 [KO:K07611]
104019277  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
104019350  FHL2; four and a half LIM domains protein 2 [KO:K14380]
104019401  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104019484  NID2; nidogen-2 [KO:K06826]
104019546  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
104019772  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
104019806  DSG2; LOW QUALITY PROTEIN: desmoglein-2 [KO:K07597]
104019875  NID1; nidogen-1 [KO:K06826]
104019924  MYH7B; myosin-7B [KO:K24220]
104019952  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
104019979  SNTA1; alpha-1-syntrophin [KO:K24063]
104020090  DMD; dystrophin [KO:K10366]
104020126  VCL; vinculin [KO:K05700]
104020258  PKP2; plakophilin-2 [KO:K12642]
104020266  CKM; creatine kinase M-type [KO:K27382]
104020294  THBS1; thrombospondin-1 [KO:K16857]
104020344  CAPN3; calpain-3 [KO:K08573] [EC:3.4.22.54]
104020349  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
104020386  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
104020504  THBS3; thrombospondin-3 [KO:K04659]
104020785  SGCZ; zeta-sarcoglycan [KO:K27062]
104020811  SGCB; beta-sarcoglycan [KO:K12566]
104020920  [KO:K06115]
104021196  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
104021295  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
104021503  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
104021572  MYH9; myosin-9 [KO:K10352]
104021616  SUN2; SUN domain-containing protein 2 [KO:K19347]
104021723  MYL3; myosin light chain 3 [KO:K12749]
104021756  [KO:K27381]
104021764  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
104021830  DSP; desmoplakin [KO:K10381]
104021992  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104022168  FBLN2; fibulin-2 [KO:K17307]
104022255  ITGB1; integrin beta-1 [KO:K05719]
104022337  NRAP; nebulin-related-anchoring protein [KO:K24421]
104022409  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
104022500  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
104022591  FBN2; fibrillin-2 isoform X1 [KO:K23342]
104022604  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
104022642  TMOD1; tropomodulin-1 [KO:K10370]
104022852  ITGB4; integrin beta-4 [KO:K06525]
104022913  LMNB2; lamin-B2 [KO:K07611]
104022927  DAG1; LOW QUALITY PROTEIN: dystroglycan [KO:K06265]
104022980  ACTG2; LOW QUALITY PROTEIN: actin, gamma-enteric smooth muscle [KO:K12315]
104022993  VCAN; versican core protein isoform X1 [KO:K06793]
104023034  SGCG; gamma-sarcoglycan [KO:K12564]
104023144  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
104023201  COL5A1; collagen alpha-1(V) chain [KO:K19721]
104023605  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
104023616  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
nni04512  ECM-receptor interaction
nni04814  Motor proteins
KO pathway
ko04820   

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