KEGG   PATHWAY: ajm05132
Entry
ajm05132                    Pathway                                
Name
Salmonella infection - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ajm05132  Salmonella infection
ajm05132

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119064271  PODXL; podocalyxin [KO:K06817]
119053401  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
119048325  RAB5A; ras-related protein Rab-5A [KO:K07887]
119050791  ras-related protein Rab-5A-like [KO:K07887]
119048547  RAB5B; ras-related protein Rab-5B [KO:K07888]
119037516  RAB5C; ras-related protein Rab-5C [KO:K07889]
119040502  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
119039036  RAB7A; ras-related protein Rab-7a [KO:K07897]
119063693  ras-related protein Rab7-like [KO:K07897]
119058095  ras-related protein Rab7 [KO:K07897]
119056840  RAB7B; ras-related protein Rab-7b [KO:K07898]
119042696  putative pleckstrin homology domain-containing family M member 1P [KO:K23282]
119061557  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
119050784  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
119046241  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
119061297  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
119060777  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
119061222  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
119040136  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
119040915  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
119040684  rab-interacting lysosomal protein isoform X1 [KO:K13883]
119037954  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
119061505  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
119044928  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
119042900  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
119051513  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
119061893  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
119061527  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
119046624  dynein light chain 1, cytoplasmic [KO:K10418]
119062636  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
119057382  dynein light chain 1, cytoplasmic-like [KO:K10418]
119057433  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
119063271  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
119049239  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
119034983  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
119063660  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
119038365  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
119035662  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
119053851  DCTN3; dynactin subunit 3 [KO:K10425]
119061351  DCTN4; dynactin subunit 4 [KO:K10426]
119059245  DCTN5; dynactin subunit 5 [KO:K10427]
119036880  DCTN6; dynactin subunit 6 [KO:K10428]
119059665  ACTR1A; alpha-centractin [KO:K16575]
119055994  ACTR1B; beta-centractin [KO:K16575]
119045110  ACTR10; actin-related protein 10 [KO:K16576]
119044362  TUBA8; tubulin alpha-8 chain [KO:K07374]
119038898  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
119038913  tubulin alpha-3 chain-like [KO:K07374]
119042369  tubulin alpha-1A chain-like [KO:K07374]
119042383  TUBA1A; tubulin alpha-1A chain [KO:K07374]
119042392  tubulin alpha-1C chain [KO:K07374]
119056884  tubulin alpha-4A chain [KO:K07374]
119056902  tubulin alpha-1D chain [KO:K07374]
119057309  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
119057933  tubulin alpha-2 chain [KO:K07374]
119035893  tubulin beta chain-like [KO:K07375]
119036117  TUBB4B; tubulin beta-4B chain [KO:K07375]
119043932  tubulin beta chain-like [KO:K07375]
119041269  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
119051789  tubulin beta-2B chain [KO:K07375]
119051790  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
119046346  TUBB; tubulin beta chain [KO:K07375]
119047208  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
119055365  TUBB1; tubulin beta-1 chain [KO:K07375]
119063792  TUBB4A; tubulin beta-4A chain [KO:K07375]
119050603  tubulin beta-1 chain [KO:K07375]
119037602  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
119036620  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
119060783  ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955]
119049960  PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
119035670  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
119064196  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
119065583  KIF5C; kinesin heavy chain [KO:K10396]
119041903  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
119051343  KLC3; kinesin light chain 3 [KO:K10407]
119063096  KLC1; kinesin light chain 1 [KO:K10407]
119056066  KLC4; kinesin light chain 4 [KO:K10407]
119044452  ACBD3; Golgi resident protein GCP60 [KO:K23935]
119036699  RHOA; transforming protein RhoA [KO:K04513]
119059816  transforming protein RhoA-like [KO:K04513]
119047326  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
119065673  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
119046101  RAB9B; ras-related protein Rab-9B [KO:K07900]
119044129  GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
119049674  STX10; syntaxin-10 isoform X1 [KO:K23937]
119035155  PFN3; profilin-3 [KO:K05759]
119053003  PFN2; profilin-2 isoform X1 [KO:K05759]
119048602  PFN1; profilin-1 [KO:K05759]
119063841  PFN4; profilin-4 [KO:K05759]
119051411  FLNA; filamin-A isoform X1 [KO:K04437]
119058525  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
119045074  EXOC5; exocyst complex component 5 [KO:K19984]
119064227  EXOC4; exocyst complex component 4 [KO:K06111]
119047275  EXOC2; exocyst complex component 2 [KO:K17637]
119059209  ras-related protein Ral-A-like [KO:K07834]
119055899  RALA; ras-related protein Ral-A [KO:K07834]
119041512  ACTB; actin, cytoplasmic 1 [KO:K05692]
119046540  actin-5C-like [KO:K05692]
119058560  ACTG1; actin, cytoplasmic 2 [KO:K05692]
119039502  protein S100-A10-like [KO:K17274]
119060893  protein S100-A10-like [KO:K17274]
119048126  S100A10; protein S100-A10 [KO:K17274]
119042799  LOW QUALITY PROTEIN: annexin A2-like [KO:K17092]
119053464  ANXA2; annexin A2 [KO:K17092]
119035317  AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
119034871  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
119045350  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
119035391  rho-related GTP-binding protein RhoG-like [KO:K07863]
119042085  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
119035263  engulfment and cell motility protein 1 [KO:K12366]
119035264  engulfment and cell motility protein 1-like [KO:K12366]
119063242  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
119053927  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
119040469  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
119035521  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
119052883  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
119063288  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
119044655  MYL10; myosin regulatory light chain 10 [KO:K12756]
119042370  myosin regulatory light chain 12B [KO:K12757]
119042371  myosin regulatory light polypeptide 9 [KO:K12757]
119058905  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
119061902  FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
119042192  CDC42; cell division control protein 42 homolog [KO:K04393]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119051762  rho-related BTB domain-containing protein 1-like [KO:K04392]
119038645  NCKAP1; nck-associated protein 1 [KO:K05750]
119059833  NCKAP1L; nck-associated protein 1-like [KO:K05750]
119039848  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
119054357  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
119050161  ABI1; abl interactor 1 isoform X1 [KO:K23649]
119043665  protein BRICK1-like [KO:K05752]
119041444  BRK1; protein BRICK1 [KO:K05752]
119043228  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
119035060  ACTR2; actin-related protein 2 [KO:K17260]
119039251  ACTR3B; actin-related protein 3B [KO:K18584]
119048446  ACTR3; actin-related protein 3 [KO:K18584]
119058615  actin-related protein 3C-like [KO:K18584]
119043982  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
119043987  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
119043429  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
119039504  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
119048883  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
119041402  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
119061623  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
119049622  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
119044299  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119040297  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
119041116  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
119040142  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119053038  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
119042851  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
119053072  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
119056788  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
119044872  CYTH2; cytohesin-2 [KO:K18441]
119043664  cytohesin-2-like [KO:K18441]
119041510  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
119060305  CYTH4; cytohesin-4 [KO:K18441]
119058682  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
119057048  ARF6; ADP-ribosylation factor 6 [KO:K07941]
119045701  ARF1; ADP-ribosylation factor 1 [KO:K07937]
119061632  LOW QUALITY PROTEIN: ADP-ribosylation factor 2-like [KO:K07937]
119038573  SNX33; sorting nexin-33 [KO:K17923]
119034981  SNX9; sorting nexin-9 [KO:K17923]
119049171  SNX18; sorting nexin-18 [KO:K17923]
119052574  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
119055680  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
119045601  TLR6; toll-like receptor 6 [KO:K10169]
119065905  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
119041089  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
119051446  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
119040610  monocyte differentiation antigen CD14-like [KO:K04391]
119051069  CD14; monocyte differentiation antigen CD14 [KO:K04391]
119056324  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
119053418  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
119036537  TLR5; toll-like receptor 5 [KO:K10168]
119036673  toll-like receptor 9 isoform X1 [KO:K10161]
119053563  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
119061695  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119036455  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119041421  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119060232  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119057909  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119035636  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119050282  RELA; transcription factor p65 [KO:K04735]
119035221  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
119037939  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119041136  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta-3 [KO:K04079]
119046156  heat shock protein 90-5, chloroplastic-like [KO:K04079]
119061428  endoplasmin homolog [KO:K04079]
119047198  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119047665  heat shock protein 81-1 [KO:K04079]
119060253  HSP90B1; endoplasmin [KO:K09487]
119047894  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
119063234  CSE1L; exportin-2 [KO:K18423]
119039625  KPNA1; importin subunit alpha-5 [KO:K23940]
119035118  KPNA4; importin subunit alpha-3 [KO:K23583]
119059622  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
119038949  RPS3; 40S ribosomal protein S3 [KO:K02985]
119049928  40S ribosomal protein S3-3-like [KO:K02985]
119062206  HRAS; GTPase HRas isoform X1 [KO:K02833]
119044815  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119063754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119062274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119036284  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119060490  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119060539  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050071  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050081  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119061575  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
119057169  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119059334  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119049259  FOS; proto-oncogene c-Fos [KO:K04379]
119051654  JUN; transcription factor AP-1 [KO:K04448]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119045049  interleukin-1 beta-like [KO:K04519]
119065847  IL1B; interleukin-1 beta [KO:K04519]
119042560  IL6; interleukin-6 isoform X1 [KO:K05405]
119052814  CXCL8; interleukin-8 [KO:K10030]
119052819  C-X-C motif chemokine 15-like [KO:K10030]
119051448  CTNNB1; catenin beta-1 [KO:K02105]
119037608  TCF7; transcription factor 7 isoform X1 [KO:K02620]
119059869  TCF7L1; transcription factor 7-like 1 [KO:K04490]
119040094  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
119061436  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
119064823  MYC; myc proto-oncogene protein [KO:K04377]
119049697  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
119057252  FBXO22; F-box only protein 22 [KO:K10302]
119037619  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
119060225  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119061887  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
119054065  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
119054066  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
119051788  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119043154  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119059345  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119060182  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
119045596  glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic [KO:K00134] [EC:1.2.1.12]
119048587  glyceraldehyde-3-phosphate dehydrogenase 2-like [KO:K00134] [EC:1.2.1.12]
119056868  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119065099  glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic isoform X1 [KO:K00134] [EC:1.2.1.12]
119050287  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
119043451  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
119041884  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722]
119054722  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
119041863  FADD; FAS-associated death domain protein [KO:K02373]
119065511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119037319  RIPK3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
119037607  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
119041220  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
119035254  cytochrome c [KO:K08738]
119035643  cytochrome c-like [KO:K08738]
119057575  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119036917  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119040063  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
119055055  caspase-8-like [KO:K04397] [EC:3.4.22.60]
119054006  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
119043888  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
119046000  RRAS; ras-related protein R-Ras [KO:K07829]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119048932  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
119060402  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
119045416  thioredoxin H2-like [KO:K03671]
119045417  thioredoxin H2-like [KO:K03671]
119054719  TXN; thioredoxin [KO:K03671]
119062361  thioredoxin-3, mitochondrial-like [KO:K03671]
119051579  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
119037382  baculoviral IAP repeat-containing protein 1 [KO:K12807]
119052078  baculoviral IAP repeat-containing protein 1 [KO:K12807]
119050344  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
119036945  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119038029  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119051385  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
119060758  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
119056534  IL18; interleukin-18 [KO:K05482]
119060734  caspase-13-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119060770  caspase-1-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119060787  caspase-13-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119064645  GSDMD; gasdermin-D [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ajm04010  MAPK signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04210  Apoptosis
ajm04217  Necroptosis
ajm04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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