KEGG   PATHWAY: bbis05208
Entry
bbis05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Bison bison bison (American bison)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05208

Organism
Bison bison bison (American bison) [GN:bbis]
Gene
105002663  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
104992390  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
104992391  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
104992393  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
104992394  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105005138  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
104981282  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
104981662  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
104981663  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
104981664  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
104981665  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
104981667  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
104981668  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
104982614  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105002207  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105002640  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
105002642  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105002643  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105003033  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105003076  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105003120  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
104997305  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
104986953  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
104992940  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105002486  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
104984944  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105005064  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
104994319  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
104996211  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
104985114  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
104992516  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
104998949  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
104988113  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
104982372  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
104991249  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
104979755  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
104997333  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
104992211  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
104991413  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
104986581  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
104979718  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105001631  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
104993848  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
104985816  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
104999382  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105003651  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
104992487  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
104999985  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
104988316  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
104999881  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105002710  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
104987825  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
104993066  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105003689  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
104984069  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
104990360  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105001053  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105004940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105000994  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
104991945  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
104986948  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
104981278  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
104998165  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
104982907  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105002322  uncharacterized protein LOC105002322 [KO:K00235] [EC:1.3.5.1]
104984077  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
104981313  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
104996455  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
104991620  cytochrome c1, heme protein, mitochondrial [KO:K00413]
104997238  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
104986557  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
104994337  uncharacterized protein LOC104994337 isoform X1 [KO:K00416]
104983936  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
104991872  cytochrome b-c1 complex subunit 8 [KO:K00418]
104980133  cytochrome b-c1 complex subunit 9 [KO:K00419]
104991884  cytochrome b-c1 complex subunit 10 [KO:K00420]
104989916  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
104996547  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
104990981  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
104980817  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
104980053  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
104986689  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105004715  cytochrome c oxidase subunit 6B1-like [KO:K02267]
104994988  cytochrome c oxidase subunit 6B2 [KO:K02267]
104995249  cytochrome c oxidase subunit 6B1 [KO:K02267]
105005500  cytochrome c oxidase subunit 6C [KO:K02268]
104999701  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
104995277  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
104990309  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
104985374  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
104992608  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
104995784  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
105002319  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
104994451  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104982497  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105002443  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105003933  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
104987180  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
104990096  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
104988090  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
104998122  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
104991898  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
104988011  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105001340  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
104981633  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
104982380  LOW QUALITY PROTEIN: uncharacterized protein LOC104982380 [KO:K02128]
105001728  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
104983594  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
104990591  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105002940  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105000333  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
105004610  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
104987493  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
104989284  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
104991863  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104997530  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
104993226  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104983051  ADP/ATP translocase 3-like [KO:K05863]
105003222  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
104985546  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105003788  ADP/ATP translocase 2-like [KO:K05863]
104984455  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105004636  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
104982462  CAT; catalase [KO:K03781] [EC:1.11.1.6]
104984507  SLC26A1; sulfate anion transporter 1 [KO:K14700]
104996305  SLC26A2; sulfate transporter [KO:K14701]
104997236  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
104998814  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
104991054  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
104984098  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
104995373  cytochrome P450 2F3 [KO:K07416] [EC:1.14.14.1]
104990991  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
104999966  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
104997889  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
104988717  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
104984309  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
105003326  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
104994325  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
104985980  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985985  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985990  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985991  LOW QUALITY PROTEIN: dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985992  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985994  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985995  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985998  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104985999  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104986133  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
104996648  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
104984897  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
104984898  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
105004539  AHR; aryl hydrocarbon receptor [KO:K09093]
104984995  aryl hydrocarbon receptor-like [KO:K09093]
105004107  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
104991474  cytochrome b-245 light chain [KO:K08009]
104998946  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104998082  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
105002073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
104990172  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104994516  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104981942  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104999941  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104990277  SOS2; son of sevenless homolog 2 [KO:K03099]
105003692  HRAS; GTPase HRas [KO:K02833]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
104981582  NRAS; GTPase NRas [KO:K07828]
104999018  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
104999381  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104979900  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104995620  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104991715  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104990873  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104979935  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
104998999  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104992939  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104981526  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104981967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104981977  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104994938  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104994939  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105000175  JUN; transcription factor AP-1 [KO:K04448]
105000057  FOS; proto-oncogene c-Fos [KO:K04379]
104998445  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104992716  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104994333  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104999978  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105001799  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104996058  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104988870  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
104986245  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
104995356  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104989637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
105003597  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105000706  FOXO3; forkhead box protein O3 [KO:K09408]
104987190  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
104985082  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
104987508  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105002719  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104993223  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
104985237  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104987029  RELA; transcription factor p65 [KO:K04735]
104994637  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104997117  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104990365  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
104994751  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
104983540  low molecular weight phosphotyrosine protein phosphatase-like isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
104980033  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104996105  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
104980465  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105000878  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
104996021  ABL2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
104987583  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
104991069  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
104997726  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
104984862  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104993960  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
104985201  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
104982962  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104994167  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
104987656  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
105005203  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104979822  KEAP1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
105002927  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
105002802  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
bbis00190  Oxidative phosphorylation
bbis00980  Metabolism of xenobiotics by cytochrome P450
bbis04010  MAPK signaling pathway
bbis04064  NF-kappa B signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04370  VEGF signaling pathway
bbis05207  Chemical carcinogenesis - receptor activation
bbis05211  Renal cell carcinoma
bbis05215  Prostate cancer
bbis05219  Bladder cancer
bbis05221  Acute myeloid leukemia
bbis05222  Small cell lung cancer
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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