KEGG   PATHWAY: cdk04024
Entry
cdk04024                    Pathway                                
Name
cAMP signaling pathway - Camelus dromedarius (Arabian camel)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
cdk04024  cAMP signaling pathway
cdk04024

Other DBs
GO: 0019933
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105100928  VIP; VIP peptides [KO:K05264]
105097729  CRH; corticoliberin isoform X1 [KO:K05256]
105095553  CGA; glycoprotein hormones alpha chain [KO:K08522]
105102917  lutropin subunit beta [KO:K08521]
105102627  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
105086206  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
105089625  TSHB; thyrotropin subunit beta [KO:K05251]
105100044  POMC; pro-opiomelanocortin [KO:K05228]
105093688  GCG; glucagon isoform X1 [KO:K05259]
105095772  GIP; gastric inhibitory polypeptide isoform X1 [KO:K05258]
105106548  FSHB; follitropin subunit beta [KO:K05250]
105107036  NPPA; natriuretic peptide A precursor [KO:K12334]
105086153  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
105104750  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
105097013  ADRB2; beta-2 adrenergic receptor [KO:K04142]
105101941  DRD1; D(1A) dopamine receptor [KO:K04144]
105085135  DRD5; D(1B) dopamine receptor [KO:K05840]
105095191  ADORA2A; adenosine receptor A2a [KO:K04266]
105097010  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105103975  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105091422  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
105095853  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
105101918  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
105090500  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
105095848  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
105092350  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
105086050  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
105086494  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
105086763  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
105095477  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
105098811  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
105092374  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
105089423  NPR1; atrial natriuretic peptide receptor 1 isoform X3 [KO:K12323] [EC:4.6.1.2]
105095656  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
105095655  neuroendocrine secretory protein 55 [KO:K04632]
105102504  EDN1; endothelin-1 [KO:K16366]
105105487  EDN2; endothelin-2 [KO:K16367]
105095661  EDN3; endothelin-3 isoform X2 [KO:K05227]
105085836  SST; somatostatin [KO:K05237]
105095076  NPY; pro-neuropeptide Y [KO:K05232]
105093114  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
105088881  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
105087766  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
105104748  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
105084740  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
105095554  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
105091516  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105091619  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105091720  DRD2; D(2) dopamine receptor isoform X2 [KO:K04145]
105086898  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X2 [KO:K04615]
105101142  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
105092098  ADORA1; adenosine receptor A1 isoform X2 [KO:K04265]
105091204  EDNRA; endothelin-1 receptor [KO:K04197]
105094356  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
105092132  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
105085687  somatostatin receptor type 2 [KO:K04218]
105103337  SSTR5; somatostatin receptor type 5 [KO:K04221]
105102532  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
105102531  hydroxycarboxylic acid receptor 2-like [KO:K08402]
105088040  free fatty acid receptor 2-like [KO:K04328]
105095003  SUCNR1; succinate receptor 1 [KO:K10042]
105096638  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
105093178  OXTR; oxytocin receptor [KO:K04229]
105085945  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
105087520  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105085647  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
105100375  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105095715  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105094039  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105100030  ADCY3; adenylate cyclase type 3 isoform X5 [KO:K08043] [EC:4.6.1.1]
105102432  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105090284  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105103816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105097528  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105096450  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
105099828  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105086742  adenylate cyclase type 10-like isoform X7 [KO:K11265] [EC:4.6.1.1]
105092727  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
105099941  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
105088737  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
105099797  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
105097987  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
105093804  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
105088493  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
105096001  CALM1; calmodulin-1 [KO:K02183]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105104026  CALM3; calmodulin-3 [KO:K02183]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105092364  CALM2; calmodulin-2 [KO:K02183]
116147086  calmodulin-like [KO:K02183]
105089916  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
105098484  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105092453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105092345  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105095388  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
105097141  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
105090324  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
105097140  POPDC3; popeye domain-containing protein 3 [KO:K26207]
105099341  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
105093409  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
105087325  HCN4; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
105089214  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
105103807  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
105091096  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X5 [KO:K04351]
105100199  RRAS; ras-related protein R-Ras [KO:K07829]
105086689  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105085948  PLD1; phospholipase D1 isoform X5 [KO:K01115] [EC:3.1.4.4]
105101475  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
105084245  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105091591  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
105094659  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105100625  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105102039  RAP1A; ras-related protein Rap-1A [KO:K04353]
105101089  RAP1B; ras-related protein Rap-1b [KO:K07836]
105086777  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105085620  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105102810  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
105087660  VAV1; proto-oncogene vav [KO:K05730]
105101582  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105102215  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105097456  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105090802  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105091826  AFDN; afadin [KO:K05702]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105091663  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105095035  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105100776  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105099045  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
105098564  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105104430  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105102484  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105093562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
105089327  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105106926  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105105303  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105091622  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105102288  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105095833  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105091909  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105099829  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105106448  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
105086086  FOS; proto-oncogene c-Fos [KO:K04379]
105092850  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
105092340  GLI3; LOW QUALITY PROTEIN: transcriptional activator GLI3 [KO:K06230]
105100348  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
105084688  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
105091215  HHIP; hedgehog-interacting protein [KO:K06231]
105092140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105085716  LOW QUALITY PROTEIN: transcription factor SOX-9 [KO:K18435]
116157939  LOW QUALITY PROTEIN: transcription factor SOX-9-like [KO:K18435]
105103624  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
105091841  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
105103342  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
105105527  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X2 [KO:K00232] [EC:1.3.3.6]
105103850  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105084810  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105090211  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
105086272  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105091254  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105084895  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
105084979  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105098776  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
105088346  PLN; cardiac phospholamban [KO:K05852]
105102781  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105095745  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105102497  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105088820  ryanodine receptor 2 isoform X1 [KO:K04962]
105106183  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105089056  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105096536  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105104658  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105098957  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105086908  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105104134  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105095156  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
105101175  GRIA2; glutamate receptor 2 isoform X3 [KO:K05198]
105098887  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
105095418  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
105085325  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
116147050  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
105100141  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
105089616  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
105090227  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
105086324  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
105092738  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
105098894  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
105103012  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
105090183  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
105088031  FXYD1; phospholemman [KO:K13360]
105100703  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105102512  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
105103904  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105104496  ATP2B4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
105093111  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105094859  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105100748  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105093176  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105103284  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105090835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105096493  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
105086706  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
105084725  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
105096675  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
105101872  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
105087635  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
105086282  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
cdk00071  Fatty acid degradation
cdk04015  Rap1 signaling pathway
cdk04020  Calcium signaling pathway
cdk04151  PI3K-Akt signaling pathway
cdk04210  Apoptosis
cdk04260  Cardiac muscle contraction
cdk04340  Hedgehog signaling pathway
cdk04720  Long-term potentiation
cdk04740  Olfactory transduction
cdk04972  Pancreatic secretion
cdk04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system