KEGG   PATHWAY: cdk04151
Entry
cdk04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Camelus dromedarius (Arabian camel)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cdk04151  PI3K-Akt signaling pathway
cdk04151

Other DBs
GO: 0043491
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105084260  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
105084263  ITGA2; integrin alpha-2 [KO:K06481]
105084316  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105084371  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105084385  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105084403  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105084416  VEGFC; vascular endothelial growth factor C [KO:K05449]
105084522  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105084810  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
105084831  THBS4; thrombospondin-4 [KO:K04659]
105085059  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105085129  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105085161  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
105085191  TSC1; hamartin isoform X1 [KO:K07206]
105085282  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
105085321  [KO:K05099] [EC:2.7.10.1]
105085658  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
105085741  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105085924  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105086095  PGF; placenta growth factor isoform X5 [KO:K16859]
105086205  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105086379  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105086385  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105086476  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
105086582  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105086584  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105086605  FN1; fibronectin isoform X1 [KO:K05717]
105086620  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105086756  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105086861  [KO:K16198]
105086937  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
105086987  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105087002  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105087006  PRLR; prolactin receptor [KO:K05081]
105087105  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105087124  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
105087311  ITGA11; integrin alpha-11 [KO:K06587]
105087555  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105087606  EPOR; erythropoietin receptor [KO:K05079]
105087636  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105087776  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
105087982  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
105088124  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105088189  VTN; vitronectin [KO:K06251]
105088289  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
105088300  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
105088301  IRS1; insulin receptor substrate 1 [KO:K16172]
105088376  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
105088534  IL7; interleukin-7 isoform X2 [KO:K05431]
105088562  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105088586  EPO; erythropoietin [KO:K05437]
105088611  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105088633  VEGFA; vascular endothelial growth factor A [KO:K05448]
105088639  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105088734  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105088740  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105088741  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105088747  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
105088769  [KO:K06238]
105088770  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105088773  [KO:K06238]
105088827  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105088884  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105088931  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105088937  TGFA; protransforming growth factor alpha [KO:K08774]
105088956  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105088998  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105089122  PRL; prolactin isoform X2 [KO:K05439]
105089327  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105089365  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105089379  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105089538  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105089623  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105089630  NRAS; GTPase NRas [KO:K07828]
105089638  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105089663  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105089727  YWHAG; 14-3-3 protein gamma [KO:K16198]
105089868  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
105089871  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105089905  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105089940  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105090092  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105090136  IL4; interleukin 4 precursor [KO:K05430]
105090274  ITGB5; integrin beta-5 [KO:K06588]
105090279  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105090321  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105090400  [KO:K05438]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105090484  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105090493  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105090509  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105090535  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105090586  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
105090598  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
105090729  ITGA9; integrin alpha-9 [KO:K06585]
105090819  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105090854  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
105090860  TNXB; tenascin-X isoform X1 [KO:K06252]
105091062  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
105091094  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105091237  YWHAQ; 14-3-3 protein theta [KO:K16197]
105091325  FGF6; fibroblast growth factor 6 [KO:K04358]
105091327  CCND2; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2 [KO:K10151]
105091333  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
105091372  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105091410  AREG; amphiregulin [KO:K09782]
105091467  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105091500  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105091516  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105091541  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105091573  SPP1; osteopontin [KO:K06250]
105091574  IBSP; bone sialoprotein 2 [KO:K06253]
105091598  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105091619  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105091622  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105091760  NRTN; LOW QUALITY PROTEIN: neurturin [KO:K25414]
105091789  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105091790  PSPN; persephin [KO:K25416]
105091818  THBS2; thrombospondin-2 [KO:K04659]
105091928  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105091934  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105092005  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105092030  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
105092123  EREG; proepiregulin [KO:K09784]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105092482  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105092504  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105092564  PKN3; serine/threonine-protein kinase N3 isoform X3 [KO:K23692]
105092770  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105092817  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105092896  ITGB8; integrin beta-8 [KO:K06591]
105092913  [KO:K02649]
105092985  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
105093004  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
105093031  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105093049  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105093058  LAMB1; laminin subunit beta-1 [KO:K05636]
105093059  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093420  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105093441  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105093562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
105093613  TEK; angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
105093664  IL2; interleukin 2 precursor [KO:K05429]
105093669  FGF2; fibroblast growth factor 2 [KO:K18497]
105093695  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105094015  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105094076  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
105094080  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105094168  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
105094245  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105094425  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
105094574  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105094580  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105094866  KITLG; kit ligand isoform X1 [KO:K05461]
105095042  GNG5; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105095047  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105095065  IL6; interleukin-6 [KO:K05405]
105095121  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105095246  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4 [KO:K05631]
105095397  EFNA5; ephrin-A5 [KO:K05462]
105095427  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105095567  FGF16; fibroblast growth factor 16 [KO:K04358]
105095694  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105095699  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
105095814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105095833  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105095932  [KO:K05414]
105095933  IFNB1; interferon beta [KO:K05415]
105095942  RPS6; 40S ribosomal protein S6 [KO:K02991]
105095980  [KO:K13304] [EC:2.7.11.1]
105096085  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
105096092  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
105096227  LAMC2; laminin subunit gamma-2 [KO:K06246]
105096228  LAMC1; laminin subunit gamma-1 [KO:K05635]
105096330  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
105096363  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105096404  FGF9; LOW QUALITY PROTEIN: fibroblast growth factor 9 [KO:K04358]
105096434  [KO:K04289]
105096445  MYC; myc proto-oncogene protein [KO:K04377]
105096485  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
105096784  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105096838  MTCP1; protein p13 MTCP-1 [KO:K16837]
105096896  THBS1; thrombospondin-1 [KO:K16857]
105096922  ITGA8; integrin alpha-8 [KO:K06584]
105097118  FOXO3; forkhead box protein O3 [KO:K09408]
105097468  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105097473  HSP90B1; endoplasmin [KO:K09487]
105097515  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105097571  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105097742  CHAD; chondroadherin [KO:K06248]
105097761  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
105097829  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105098202  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105098214  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105098230  VWF; von Willebrand factor [KO:K03900]
105098257  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
105098452  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105098486  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105098488  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105098696  RHEB; GTP-binding protein Rheb [KO:K07208]
105098747  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105098843  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105098976  ITGAV; integrin alpha-V precursor [KO:K06487]
105098995  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105098997  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105099031  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
105099069  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105099215  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105099311  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105099347  LAMB3; laminin subunit beta-3 [KO:K06244]
105099415  YWHAH; 14-3-3 protein eta [KO:K16198]
105099434  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
105099450  OSM; oncostatin-M [KO:K05418]
105099555  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
105099582  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105099614  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105099620  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
105099662  TLR2; toll-like receptor 2 [KO:K10159]
105099701  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
105099710  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105099714  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105099963  TNR; tenascin-R [KO:K06252]
105099990  TNN; tenascin-N isoform X1 [KO:K06252]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105100207  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105100330  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105100369  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105100389  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105100399  VEGFD; vascular endothelial growth factor D [KO:K05449]
105100473  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105100622  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105100650  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105100821  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
105100875  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105101003  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
105101050  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105101086  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105101177  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105101330  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
105101542  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105101578  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
105101802  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105101858  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105101885  COMP; cartilage oligomeric matrix protein [KO:K04659]
105101970  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105102061  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105102288  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105102343  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
105102396  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105102409  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105102628  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105102783  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105102821  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105102875  COL6A3; collagen alpha-3(VI) chain isoform X3 [KO:K06238]
105102886  NTF4; neurotrophin-4 [KO:K12457]
105102888  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105102899  FGF21; fibroblast growth factor 21 [KO:K22429]
105102978  [KO:K06856]
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105103091  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
105103187  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105103232  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
105103374  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105103393  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105103462  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105103654  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105103737  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105103741  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
105103745  TNC; tenascin isoform X7 [KO:K06252]
105103802  COL2A1; collagen alpha-1(II) chain [KO:K19719]
105104028  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X5 [KO:K04544]
105104060  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
105104066  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
105104114  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105104131  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
105104308  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105104393  CCND1; LOW QUALITY PROTEIN: G1/S-specific cyclin-D1 [KO:K04503]
105104425  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105104468  FGF4; fibroblast growth factor 4 [KO:K04358]
105104469  FGF19; fibroblast growth factor 19 [KO:K22603]
105104576  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105104642  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105104653  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105104761  FGF7; fibroblast growth factor 7 [KO:K04358]
105104820  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
105104827  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105104837  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105105233  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X2 [KO:K03259]
105105270  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105105303  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105105457  [KO:K05414]
105105461  [KO:K05414]
105105541  [KO:K05414]
105105557  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105105619  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105105672  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105105766  [KO:K05855] [EC:2.7.10.2]
105105831  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105105882  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105105969  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105106263  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105106306  RXRA; LOW QUALITY PROTEIN: retinoic acid receptor RXR-alpha [KO:K08524]
105106402  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105106413  [KO:K05855] [EC:2.7.10.2]
105106448  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
105106603  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105106632  [KO:K06583]
105106827  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
105106926  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105106940  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105106998  GHR; growth hormone receptor isoform X1 [KO:K05080]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105107071  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105107124  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105107148  FGF10; fibroblast growth factor 10 [KO:K04358]
116148121  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116148370  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116149854  [KO:K05855] [EC:2.7.10.2]
116151844  [KO:K06856]
116152037  INS; insulin [KO:K04526]
116152527  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116152603  [KO:K05414]
116152604  [KO:K05414]
116153639  [KO:K06856]
116155424  PDGFD; platelet-derived growth factor D [KO:K05450]
116156024  [KO:K04541]
116156911  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116156962  ARTN; artemin [KO:K25415]
116157091  [KO:K04358]
116157907  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cdk00010  Glycolysis / Gluconeogenesis
cdk04010  MAPK signaling pathway
cdk04012  ErbB signaling pathway
cdk04062  Chemokine signaling pathway
cdk04064  NF-kappa B signaling pathway
cdk04068  FoxO signaling pathway
cdk04110  Cell cycle
cdk04115  p53 signaling pathway
cdk04150  mTOR signaling pathway
cdk04210  Apoptosis
cdk04370  VEGF signaling pathway
cdk04510  Focal adhesion
cdk04620  Toll-like receptor signaling pathway
cdk04630  JAK-STAT signaling pathway
cdk04662  B cell receptor signaling pathway
cdk04910  Insulin signaling pathway
KO pathway
ko04151   

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