Entry Name Platelet activation - Canis lupus familiaris (dog)
Description Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Canis lupus familiaris (dog) [GN:
cfa ]
Gene 488942 F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914 ]
490901 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639 ]
100856354 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X4 [KO:K12330 ]
479409 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
403557 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
403558 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
403609 PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
475411 PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270 ]
480193 MYL12B; myosin regulatory light chain 12B [KO:K12757 ]
607207 myosin regulatory light polypeptide 9 isoform X2 [KO:K12757 ]
486261 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
476548 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
486628 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959 ]
481746 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
608643 STIM1; stromal interaction molecule 1 isoform X5 [KO:K16059 ]
403928 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
477160 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
485773 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
476034 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
100856190 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
478255 RASGRP1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350 ]
612101 RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361 ]
483225 RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353 ]
477985 APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
442957 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
478227 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
611810 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha isoform X2 [KO:K04630 ]
607357 ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 isoform X5 [KO:K08041 ] [EC:4.6.1.1 ]
403943 GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
483266 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289 ] [EC:2.7.1.153 ]
612805 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
608225 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X5 [KO:K21290 ]
479975 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345 ] [EC:2.7.11.11 ]
403936 VASP; vasodilator-stimulated phosphoprotein [KO:K06274 ]
403543 ARHGAP35; rho GTPase-activating protein 35 [KO:K05732 ]
403651 COL1A1; collagen alpha-1(I) chain precursor [KO:K06236 ]
403824 COL1A2; collagen alpha-2(I) chain precursor [KO:K06236 ]
478835 COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720 ]
403798 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma precursor [KO:K07983 ]
488084 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
489644 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
477085 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
609956 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
487235 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
100856339 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
489692 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
403638 GP1BA; platelet glycoprotein Ib alpha chain precursor [KO:K06261 ]
478268 SNAP23; synaptosomal-associated protein 23 [KO:K08508 ]
102151885 LOW QUALITY PROTEIN: synaptosomal-associated protein 23-like [KO:K08508 ]
609784 VAMP8; vesicle-associated membrane protein 8 [KO:K08512 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Li Z, Delaney MK, O'Brien KA, Du X
Title Signaling during platelet adhesion and activation.
Journal Reference Authors Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title Blood platelet biochemistry.
Journal Reference Authors Jurk K, Kehrel BE
Title Platelets: physiology and biochemistry.
Journal Reference Authors Offermanns S
Title Activation of platelet function through G protein-coupled receptors.
Journal Reference Authors Varga-Szabo D, Pleines I, Nieswandt B
Title Cell adhesion mechanisms in platelets.
Journal Reference Authors Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal Reference Authors Bergmeier W, Stefanini L
Title Novel molecules in calcium signaling in platelets.
Journal Reference Authors Cifuni SM, Wagner DD, Bergmeier W
Title CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal Reference Authors Heemskerk JW, Mattheij NJ, Cosemans JM
Title Platelet-based coagulation: different populations, different functions.
Journal Reference Authors Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title Platelet receptors and signaling in the dynamics of thrombus formation.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Angiolillo DJ, Ferreiro JL
Title Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal Reference Authors Joo SJ
Title Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal Reference Authors Harper MT, Poole AW
Title Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal Reference Authors Fitch-Tewfik JL, Flaumenhaft R
Title Platelet granule exocytosis: a comparison with chromaffin cells.
Journal Reference Authors Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal Related cfa04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
