KEGG   PATHWAY: cfa04151
Entry
cfa04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Canis lupus familiaris (dog)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cfa04151  PI3K-Akt signaling pathway
cfa04151

Other DBs
GO: 0043491
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
403657  EGF; pro-epidermal growth factor precursor [KO:K04357]
403431  TGFA; protransforming growth factor alpha [KO:K08774]
611946  EREG; proepiregulin [KO:K09784]
475176  AREG; amphiregulin isoform X3 [KO:K09782]
607724  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
403857  FGF2; fibroblast growth factor 2 isoform X5 [KO:K18497]
611641  FGF18; fibroblast growth factor 18 [KO:K04358]
491974  FGF16; fibroblast growth factor 16 [KO:K04358]
612454  FGF10; fibroblast growth factor 10 [KO:K04358]
486735  FGF6; fibroblast growth factor 6 [KO:K04358]
483680  FGF4; fibroblast growth factor 4 [KO:K04358]
611707  FGF3; fibroblast growth factor 3 [KO:K04358]
608459  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
607952  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
403915  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
477340  FGF9; fibroblast growth factor 9 [KO:K04358]
612404  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100855820  FGF20; fibroblast growth factor 20 [KO:K04358]
403868  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
483681  FGF19; fibroblast growth factor 19 isoform X1 [KO:K22603]
484395  FGF21; fibroblast growth factor 21 [KO:K22429]
611773  FGF23; fibroblast growth factor 23 [KO:K22428]
403402  NGF; beta-nerve growth factor precursor [KO:K02582]
403461  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
486731  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
483665  INS; insulin precursor [KO:K04526]
610255  IGF1; insulin-like growth factor I precursor [KO:K05459]
483664  IGF2; insulin-like growth factor II isoform b precursor [KO:K13769]
491597  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
442986  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
479460  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
482666  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
611795  CSF1; macrophage colony-stimulating factor 1 isoform X4 [KO:K05453]
403507  KITLG; kit ligand precursor [KO:K05461]
442938  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
403802  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
476036  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100855780  PGF; placenta growth factor isoform X3 [KO:K16859]
482932  VEGFC; vascular endothelial growth factor C [KO:K05449]
491749  VEGFD; vascular endothelial growth factor D isoform X2 [KO:K05449]
403441  HGF; hepatocyte growth factor precursor [KO:K05460]
403656  ANGPT1; angiopoietin-1 precursor [KO:K05465]
607616  ANGPT2; angiopoietin-2 precursor [KO:K05466]
609626  ANGPT4; angiopoietin-4 isoform X4 [KO:K05467]
490431  EFNA1; ephrin-A1 isoform X3 [KO:K05462]
608458  EFNA5; ephrin-A5 isoform X4 [KO:K05462]
490433  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100856705  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
119864601  EFNA2; ephrin-A2 [KO:K05462]
611764  NRTN; neurturin [KO:K25414]
119868041  ARTN; artemin [KO:K25415]
611734  PSPN; LOW QUALITY PROTEIN: persephin isoform X1 [KO:K25416]
404306  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
403883  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
481105  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
488508  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
100856477  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
415125  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
488808  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
489095  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
491071  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X3 [KO:K02583]
490404  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
484147  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
484990  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
442951  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
442860  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
442985  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
489188  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
403811  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
486025  FLT3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
403727  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
481464  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
482154  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
403438  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
403714  TEK; angiopoietin-1 receptor isoform X3 [KO:K05121] [EC:2.7.10.1]
487421  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
403494  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
490682  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
403871  KRAS; GTPase KRas isoform X1 [KO:K07827]
403872  NRAS; GTPase NRas [KO:K07828]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
611939  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
486148  IRS1; insulin receptor substrate 1 [KO:K16172]
448807  TLR2; toll-like receptor 2 precursor [KO:K10159]
403417  TLR4; toll-like receptor 4 precursor [KO:K10160]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
111097183  LOW QUALITY PROTEIN: immunoglobulin gamma-1 heavy chain-like isoform X1 [KO:K06856]
484196  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
607898  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
608653  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
403795  GH1; somatotropin precursor [KO:K05438]
488241  PRL; prolactin precursor [KO:K05439]
611921  OSM; oncostatin-M [KO:K05418]
403989  IL2; interleukin-2 precursor [KO:K05429]
481497  IL3; interleukin-3 precursor [KO:K04736]
403985  IL6; interleukin-6 precursor [KO:K05405]
403785  IL4; interleukin-4 precursor [KO:K05430]
751768  IL7; interleukin-7 precursor [KO:K05431]
474181  IFNA7; interferon alpha-1/2 precursor [KO:K05414]
442934  IFNA5; interferon alpha-3 precursor [KO:K05414]
611406  interferon alpha-1/2-like isoform X1 [KO:K05414]
100686162  interferon alpha-2-like [KO:K05414]
100682977  interferon alpha-1/2 isoform X5 [KO:K05414]
100683045  LOW QUALITY PROTEIN: interferon alpha-1/2 isoform X5 [KO:K05414]
100683567  interferon alpha-1/2-like isoform X1 [KO:K05414]
100688005  interferon alpha-1/2 [KO:K05414]
100685213  interferon alpha-1/2 [KO:K05414]
100688084  interferon alpha-1/2 isoform X1 [KO:K05414]
481558  IFNB1; interferon beta precursor [KO:K05415]
404002  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
608246  CSF3; granulocyte colony-stimulating factor [KO:K05423]
403721  GHR; growth hormone receptor precursor [KO:K05080]
479363  PRLR; prolactin receptor isoform X2 [KO:K05081]
489223  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
403870  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
403439  IL2RB; interleukin-2 receptor subunit beta isoform 2 precursor [KO:K05069]
403851  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
609293  IL3RA; interleukin-3 receptor subunit alpha isoform X16 [KO:K04737]
612271  IL6R; interleukin-6 receptor subunit alpha isoform X3 [KO:K05055]
489957  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
612582  IL7R; interleukin-7 receptor subunit alpha isoform X2 [KO:K05072]
609830  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100856468  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
484943  EPOR; erythropoietin receptor precursor [KO:K05079]
607605  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
442952  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
484185  JAK2; tyrosine-protein kinase JAK2 isoform X13 [KO:K04447] [EC:2.7.10.2]
610004  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
403651  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
403824  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
403826  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
403841  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
403840  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
403466  COL4A5; collagen alpha-5(IV) chain precursor [KO:K06237]
403843  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
403496  COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237]
403842  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
403582  COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238]
610649  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
610614  collagen alpha-4(VI) chain-like isoform X4 [KO:K06238]
100856491  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
403668  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
485659  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
481873  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
607609  COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131]
612430  COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131]
100683420  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102156629  LAMA1; laminin subunit alpha-1 [KO:K05637]
480173  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
442954  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
475034  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 isoform X1 [KO:K06241]
475882  LAMB1; laminin subunit beta-1 [KO:K05636]
476626  LAMB2; laminin subunit beta-2 isoform X5 [KO:K06243]
442953  LAMB3; laminin subunit beta-3 [KO:K06244]
483260  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
480034  LAMC1; laminin subunit gamma-1 [KO:K05635]
442939  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
491290  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
609296  CHAD; chondroadherin [KO:K06248]
483273  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
487486  THBS1; thrombospondin-1 [KO:K16857]
610359  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
484087  THBS2; thrombospondin-2 precursor [KO:K04659]
488930  THBS4; thrombospondin-4 [KO:K04659]
476665  COMP; cartilage oligomeric matrix protein [KO:K04659]
403845  FN1; fibronectin [KO:K05717]
478471  SPP1; osteopontin isoform X2 [KO:K06250]
480621  VTN; vitronectin [KO:K06251]
490335  TNN; tenascin-N isoform X6 [KO:K06252]
490334  TNR; tenascin-R [KO:K06252]
481689  TNC; tenascin precursor [KO:K06252]
100682877  TNXB; tenascin-X isoform X16 [KO:K06252]
399544  VWF; von Willebrand factor precursor [KO:K03900]
609146  IBSP; bone sialoprotein 2 [KO:K06253]
489210  ITGA1; integrin alpha-1 [KO:K06480]
489208  ITGA2; integrin alpha-2 [KO:K06481]
403789  ITGA2B; integrin alpha-IIb [KO:K06476]
491074  ITGA3; integrin alpha-3 [KO:K06482]
488429  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
486493  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100856563  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
481097  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
487119  ITGA8; integrin alpha-8 [KO:K06584]
477021  ITGA9; integrin alpha-9 [KO:K06585]
608287  ITGA10; integrin alpha-10 isoform X5 [KO:K06586]
478353  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
488437  ITGAV; integrin alpha-V isoform X5 [KO:K06487]
477956  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
403788  ITGB3; integrin beta-3 precursor [KO:K06493]
483318  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
608977  ITGB5; integrin beta-5 [KO:K06588]
488368  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
477598  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
475253  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
475108  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100856339  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
488942  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
483776  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
403858  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
474800  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
484802  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
490187  LPAR3; lysophosphatidic acid receptor 3 isoform X2 [KO:K04294]
491978  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
486724  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100856069  LPAR6; lysophosphatidic acid receptor 6 isoform X2 [KO:K04273]
403912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
479733  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
403511  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
488087  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
608623  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
610817  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
483783  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
607513  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100683432  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
612139  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106559760  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100534634  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119863873  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100855806  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
611002  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
100686332  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
611349  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
403895  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
403617  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
483266  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289] [EC:2.7.1.153]
612805  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
608225  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X5 [KO:K21290]
479875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
485088  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
479351  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
489571  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
489038  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
480688  TSC1; hamartin isoform X1 [KO:K07206]
479883  TSC2; tuberin isoform X1 [KO:K07207]
475545  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
610936  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
478232  MTOR; serine/threonine-protein kinase mTOR isoform X5 [KO:K07203] [EC:2.7.11.1]
608378  RPTOR; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
475590  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
487870  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
610238  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
489099  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
611215  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
100685582  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
480580  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
610499  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
477600  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
474722  RPS6; 40S ribosomal protein S6 [KO:K02991]
488146  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
100686736  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
106559872  40S ribosomal protein S6-like [KO:K02991]
608772  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like isoform X4 [KO:K02991]
490904  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100856398  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
490174  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
491313  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
403647  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
610835  SGK2; serine/threonine-protein kinase Sgk2 isoform X12 [KO:K13303] [EC:2.7.11.1]
486981  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
476565  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
475904  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12 [KO:K05629]
403832  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
609163  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X7 [KO:K16339] [EC:3.1.2.2]
403608  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
482873  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
484335  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
479444  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
477374  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X6 [KO:K04354]
610262  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
491587  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
478053  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
480289  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
485672  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
100855509  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
483755  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
480436  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
481806  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
480349  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3 [KO:K11584]
490280  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
480438  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
474919  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100687242  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
404019  HSP90B1; endoplasmin precursor [KO:K09487]
484955  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
612305  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
476179  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
489724  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
119872954  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
612418  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
492265  MTCP1; protein p13 MTCP-1 [KO:K16837]
403784  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
403437  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
478575  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
403737  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
611993  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
403560  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
480255  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
403492  G6PC1; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
488389  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
490942  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
403924  MYC; myc proto-oncogene protein [KO:K04377]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
474890  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
403429  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100855704  CDK2; cyclin-dependent kinase 2 isoform X3 [KO:K02206] [EC:2.7.11.22]
481131  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
612475  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
609920  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
611782  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
608847  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
484610  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
487057  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
481954  FOXO3; forkhead box protein O3 [KO:K09408]
478127  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
442968  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
612867  BCL2L11; bcl-2-like protein 11 isoform X4 [KO:K16341]
475864  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
477237  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
607060  YWHAQ; 14-3-3 protein theta [KO:K16197]
479459  LOW QUALITY PROTEIN: 14-3-3 protein theta-like [KO:K16197]
100855903  14-3-3 protein zeta/delta-like isoform X3 [KO:K16197]
609669  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
480645  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
608573  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
100687866  YWHAH; 14-3-3 protein eta [KO:K16198]
489818  YWHAG; 14-3-3 protein gamma [KO:K16198]
483763  BAD; bcl2-associated agonist of cell death [KO:K02158]
403618  BCL2L1; bcl-2-like protein 1 [KO:K04570]
403416  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
487432  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
607922  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
478806  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
474503  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
611934  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X2 [KO:K09048]
483636  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
491369  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
485046  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
612303  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
475266  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X5 [KO:K09047]
474855  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
403537  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
491278  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
403897  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
477796  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
482839  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
483729  RELA; transcription factor p65 isoform X2 [KO:K04735]
442859  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
483995  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
403693  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cfa00010  Glycolysis / Gluconeogenesis
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04062  Chemokine signaling pathway
cfa04064  NF-kappa B signaling pathway
cfa04068  FoxO signaling pathway
cfa04110  Cell cycle
cfa04115  p53 signaling pathway
cfa04150  mTOR signaling pathway
cfa04210  Apoptosis
cfa04370  VEGF signaling pathway
cfa04510  Focal adhesion
cfa04620  Toll-like receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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