KEGG   PATHWAY: cge05160
Entry
cge05160                    Pathway                                
Name
Hepatitis C - Cricetulus griseus (Chinese hamster)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
cge05160  Hepatitis C
cge05160

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100689399  Ldlr; low-density lipoprotein receptor precursor [KO:K12473]
100736552  Scarb1; scavenger receptor class B member 1 [KO:K13885]
100759632  Cd81; CD81 antigen [KO:K06508]
100752491  claudin-34-like [KO:K06087]
100755597  Claudin-18; claudin-34 [KO:K06087]
100771737  Cldn1; claudin-1 [KO:K06087]
100771924  Cldn17; claudin-17 [KO:K06087]
100772201  Cldn8; claudin-8 [KO:K06087]
100762571  Cldn10; claudin-10 isoform X1 [KO:K06087]
103163880  claudin-22-like [KO:K06087]
100768680  claudin-13 isoform X1 [KO:K06087]
100770792  claudin-4 [KO:K06087]
100756403  Cldn25; putative claudin-25 [KO:K06087]
100751792  Cldn16; claudin-16 [KO:K06087]
100766489  claudin-3 [KO:K06087]
100771740  Cldn20; claudin-20 [KO:K06087]
100769217  Cldn6; claudin-6 [KO:K06087]
100769504  Cldn9; claudin-9 [KO:K06087]
100758840  Cldn15; claudin-15 [KO:K06087]
100769480  Cldn5; claudin-5 isoform X2 [KO:K06087]
100765050  Cldn11; claudin-11 [KO:K06087]
100768379  Cldn19; claudin-19 [KO:K06087]
100766949  Cldn7; claudin-7 [KO:K06087]
100770787  Cldn23; claudin-23 [KO:K06087]
100751181  Cldn14; claudin-14 [KO:K06087]
100762065  Cldn2; claudin-2 [KO:K06087]
100769098  Cldn18; claudin-18 isoform X1 [KO:K06087]
113830703  claudin-22 [KO:K06087]
100769202  Cldn12; claudin-12 [KO:K06087]
100764814  claudin-34-like [KO:K06087]
100762373  claudin-34-like [KO:K06087]
100762956  claudin-34-like [KO:K06087]
100772862  Ocln; occludin isoform X2 [KO:K06088]
100770794  2'-5'-oligoadenylate synthase 1A isoform X1 [KO:K14216] [EC:2.7.7.84]
100768468  2'-5'-oligoadenylate synthase 1A isoform X1 [KO:K14216] [EC:2.7.7.84]
100761048  2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
100768763  2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
100769624  2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
100767905  2'-5'-oligoadenylate synthase 1A isoform X1 [KO:K14216] [EC:2.7.7.84]
100769335  2'-5'-oligoadenylate synthase 1A isoform X1 [KO:K14216] [EC:2.7.7.84]
100769916  Oas3; 2'-5'-oligoadenylate synthase 3 isoform X2 [KO:K14216] [EC:2.7.7.84]
113831143  Oas2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100768193  2'-5'-oligoadenylate synthase 1A isoform X2 [KO:K14216] [EC:2.7.7.84]
100763013  Rnasel; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
100766319  Ddx58; antiviral innate immune response receptor RIG-I isoform X2 [KO:K12646] [EC:5.6.2.6]
100764931  Mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100756323  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100770091  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
100761646  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X11 [KO:K07211] [EC:2.7.11.10]
100765676  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
100755889  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100760028  interferon alpha-12 [KO:K05414]
100760616  interferon alpha-9 isoform X2 [KO:K05414]
100760323  interferon alpha-12 [KO:K05414]
100762064  interferon alpha-12 [KO:K05414]
100762655  interferon alpha-9 [KO:K05414]
100763520  interferon alpha-3 [KO:K05414]
100765269  interferon alpha-9 [KO:K05414]
100765849  interferon alpha-12 [KO:K05414]
100766144  interferon alpha-12 [KO:K05414]
100766726  interferon alpha-12 [KO:K05414]
100759741  interferon alpha-12 [KO:K05414]
100750635  interferon alpha-12 [KO:K05414]
100750928  interferon alpha-2-like [KO:K05414]
100751221  interferon alpha-12 [KO:K05414]
100769352  interferon alpha-12 [KO:K05414]
100769640  interferon alpha-9 [KO:K05414]
103160615  Ifnb1; interferon beta [KO:K05415]
100768486  Ifng; interferon gamma isoform X2 [KO:K04687]
100750454  Tlr3; toll-like receptor 3 [KO:K05401]
100769672  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
100753700  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100761116  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100754153  Nfkbia; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100764780  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
100770195  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
100764727  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X2 [KO:K16194] [EC:2.7.11.1]
100757909  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100765343  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2 [KO:K08860] [EC:2.7.11.1]
100763206  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
107977044  interferon-induced protein with tetratricopeptide repeats 1-like isoform X2 [KO:K14217]
100772509  interferon-induced protein with tetratricopeptide repeats 1 isoform X1 [KO:K14217]
100774174  interferon-induced protein with tetratricopeptide repeats 1-like isoform X2 [KO:K14217]
100767358  LOW QUALITY PROTEIN: interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
100771190  Eif3e; eukaryotic translation initiation factor 3 subunit E isoform X2 [KO:K03250]
100761915  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100755865  Stat3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
100769267  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
100768581  Ifnar1; interferon alpha/beta receptor 1 isoform X2 [KO:K05130]
100768006  interferon alpha/beta receptor 2 isoform X4 [KO:K05131]
100754824  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100760469  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100755609  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
100764772  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100760392  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100762031  interferon-induced GTP-binding protein Mx2 [KO:K14754]
100764653  interferon-induced GTP-binding protein Mx1-like isoform X2 [KO:K14754]
100753921  Rsad2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
100771272  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
100773447  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
100750924  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
100758873  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100774343  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
100763205  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
100757400  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
103164195  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
118237628  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
100757208  Pias1; E3 SUMO-protein ligase PIAS1 isoform X4 [KO:K04706] [EC:2.3.2.-]
100763146  Egf; pro-epidermal growth factor isoform X2 [KO:K04357]
100774580  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100769627  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100757521  Sos1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100769325  Sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100771486  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100751432  Araf; serine/threonine-protein kinase A-Raf isoform X5 [KO:K08845] [EC:2.7.11.1]
100757122  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
100758637  14-3-3 protein theta [KO:K16197]
100766119  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
100751694  Ywhaq; 14-3-3 protein theta [KO:K16197]
100753603  14-3-3 protein epsilon isoform X2 [KO:K06630]
100771398  Ywhah; 14-3-3 protein eta isoform X2 [KO:K16198]
100770325  14-3-3 protein gamma isoform X2 [KO:K16198]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100760865  Gsk3b; glycogen synthase kinase-3 beta isoform X7 [KO:K03083] [EC:2.7.11.26]
100773307  Ctnnb1; catenin beta-1 [KO:K02105]
100760426  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100760122  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100764515  Cdk6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100752928  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X2 [KO:K06618]
100758556  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 isoform X2 [KO:K17454]
100754522  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
100754647  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
100765017  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
100758679  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100762099  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100773293  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100762537  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100774599  Fadd; FAS-associated death domain protein isoform X1 [KO:K02373]
100689369  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100689061  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100757136  Cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
100754606  Bid; BH3-interacting domain death agonist [KO:K04726]
100689032  Bax; apoptosis regulator BAX [KO:K02159]
100689368  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
107977792  cytochrome c-like [KO:K08738]
103160806  cytochrome c-like [KO:K08738]
100757098  cytochrome c, somatic [KO:K08738]
100764460  cytochrome c, testis-specific [KO:K08738]
100773626  cytochrome c, somatic [KO:K08738]
100754043  cytochrome c, somatic [KO:K08738]
100768478  cytochrome c [KO:K08738]
103164112  cytochrome c-like [KO:K08738]
100751857  cytochrome c, somatic-like [KO:K08738]
100758500  apoptotic protease-activating factor 1 isoform X4 [KO:K02084]
103160479  caspase-9-like [KO:K04399] [EC:3.4.22.62]
100689370  caspase-9 [KO:K04399] [EC:3.4.22.62]
113833881  caspase-9-like [KO:K04399] [EC:3.4.22.62]
100762340  Psme3; proteasome activator complex subunit 3 [KO:K06698]
100768377  Rxra; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
100758990  Ppara; peroxisome proliferator-activated receptor alpha isoform X3 [KO:K07294]
100756988  Nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100773301  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
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World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
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J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
cge03320  PPAR signaling pathway
cge04010  MAPK signaling pathway
cge04144  Endocytosis
cge04210  Apoptosis
cge04514  Cell adhesion molecules
cge04620  Toll-like receptor signaling pathway
cge04622  RIG-I-like receptor signaling pathway
cge04630  JAK-STAT signaling pathway
cge04668  TNF signaling pathway
KO pathway
ko05160   
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