KEGG   PATHWAY: dro05168
Entry
dro05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Desmodus rotundus (common vampire bat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
dro05168  Herpes simplex virus 1 infection
dro05168

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112302069  LTA; lymphotoxin-alpha [KO:K05468]
112312184  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
112299457  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
112306448  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112296542  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112300474  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112296261  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112296519  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112317202  RELA; transcription factor p65 [KO:K04735]
112317544  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
112317519  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
112308943  C-C motif chemokine 2-like [KO:K14624]
112312974  NECTIN1; nectin-1 [KO:K06081]
112312912  NECTIN2; nectin-2 isoform X1 [KO:K06531]
112314988  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
112314972  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
112310448  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
112318448  ITGA5; integrin alpha-5 [KO:K06484]
112316322  ITGB3; integrin beta-3 [KO:K06493]
112303920  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112307282  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112306324  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
112310089  IRF3; interferon regulatory factor 3 [KO:K05411]
112300024  IFNB1; interferon beta [KO:K05415]
112308825  TP53; cellular tumor antigen p53 [KO:K04451]
112312430  C3; complement C3 [KO:K03990]
112306366  C5; complement C5 isoform X1 [KO:K03994]
112322486  CFP; properdin [KO:K15412]
112312607  TLR2; toll-like receptor 2 [KO:K10159]
112309685  toll-like receptor 9 isoform X1 [KO:K10161]
112309628  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112317444  IRF7; interferon regulatory factor 7 [KO:K09447]
112306726  TLR3; toll-like receptor 3 [KO:K05401]
112312662  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112318391  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112296346  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112303407  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
112296959  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112322023  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112297111  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112302944  IL1B; interleukin-1 beta [KO:K04519]
112298838  CCL5; C-C motif chemokine 5 [KO:K12499]
112306851  IL6; interleukin-6 [KO:K05405]
112302067  TNF; tumor necrosis factor isoform X1 [KO:K03156]
112304655  IL12A; interleukin-12 subunit alpha [KO:K05406]
112319648  IL12B; interleukin-12 subunit beta [KO:K05425]
112304475  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
112322284  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
112303983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
112311693  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
112318201  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112319039  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112297048  interferon alpha-4-like [KO:K05414]
112302798  interferon alpha-4-like [KO:K05414]
112302800  interferon alpha-4-like [KO:K05414]
112319268  CGAS; LOW QUALITY PROTEIN: cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
112318146  TMEM173; stimulator of interferon genes protein [KO:K12654]
112297802  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112317227  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112310655  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112319445  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
112298045  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112297566  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
112311276  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
112311304  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112310659  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
112311651  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
112314548  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
112297787  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
112307901  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
112310771  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
112317826  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
112310467  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112296814  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
112296272  HCFC1; host cell factor 1 [KO:K14966]
112321997  HCFC2; host cell factor 2 [KO:K27390]
112312977  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
112298729  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
112320100  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
112305552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112305536  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112298802  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112309187  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112301524  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112307780  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112319116  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112301148  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112300601  ZNF19; LOW QUALITY PROTEIN: zinc finger protein 19 [KO:K09228]
112321247  zinc finger protein 883-like [KO:K09228]
112321248  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
112321249  zinc finger protein 883-like [KO:K09228]
112321253  ZNF331; zinc finger protein 331 [KO:K09228]
112321254  LOW QUALITY PROTEIN: zinc finger protein 595-like [KO:K09228]
112321278  LOW QUALITY PROTEIN: zinc finger protein 675-like [KO:K09228]
112304008  ZNF133; zinc finger protein 133 [KO:K09228]
112305413  ZNF25; zinc finger protein 25 [KO:K09228]
112305414  ZNF248; zinc finger protein 248 [KO:K09228]
112316046  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
112321315  ZNF596; zinc finger protein 596 [KO:K09228]
112312449  ZNF558; zinc finger protein 558 [KO:K09228]
112313780  zinc finger protein 660-like [KO:K09228]
112320256  ZNF569; LOW QUALITY PROTEIN: zinc finger protein 569 [KO:K09228]
112320258  zinc finger protein 420 isoform X1 [KO:K09228]
112320259  ZNF570; zinc finger protein 570 [KO:K09228]
112320260  zinc finger protein 30 homolog [KO:K09228]
112301364  zinc finger protein 14-like [KO:K09228]
112301365  zinc finger protein 791-like isoform X1 [KO:K09228]
112301366  zinc finger protein 709-like [KO:K09228]
112301367  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112301368  zinc finger protein 709-like [KO:K09228]
112301369  zinc finger protein 14-like [KO:K09228]
112301370  zinc finger protein 14-like [KO:K09228]
112301371  zinc finger protein 709-like [KO:K09228]
112301372  zinc finger protein 709-like [KO:K09228]
112301373  zinc finger protein 699 isoform X1 [KO:K09228]
112301376  ZNF177; zinc finger protein 177 [KO:K09228]
112301381  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
112301398  ZNF846; zinc finger protein 846 [KO:K09228]
112301411  LOW QUALITY PROTEIN: zinc finger protein 670-like [KO:K09228]
112301416  zinc finger protein 791-like [KO:K09228]
112302732  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
112306768  zinc finger protein 596-like isoform X1 [KO:K09228]
112313462  endothelial zinc finger protein induced by tumor necrosis factor alpha-like isoform X1 [KO:K09228]
112313464  zinc finger protein 471-like [KO:K09228]
112313465  zinc finger protein 420-like isoform X1 [KO:K09228]
112313466  ZNF304; zinc finger protein 304 [KO:K09228]
112313467  endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228]
112313468  endothelial zinc finger protein induced by tumor necrosis factor alpha-like isoform X1 [KO:K09228]
112313471  zinc finger protein 883-like [KO:K09228]
112313473  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
112313475  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
112313476  ZNF582; zinc finger protein 582 [KO:K09228]
112313485  LOW QUALITY PROTEIN: zinc finger protein 805-like [KO:K09228]
112313486  ZNF667; LOW QUALITY PROTEIN: zinc finger protein 667 [KO:K09228]
112313487  zinc finger protein 28 homolog [KO:K09228]
112313490  zinc finger protein 17-like [KO:K09228]
112313491  ZNF550; zinc finger protein 550 isoform X1 [KO:K09228]
112313492  zinc finger protein 548-like [KO:K09228]
112313493  zinc finger protein 773-like [KO:K09228]
112313495  LOW QUALITY PROTEIN: zinc finger protein 416-like [KO:K09228]
112313532  zinc finger protein 345-like [KO:K09228]
112313535  LOW QUALITY PROTEIN: zinc finger protein 211-like [KO:K09228]
112312541  zinc finger protein 77-like [KO:K09228]
112312550  zinc finger protein 57-like [KO:K09228]
112313819  zinc finger protein 883-like [KO:K09228]
112313820  zinc finger protein OZF-like [KO:K09228]
112313823  zinc finger protein 256-like [KO:K09228]
112313862  zinc finger protein 551-like [KO:K09228]
112319977  ZNF792; zinc finger protein 792 [KO:K09228]
112319978  ZNF181; zinc finger protein 181 isoform X1 [KO:K09228]
112320019  ZNF546; LOW QUALITY PROTEIN: zinc finger protein 546 [KO:K09228]
112299200  ZFP69B; LOW QUALITY PROTEIN: zinc finger protein ZFP69B [KO:K09228]
112299207  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
112301832  ZNF74; zinc finger protein 74 [KO:K09228]
112304656  ZNF768; zinc finger protein 768 [KO:K09228]
112304657  ZNF689; zinc finger protein 689 [KO:K09228]
112304658  zinc finger protein 764-like [KO:K09228]
112304660  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
112309948  zinc finger protein 621-like isoform X1 [KO:K09228]
112312575  LOW QUALITY PROTEIN: zinc finger protein 555-like [KO:K09228]
112301451  zinc finger protein 791-like isoform X1 [KO:K09228]
112302851  zinc finger protein 510-like isoform X1 [KO:K09228]
112302852  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
112308151  zinc finger protein 501-like [KO:K09228]
112312268  LOW QUALITY PROTEIN: zinc finger protein 77-like [KO:K09228]
112312269  zinc finger protein 77-like [KO:K09228]
112312271  ZNF554; LOW QUALITY PROTEIN: zinc finger protein 554 [KO:K09228]
112313566  zinc finger protein 850 isoform X1 [KO:K09228]
112313568  zinc finger protein 345-like [KO:K09228]
112313569  zinc finger protein 345-like [KO:K09228]
112313570  zinc finger protein 345-like isoform X1 [KO:K09228]
112313571  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
112313572  zinc finger protein 345-like isoform X1 [KO:K09228]
112313573  zinc finger protein 345-like [KO:K09228]
112313575  ZNF184; zinc finger protein 184 [KO:K09228]
112313576  zinc finger protein 345-like [KO:K09228]
112313577  ZNF544; zinc finger protein 544 isoform X1 [KO:K09228]
112313578  zinc finger protein 324A-like [KO:K09228]
112313585  zinc finger protein 418-like isoform X1 [KO:K09228]
112313586  zinc finger protein 211-like [KO:K09228]
112313587  zinc finger protein 211-like [KO:K09228]
112313588  zinc finger protein 345-like [KO:K09228]
112313591  LOW QUALITY PROTEIN: zinc finger protein 660-like [KO:K09228]
112313592  ZNF8; zinc finger protein 8 [KO:K09228]
112313597  zinc finger protein 132-like [KO:K09228]
112320041  ZNF527; zinc finger protein 527 [KO:K09228]
112320050  zinc finger protein 550-like [KO:K09228]
112313892  zinc finger protein 420-like [KO:K09228]
112313893  LOW QUALITY PROTEIN: zinc finger protein 585A-like [KO:K09228]
112313895  zinc finger protein 585B-like [KO:K09228]
112313896  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
112313903  zinc finger protein 548-like [KO:K09228]
112313904  zinc finger protein 772-like [KO:K09228]
112313910  LOW QUALITY PROTEIN: putative uncharacterized zinc finger protein 814 [KO:K09228]
112313915  zinc finger protein 883-like [KO:K09228]
112313920  zinc finger protein 883-like [KO:K09228]
112313921  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112313923  LOW QUALITY PROTEIN: zinc finger protein 211-like [KO:K09228]
112320061  zinc finger protein 565-like [KO:K09228]
112308650  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
112310052  zinc finger protein 883-like [KO:K09228]
112310053  ZNF473; zinc finger protein 473 [KO:K09228]
112310054  zinc finger protein 350-like isoform X1 [KO:K09228]
112310073  ZNF114; zinc finger protein 114 [KO:K09228]
112313957  zinc finger protein 418-like [KO:K09228]
112314014  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
112314017  zinc finger protein 883-like [KO:K09228]
112315396  zinc finger protein 420-like [KO:K09228]
112301513  zinc finger protein 709-like [KO:K09228]
112301557  zinc finger protein 709-like [KO:K09228]
112301567  zinc finger protein 709-like isoform X1 [KO:K09228]
112308273  ZNF786; zinc finger protein 786 isoform X1 [KO:K09228]
112308291  zinc finger protein 398 [KO:K09228]
112308296  LOW QUALITY PROTEIN: zinc finger protein 250-like [KO:K09228]
112308297  zinc finger protein 212-like [KO:K09228]
112308298  zinc finger protein 282 [KO:K09228]
112308299  ZNF746; zinc finger protein 746 [KO:K09228]
112313603  zinc finger protein 256-like [KO:K09228]
112313604  ZNF584; zinc finger protein 584 [KO:K09228]
112314947  ZNF713; zinc finger protein 713 [KO:K09228]
112314974  ZNF3; zinc finger protein 3 [KO:K09228]
112320135  ZNF567; zinc finger protein 567 isoform X1 [KO:K09228]
112320136  zinc finger protein 568-like isoform X1 [KO:K09228]
112320137  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
112320140  ZNF565; zinc finger protein 565 isoform X1 [KO:K09228]
112320142  zinc finger protein 566 isoform X1 [KO:K09228]
112320146  LOW QUALITY PROTEIN: zinc finger protein 82 homolog [KO:K09228]
112299396  ZFP69; zinc finger protein ZFP69 [KO:K09228]
112299397  ZNF684; zinc finger protein 684 [KO:K09228]
112303469  ZNF214; LOW QUALITY PROTEIN: zinc finger protein 214 [KO:K09228]
112310129  zinc finger protein 211-like [KO:K09228]
112310130  zinc finger protein 211-like [KO:K09228]
112310158  zinc finger protein 883-like [KO:K09228]
112310159  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
112310169  LOW QUALITY PROTEIN: zinc finger protein 256-like [KO:K09228]
112312756  ZNF317; zinc finger protein 317 [KO:K09228]
112312805  ZNF112; zinc finger protein 112 [KO:K09228]
112312806  zinc finger protein 235-like isoform X1 [KO:K09228]
112314083  zinc finger protein 551-like [KO:K09228]
112319401  ZNF2; zinc finger protein 2 isoform X1 [KO:K09228]
112319402  zinc finger protein 501-like [KO:K09228]
112319409  ZNF514; LOW QUALITY PROTEIN: zinc finger protein 514 [KO:K09228]
112296304  ZFP92; zinc finger protein 92 homolog [KO:K09228]
112296344  ZNF275; zinc finger protein 275 [KO:K09228]
112296372  ZNF354A; zinc finger protein 354A isoform X1 [KO:K09228]
112308338  ZNF777; zinc finger protein 777 [KO:K09228]
112313677  zinc finger protein 271-like [KO:K09228]
112300744  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
112300767  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
112300799  ZFP90; zinc finger protein 90 homolog [KO:K09228]
112306272  ZNF79; zinc finger protein 79 [KO:K09228]
112308791  ZNF624; zinc finger protein 624 [KO:K09228]
112310214  zinc finger protein 211-like [KO:K09228]
112310218  ZNF175; LOW QUALITY PROTEIN: zinc finger protein 175 [KO:K09228]
112310220  zinc finger protein 268-like [KO:K09228]
112310221  LOW QUALITY PROTEIN: zinc finger protein 615-like [KO:K09228]
112310222  ZNF613; LOW QUALITY PROTEIN: zinc finger protein 613 [KO:K09228]
112310223  zinc finger protein 268-like isoform X1 [KO:K09228]
112310226  zinc finger protein 615-like [KO:K09228]
112310227  ZNF614; zinc finger protein 614 [KO:K09228]
112310239  zinc finger protein 432-like [KO:K09228]
112312815  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
112312824  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
112312840  zinc finger protein OZF-like [KO:K09228]
112312841  zinc finger protein OZF-like [KO:K09228]
112312861  uncharacterized protein LOC112312861 [KO:K09228]
112312876  ZNF180; zinc finger protein 180 [KO:K09228]
112304424  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
112298334  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
112298345  ZNF200; zinc finger protein 200 [KO:K09228]
112302189  ZFP57; zinc finger protein 57 homolog [KO:K09228]
112303680  ZNF343; zinc finger protein 343 [KO:K09228]
112304966  zinc finger protein 879-like [KO:K09228]
112304980  ZNF354C; LOW QUALITY PROTEIN: zinc finger protein 354C [KO:K09228]
112304983  ZNF454; LOW QUALITY PROTEIN: zinc finger protein 454 [KO:K09228]
112310343  ZNF268; zinc finger protein 268 [KO:K09228]
112310344  zinc finger protein 84 isoform X1 [KO:K09228]
112310348  ZNF10; zinc finger protein 10 [KO:K09228]
112310349  ZNF891; zinc finger protein 891 [KO:K09228]
112310350  ZNF26; zinc finger protein 26 [KO:K09228]
112310351  ZNF605; zinc finger protein 605 [KO:K09228]
112312916  zinc finger protein 883-like [KO:K09228]
112312930  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
112312931  zinc finger protein 233-like [KO:K09228]
112312932  LOW QUALITY PROTEIN: zinc finger protein 235-like [KO:K09228]
112319557  ZNF300; zinc finger protein 300 [KO:K09228]
112319559  zinc finger protein 300-like [KO:K09228]
112303768  ZNF334; zinc finger protein 334 [KO:K09228]
112312941  ZNF229; LOW QUALITY PROTEIN: zinc finger protein 229 [KO:K09228]
112312952  zinc finger protein 45-like isoform X1 [KO:K09228]
112312954  zinc finger protein 234-like [KO:K09228]
112315658  zinc finger protein 623-like isoform X1 [KO:K09228]
112315660  zinc finger protein 7-like isoform X1 [KO:K09228]
112315666  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
112322342  zinc finger protein 501-like [KO:K09228]
112313059  putative uncharacterized zinc finger protein 814 [KO:K09228]
112319672  ZNF316; LOW QUALITY PROTEIN: zinc finger protein 316 [KO:K09228]
112322436  zinc finger protein 182 isoform X1 [KO:K09228]
112306499  ZFP37; LOW QUALITY PROTEIN: zinc finger protein 37 homolog [KO:K09228]
112318386  ZNF641; zinc finger protein 641 isoform X1 [KO:K09228]
112319735  ZNF853; LOW QUALITY PROTEIN: zinc finger protein 853 [KO:K09228]
112319748  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
112319749  ZNF12; zinc finger protein 12 [KO:K09228]
112319750  zinc finger protein 33B isoform X1 [KO:K09228]
112322482  zinc finger protein 157 isoform X1 [KO:K09228]
112322483  ZNF41; zinc finger protein 41 [KO:K09228]
112298483  ZNF597; LOW QUALITY PROTEIN: zinc finger protein 597 [KO:K09228]
112321251  zinc finger protein 501-like [KO:K09228]
112321279  zinc finger protein 501-like [KO:K09228]
112322700  ZNF397; zinc finger protein 397 [KO:K09228]
112313472  zinc finger protein OZF-like [KO:K09228]
112313474  zinc finger protein OZF-like [KO:K09228]
112313579  zinc finger protein 256-like [KO:K09228]
112313580  zinc finger protein 883-like isoform X1 [KO:K09228]
112313599  zinc finger protein 256-like [KO:K09228]
112313607  zinc finger protein 154-like [KO:K09228]
112313612  zinc finger protein 211-like [KO:K09228]
112313918  zinc finger protein 211-like [KO:K09228]
112314175  zinc finger protein OZF-like [KO:K09228]
112312842  zinc finger protein 418-like [KO:K09228]
112313470  LOW QUALITY PROTEIN: zinc finger protein 264-like [KO:K09228]
112305272  BST2; LOW QUALITY PROTEIN: bone marrow stromal antigen 2 [KO:K06731]
112319176  IFNG; interferon gamma [KO:K04687]
112297082  IFNGR1; interferon gamma receptor 1 [KO:K05132]
112308734  IFNGR2; interferon gamma receptor 2 [KO:K05133]
112299737  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112302087  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
112307748  SP100; nuclear autoantigen Sp-100 [KO:K15413]
112301759  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
112302332  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
112302216  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112302089  TAPBP; tapasin isoform X1 [KO:K08058]
112311189  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112301566  CALR; calreticulin [KO:K08057]
112297492  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
112313872  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
112313873  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
112313875  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112313876  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
112313879  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-39 alpha chain-like [KO:K06751]
112313880  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
112314045  HLA class I histocompatibility antigen, A-36 alpha chain-like isoform X1 [KO:K06751]
112314059  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
112314061  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
112314062  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
112314063  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112314064  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302342  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302447  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
112302469  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112311727  B2M; beta-2-microglobulin [KO:K08055]
112302159  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112302160  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
112302240  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
112302328  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112302354  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112319701  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112306281  TSC1; hamartin [KO:K07206]
112298303  TSC2; tuberin isoform X1 [KO:K07207]
112308268  RHEB; GTP-binding protein Rheb [KO:K07208]
112299108  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112306701  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112302091  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
112316239  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112298680  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
112302234  SRSF3; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 3 [KO:K12892]
112299287  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
112311485  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
112304014  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112297975  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
112310600  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
112296854  nuclear RNA export factor 2-like [KO:K14284]
112296855  NXF3; nuclear RNA export factor 3 [KO:K14284]
112321362  NXF5; nuclear RNA export factor 5 isoform X1 [KO:K14284]
112317185  NXF1; nuclear RNA export factor 1 [KO:K14284]
112298936  ALYREF; THO complex subunit 4 [KO:K12881]
112297049  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112307358  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112321955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112300831  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112317320  FADD; FAS-associated death domain protein [KO:K02373]
112307787  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112310499  BID; BH3-interacting domain death agonist [KO:K04726]
112310132  BAX; apoptosis regulator BAX [KO:K02159]
112302219  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112317275  BAD; bcl2-associated agonist of cell death [KO:K02158]
112322759  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112304196  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112306993  cytochrome c [KO:K08738]
112320658  cytochrome c-like [KO:K08738]
112322221  cytochrome c-like [KO:K08738]
112321814  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
112299456  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112306749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
dro03040  Spliceosome
dro03050  Proteasome
dro04115  p53 signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04210  Apoptosis
dro04610  Complement and coagulation cascades
dro04612  Antigen processing and presentation
dro04620  Toll-like receptor signaling pathway
dro04622  RIG-I-like receptor signaling pathway
dro04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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