KEGG   PATHWAY: esp05132
Entry
esp05132                    Pathway                                
Name
Salmonella infection - Etheostoma spectabile (orangethroat darter)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
esp05132  Salmonella infection
esp05132

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116679353  mucin-2-like [KO:K06817]
116695398  receptor-type tyrosine-protein phosphatase C-like isoform X1 [KO:K06478] [EC:3.1.3.48]
116695763  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
116691143  ras-related protein Rab-5A [KO:K07887]
116702199  ras-related protein Rab-5A [KO:K07887]
116688990  ras-related protein Rab-5B-like [KO:K07888]
116671114  ras-related protein Rab-5C-like [KO:K07889]
116703299  rab5c; ras-related protein Rab-5C [KO:K07889]
116706994  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
116688413  ras-related protein rab7-like [KO:K07897]
116688563  ras-related protein rab7-like [KO:K07897]
116688634  ras-related protein rab7 [KO:K07897]
116670951  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
116700126  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
116706442  vps18; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
116686808  vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182]
116686120  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
116672199  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116687139  RILP-like protein 1 isoform X1 [KO:K13883]
116670434  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
116681765  cytoplasmic dynein 2 heavy chain 1-like [KO:K10414]
116697613  dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
116698841  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
116701805  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
116701318  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
116696974  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
116704923  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
116679321  dynein light chain 2, cytoplasmic [KO:K10418]
116700048  dynein light chain 2, cytoplasmic-like [KO:K10418]
116689750  dynein light chain 2, cytoplasmic-like [KO:K10418]
116694721  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
116697807  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
116705823  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
116706907  dynactin subunit 1-like isoform X1 [KO:K04648]
116686104  dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
116687897  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
116691589  dctn3; dynactin subunit 3 [KO:K10425]
116697357  dctn4; dynactin subunit 4 [KO:K10426]
116702338  dctn5; dynactin subunit 5 [KO:K10427]
116707094  dynactin subunit 6-like [KO:K10428]
116695186  dynactin subunit 6-like [KO:K10428]
116685810  beta-centractin isoform X1 [KO:K16575]
116706036  actr10; actin-related protein 10 [KO:K16576]
116673929  tubulin alpha-1C chain-like [KO:K07374]
116674218  tubulin alpha chain-like [KO:K07374]
116674221  tubulin alpha-1A chain-like [KO:K07374]
116697694  tubulin alpha chain [KO:K07374]
116697695  tubulin alpha chain-like [KO:K07374]
116691965  tubulin alpha chain [KO:K07374]
116692072  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
116693285  tubulin alpha-1B chain isoform X1 [KO:K07374]
116693286  tubulin alpha chain-like [KO:K07374]
116693287  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
116671435  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
116671438  tubulin alpha-1B chain-like [KO:K07374]
116689941  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
116691258  tubulin beta chain [KO:K07375]
116691558  tubulin beta-1 chain [KO:K07375]
116699168  tubulin beta-2A chain isoform X1 [KO:K07375]
116670648  tubulin beta-4B chain isoform X1 [KO:K07375]
116688613  tubulin beta chain-like [KO:K07375]
116689501  tubulin beta chain [KO:K07375]
116703675  tubulin beta-4B chain-like [KO:K07375]
116703938  tubb4b; tubulin beta-4B chain [KO:K07375]
116698510  LOW QUALITY PROTEIN: FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
116695391  fyco1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
116687337  arl8b; ADP-ribosylation factor-like protein 8B [KO:K07955]
116687724  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
116692554  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
116674014  kif5c; kinesin heavy chain isoform X1 [KO:K10396]
116678291  LOW QUALITY PROTEIN: kinesin heavy chain-like [KO:K10396]
116698783  kinesin-1 heavy chain [KO:K10396]
116692636  kinesin heavy chain-like isoform X1 [KO:K10396]
116684578  kinesin heavy chain-like [KO:K10396]
116687962  kif5a; kinesin heavy chain isoform X1 [KO:K10396]
116671897  kif5b; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
116669420  klc2; kinesin light chain 2 [KO:K10407]
116693657  kinesin light chain 1-like isoform X1 [KO:K10407]
116686974  kinesin light chain 1-like isoform X1 [KO:K10407]
116696278  klc1; kinesin light chain 1 isoform X1 [KO:K10407]
116706398  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
116691940  rho-related GTP-binding protein RhoA-C [KO:K04513]
116692018  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
116692455  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
116687703  rho-related GTP-binding protein RhoA-B [KO:K04513]
116688259  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
116691281  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
116674153  ras-related protein Rab-9A-like isoform X1 [KO:K07899]
116697950  rab9a; ras-related protein Rab-9A [KO:K07899]
116697397  ras-related protein Rab-9B-like [KO:K07900]
116698163  LOW QUALITY PROTEIN: GRIP and coiled-coil domain-containing protein 2-like [KO:K20282]
116699236  profilin-2-like isoform X1 [KO:K05759]
116695178  pfn2; profilin-2 isoform X1 [KO:K05759]
116693200  filamin-A-like isoform X1 [KO:K04437]
116669899  exoc5; exocyst complex component 5 [KO:K19984]
116672961  exoc4; exocyst complex component 4 [KO:K06111]
116695560  exoc2; exocyst complex component 2 [KO:K17637]
116672060  rala; ras-related protein Ral-A [KO:K07834]
116701733  actin, cytoplasmic 2 [KO:K05692]
116703193  actb; actin, cytoplasmic 1 [KO:K05692]
116690523  protein S100-A1-like [KO:K17274]
116701697  protein S100-A1-like [KO:K17274]
116693338  anxa2; annexin A2 [KO:K17092]
116701973  annexin A2-like isoform X1 [KO:K17092]
116697309  LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
116705623  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
116674513  arhgef26; rho guanine nucleotide exchange factor 26 [KO:K13744]
116696943  rho-related GTP-binding protein RhoG-like [KO:K07863]
116701312  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
116687302  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
116705871  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
116670634  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116686662  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
116687400  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116689310  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
116689632  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
116688064  myosin regulatory light polypeptide 9 [KO:K12755]
116698538  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
116672459  myosin regulatory light polypeptide 9 [KO:K12757]
116671334  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
116703217  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
116669379  FH1/FH2 domain-containing protein 1-like [KO:K23938]
116691327  cell division control protein 42 homolog [KO:K04393]
116692170  cell division control protein 42 homolog isoform X1 [KO:K04393]
116701833  cell division control protein 42 homolog [KO:K04393]
116688288  cell division control protein 42 homolog isoform X1 [KO:K04393]
116670942  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116702491  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116704991  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
116687422  nckap1l; nck-associated protein 1-like [KO:K05750]
116697371  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
116696034  cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
116698759  abl interactor 1-like isoform X1 [KO:K23649]
116672446  abi1; abl interactor 1 isoform X1 [KO:K23649]
116688444  brk1; protein BRICK1 [KO:K05752]
116679482  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
116700057  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
116707113  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
116672557  wasf3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
116705039  actr2; actin-related protein 2 [KO:K17260]
116707305  actin-related protein 2-like [KO:K17260]
116673892  actin-related protein 3 [KO:K18584]
116697845  actin-related protein 3-like [KO:K18584]
116695030  actin-related protein 2/3 complex subunit 1B-B-like [KO:K05757]
116695039  actin-related protein 2/3 complex subunit 1A [KO:K05757]
116702588  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
116674147  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116704553  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116687761  actin-related protein 2/3 complex subunit 4 [KO:K05755]
116688418  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
116699669  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
116694979  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116685041  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116700229  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
116706672  unconventional myosin-VI-like [KO:K10358]
116670071  unconventional myosin-VI-like isoform X1 [KO:K10358]
116675754  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116678381  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116699195  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116692529  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116695417  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116673408  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
116691879  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
116693588  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
116694205  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
116704728  LOW QUALITY PROTEIN: cytohesin-4-like [KO:K18441]
116691514  cyth2; cytohesin-2 [KO:K18441]
116707110  cytohesin-1-like isoform X1 [KO:K18441]
116671663  cyth3; cytohesin-3 [KO:K18441]
116702701  cytohesin-4-like isoform X1 [KO:K18441]
116702864  cytohesin-1 isoform X1 [KO:K18441]
116671747  cytohesin-1-like isoform X1 [KO:K18441]
116703144  cytohesin-3 isoform X1 [KO:K18441]
116705812  ADP-ribosylation factor 6-like [KO:K07941]
116669894  ADP-ribosylation factor 6 [KO:K07941]
116698938  arf1; ADP-ribosylation factor 1 [KO:K07937]
116703282  ADP-ribosylation factor 1-like [KO:K07937]
116704345  sorting nexin-18-like [KO:K17923]
116705911  snx9; sorting nexin-9 isoform X1 [KO:K17923]
116694529  snx33; sorting nexin-33 [KO:K17923]
116689061  snx18; sorting nexin-18 [KO:K17923]
116693736  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
116672982  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
116688401  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
116697990  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
116703659  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
116673192  toll-like receptor 1 [KO:K10169]
116690715  toll-like receptor 2 type-1 [KO:K10159]
116690724  tlr2; toll-like receptor 2 [KO:K10159]
116684852  tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
116672056  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
116706584  tlr5; toll-like receptor 5 [KO:K10168]
116694099  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116689192  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116706210  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116669778  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
116700613  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
116705943  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116695153  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
116693209  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116705198  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
116670894  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
116688937  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116706183  NF-kappa-B inhibitor alpha-like [KO:K04734]
116670651  nfkbia; NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
116707180  putative transcription factor p65 homolog isoform X1 [KO:K04735]
116690780  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
116706735  hsp90aa1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
116694661  hsp90b1; endoplasmin [KO:K09487]
116699318  LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
116688030  cse1l; exportin-2 [KO:K18423]
116672070  kpna1; importin subunit alpha-5 [KO:K23940]
116697754  kpna3; LOW QUALITY PROTEIN: importin subunit alpha-4 [KO:K23583]
116686464  kpna4; importin subunit alpha-3 [KO:K23583]
116685748  rps3; 40S ribosomal protein S3 [KO:K02985]
116694245  hras; GTPase HRas [KO:K02833]
116693071  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116699426  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116699428  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116695172  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116703753  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
116671244  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116702724  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
116691890  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
116692206  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116693198  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
116693572  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
116687835  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
116673128  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116673224  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116705506  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04430] [EC:2.7.12.2]
116671100  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
116703458  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116705548  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116697416  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
116705432  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
116671539  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116703876  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116706488  proto-oncogene c-Fos-like [KO:K04379]
116706489  proto-oncogene c-Fos-like [KO:K04379]
116670054  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
116677748  transcription factor AP-1-like [KO:K04448]
116698745  transcription factor AP-1-like [KO:K04448]
116695201  transcription factor AP-1-like [KO:K04448]
116704060  transcription factor AP-1-like [KO:K04448]
116702065  tumor necrosis factor-like [KO:K03156]
116689682  il1b; interleukin-1 beta [KO:K04519]
116701753  interleukin-6-like [KO:K05405]
116706100  permeability factor 2-like [KO:K10030]
116707268  interleukin-8-like [KO:K10030]
116691343  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
116701310  catenin beta-1-like [KO:K02105]
116679407  transcription factor 7-like [KO:K02620]
116700180  tcf7; transcription factor 7 isoform X1 [KO:K02620]
116685754  transcription factor 7-like 1-B isoform X1 [KO:K04490]
116686075  transcription factor 7-like 1-A isoform X1 [KO:K04490]
116671026  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
116670487  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116672376  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
116705542  pkn1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
116702261  serine/threonine-protein kinase N2-like [KO:K06071] [EC:2.7.11.13]
116688022  fbxo22; F-box only protein 22 [KO:K10302]
116700182  skp1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094]
116691264  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
116690145  LOW QUALITY PROTEIN: TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
116704577  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
116703984  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
116687375  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116700009  inhibitor of apoptosis protein-like [KO:K16060]
116698944  ripk1; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
116691277  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
116701905  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
116670496  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
116672626  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
116704227  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
116688942  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722]
116690512  fadd; FAS-associated death domain protein [KO:K02373]
116698760  caspase-8-like [KO:K04398] [EC:3.4.22.61]
116698766  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
116676848  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
116678473  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
116684150  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
116707151  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
116694699  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
116702278  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08847] [EC:2.7.11.1]
116683326  apoptosis regulator BAX-like [KO:K02159]
116686021  LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer-like [KO:K02159]
116703270  bax; apoptosis regulator BAX [KO:K02159]
116675297  apoptosis regulator BAX-like isoform X1 [KO:K02159]
116703331  apoptosis regulator BAX-like isoform X1 [KO:K02159]
116705015  cytochrome c [KO:K08738]
116698216  cytochrome c-like [KO:K08738]
116698657  apoptosis regulator Bcl-2-like [KO:K02161]
116669567  caspase-3-like [KO:K02187] [EC:3.4.22.56]
116697073  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
116670737  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
116706418  rho-related GTP-binding protein RhoB-like [KO:K07856]
116706017  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
116673342  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116705099  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116670120  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116673142  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
116693755  mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
116707030  txn; thioredoxin [KO:K03671]
116702841  txn2; thioredoxin, mitochondrial [KO:K03671]
116691564  uncharacterized protein LOC116691564 [KO:K12799]
116672700  caspase-1-like [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
esp04010  MAPK signaling pathway
esp04210  Apoptosis
esp04217  Necroptosis
esp04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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