KEGG   PATHWAY: etf05205
Entry
etf05205                    Pathway                                
Name
Proteoglycans in cancer - Echinops telfairi (small Madagascar hedgehog)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
etf05205  Proteoglycans in cancer
etf05205

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101655560  CD44; CD44 antigen isoform X11 [KO:K06256]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101651907  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
101659990  CTTN; src substrate cortactin [KO:K06106]
101647544  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101638863  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101639268  VAV1; proto-oncogene vav [KO:K05730]
101656425  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101657858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101655065  MRAS; ras-related protein M-Ras [KO:K07831]
101657046  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101648298  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101651283  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101647149  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101650948  ESR1; estrogen receptor [KO:K08550]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101659333  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
101650939  FLNA; filamin-A isoform X1 [KO:K04437]
101645746  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101647656  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101642345  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101646611  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101650952  ANK2; ankyrin-2 isoform X1 [KO:K09255]
101648338  ANK3; ankyrin-3 isoform X1 [KO:K09259]
101653483  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101656593  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101646224  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
101662729  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
101648322  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101646828  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101659910  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101654141  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101638553  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101657031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101659132  LOW QUALITY PROTEIN: homeobox protein NANOG-like [KO:K10164]
101644118  homeobox protein NANOG-like [KO:K10164]
105978496  LOW QUALITY PROTEIN: homeobox protein NANOG-like [KO:K10164]
101649159  homeobox protein NANOG [KO:K10164]
101661415  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101643558  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
101656698  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101662323  TWIST2; twist-related protein 2 [KO:K09069]
101640783  TWIST1; twist-related protein 1 [KO:K09069]
101658966  HOXD10; homeobox protein Hox-D10 [KO:K09295]
101661276  DCN; decorin [KO:K04660]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101643319  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101661509  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101652873  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101653358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101661542  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105979636  40S ribosomal protein S6-like [KO:K02991]
101649610  RPS6; 40S ribosomal protein S6 [KO:K02991]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101655882  CAV1; caveolin-1 [KO:K06278]
101655557  CAV2; caveolin-2 [KO:K12958]
101646670  CAV3; caveolin-3 [KO:K12959]
101640768  CD63; CD63 antigen [KO:K06497]
101660587  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101660600  TLR4; toll-like receptor 4 [KO:K10160]
101644655  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
101654642  TNF; tumor necrosis factor [KO:K03156]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
101663176  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101652176  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101649029  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101656388  CTNNB1; catenin beta-1 [KO:K02105]
101658427  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
101662665  TFAP4; transcription factor AP-4 [KO:K09108]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101649648  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101656527  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
101655753  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101662935  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101662217  LUM; lumican [KO:K08122]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101642964  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101641929  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
101642651  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
101638944  SDC1; syndecan-1 [KO:K06257]
101644662  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
101662271  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
101647520  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101647433  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101651459  ITGA2; integrin alpha-2 [KO:K06481]
101652501  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101658038  VTN; vitronectin [KO:K06251]
101643277  ITGAV; integrin alpha-V [KO:K06487]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101653760  FN1; fibronectin [KO:K05717]
101645557  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101648285  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101640257  FZD7; frizzled-7 [KO:K02432]
101643067  FZD1; frizzled-1 [KO:K02432]
101643509  FZD2; frizzled-2 [KO:K02235]
101664566  FZD3; frizzled-3 [KO:K02329]
101657948  FZD4; frizzled-4 [KO:K02354]
101647407  FZD5; frizzled-5 [KO:K02375]
101639796  FZD6; frizzled-6 isoform X1 [KO:K02376]
101652101  FZD10; frizzled-10 [KO:K02842]
101650133  FZD9; frizzled-9 [KO:K02842]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101649232  SDC2; syndecan-2 [KO:K16336]
101658452  EZR; ezrin [KO:K08007]
101647335  RDX; radixin [KO:K05762]
101646749  MSN; moesin [KO:K05763]
101658204  SDC4; syndecan-4 [KO:K16338]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101656564  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
101642693  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101651012  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101644253  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101638380  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
101653688  PXN; paxillin [KO:K05760]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101645564  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
101642232  GPC1; glypican-1 [KO:K08107]
101657076  IGF2; insulin-like growth factor II [KO:K13769]
101639276  GPC3; glypican-3 [KO:K08109]
101660424  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
101651785  WNT2; protein Wnt-2 [KO:K00182]
101638407  WNT3A; protein Wnt-3a [KO:K00312]
101653676  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101647219  WNT4; protein Wnt-4 [KO:K00408]
101658376  WNT5B; protein Wnt-5b [KO:K00444]
101663396  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101661610  WNT6; protein Wnt-6 [KO:K00445]
101651048  WNT7A; protein Wnt-7a [KO:K00572]
101656448  WNT7B; protein Wnt-7b [KO:K00572]
101644829  WNT8A; protein Wnt-8a [KO:K00714]
101637931  WNT8B; protein Wnt-8b [KO:K00714]
101653050  WNT9B; protein Wnt-9b [KO:K01064]
101664591  WNT9A; protein Wnt-9a [KO:K01064]
101662542  WNT10A; protein Wnt-10a [KO:K01357]
101648596  WNT10B; protein Wnt-10b [KO:K01357]
101642476  WNT11; protein Wnt-11 [KO:K01384]
101653677  WNT16; protein Wnt-16 [KO:K01558]
101639628  SHH; sonic hedgehog protein [KO:K11988]
101662543  IHH; indian hedgehog protein [KO:K11989]
101661574  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101641005  SMO; smoothened homolog [KO:K06226]
101640364  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101663773  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
101641886  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101644475  HSPB2; heat shock protein beta-2 [KO:K09543]
101662456  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
etf04010  MAPK signaling pathway
etf04020  Calcium signaling pathway
etf04066  HIF-1 signaling pathway
etf04150  mTOR signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04310  Wnt signaling pathway
etf04340  Hedgehog signaling pathway
etf04350  TGF-beta signaling pathway
etf04370  VEGF signaling pathway
etf04510  Focal adhesion
etf04520  Adherens junction
etf04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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