KEGG   PATHWAY: lav04510
Entry
lav04510                    Pathway                                
Name
Focal adhesion - Loxodonta africana (African savanna elephant)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
lav04510  Focal adhesion
lav04510

Other DBs
GO: 0005925
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100668620  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100671297  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
100675826  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
100664111  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100664398  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100677472  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100667607  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100667893  collagen alpha-6(IV) chain [KO:K06237]
100677754  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
100655197  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100663273  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100662988  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
100665075  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
100665360  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100664786  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
100668022  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100675250  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
100671962  collagen alpha-2(IX) chain [KO:K08131]
100672596  LAMA1; laminin subunit alpha-1 [KO:K05637]
100677404  LAMA2; laminin subunit alpha-2 [KO:K05637]
104845537  LAMA3; laminin subunit alpha-3 [KO:K06240]
100676944  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
111749628  laminin subunit alpha-3-like [KO:K06240]
100662531  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
100675837  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100655070  LAMB2; laminin subunit beta-2 [KO:K06243]
100666736  LAMB3; LOW QUALITY PROTEIN: laminin subunit beta-3 [KO:K06244]
100658659  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100671561  LAMC1; laminin subunit gamma-1 [KO:K05635]
100661346  LAMC2; laminin subunit gamma-2 [KO:K06246]
100670126  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
100669678  CHAD; chondroadherin [KO:K06248]
100655250  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
100667431  THBS1; thrombospondin-1 [KO:K16857]
100673862  THBS4; thrombospondin-4 [KO:K04659]
100657841  THBS3; thrombospondin-3 isoform X2 [KO:K04659]
100677407  THBS2; thrombospondin-2 [KO:K04659]
100667600  COMP; cartilage oligomeric matrix protein [KO:K04659]
100667853  FN1; fibronectin isoform X8 [KO:K05717]
100670250  SPP1; osteopontin [KO:K06250]
100653772  VTN; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
100655345  TNC; tenascin isoform X1 [KO:K06252]
100667593  TNN; tenascin-N [KO:K06252]
100656584  TNR; tenascin-R isoform X1 [KO:K06252]
100657780  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100671560  VWF; von Willebrand factor [KO:K03900]
100675022  IBSP; bone sialoprotein 2 [KO:K06253]
100674420  ITGA1; integrin alpha-1 [KO:K06480]
100674705  ITGA2; integrin alpha-2 [KO:K06481]
100654429  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100671578  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
100674409  ITGA4; integrin alpha-4 [KO:K06483]
100676951  ITGA5; integrin alpha-5 [KO:K06484]
100661035  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100665471  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
100674808  ITGA8; integrin alpha-8 [KO:K06584]
100660884  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
100667832  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100670461  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100671252  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100664978  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100660405  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100671877  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100676335  ITGB5; integrin beta-5 [KO:K06588]
100664907  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
100661118  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100661984  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100657852  EMP2; epithelial membrane protein 2 [KO:K26256]
100663544  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100661451  PDGFD; platelet-derived growth factor D [KO:K05450]
100672750  PDGFC; platelet-derived growth factor C [KO:K05450]
100670137  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
100664710  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100661392  VEGFA; vascular endothelial growth factor A [KO:K05448]
100668949  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100674895  PGF; placenta growth factor isoform X2 [KO:K16859]
100657845  VEGFC; vascular endothelial growth factor C [KO:K05449]
100665819  VEGFD; vascular endothelial growth factor D [KO:K05449]
100665493  HGF; hepatocyte growth factor [KO:K05460]
100670735  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100671240  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100655087  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100656232  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100659125  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100668928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100677038  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100656285  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100662583  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
100675264  EMP1; epithelial membrane protein 1 [KO:K26255]
100675475  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100667574  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100667102  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
100677447  RHOA; transforming protein RhoA [KO:K04513]
100662066  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
100657418  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100658857  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100654026  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
100657954  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100672436  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100670066  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
100660456  myosin regulatory light chain 12B [KO:K12757]
100660948  myosin regulatory light polypeptide 9 [KO:K12757]
100660199  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100673814  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100671604  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100673922  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
100675940  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
100669550  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100665634  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100656405  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100677183  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
100674713  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
100655311  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
100675521  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100670743  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100654618  ACTB; actin, cytoplasmic 1 [KO:K05692]
100662772  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100663804  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100661051  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
100655307  ACTN4; alpha-actinin-4 [KO:K05699]
100666245  TLN1; talin-1 [KO:K06271]
100662514  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
100674763  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
100655159  FLNB; filamin-B isoform X1 [KO:K27392]
100671127  PXN; paxillin isoform X5 [KO:K05760]
100666830  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
100674787  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100654211  VCL; vinculin [KO:K05700]
100663135  PARVA; alpha-parvin [KO:K06275]
100674376  PARVG; gamma-parvin [KO:K06275]
100674660  beta-parvin [KO:K06275]
100660030  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100675105  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100670988  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
100665537  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100672078  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100671733  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100668436  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100660561  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100662747  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100673242  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100677422  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100664204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100670080  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100668003  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
100664379  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100668837  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
100661100  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100666744  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100660904  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
100664103  CDC42; cell division control protein 42 homolog [KO:K04393]
100675124  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100659273  CRK; adapter molecule crk isoform X1 [KO:K04438]
100662046  CRKL; crk-like protein [KO:K04438]
100663543  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
100668712  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
100676220  RAP1A; ras-related protein Rap-1A [KO:K04353]
100665185  RAP1B; ras-related protein Rap-1b [KO:K07836]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100670432  JUN; transcription factor AP-1 [KO:K04448]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100655995  CAV1; caveolin-1 [KO:K06278]
100655716  CAV2; caveolin-2 isoform X1 [KO:K12958]
100663316  CAV3; LOW QUALITY PROTEIN: caveolin-3 [KO:K12959]
100675535  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
100653766  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100659669  SHC3; SHC-transforming protein 3 [KO:K17448]
100654827  SHC4; SHC-transforming protein 4 [KO:K17449]
100655474  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100657379  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100656200  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100670835  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100669703  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100668070  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100668683  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100659163  baculoviral IAP repeat-containing protein 3 [KO:K16060]
100659446  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100657657  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100668387  BAD; bcl2-associated agonist of cell death [KO:K02158]
100675268  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
lav04010  MAPK signaling pathway
lav04060  Cytokine-cytokine receptor interaction
lav04070  Phosphatidylinositol signaling system
lav04110  Cell cycle
lav04151  PI3K-Akt signaling pathway
lav04310  Wnt signaling pathway
lav04512  ECM-receptor interaction
lav04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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