KEGG   PATHWAY: lco05132
Entry
lco05132                    Pathway                                
Name
Salmonella infection - Larimichthys crocea (large yellow croaker)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
lco05132  Salmonella infection
lco05132

Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
109138213  podxl; podocalyxin [KO:K06817]
104921845  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
104931780  rab5a; ras-related protein Rab-5A [KO:K07887]
104923118  ras-related protein Rab-5A [KO:K07887]
104938166  ras-related protein Rab-5B [KO:K07888]
104924139  ras-related protein Rab-5C-like [KO:K07889]
104926007  rab5c; ras-related protein Rab-5C [KO:K07889]
104932921  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
104933016  ras-related protein rab7 [KO:K07897]
104939439  ras-related protein rab7 [KO:K07897]
104933106  ras-related protein rab7 [KO:K07897]
104928473  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
104935116  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104934016  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
104929762  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104921712  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
104935355  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
104925286  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
104922874  RILP-like protein 1 isoform X1 [KO:K13883]
104931694  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X2 [KO:K10413]
104920114  cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
104927776  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104933936  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
104922839  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
104922709  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
104922056  cytoplasmic dynein 1 light intermediate chain 1 isoform X2 [KO:K10416]
104928427  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
104923525  dynein light chain 2, cytoplasmic [KO:K10418]
104932894  dynein light chain 2, cytoplasmic [KO:K10418]
104921657  dynein light chain 2, cytoplasmic [KO:K10418]
104936808  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
109137416  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
104937236  dynein light chain Tctex-type 1-like [KO:K10420]
104932353  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
104925200  dynactin subunit 1 isoform X1 [KO:K04648]
104932475  dynactin subunit 1 isoform X1 [KO:K04648]
104919969  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
109138719  dctn3; dynactin subunit 3 [KO:K10425]
104924210  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
104917636  dctn5; dynactin subunit 5 [KO:K10427]
104923984  dynactin subunit 6 [KO:K10428]
104930924  dctn6; dynactin subunit 6 [KO:K10428]
104936322  beta-centractin [KO:K16575]
104919816  actr10; actin-related protein 10 [KO:K16576]
104937214  tubulin alpha-1B chain isoform X3 [KO:K07374]
104929096  tubulin alpha chain [KO:K07374]
104928615  tubulin alpha chain [KO:K07374]
104928608  tubulin alpha chain [KO:K07374]
104928597  tubulin alpha chain [KO:K07374]
109138324  tubulin alpha-1C chain [KO:K07374]
104934618  tubulin alpha-1D chain [KO:K07374]
104934610  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
104931313  tubulin alpha-1C chain [KO:K07374]
104919932  tubulin alpha-8 chain [KO:K07374]
104937218  tubulin alpha chain isoform X1 [KO:K07374]
104935199  tubulin beta-4B chain [KO:K07375]
104938425  tubulin beta-5 chain isoform X2 [KO:K07375]
109140809  tubulin beta chain-like [KO:K07375]
104929325  tubulin beta chain isoform X1 [KO:K07375]
104929038  tubulin beta chain [KO:K07375]
104923784  tubulin beta-1 chain [KO:K07375]
104937097  tubulin beta-4B chain [KO:K07375]
104918600  tubulin beta-4B chain [KO:K07375]
104922243  tubb; tubulin beta chain [KO:K07375]
104917754  FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
104918454  fyco1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
109139495  ADP-ribosylation factor-like protein 8A [KO:K07955]
104933621  ADP-ribosylation factor-like protein 8B [KO:K07955]
104920499  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
104927140  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
104919968  kif5a; kinesin heavy chain isoform X1 [KO:K10396]
104926424  kinesin heavy chain-like [KO:K10396]
104926228  kif5c; kinesin heavy chain [KO:K10396]
104926299  kif5b; kinesin-1 heavy chain isoform X2 [KO:K10396]
104932574  kinesin-1 heavy chain [KO:K10396]
104935814  kinesin heavy chain-like [KO:K10396]
104932302  klc2; kinesin light chain 2 [KO:K10407]
104938950  klc1; kinesin light chain 1 isoform X3 [KO:K10407]
104931227  kinesin light chain 1-like [KO:K10407]
104925708  kinesin light chain 1 isoform X1 [KO:K10407]
104921988  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
104933039  rho-related GTP-binding protein RhoA-C [KO:K04513]
104933314  transforming protein RhoA [KO:K04513]
104931794  rho-related GTP-binding protein RhoA-C [KO:K04513]
104932082  transforming protein RhoA [KO:K04513]
104918352  rho-related GTP-binding protein RhoA-B [KO:K04513]
104929022  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104925019  ras-related protein Rab-9A isoform X1 [KO:K07899]
104935060  ras-related protein Rab-9A [KO:K07899]
104923185  ras-related protein Rab-9B [KO:K07900]
104918664  gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
104924520  stx10; syntaxin-10 [KO:K23937]
104921276  profilin-2-like [KO:K05759]
104923512  pfn2; profilin-2 isoform X1 [KO:K05759]
104937620  profilin-1 [KO:K05759]
104935653  filamin-A isoform X1 [KO:K04437]
104928158  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
104921420  exoc5; exocyst complex component 5 [KO:K19984]
104923698  exoc4; exocyst complex component 4 isoform X1 [KO:K06111]
104932402  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
104933802  rala; ras-related protein Ral-A [KO:K07834]
104939525  actin, cytoplasmic [KO:K05692]
104921174  actin, cytoplasmic 2 [KO:K05692]
104932075  actb; actin, cytoplasmic 1 [KO:K05692]
104927535  protein S100-A1 [KO:K17274]
104918196  protein S100-A1 [KO:K17274]
104917853  annexin A2 [KO:K17092]
104937699  annexin A2 [KO:K17092]
104928443  annexin A2-like [KO:K17092]
104929388  neuroblast differentiation-associated protein AHNAK [KO:K23934]
104920005  ahnak; neuroblast differentiation-associated protein AHNAK [KO:K23934]
104932447  protein AHNAK2-like [KO:K23934]
104933029  neuroblast differentiation-associated protein AHNAK [KO:K23934]
104927645  arhgef26; rho guanine nucleotide exchange factor 26 [KO:K13744]
104923191  rho-related GTP-binding protein RhoG [KO:K07863]
109141109  rho-related GTP-binding protein RhoG-like isoform X1 [KO:K07863]
109141110  rho-related GTP-binding protein RhoG isoform X1 [KO:K07863]
104926123  rho-related GTP-binding protein RhoG [KO:K07863]
104931821  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
104924772  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
104926776  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
104926365  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104927948  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104939604  myosin light chain 5 isoform X1 [KO:K12753]
104922971  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
104936390  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12755]
104931269  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104918953  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104922583  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
104925296  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
104926897  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
104930230  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
104925757  FH1/FH2 domain-containing protein 1-like isoform X2 [KO:K23938]
104924679  cell division control protein 42 homolog isoform X1 [KO:K04393]
104932543  cell division control protein 42 homolog [KO:K04393]
104935006  cell division control protein 42 homolog [KO:K04393]
104923623  cell division control protein 42 homolog isoform X1 [KO:K04393]
104918062  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104918805  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104919952  nckap1l; nck-associated protein 1-like isoform X2 [KO:K05750]
109138222  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
104923893  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
104929481  cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
104934146  abl interactor 1 isoform X1 [KO:K23649]
104936690  abi1; abl interactor 1 isoform X1 [KO:K23649]
104920511  brk1; protein BRICK1 [KO:K05752]
104938127  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
104924972  wasf3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
104934531  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
104930021  actin-related protein 2-A [KO:K17260]
104918538  actin-related protein 2-B [KO:K17260]
104932299  actin-related protein 2 [KO:K17260]
104928563  actin-related protein 3 [KO:K18584]
104923131  actin-related protein 3 [KO:K18584]
104927173  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
104921185  actin-related protein 2/3 complex subunit 1A [KO:K05757]
104921186  actin-related protein 2/3 complex subunit 1B [KO:K05757]
104935055  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104928255  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104938980  actin-related protein 2/3 complex subunit 4 [KO:K05755]
104933105  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
104934801  actin-related protein 2/3 complex subunit 5 [KO:K05754]
104921830  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104935297  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104928544  LOW QUALITY PROTEIN: unconventional myosin-VI [KO:K10358]
104922148  unconventional myosin-VI [KO:K10358]
104927097  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104919391  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104934900  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104921281  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104933269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104933235  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104931247  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
104940676  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
104937642  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
104921784  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
104925066  cytohesin-1 isoform X1 [KO:K18441]
104918807  cytohesin-3 isoform X2 [KO:K18441]
109136990  cyth2; cytohesin-2 [KO:K18441]
104933894  cytohesin-1 isoform X1 [KO:K18441]
104934492  cytohesin-2 isoform X2 [KO:K18441]
104918061  cyth3; cytohesin-3 [KO:K18441]
104925981  cytohesin-4-like [KO:K18441]
104921389  ADP-ribosylation factor 6 [KO:K07941]
104919820  ADP-ribosylation factor 6 [KO:K07941]
104938681  ADP-ribosylation factor 1-like [KO:K07937]
104917685  arf1; ADP-ribosylation factor 1 [KO:K07937]
104923917  ADP-ribosylation factor 1-like 2 [KO:K07937]
104922378  snx33; sorting nexin-33 [KO:K17923]
104921073  sorting nexin-18 [KO:K17923]
104934005  sorting nexin-9 isoform X1 [KO:K17923]
104922980  snx18; sorting nexin-18 [KO:K17923]
104932583  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
104927978  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein [KO:K23612]
104925389  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
104918589  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
104918033  toll-like receptor 6 [KO:K10169]
104934739  toll-like receptor 2 [KO:K10159]
104938453  toll-like receptor 2 type-2 [KO:K10159]
104923941  toll-like receptor 2 type-2 [KO:K10159]
104940498  tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
104937116  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104926138  toll-like receptor 5 [KO:K10168]
104935488  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
104933859  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104920634  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104928162  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
104924081  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104925439  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104918319  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
104920245  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
104933745  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104930409  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104928982  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104921662  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104931204  NF-kappa-B inhibitor alpha [KO:K04734]
104928653  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
109141199  putative transcription factor p65 homolog isoform X1 [KO:K04735]
104925478  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
104924694  heat shock protein HSP 90-alpha 1 [KO:K04079]
104924933  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109136649  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
104940626  hsp90b1; endoplasmin [KO:K09487]
104920921  ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
104928128  cse1l; exportin-2 [KO:K18423]
104936890  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
104924739  kpna4; importin subunit alpha-3 [KO:K23583]
104931212  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
104920460  hras; GTPase HRas [KO:K02833]
104940217  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104922316  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104920827  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104929670  dual specificity mitogen-activated protein kinase kinase 2-like isoform X1 [KO:K04369] [EC:2.7.12.2]
104929510  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104932685  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104925053  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104928151  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
104919509  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104923726  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104925765  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
104939458  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
104926599  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
104924523  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104924524  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104919484  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
104933979  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
104934939  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104926477  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104922720  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
104924269  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
104928586  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104922421  proto-oncogene c-Fos isoform X2 [KO:K04379]
104922420  proto-oncogene c-Fos [KO:K04379]
109141650  fos; proto-oncogene c-Fos [KO:K04379]
104927418  jun; transcription factor AP-1 [KO:K04448]
104926010  transcription factor AP-1 [KO:K04448]
104937023  transcription factor AP-1 [KO:K04448]
104931067  tumor necrosis factor [KO:K03156]
104931068  tumor necrosis factor-like [KO:K03156]
104933337  tumor necrosis factor-like [KO:K03156]
104923462  interleukin-1 beta [KO:K04519]
104938000  interleukin-8 [KO:K10030]
104938003  growth-regulated alpha protein [KO:K10030]
104924350  interleukin-8 [KO:K10030]
104924349  interleukin-8-like precursor [KO:K10030]
104922057  catenin beta-1 [KO:K02105]
104928105  catenin beta-1 [KO:K02105]
104924428  lymphoid enhancer-binding factor 1 isoform X2 [KO:K02620]
104935330  transcription factor 7-like 1-B isoform X1 [KO:K04490]
104937897  transcription factor 7-like 1-A isoform X1 [KO:K04490]
104932553  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
104927262  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
104938695  transcriptional regulator Myc-2 [KO:K04377]
104935616  myc; myc proto-oncogene protein [KO:K04377]
104934318  transcriptional regulator Myc-B [KO:K04377]
104931376  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
104934938  pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
104918198  fbxo22; F-box only protein 22 [KO:K10302]
104924374  skp1; S-phase kinase-associated protein 1 [KO:K03094]
104929001  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104930866  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
104939546  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
104925037  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104930371  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104934542  inhibitor of apoptosis protein [KO:K16060]
104931522  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
104929005  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
104936375  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
104920041  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104939189  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104936786  tumor necrosis factor receptor superfamily member 10B-like precursor [KO:K04722]
104939559  tumor necrosis factor receptor superfamily member 10B isoform X3 [KO:K04722]
104933825  FAS-associated death domain protein [KO:K02373]
104938225  caspase-8 [KO:K04398] [EC:3.4.22.61]
104938227  caspase-8 [KO:K04398] [EC:3.4.22.61]
104924422  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
104936986  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
104933823  apoptosis regulator BAX [KO:K02159]
104923927  apoptosis regulator BAX [KO:K02159]
104927165  apoptosis regulator BAX isoform X2 [KO:K02159]
104934161  cytochrome c [KO:K08738]
104924425  cytochrome c [KO:K08738]
104940584  cytochrome c-a [KO:K08738]
104918293  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
104939569  apoptosis regulator Bcl-2-like [KO:K02161]
104936945  caspase-3; caspase-3-like [KO:K02187] [EC:3.4.22.56]
104928227  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104927890  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104937898  caspase-3 isoform X1 [KO:K04397] [EC:3.4.22.60]
104926752  rhob; rho-related GTP-binding protein RhoB [KO:K07856]
104934852  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
104918516  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104940519  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104931217  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104924791  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104935530  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104934603  mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
104939715  txn2; thioredoxin, mitochondrial [KO:K03671]
104932912  thioredoxin [KO:K03671]
104924727  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109142120  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
104924732  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
lco04010  MAPK signaling pathway
lco04210  Apoptosis
lco04217  Necroptosis
lco04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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