Entry Name T cell receptor signaling pathway - Marmota marmota marmota (Alpine marmot)
Description Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Marmota marmota marmota (Alpine marmot) [GN:
mmma ]
Gene 107145809 T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450 ]
107147426 Cd247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453 ]
107146887 Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362 ]
107159137 Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
107156565 Vav3; guanine nucleotide exchange factor VAV3 isoform X3 [KO:K05730 ]
107142153 Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
107153931 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107154781 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107153998 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X5 [KO:K04446 ]
107137245 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332 ]
107151069 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
107155973 Card11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
107139306 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
107141352 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
107138627 Cd28; T-cell-specific surface glycoprotein CD28 isoform X2 [KO:K06470 ]
107139438 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
107141811 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
107145061 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
107143149 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107149519 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107155522 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107148131 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
107145870 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456 ]
107159012 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
107153732 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
107138910 Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354 ]
107152929 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
107153907 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
107147135 Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
107143155 Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583 ]
107135990 Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
107143927 Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584 ]
107150625 Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584 ]
107145931 Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
107140569 Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
107148177 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Chen L.
Title Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Journal Reference Authors Macian F.
Title NFAT proteins: key regulators of T-cell development and function.
Journal Reference Authors Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
Title Tec family kinases in T lymphocyte development and function.
Journal Reference Authors Huang Y, Wange RL.
Title T cell receptor signaling: beyond complex complexes.
Journal Reference Authors Schmitz ML, Bacher S, Dienz O.
Title NF-kappaB activation pathways induced by T cell costimulation.
Journal Reference Authors Alegre ML, Frauwirth KA, Thompson CB.
Title T-cell regulation by CD28 and CTLA-4.
Journal Reference Authors Horejsi V, Zhang W, Schraven B.
Title Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
Journal Reference Authors Baniyash M.
Title TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.
Journal Reference Authors Sechi AS, Wehland J.
Title Interplay between TCR signalling and actin cytoskeleton dynamics.
Journal Reference Authors Okkenhaug K, Vanhaesebroeck B.
Title PI3K in lymphocyte development, differentiation and activation.
Journal Reference Authors Palacios EH, Weiss A.
Title Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Journal Reference Authors Kane LP, Lin J, Weiss A.
Title It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
Journal Reference Authors Acuto O, Michel F.
Title CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Journal Reference Authors Finkelstein LD, Schwartzberg PL.
Title Tec kinases: shaping T-cell activation through actin.
Journal Reference Authors Duan L, Reddi AL, Ghosh A, Dimri M, Band H.
Title The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.
Journal Reference Authors Schrum AG, Turka LA, Palmer E.
Title Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
Journal Reference Authors Smith-Garvin JE, Koretzky GA, Jordan MS
Title T cell activation.
Journal Reference Authors Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
Title Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Journal Reference Authors Blonska M, Lin X
Title CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
Journal Reference Authors Rebeaud F, Hailfinger S, Thome M
Title Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Journal Reference Authors Ashwell JD
Title The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Journal Reference Authors Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
Title Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Journal Related KO pathway LinkDB All DBs
