KEGG   PATHWAY: mthb04015
Entry
mthb04015                   Pathway                                
Name
Rap1 signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04015  Rap1 signaling pathway
mthb04015

Other DBs
GO: 0007264
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126930173  ras-related protein Rap-1A [KO:K04353]
126930986  ras-related protein Rap-1b [KO:K07836]
126937705  ras-related protein Rap-1b-like [KO:K07836]
126948197  ras-related protein M-Ras isoform X1 [KO:K07831]
126950012  rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
126949809  dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
126936897  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
126944576  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
126930739  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
126957589  proteinase-activated receptor 1 [KO:K03914]
126942286  proteinase-activated receptor 4 [KO:K04236]
126947504  P2Y purinoceptor 1 [KO:K04270]
126943054  fMet-Leu-Phe receptor [KO:K04172]
126937741  lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
126935655  lysophosphatidic acid receptor 1-like isoform X1 [KO:K04289]
126942297  lysophosphatidic acid receptor 2 [KO:K04291]
126963632  lysophosphatidic acid receptor 3 [KO:K04294]
126946250  lysophosphatidic acid receptor 4 [KO:K04275]
126930445  lysophosphatidic acid receptor 5 [KO:K08390]
126929656  adenosine receptor A2a [KO:K04266]
126938806  adenosine receptor A2b [KO:K04267]
126929358  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
126929369  neuroendocrine secretory protein 55 [KO:K04632]
126950155  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
126956053  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126933644  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
126958798  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
126949094  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126930150  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126944901  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
126961343  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
126944580  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
126930152  rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
126932480  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
126937577  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126934266  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
126935564  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126954986  fibroblast growth factor 2 [KO:K18497]
126942993  fibroblast growth factor 22 [KO:K04358]
126962737  fibroblast growth factor 8 isoform X1 [KO:K04358]
126931752  fibroblast growth factor 6 [KO:K04358]
126956981  fibroblast growth factor 18 [KO:K04358]
126957199  fibroblast growth factor 10 [KO:K04358]
126946335  fibroblast growth factor 16 [KO:K04358]
126958707  fibroblast growth factor 7 [KO:K04358]
126940532  fibroblast growth factor 9 [KO:K04358]
126935967  fibroblast growth factor 3 [KO:K04358]
126935973  fibroblast growth factor 4 [KO:K04358]
126960920  fibroblast growth factor 20 [KO:K04358]
126961295  fibroblast growth factor 17 isoform X1 [KO:K04358]
126935968  fibroblast growth factor 19 [KO:K22603]
126943598  fibroblast growth factor 21 [KO:K22429]
126931744  fibroblast growth factor 23 [KO:K22428]
126930848  beta-nerve growth factor [KO:K02582]
126935873  insulin isoform X1 [KO:K04526]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126950578  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126963759  platelet-derived growth factor subunit B [KO:K17386]
126936264  platelet-derived growth factor D isoform X1 [KO:K05450]
126954312  platelet-derived growth factor C [KO:K05450]
126929640  macrophage colony-stimulating factor 1 [KO:K05453]
126929998  kit ligand isoform X1 [KO:K05461]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126935608  vascular endothelial growth factor B isoform X1 [KO:K16858]
126959573  placenta growth factor isoform X1 [KO:K16859]
126955710  vascular endothelial growth factor C isoform X1 [KO:K05449]
126946911  vascular endothelial growth factor D isoform X1 [KO:K05449]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126961624  angiopoietin-1 isoform X1 [KO:K05465]
126961064  angiopoietin-2 isoform X1 [KO:K05466]
126964222  angiopoietin-4 isoform X1 [KO:K05467]
126942796  ephrin-A2 [KO:K05462]
126957121  ephrin-A5 isoform X1 [KO:K05462]
126934418  ephrin-A4 isoform X1 [KO:K05462]
126934582  ephrin-A3 isoform X1 [KO:K05462]
126934657  ephrin-A1 [KO:K05462]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126961189  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126962662  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126955560  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
126956321  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
126939872  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126954734  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126956582  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126956584  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126954735  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
126940714  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126956306  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
126954733  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126937984  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
126956768  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126938875  adapter molecule crk isoform X1 [KO:K04438]
126929691  crk-like protein [KO:K04438]
126936885  rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
126943713  breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
126944055  cadherin-1 [KO:K05689]
126948505  catenin beta-1 isoform X1 [KO:K02105]
126947634  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
126949884  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
126930314  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
126954894  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126955962  rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
126958307  uncharacterized protein LOC126958307 [KO:K10784]
126951109  LOW QUALITY PROTEIN: M1-specific T cell receptor beta chain-like [KO:K10785]
126944473  linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
126956446  FYN-binding protein 1 isoform X1 [KO:K17698]
126956975  lymphocyte cytosolic protein 2 [KO:K07361]
126938516  src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
126963902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126943412  serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
126933541  serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
126959387  serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
126935923  D(2) dopamine receptor [KO:K04145]
126951988  cannabinoid receptor 1 [KO:K04277]
126929846  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
126949885  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
126948709  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
126943869  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126954840  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
126958761  signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
126935330  signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
126942249  signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
126941962  signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
126964315  DNA-binding protein inhibitor ID-1 [KO:K04680]
126957930  thrombospondin-1 [KO:K16857]
126929778  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929779  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929780  ral-GDS-related protein-like [KO:K08732]
126936899  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
126964069  ral-GDS-related protein-like [KO:K08732]
126947346  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929238  ral-GDS-related protein-like [KO:K08732]
126929502  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929506  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929550  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929580  ral-GDS-related protein-like isoform X1 [KO:K08732]
126929584  ral-GDS-related protein-like [KO:K08732]
126929625  ral-GDS-related protein-like [KO:K08732]
126950131  ras-related protein Ral-A [KO:K07834]
126933156  ras-related protein Ral-B [KO:K07835]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126963767  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126939124  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126962868  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1 [KO:K17704]
126938021  talin-1 isoform X1 [KO:K06271]
126958725  talin-2 isoform X1 [KO:K06271]
126938666  integrin alpha-IIb [KO:K06476]
126939509  integrin beta-3 [KO:K06493]
126956385  profilin-3 [KO:K05759]
126933676  profilin-4 [KO:K05759]
126939800  profilin-1 isoform X1 [KO:K05759]
126946576  profilin-2-like [KO:K05759]
126948247  profilin-2 isoform X1 [KO:K05759]
126953165  profilin-2-like [KO:K05759]
126943479  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
126937073  protein enabled homolog isoform X1 [KO:K05746]
126958430  ena/VASP-like protein isoform X1 [KO:K23487]
126932601  actin, cytoplasmic 2 [KO:K05692]
126939111  actin, cytoplasmic 2 [KO:K05692]
126950494  actin, cytoplasmic 1 isoform X1 [KO:K05692]
126957237  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
126948741  transforming protein RhoA [KO:K04513]
126964210  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126932783  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126942510  proto-oncogene vav [KO:K05730]
126936911  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
126947777  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
126951691  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
126962979  partitioning defective 3 homolog isoform X1 [KO:K04237]
126944023  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
126964388  partitioning defective 6 homolog beta [KO:K06093]
126941471  LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma-like [KO:K06093]
126951757  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
126947535  protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
126952445  afadin isoform X1 [KO:K05702]
126936086  catenin delta-1 isoform X1 [KO:K05690]
126949909  krev interaction trapped protein 1 isoform X1 [KO:K17705]
126956332  regulator of G-protein signaling 14 isoform X1 [KO:K17706]
126938008  ras association domain-containing protein 5 isoform X1 [KO:K08015]
126944173  integrin alpha-L [KO:K05718]
126944175  integrin alpha-M isoform X1 [KO:K06461]
126950616  integrin beta-2 isoform X1 [KO:K06464]
126962945  integrin beta-1 isoform X1 [KO:K05719]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126939044  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
126939854  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126962017  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126943140  ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mthb04010  MAPK signaling pathway
mthb04014  Ras signaling pathway
mthb04020  Calcium signaling pathway
mthb04151  PI3K-Akt signaling pathway
mthb04510  Focal adhesion
mthb04520  Adherens junction
mthb04660  T cell receptor signaling pathway
mthb04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
LinkDB

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