Entry Name Phospholipase D signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Organism Macaca thibetana thibetana (Pere David's macaque) [GN:
mthb ]
Gene 126936899 ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732 ]
126952893 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126961422 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
126956531 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
126942202 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
126936516 high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
126935504 high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
126936944 high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
126938356 guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639 ]
126939669 phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
126929358 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
Compound C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C06124 Sphingosine 1-phosphate
Reference Authors Oude Weernink PA, Lopez de Jesus M, Schmidt M
Title Phospholipase D signaling: orchestration by PIP2 and small GTPases.
Journal Reference Authors Selvy PE, Lavieri RR, Lindsley CW, Brown HA
Title Phospholipase D: enzymology, functionality, and chemical modulation.
Journal Reference Authors Brandenburg LO, Pufe T, Koch T
Title Role of phospholipase d in g-protein coupled receptor function.
Journal Reference Authors Oude Weernink PA, Han L, Jakobs KH, Schmidt M
Title Dynamic phospholipid signaling by G protein-coupled receptors.
Journal Reference Authors Foster DA, Salloum D, Menon D, Frias MA
Title Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
Journal Reference Authors Jenkins GM, Frohman MA
Title Phospholipase D: a lipid centric review.
Journal Reference Authors Metcalfe DD, Peavy RD, Gilfillan AM
Title Mechanisms of mast cell signaling in anaphylaxis.
Journal Reference Authors Kalesnikoff J, Galli SJ
Title New developments in mast cell biology.
Journal Reference Authors Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
Title Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
Journal Reference Authors Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
Title The roles of phospholipase D in EGFR signaling.
Journal Reference Authors Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
Title The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
Journal Reference Authors Kam Y, Exton JH
Title Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
Journal Reference Authors Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
Title Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
Journal Reference Authors Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
Title Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
Journal Reference Authors Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
Title Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
Journal Reference Authors Freeman EJ
Title The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
Journal Reference Authors Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
Title Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
Journal Reference Authors Murdoch C, Finn A
Title Chemokine receptors and their role in inflammation and infectious diseases.
Journal Blood 95:3032-43 (2000)
Reference Authors Sugiyama T, Sakai T, Nozawa Y, Oka N
Title Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
Journal Reference Authors Foster DA
Title Regulation of mTOR by phosphatidic acid?
Journal Reference Authors Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
Title Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
Journal Reference Authors Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
Title Phospholipase signalling networks in cancer.
Journal Reference Authors Foster DA
Title Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
Journal Related KO pathway LinkDB All DBs
