KEGG   PATHWAY: ngi04810
Entry
ngi04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Nannospalax galili (Upper Galilee mountains blind mole rat)
Class
Cellular Processes; Cell motility
Pathway map
ngi04810  Regulation of actin cytoskeleton
ngi04810

Other DBs
GO: 0030036
Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103732526  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
103726831  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
103737817  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
103727518  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
103745020  Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031]
103734615  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
103742495  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
103752270  F2r; coagulation factor II thrombin receptor [KO:K03914]
103738986  Ins; insulin [KO:K04526]
103742642  Egf; epidermal growth factor [KO:K04357]
103736084  Fgf1; fibroblast growth factor 1 [KO:K18496]
103746947  Fgf2; fibroblast growth factor 2 [KO:K18497]
103733041  Fgf7; fibroblast growth factor 7 [KO:K04358]
103734036  Fgf10; fibroblast growth factor 10 [KO:K04358]
103737833  Fgf16; fibroblast growth factor 16 [KO:K04358]
103737403  Fgf22; fibroblast growth factor 22 [KO:K04358]
103742625  Fgf5; fibroblast growth factor 5 [KO:K04358]
103743281  Fgf20; fibroblast growth factor 20 [KO:K04358]
103744005  Fgf8; fibroblast growth factor 8 [KO:K04358]
103748184  Fgf18; fibroblast growth factor 18 [KO:K04358]
103751508  Fgf3; fibroblast growth factor 3 [KO:K04358]
103751500  Fgf4; fibroblast growth factor 4 [KO:K04358]
103747727  Fgf17; fibroblast growth factor 17 [KO:K04358]
103727190  Fgf9; fibroblast growth factor 9 [KO:K04358]
103727544  Fgf6; fibroblast growth factor 6 [KO:K04358]
103751507  Fgf19; fibroblast growth factor 19 [KO:K22603]
103743629  Fgf21; fibroblast growth factor 21 [KO:K22429]
103727545  Fgf23; fibroblast growth factor 23 [KO:K22428]
103748699  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
103748570  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
103731702  Pdgfd; platelet derived growth factor D [KO:K05450]
103751038  Pdgfc; platelet derived growth factor C [KO:K05450]
103752084  Insrr; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
103748852  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103745770  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103729272  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103741127  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103732354  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103734393  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103747076  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103727691  Fn1; fibronectin 1 [KO:K05717]
103734043  Itga1; integrin subunit alpha 1 [KO:K06480]
103734059  Itga2; integrin subunit alpha 2 [KO:K06481]
103738294  Itga2b; integrin subunit alpha 2b [KO:K06476]
103738376  Itga3; integrin subunit alpha 3 [KO:K06482]
103729874  Itga4; integrin subunit alpha 4 [KO:K06483]
103738966  Itga5; integrin subunit alpha 5 [KO:K06484]
103751741  Itga6; integrin subunit alpha 6 [KO:K06485]
103738830  Itga7; integrin subunit alpha 7 [KO:K06583]
103734817  Itga8; integrin subunit alpha 8 [KO:K06584]
103752249  Itga9; integrin subunit alpha 9 [KO:K06585]
103729511  Itga10; integrin subunit alpha 10 [KO:K06586]
103736909  Itga11; integrin subunit alpha 11 [KO:K06587]
103728788  Itgav; integrin subunit alpha V [KO:K06487]
103726419  Itgal; integrin subunit alpha L [KO:K05718]
103726316  Itgam; integrin subunit alpha M [KO:K06461]
103726315  Itgax; integrin subunit alpha X [KO:K06462]
103726416  Itgad; integrin subunit alpha D [KO:K06594]
103752019  Itgae; integrin subunit alpha E [KO:K06524]
103745645  Itgb1; integrin subunit beta 1 [KO:K05719]
103739950  Itgb2; integrin subunit beta 2 [KO:K06464]
103724762  Itgb3; integrin subunit beta 3 [KO:K06493]
103732717  Itgb4; integrin subunit beta 4 [KO:K06525]
103741999  Itgb5; integrin subunit beta 5 [KO:K06588]
103744081  Itgb6; integrin subunit beta 6 [KO:K06589]
103738472  Itgb7; integrin subunit beta 7 [KO:K06590]
103733702  Itgb8; integrin subunit beta 8 [KO:K06591]
103726185  Kng1; kininogen 1 [KO:K03898]
103727686  Bdkrb1; bradykinin receptor B1 [KO:K03915]
103727666  Bdkrb2; bradykinin receptor B2 [KO:K03916]
103737656  Chrm1; cholinergic receptor muscarinic 1 [KO:K04129]
103726078  Chrm2; cholinergic receptor muscarinic 2 [KO:K04130]
103740661  Chrm3; cholinergic receptor muscarinic 3 [KO:K04131]
103748793  Chrm4; cholinergic receptor muscarinic 4 [KO:K04132]
103740509  Chrm5; cholinergic receptor muscarinic 5 [KO:K04133]
103734494  complement C5-like [KO:K03994]
103741375  C6; complement C6 [KO:K03995]
103741372  C7; complement C7 [KO:K03996]
103732494  C8a; complement C8 alpha chain [KO:K03997]
103732454  C8b; complement C8 beta chain [KO:K03998]
103728304  complement component C8 gamma chain-like [KO:K03999]
103741184  C8g; complement C8 gamma chain [KO:K03999]
103741368  C9; complement C9 [KO:K04000]
103748670  Gna12; G protein subunit alpha 12 [KO:K04346]
103742208  Gna13; G protein subunit alpha 13 [KO:K04639]
103743355  Gng12; G protein subunit gamma 12 [KO:K04347]
103751889  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
103738658  Fgd1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
103749917  Fgd3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
103748419  Ptk2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103725688  Bcar1; BCAR1, Cas family scaffolding protein [KO:K05726]
103741458  Crkl; CRK like proto-oncogene, adaptor protein [KO:K04438]
103730505  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
103744273  dedicator of cytokinesis protein 1-like [KO:K13708]
103733379  dedicator of cytokinesis protein 1 [KO:K13708]
103752029  Src; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103743944  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103731514  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103743672  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
103750424  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
103737601  Mras; muscle RAS oncogene homolog [KO:K07831]
103740148  Arhgef6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103737178  Vav1; vav guanine nucleotide exchange factor 1 [KO:K05730]
103742820  Vav2; vav guanine nucleotide exchange factor 2 [KO:K05730]
103745151  guanine nucleotide exchange factor VAV3 [KO:K05730]
103730717  Vav3; vav guanine nucleotide exchange factor 3 [KO:K05730]
103736475  Tiam1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
103741627  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103726107  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103734183  Mos; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103751295  Rgcc; regulator of cell cycle [KO:K26108]
103744614  Arhgef1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
103727935  Arhgef12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
103724803  Arhgap35; Rho GTPase activating protein 35 [KO:K05732]
103743359  transforming protein RhoA-like [KO:K04513]
103750189  Rhoa; ras homolog family member A [KO:K04513]
103726484  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103748617  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103746394  Cdc42; cell division cycle 42 [KO:K04393]
103743005  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103738502  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103750017  Pak3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
103750732  Pak4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
103729196  Pak5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
103741500  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103746275  Arhgef7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
103730545  Git1; GIT ArfGAP 1 [KO:K05737]
103728977  Rock1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103747607  Rock2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103731078  Mylk2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
103737011  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103741992  Mylk; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
103745443  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103739088  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
103725581  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
103730228  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
103749250  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
103731836  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103744825  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
103745580  Myl2; myosin light chain 2 [KO:K10351]
103728712  Myl5; myosin light chain 5 [KO:K12753]
103734981  Myl7; myosin light chain 7 [KO:K12754]
103740213  Myl9; myosin light chain 9 [KO:K12755]
103748521  myosin regulatory light polypeptide 9 [KO:K12755]
103733488  Myl10; myosin light chain 10 [KO:K12756]
103735401  myosin regulatory light polypeptide 9 [KO:K12757]
103735402  myosin regulatory light chain 12B [KO:K12757]
103726360  Mylpf; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
103743690  Myh14; myosin heavy chain 14 [KO:K10352]
103752230  Myh10; myosin heavy chain 10 [KO:K10352]
103731546  Myh11; myosin heavy chain 11 [KO:K10352]
103751391  Myh9; myosin heavy chain 9 [KO:K10352]
103736070  Diaph1; diaphanous related formin 1 [KO:K05740]
103746218  Diaph2; diaphanous related formin 2 [KO:K05741]
103737082  Slc9a1; solute carrier family 9 member A1 [KO:K05742]
103737261  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
103749401  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
103730072  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
103732986  Pip4k2a; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
103742907  Pip4k2c; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
103743802  Pip4k2b; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
103744454  Pikfyve; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
103748493  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103740428  Limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103725611  Diaph3; diaphanous related formin 3 [KO:K05745]
103730496  Baiap2; BAI1 associated protein 2 [KO:K05627]
103726260  Enah; enabled homolog (Drosophila) [KO:K05746]
103727083  Wasl; Wiskott-Aldrich syndrome like [KO:K23612]
103737074  Wasf2; WAS protein family member 2 [KO:K05748]
103734610  Cyfip1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
103745477  Cyfip2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
103738991  Nckap1l; NCK associated protein 1 like [KO:K05750]
103729865  Nckap1; NCK associated protein 1 [KO:K05750]
103744424  Abi2; abl interactor 2 [KO:K05751]
103751432  Brk1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
103749551  Wasf1; WAS protein family member 1 [KO:K05753]
103749563  Actr2; ARP2 actin related protein 2 homolog [KO:K17260]
103735321  Actr3; ARP3 actin related protein 3 homolog [KO:K18584]
103745329  Actr3b; ARP3 actin related protein 3 homolog B [KO:K18584]
103726464  Arpc1a; actin related protein 2/3 complex subunit 1A [KO:K05757]
103726465  Arpc1b; actin related protein 2/3 complex subunit 1B [KO:K05757]
103727709  Arpc2; actin related protein 2/3 complex subunit 2 [KO:K05758]
103739080  Arpc3; actin related protein 2/3 complex subunit 3 [KO:K05756]
103751421  Arpc4; actin related protein 2/3 complex subunit 4 [KO:K05755]
103726672  Arpc5; actin related protein 2/3 complex subunit 5 [KO:K05754]
103726954  Arpc5l; actin related protein 2/3 complex subunit 5 like [KO:K05754]
103730387  Actg1; actin gamma 1 [KO:K05692]
103748659  Actb; actin beta [KO:K05692]
103743170  profilin-2-like [KO:K05759]
103746532  Pfn4; profilin family member 4 [KO:K05759]
103752201  Pfn1; profilin 1 [KO:K05759]
103730738  Pfn2; profilin 2 [KO:K05759]
103732352  profilin-2-like [KO:K05759]
103732365  Pfn3; profilin 3 [KO:K05759]
103739977  Pxn; paxillin [KO:K05760]
103739279  Ezr; ezrin [KO:K08007]
103733898  Rdx; radixin [KO:K05762]
103743136  Msn; moesin [KO:K05763]
103749967  Tmsb4x; thymosin beta 4, X-linked [KO:K05764]
103736273  thymosin beta-4-like [KO:K05764]
103731431  Cfl2; cofilin 2 [KO:K05765]
103725002  Cfl1; cofilin 1 [KO:K05765]
103746688  Ssh1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103725577  Ssh3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103730482  Ssh2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103747454  Vcl; vinculin [KO:K05700]
103749878  Iqgap1; IQ motif containing GTPase activating protein 1 [KO:K16848]
103750454  Iqgap3; IQ motif containing GTPase activating protein 3 [KO:K05767]
103752272  Iqgap2; IQ motif containing GTPase activating protein 2 [KO:K05767]
103734490  Gsn; gelsolin [KO:K05768]
103730156  Scin; scinderin [KO:K05768]
103750716  Actn4; actinin alpha 4 [KO:K05699]
103749304  Actn1; actinin alpha 1 [KO:K05699]
103737324  Apc2; APC2, WNT signaling pathway regulator [KO:K02085]
103735168  Apc; APC, WNT signaling pathway regulator [KO:K02085]
103746152  Arhgef4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
103727182  Spata13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ngi04010  MAPK signaling pathway
ngi04510  Focal adhesion
ngi04520  Adherens junction
KO pathway
ko04810   
LinkDB

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