KEGG   PATHWAY: oml05168
Entry
oml05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Oryzias melastigma (Indian medaka)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
oml05168  Herpes simplex virus 1 infection
oml05168

Organism
Oryzias melastigma (Indian medaka) [GN:oml]
Gene
112136647  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
112137479  tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
112146585  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
112140016  tumor necrosis factor receptor superfamily member 14 [KO:K05152]
112141326  tumor necrosis factor receptor superfamily member 14 [KO:K05152]
112141327  tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
112141917  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
112162880  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112163300  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112137707  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112157264  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112148770  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112154264  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112162018  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112158682  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112149154  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b isoform X1 [KO:K04734]
112158034  NF-kappa-B inhibitor alpha [KO:K04734]
112137892  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
112155860  rela; transcription factor p65 [KO:K04735]
112142434  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112140806  nectin1a; nectin cell adhesion molecule 1a isoform X1 [KO:K06081]
112154736  nectin-4 [KO:K06081]
112154737  nectin-1 [KO:K06081]
112149119  nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081]
112155298  poliovirus receptor [KO:K06081]
112155326  nectin-1 [KO:K06081]
112142143  nectin-2-like [KO:K06531]
112143668  si:ch73-22o12.1; nectin-2 [KO:K06531]
112162955  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
112159720  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
112145770  integrin alpha-5 [KO:K06484]
112158870  itga5; integrin alpha-5 isoform X2 [KO:K06484]
112154448  integrin beta-3 [KO:K06493]
112146702  integrin beta-3 [KO:K06493]
112144970  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112158705  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112140450  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112139199  syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112148878  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
112154159  irf3; interferon regulatory factor 3 [KO:K05411]
112156259  tp53; cellular tumor antigen p53 isoform X2 [KO:K04451]
112137453  complement C3 isoform X1 [KO:K03990]
112137454  complement C3 [KO:K03990]
112137455  complement C3 [KO:K03990]
112137456  complement C3 isoform X1 [KO:K03990]
112136338  c5; complement C5 [KO:K03994]
112141881  properdin [KO:K15412]
112155905  toll-like receptor 2 isoform X2 [KO:K10159]
112156495  toll-like receptor 2 [KO:K10159]
112136553  tlr18; toll-like receptor 18 isoform X2 [KO:K10159]
112151085  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
112152165  irf7; interferon regulatory factor 7 [KO:K09447]
112137631  tlr3; toll-like receptor 3 isoform X2 [KO:K05401]
112147833  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
112142118  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112152049  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112159797  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
112161172  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112154196  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
112158233  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
112137107  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
112158259  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112148302  interleukin-1 beta [KO:K04519]
112137441  interleukin-6-like [KO:K05405]
112161658  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
112139461  tumor necrosis factor-like [KO:K03156]
112149667  il12a; interleukin-12 subunit alpha [KO:K05406]
112139606  interleukin-12 subunit alpha [KO:K05406]
112148544  si:dkey-88e18.2; interleukin-12 subunit beta isoform X1 [KO:K05425]
112142961  il12bb; interleukin-12 subunit beta [KO:K05425]
112153451  il12ba; interleukin 12Ba [KO:K05425]
112154928  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
112143451  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
112141746  traf3; TNF receptor-associated factor 3 [KO:K03174]
112145751  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
112157575  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112153944  interferon omega-2 isoform X1 [KO:K05414]
112154525  interferon a3-like [KO:K05414]
112154638  interferon a3-like [KO:K05414]
112162124  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
112153054  sting1; stimulator of interferon genes protein [KO:K12654]
112147529  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112154198  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
112148595  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
112156029  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112146006  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
112153856  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
112145634  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112144857  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
112157673  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
112162950  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
112158527  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
112147791  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
112158313  eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680]
112147505  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
112145112  hcfc1a; host cell factor 1a [KO:K14966]
112160227  hcfc2; host cell factor 2 [KO:K27390]
112154842  pou2f1b; POU domain, class 2, transcription factor 1b isoform X1 [KO:K09364]
112143646  pou2f2a; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
112137261  POU domain, class 2, transcription factor 2 [KO:K09364]
112139332  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
112155356  interferon alpha/beta receptor 2 [KO:K05131]
112155567  uncharacterized protein LOC112155567 isoform X1 [KO:K05131]
112154540  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
112145844  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
112150103  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112146551  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112154777  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112156680  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
112144620  stat2; signal transducer and activator of transcription 2 [KO:K11221]
112151369  irf9; interferon regulatory factor 9 [KO:K04693]
112139787  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112139788  oocyte zinc finger protein XlCOF6 [KO:K09228]
112139789  zinc finger protein 436 [KO:K09228]
112139857  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112139899  zinc finger and SCAN domain-containing protein 2 [KO:K09228]
112139900  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112139903  zinc finger and SCAN domain-containing protein 2 [KO:K09228]
112140040  zinc finger and SCAN domain-containing protein 2 [KO:K09228]
112140068  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112140214  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112140321  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112140322  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112140377  zinc finger protein 37-like [KO:K09228]
112140462  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112140463  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
112140464  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
112140465  oocyte zinc finger protein XlCOF19 [KO:K09228]
112140523  im:7147486; zinc finger protein 616 [KO:K09228]
112140526  si:dkeyp-84f3.5; zinc finger protein 91 [KO:K09228]
112140605  oocyte zinc finger protein XlCOF6 isoform X1 [KO:K09228]
112140608  gastrula zinc finger protein XlCGF26.1 [KO:K09228]
112140663  oocyte zinc finger protein XlCOF8.4-like [KO:K09228]
112140693  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112140825  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112140826  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
112140913  gastrula zinc finger protein XlCGF57.1-like isoform X2 [KO:K09228]
112140914  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112140916  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112147644  zinc finger protein 16 [KO:K09228]
112154392  zinc finger protein 37 [KO:K09228]
118597845  zinc finger protein 436-like [KO:K09228]
112141209  uncharacterized protein LOC112141209 [KO:K09228]
112141210  zinc finger protein 578 [KO:K09228]
112148161  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112148224  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112154488  zinc finger protein 99 [KO:K09228]
112141710  zinc finger protein 883-like [KO:K09228]
112141711  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112141712  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112141713  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112141714  zinc finger protein 568-like [KO:K09228]
112141716  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112141718  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112141727  zinc finger protein 184-like [KO:K09228]
112141883  gastrula zinc finger protein XlCGF57.1-like isoform X2 [KO:K09228]
112141884  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112142182  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112142184  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112142186  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
112142236  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112142239  gastrula zinc finger protein XlCGF28.1-like isoform X2 [KO:K09228]
112142241  zinc finger protein 37-like [KO:K09228]
112148782  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112162391  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112142705  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
112155788  zinc finger protein ZFMSA12A [KO:K09228]
112155790  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112155803  zinc finger protein 501-like [KO:K09228]
112162584  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112162693  zinc finger protein 239 [KO:K09228]
112149725  zinc finger protein 345 [KO:K09228]
112143659  oocyte zinc finger protein XlCOF6 isoform X1 [KO:K09228]
112156761  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112156766  oocyte zinc finger protein XlCOF22 isoform X1 [KO:K09228]
112156768  zinc finger protein 184 [KO:K09228]
112156769  zinc finger protein 436 isoform X1 [KO:K09228]
112156780  zinc finger protein 568 isoform X1 [KO:K09228]
112156789  zinc finger protein OZF isoform X1 [KO:K09228]
112156790  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112156796  zinc finger protein 391-like [KO:K09228]
112156799  zinc finger protein 664 [KO:K09228]
112156800  oocyte zinc finger protein XlCOF22 [KO:K09228]
112156807  gastrula zinc finger protein XlCGF17.1 [KO:K09228]
112156812  zinc finger protein 37 [KO:K09228]
112156816  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
112156819  zinc finger protein 84 [KO:K09228]
112144263  zinc finger protein 2 homolog isoform X1 [KO:K09228]
118597860  zinc finger protein 26-like isoform X1 [KO:K09228]
112144271  zinc finger protein 345 [KO:K09228]
112144273  oocyte zinc finger protein XlCOF6 [KO:K09228]
112150675  zinc finger protein 239 isoform X1 [KO:K09228]
118598267  zinc finger protein 77-like [KO:K09228]
112141725  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
112138303  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112139790  zinc finger protein 239 [KO:K09228]
112141211  zinc finger protein 436 [KO:K09228]
112139855  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112139854  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112140067  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112141891  gastrula zinc finger protein xLCGF3.1-like [KO:K09228]
118598517  zinc finger protein 37-like [KO:K09228]
118598818  zinc finger protein 2 homolog [KO:K09228]
118598926  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112158675  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
112136152  zinc finger protein 135 [KO:K09228]
112136377  zinc finger protein 501 [KO:K09228]
112144288  zinc finger protein 391 [KO:K09228]
112144290  oocyte zinc finger protein XlCOF6 isoform X1 [KO:K09228]
112144300  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112144306  zinc finger protein 2 [KO:K09228]
112144326  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112144327  oocyte zinc finger protein XlCOF6.1 [KO:K09228]
112144336  zinc finger protein 2 [KO:K09228]
112144348  gastrula zinc finger protein XlCGF8.2DB [KO:K09228]
118599482  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112149411  oocyte zinc finger protein XlCOF6 isoform X1 [KO:K09228]
112156775  zinc finger protein 184 [KO:K09228]
112136605  zinc finger protein 436 [KO:K09228]
112145042  zinc finger protein 436 [KO:K09228]
112145046  zinc finger protein OZF-like [KO:K09228]
112145048  gastrula zinc finger protein XlCGF28.1 isoform X1 [KO:K09228]
112145051  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112145052  gastrula zinc finger protein XlCGF17.1 [KO:K09228]
112157959  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112157960  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112157962  gastrula zinc finger protein XlCGF8.2DB [KO:K09228]
118599702  oocyte zinc finger protein XlCOF6-like [KO:K09228]
118599918  zinc finger protein with KRAB and SCAN domains 1-like [KO:K09228]
112155784  zinc finger protein 595 [KO:K09228]
118600040  zinc finger protein 2-like isoform X1 [KO:K09228]
112137119  zinc finger protein 436 [KO:K09228]
112152024  zinc finger protein OZF [KO:K09228]
112158672  zinc finger protein 391 [KO:K09228]
112158673  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112158674  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112137432  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112137434  zinc finger protein OZF-like [KO:K09228]
112137573  zinc finger protein 585A [KO:K09228]
112137726  zinc finger protein OZF isoform X1 [KO:K09228]
112137730  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
112152232  gastrula zinc finger protein XlCGF71.1 [KO:K09228]
112158969  zinc finger protein 436 isoform X1 [KO:K09228]
112138150  zinc finger protein 260-like isoform X1 [KO:K09228]
112138192  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112138234  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138253  gastrula zinc finger protein XlCGF57.1 isoform X2 [KO:K09228]
112138255  zinc finger protein 391 [KO:K09228]
112138256  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138302  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
112138305  gastrula zinc finger protein XlCGF49.1-like [KO:K09228]
112138333  zinc finger protein 260 isoform X2 [KO:K09228]
112138449  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138466  zinc finger protein 436 [KO:K09228]
112138467  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138468  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138470  zinc finger protein 568-like [KO:K09228]
112138725  zinc finger protein 583-like [KO:K09228]
112138727  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138729  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138731  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
112138752  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112138783  oocyte zinc finger protein XlCOF6-like [KO:K09228]
112153220  zinc finger protein 11 [KO:K09228]
112159945  zinc finger protein 184 [KO:K09228]
112139065  zinc finger protein 436 [KO:K09228]
112139167  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112139263  zinc finger protein 2 homolog [KO:K09228]
112139560  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
112139588  gastrula zinc finger protein XlCGF28.1 [KO:K09228]
112160372  zinc finger protein 501 [KO:K09228]
112162119  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
112156998  interferon gamma receptor 1-like [KO:K05132]
112148412  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112163270  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
112144754  daxx; death domain-associated protein 6 [KO:K02308]
112136733  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112154648  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112159448  tap2a; antigen peptide transporter 2a isoform X2 [KO:K05654] [EC:7.4.2.14]
112144755  tapbp.1; TAP binding protein (tapasin), tandem duplicate 1 [KO:K08058]
112162485  pdia8; protein disulfide isomerase family A, member 8 [KO:K08056] [EC:5.3.4.1]
112151949  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112147713  calr3b; calreticulin 3b [KO:K08057]
112150092  calr; calreticulin [KO:K08057]
112136810  calreticulin [KO:K08057]
112139742  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112140061  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
112140148  major histocompatibility complex class I-related gene protein [KO:K06751]
112140149  major histocompatibility complex class I-related gene protein [KO:K06751]
112140150  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112161787  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112161849  zinc-alpha-2-glycoprotein-like isoform X2 [KO:K06751]
112161855  major histocompatibility complex class I-related gene protein isoform X2 [KO:K06751]
112161861  major histocompatibility complex class I-related gene protein [KO:K06751]
112161877  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112161885  major histocompatibility complex class I-related gene protein [KO:K06751]
112161890  major histocompatibility complex class I-related gene protein [KO:K06751]
112162437  H-2 class I histocompatibility antigen, L-D alpha chain isoform X1 [KO:K06751]
112162561  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
112162562  H-2 class I histocompatibility antigen, alpha chain isoform X1 [KO:K06751]
112162565  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
112162566  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
112162569  H-2 class I histocompatibility antigen, Q7 alpha chain [KO:K06751]
112143896  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
118597892  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112138316  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112162438  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
112162568  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
112162571  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
112138328  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112161846  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112162570  HLA class I histocompatibility antigen, B alpha chain [KO:K06751]
112144752  major histocompatibility complex class I-related gene protein [KO:K06751]
112144753  major histocompatibility complex class I-related gene protein [KO:K06751]
112144757  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
112138608  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
112138609  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
112138610  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
112139674  uncharacterized protein LOC112139674 [KO:K06751]
112140043  b2m; beta-2-microglobulin [KO:K08055]
112140045  beta-2-microglobulin [KO:K08055]
118598334  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
112144589  rano class II histocompatibility antigen, A beta chain [KO:K06752]
118599785  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
112145229  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
112145295  boLa class II histocompatibility antigen, DQB*0101 beta chain [KO:K06752]
112139695  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
112153807  cd74a; CD74 molecule, major histocompatibility complex, class II invariant chain a [KO:K06505]
112147412  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112150459  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112136442  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112159170  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
112147562  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112163049  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112150193  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
112150308  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112138447  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112140005  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112154973  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112161991  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112149157  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112157322  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112140338  tsc1b; TSC complex subunit 1b [KO:K07206]
112148929  tsc1a; hamartin [KO:K07206]
112137715  hamartin isoform X1 [KO:K07206]
112137256  tsc2; tuberin isoform X1 [KO:K07207]
112141897  GTP-binding protein Rheb [KO:K07208]
112151125  rheb; GTP-binding protein Rheb [KO:K07208]
112144822  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
112158714  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112148907  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112163161  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112158854  srpk1a; SRSF protein kinase 1a isoform X1 [KO:K15409] [EC:2.7.11.1]
112139316  srpk1b; SRSF protein kinase 1b isoform X1 [KO:K15409] [EC:2.7.11.1]
112140724  srsf1b; serine/arginine-rich splicing factor 1B [KO:K12890]
112149378  srsf1a; serine/arginine-rich splicing factor 1A [KO:K12890]
112154460  srsf2a; serine and arginine rich splicing factor 2a isoform X1 [KO:K12891]
112146836  srsf2b; serine/arginine-rich splicing factor 2b [KO:K12891]
112144586  srsf3b; serine/arginine-rich splicing factor 3b [KO:K12892]
112144809  srsf3a; serine/arginine-rich splicing factor 3a [KO:K12892]
112140987  srsf5b; serine and arginine rich splicing factor 5b [KO:K12893]
112148547  srsf5a; serine and arginine rich splicing factor 5a isoform X1 [KO:K12893]
112161630  srsf4; serine/arginine-rich splicing factor 4 [KO:K12893]
112159034  serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
112149522  srsf7a; serine and arginine rich splicing factor 7a isoform X1 [KO:K12896]
112163197  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
112153319  zgc:153681; nuclear RNA export factor 1 isoform X1 [KO:K14284]
112157564  aly/REF export factor 2 [KO:K12881]
112146590  alyref; THO complex subunit 4 [KO:K12881]
112150637  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
112153304  cd40lg; CD40 ligand [KO:K04389]
112161604  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112143685  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112161095  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
112160870  fadd; protein FADD [KO:K02373]
112147424  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112147426  caspase-8 [KO:K04398] [EC:3.4.22.61]
112158138  apoptosis regulator BAX-like [KO:K02159]
112145947  apoptosis regulator BAX [KO:K02159]
112155974  badb; BCL2 associated agonist of cell death b [KO:K02158]
112147591  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
112144934  bcl-2-like protein 1 [KO:K04570]
112159139  bcl2l1; bcl-2-like protein 1 [KO:K04570]
112154732  cytochrome c iso-1/iso-2 [KO:K08738]
112138721  cytochrome c iso-1/iso-2 isoform X1 [KO:K08738]
112157788  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
112159047  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112137236  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
112153020  caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
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MacLeod IJ, Minson T
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Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
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PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
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Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
  Authors
Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
PMID:21146386
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
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Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
oml03040  Spliceosome
oml03050  Proteasome
oml04115  p53 signaling pathway
oml04210  Apoptosis
oml04620  Toll-like receptor signaling pathway
oml04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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