KEGG   PATHWAY: otw04110
Entry
otw04110                    Pathway                                
Name
Cell cycle - Oncorhynchus tshawytscha (Chinook salmon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
otw04110  Cell cycle
otw04110

Other DBs
GO: 0000278
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112218887  G1/S-specific cyclin-D1 [KO:K04503]
112252678  G1/S-specific cyclin-D1 [KO:K04503]
112263573  G1/S-specific cyclin-D1 [KO:K04503]
112249039  G1/S-specific cyclin-D1 [KO:K04503]
112214224  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112252585  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112216983  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112218786  ccnd2a; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112259254  ccndx; LOW QUALITY PROTEIN: cyclin Dx [KO:K10151]
112254562  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
112216345  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112254694  cyclin-dependent kinase 4-like isoform X1 [KO:K02089] [EC:2.7.11.22]
112259968  cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
112258622  cdk21; cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
112229496  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112228649  rb1; retinoblastoma-associated protein [KO:K06618]
112266855  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
112218825  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112252634  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112264064  retinoblastoma-like protein 2 [KO:K16332]
112249362  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112230988  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
112219306  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
112256602  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
112261930  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
112217522  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
112238954  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
112239916  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
121838745  hdac1; LOW QUALITY PROTEIN: histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
112244985  transcription factor E2F1 [KO:K17454]
112221983  e2f1; transcription factor E2F1 [KO:K17454]
112262220  transcription factor E2F2-like [KO:K09389]
112255724  e2f2; transcription factor E2F2 [KO:K09389]
112238727  transcription factor E2F3 [KO:K06620]
112236875  e2f3; transcription factor E2F3 [KO:K06620]
112243729  transcription factor E2F3-like [KO:K06620]
112249215  transcription factor E2F4 isoform X1 [KO:K04682]
112260341  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
112252590  e2f4; transcription factor E2F4 [KO:K04682]
112263742  transcription factor E2F4 [KO:K04682]
112218793  transcription factor E2F4 [KO:K04682]
112225344  transcription factor Dp-1 isoform X1 [KO:K04683]
112242285  transcription factor Dp-1 isoform X2 [KO:K04683]
112242011  transcription factor Dp-1-like isoform X1 [KO:K04683]
112216691  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
112225427  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112241148  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112253980  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112266570  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112231247  transforming growth factor beta-1 proprotein [KO:K13375]
112228884  transforming growth factor beta-1 proprotein [KO:K13375]
112240152  transforming growth factor beta-1 proprotein-like [KO:K13375]
112255920  transforming growth factor beta-2 proprotein-like [KO:K13376]
112223175  transforming growth factor beta-2 proprotein [KO:K13376]
112234066  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
112221169  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
112217963  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112256698  transforming growth factor beta-3 proprotein [KO:K13377]
112238812  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112233166  transforming growth factor beta-3 proprotein-like [KO:K13377]
112263143  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112248205  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112235777  mothers against decapentaplegic homolog 3 [KO:K23605]
112238080  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
112228561  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
112229740  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112257537  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112248311  mothers against decapentaplegic homolog 4 [KO:K04501]
112222845  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112219493  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
112263427  mothers against decapentaplegic homolog 4 [KO:K04501]
112264720  mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
112250064  mycb; transcriptional regulator Myc-B isoform X1 [KO:K04377]
112215682  transcriptional regulator Myc [KO:K04377]
112266912  mych; myelocytomatosis oncogene homolog [KO:K04377]
112254112  transcriptional regulator Myc-2 [KO:K04377]
112227947  transcriptional regulator Myc [KO:K04377]
112232573  zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
112222015  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
112238791  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
112251012  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
112230133  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
112214453  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112216753  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112218171  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112240696  cyclin-dependent kinase inhibitor 1B [KO:K06624]
112238189  cyclin-dependent kinase inhibitor 1B [KO:K09993]
112218381  cdkn1cb; cyclin-dependent kinase inhibitor 1B [KO:K09993]
112217839  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112254565  cyclin-dependent kinase inhibitor 1C [KO:K06625]
112214357  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112216848  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112222881  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
112263558  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
112249067  G1/S-specific cyclin-E1 [KO:K06626]
112222880  G1/S-specific cyclin-E2-like [KO:K06626]
112254710  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112216259  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112258093  S-phase kinase-associated protein 1 [KO:K03094]
112228203  S-phase kinase-associated protein 1 [KO:K03094]
112226890  cullin-1 [KO:K03347]
112260517  cullin-1 [KO:K03347]
112215485  cul1b; cullin-1b isoform X1 [KO:K03347]
112226161  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
112258810  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
112247600  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
112257530  S-phase kinase-associated protein 2 [KO:K03875]
112256353  cyclin-A2 [KO:K06627]
112221066  cyclin-A2 [KO:K06627]
112238479  ccna1; cyclin-A1 [KO:K06627]
112245660  cell division control protein 6 homolog [KO:K02213]
121840338  LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
112249113  DNA replication factor Cdt1 [KO:K10727]
112236972  DNA replication factor Cdt1-like [KO:K10727]
112251632  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
112241184  orc2; origin recognition complex subunit 2 [KO:K02604]
112262042  orc3; origin recognition complex subunit 3 [KO:K02605]
112266286  orc4; origin recognition complex subunit 4 [KO:K02606]
112267825  origin recognition complex subunit 5-like isoform X1 [KO:K02607]
112217204  origin recognition complex subunit 5-like [KO:K02607]
112232213  orc6; origin recognition complex subunit 6 [KO:K02608]
112222032  DNA replication licensing factor mcm2-like [KO:K02540] [EC:5.6.2.3]
112246280  DNA replication licensing factor mcm2 [KO:K02540] [EC:5.6.2.3]
112251297  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
112249817  zygotic DNA replication licensing factor mcm3-like [KO:K02541] [EC:5.6.2.3]
112260610  DNA replication licensing factor mcm4 [KO:K02212] [EC:5.6.2.3]
112226810  DNA replication licensing factor mcm4 [KO:K02212] [EC:5.6.2.3]
112247021  DNA replication licensing factor mcm5 [KO:K02209] [EC:5.6.2.3]
121844909  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
112260518  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
112247427  zygotic DNA replication licensing factor mcm6-B-like [KO:K02542] [EC:5.6.2.3]
112221123  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
112262749  cdc45; cell division control protein 45 homolog [KO:K06628]
112247918  ticrr; treslin isoform X1 [KO:K26117]
112225057  mdm2-binding protein isoform X1 [KO:K26116]
112227099  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
112222702  dbf4; protein DBF4 homolog A [KO:K06629]
112225483  protein DBF4 homolog A isoform X1 [KO:K06629]
112223759  dbf4b; protein DBF4 homolog B [KO:K06629]
112253102  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112255192  cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112230962  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112220405  G2/mitotic-specific cyclin-B1 [KO:K05868]
112264049  G2/mitotic-specific cyclin-B1-like [KO:K05868]
112249181  G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
112263712  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
112259703  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
112231150  G2/mitotic-specific cyclin-B3 [KO:K21771]
112236264  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112237367  cdc25b; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
112231192  M-phase inducer phosphatase 1-A [KO:K05867] [EC:3.1.3.48]
112249985  14-3-3 protein zeta [KO:K16197]
112266691  14-3-3 protein beta/alpha-1 [KO:K16197]
112215721  14-3-3 protein beta/alpha-2 [KO:K16197]
112254137  14-3-3 protein beta/alpha-1 [KO:K16197]
112247291  14-3-3 protein zeta-like [KO:K16197]
112256506  14-3-3 protein beta/alpha-1 [KO:K16197]
112217457  ywhaqa; 14-3-3 protein zeta [KO:K16197]
112222274  14-3-3 protein beta/alpha-2 [KO:K16197]
112247829  14-3-3 protein beta/alpha-A-like [KO:K16197]
112258043  14-3-3 protein epsilon isoform X1 [KO:K06630]
112266813  14-3-3 protein epsilon isoform X1 [KO:K06630]
112265170  14-3-3 protein epsilon isoform X1 [KO:K06630]
112228389  14-3-3 protein epsilon isoform X1 [KO:K06630]
112258338  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
112231073  14-3-3 protein eta [KO:K16198]
112267079  14-3-3 protein gamma-2 [KO:K16198]
112219392  ywhah; 14-3-3 protein eta [KO:K16198]
112229073  14-3-3 protein gamma-1 [KO:K16198]
112265502  14-3-3 protein gamma-2 [KO:K16198]
112241904  plk1; serine/threonine-protein kinase PLK1 isoform X1 [KO:K06631] [EC:2.7.11.21]
112249316  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
112218334  wee1; wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
112218244  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
112263837  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
112218768  wee2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
112223869  LOW QUALITY PROTEIN: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
112263374  ccnh; cyclin-H isoform X1 [KO:K06634]
112248573  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
112255651  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
112230964  anaphase-promoting complex subunit 2-like [KO:K03349]
112220409  anapc2; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2 [KO:K03349]
112225895  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
112258498  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
112251116  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
112263014  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
112225065  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
112234729  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
112248356  anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
112264097  anaphase-promoting complex subunit 7 [KO:K03354]
112231189  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
112228929  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
112239046  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
112245845  anaphase-promoting complex subunit 11 [KO:K03358]
112264644  anaphase-promoting complex subunit 11 [KO:K03358]
112220304  anaphase-promoting complex subunit CDC26 [KO:K03359]
112230798  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
112257985  anapc13; anaphase-promoting complex subunit 13 isoform X2 [KO:K12456]
112228106  anaphase-promoting complex subunit 13-like [KO:K12456]
112267300  anaphase-promoting complex subunit 15 isoform X6 [KO:K25228]
112253219  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
112226871  cell division cycle protein 20 homolog [KO:K03363]
112240452  cell division cycle protein 20 homolog B-like [KO:K03363]
112257105  pttg1; securin [KO:K06635]
112217676  espl1; separin [KO:K02365] [EC:3.4.22.49]
112216366  structural maintenance of chromosomes protein 1A-like [KO:K06636]
112219026  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
112221677  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
112263419  smc3; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 3 [KO:K06669]
112229937  rad21b; double-strand-break repair protein rad21 homolog A [KO:K06670]
112221891  rad21l1; double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
112215215  double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
112264896  double-strand-break repair protein rad21 homolog A isoform X1 [KO:K06670]
112239358  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
112257741  cohesin subunit SA-2 [KO:K06671]
112228664  cohesin subunit SA-2 isoform X1 [KO:K06671]
112221124  cohesin subunit SA-2 isoform X2 [KO:K06671]
112225072  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
112240048  LOW QUALITY PROTEIN: cohesin subunit SA-1 [KO:K06671]
112236103  cohesin subunit SA-1-like [KO:K06671]
112236575  cohesin subunit SA-2-like [KO:K06671]
112250222  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
112232729  transcriptional regulator ATRX isoform X1 [KO:K10779]
112225770  transcriptional regulator ATRX [KO:K10779]
112259091  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
112223949  transcriptional regulator ATRX-like [KO:K10779]
112218627  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
112257534  nipped-B-like protein B isoform X3 [KO:K06672]
112246661  nipped-B-like protein A [KO:K06672]
112219499  nipped-B-like protein isoform X1 [KO:K06672]
112250835  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
112260853  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
112244757  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
112247702  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
112214503  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
112250174  N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
112217610  N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
112235957  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
112223482  wings apart-like protein homolog [KO:K25163]
112224759  waplb; wings apart-like protein homolog isoform X1 [KO:K25163]
112254894  wings apart-like protein homolog [KO:K25163]
112228832  sororin [KO:K17390]
112230612  sororin-B [KO:K17390]
112218878  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
112252665  aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
112264390  sgo1; shugoshin 1 isoform X2 [KO:K11580]
112255883  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112258092  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
112247251  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112248938  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112246744  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112221252  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
112228204  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
112266709  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112265053  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112249955  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112217877  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112214486  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
112250544  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112252899  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
112253491  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112261700  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112248704  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112262090  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112256394  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112217429  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112237959  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112246653  kinetochore protein NDC80 homolog [KO:K11547]
121846341  kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
112250382  knl1; uncharacterized protein knl1 [KO:K11542]
112232505  dual specificity protein kinase Ttk-like isoform X1 [KO:K08866] [EC:2.7.12.1]
112223148  dual specificity protein kinase Ttk-like isoform X1 [KO:K08866] [EC:2.7.12.1]
112241787  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
112216909  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
112214816  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
112260095  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
121839405  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
112221991  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
112261851  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
112241307  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
112217492  mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
112250026  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
112238637  trip13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
112258182  MAD2L1-binding protein isoform X1 [KO:K26093]
112260833  fizzy-related protein homolog [KO:K03364]
112251030  fizzy-related protein homolog isoform X1 [KO:K03364]
112226595  fizzy-related protein homolog isoform X1 [KO:K03364]
112260697  fzr1b; fizzy-related protein homolog [KO:K03364]
112253144  fbxo5; F-box only protein 5 [KO:K10292]
112255663  F-box only protein 5 [KO:K10292]
112250703  dual specificity protein phosphatase CDC14AB-like isoform X6 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112260382  dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112252087  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112248814  cdc14b; dual specificity protein phosphatase CDC14B isoform X3 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112262601  dual specificity protein phosphatase CDC14C isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112226125  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112224788  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112258529  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
112225784  crebbpb; LOW QUALITY PROTEIN: CREB binding protein b [KO:K04498] [EC:2.3.1.48]
112238381  crebbpa; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
112258813  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
112215359  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
112267688  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
112267156  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
112262208  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112260048  cellular tumor antigen p53 [KO:K04451]
112214763  cellular tumor antigen p53 isoform X1 [KO:K04451]
112229014  tp53; cellular tumor antigen p53 [KO:K04451]
112250716  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112251192  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
112260284  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112249878  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112252104  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112263967  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112230512  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112219828  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
112219829  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112230565  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112248817  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
112227088  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112248619  proliferating cell nuclear antigen [KO:K04802]
112262735  proliferating cell nuclear antigen [KO:K04802]
112236999  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
112248230  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
112263301  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
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Surfing the p53 network.
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Nature 408:307-10 (2000)
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PMID:7973727
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Cell Cycle 9:3904-12 (2010)
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Related
pathway
otw03030  DNA replication
otw04010  MAPK signaling pathway
otw04120  Ubiquitin mediated proteolysis
otw04210  Apoptosis
KO pathway
ko04110   
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