KEGG   PATHWAY: rbb04072
Entry
rbb04072                    Pathway                                
Name
Phospholipase D signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04072  Phospholipase D signaling pathway
rbb04072

Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108528921  KITLG; kit ligand [KO:K05461]
108539226  INS; insulin isoform X1 [KO:K04526]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108533749  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
108534554  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
108537414  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108517109  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
108543205  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
108526812  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
108533994  SHC-transforming protein 2-like [KO:K17447]
108531776  SHC2; SHC-transforming protein 2 [KO:K17447]
108532239  SHC3; SHC-transforming protein 3 [KO:K17448]
108530104  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
108540455  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
108513636  SOS2; son of sevenless homolog 2 [KO:K03099]
108520869  SOS1; son of sevenless homolog 1 [KO:K03099]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108528122  NRAS; GTPase NRas [KO:K07828]
108544611  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108535827  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
108535524  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
108513486  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
108528764  ral-GDS-related protein-like [KO:K08732]
108526577  RALA; ras-related protein Ral-A isoform X1 [KO:K07834]
108542108  RALB; ras-related protein Ral-B [KO:K07835]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108513580  TSC1; hamartin isoform X1 [KO:K07206]
108519399  TSC2; tuberin isoform X1 [KO:K07207]
108523126  RHEB; GTP-binding protein Rheb [KO:K07208]
108539366  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108536791  ARF1; ADP-ribosylation factor 1 [KO:K07937]
108529365  ADP-ribosylation factor 2-like isoform X1 [KO:K07937]
108513680  ARF6; ADP-ribosylation factor 6 [KO:K07941]
108519825  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108539491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108522153  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108511997  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108512001  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 isoform X1 [KO:K06856]
108520828  uncharacterized protein LOC108520828 [KO:K06856]
108519975  uncharacterized protein LOC108519975 [KO:K06856]
108519976  LOW QUALITY PROTEIN: uncharacterized protein LOC108519976 [KO:K06856]
108519983  uncharacterized protein LOC108519983 [KO:K06856]
108519992  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108524775  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
108531905  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
108541302  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
108521184  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
108512073  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
108516810  tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
108538610  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108524801  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
108540404  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
108540165  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
108523179  PLA2G4A; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108544325  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108544332  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
108544335  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
108517617  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108519889  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
108542907  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
108539817  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
108527988  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
108516721  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
108537441  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108523630  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108512667  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108512122  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108533237  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108530266  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
108519243  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
108538095  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
108525505  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
108514132  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
108516050  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
108530314  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
108520097  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
108540079  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
108524355  DGKQ; LOW QUALITY PROTEIN: diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
108532446  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
108530983  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
108532937  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
108531774  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
108521952  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
108537839  AGT; LOW QUALITY PROTEIN: angiotensinogen [KO:K09821]
108529971  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
108523449  CXCL8; interleukin-8 [KO:K10030]
108518305  AGTR1; type-1 angiotensin II receptor [KO:K04166]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108539926  GRM2; metabotropic glutamate receptor 2 isoform X1 [KO:K04605]
108515138  GRM3; metabotropic glutamate receptor 3 [KO:K04606]
108516261  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
108539155  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
108539295  GRM6; LOW QUALITY PROTEIN: metabotropic glutamate receptor 6 [KO:K04608]
108530952  GRM7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
108530774  GRM8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
108537929  AVPR1A; vasopressin V1a receptor [KO:K04226]
108535121  AVPR1B; vasopressin V1b receptor [KO:K04227]
108535070  LOW QUALITY PROTEIN: vasopressin V2 receptor-like [KO:K04228]
108535071  AVPR2; vasopressin V2 receptor [KO:K04228]
108513979  lysophosphatidic acid receptor 1 [KO:K04289]
108515641  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108527700  LPAR3; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 3 [KO:K04294]
108529808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108542054  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108530743  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
108534641  PTGFR; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
108541855  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108543875  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
108537591  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108517753  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
108540484  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
108513498  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
108513507  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
108534177  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
108523991  CYTH3; cytohesin-3 [KO:K18441]
108523118  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
108512773  CYTH4; cytohesin-4 [KO:K18441]
108541624  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
108541626  neuroendocrine secretory protein 55 [KO:K04632]
108534793  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108536960  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108543021  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108540946  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108517430  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
108543933  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
108522948  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108514094  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108538326  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108515949  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
108518542  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
108512814  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
108526256  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
108522813  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
108522812  dynamin-2-like [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
rbb00561  Glycerolipid metabolism
rbb04010  MAPK signaling pathway
rbb04014  Ras signaling pathway
rbb04020  Calcium signaling pathway
rbb04024  cAMP signaling pathway
rbb04071  Sphingolipid signaling pathway
rbb04144  Endocytosis
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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