KEGG   PATHWAY: pcoq05205
Entry
pcoq05205                   Pathway                                
Name
Proteoglycans in cancer - Propithecus coquereli (Coquerel's sifaka)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
pcoq05205  Proteoglycans in cancer
pcoq05205

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805017  NANOG; homeobox protein NANOG [KO:K10164]
105805036  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
105805907  [KO:K02991]
105805953  ACTB; actin, cytoplasmic 1 [KO:K05692]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806844  PTCH1; protein patched homolog 1 [KO:K06225]
105807089  FZD9; frizzled-9 [KO:K02842]
105807166  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105807217  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105807545  KRAS; GTPase KRas [KO:K07827]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105807691  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105808035  ITGB5; integrin beta-5 [KO:K06588]
105808091  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
105808138  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105808139  WNT3A; protein Wnt-3a [KO:K00312]
105808252  FZD4; frizzled-4 [KO:K02354]
105808403  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
105808525  ITGB1; integrin beta-1 [KO:K05719]
105808761  IHH; indian hedgehog protein [KO:K11989]
105808762  WNT10A; protein Wnt-10a [KO:K01357]
105808766  WNT6; protein Wnt-6 [KO:K00445]
105808878  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
105808974  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
105809239  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
105809401  RRAS; ras-related protein R-Ras [KO:K07829]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809703  MSN; moesin [KO:K05763]
105809772  SDC2; syndecan-2 [KO:K16336]
105809796  FZD6; frizzled-6 isoform X1 [KO:K02376]
105809829  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810548  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105810591  NRAS; GTPase NRas [KO:K07828]
105810592  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105810690  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
105810764  IL12B; interleukin-12 subunit beta [KO:K05425]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810828  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811016  HGF; hepatocyte growth factor [KO:K05460]
105811134  TLR2; toll-like receptor 2 [KO:K10159]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105811413  WNT11; protein Wnt-11 [KO:K01384]
105811507  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105811736  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105811845  VAV1; proto-oncogene vav [KO:K05730]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105812010  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
105812040  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105812283  CAV3; caveolin-3 [KO:K12959]
105812377  ESR1; estrogen receptor isoform X1 [KO:K08550]
105812395  EZR; ezrin isoform X1 [KO:K08007]
105812493  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812648  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105812777  [KO:K06643] [EC:2.3.2.27]
105812910  WNT5B; protein Wnt-5b [KO:K00444]
105813018  TFAP4; transcription factor AP-4 [KO:K09108]
105813090  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105813130  NUDT16L1; protein syndesmos [KO:K16867]
105813132  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105813491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105813545  VTN; vitronectin [KO:K06251]
105813657  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105813732  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105813980  TWIST2; twist-related protein 2 [KO:K09069]
105814034  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814426  THBS1; thrombospondin-1 [KO:K16857]
105814589  CD44; CD44 antigen isoform X1 [KO:K06256]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105815054  [KO:K05760]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815256  FGF2; fibroblast growth factor 2 [KO:K18497]
105815541  HOXD10; homeobox protein Hox-D10 [KO:K09295]
105815659  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
105815675  WNT4; protein Wnt-4 [KO:K00408]
105815695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105815854  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105815903  WNT10B; protein Wnt-10b [KO:K01357]
105815912  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105816133  FN1; fibronectin [KO:K05717]
105816430  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
105816530  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105816606  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105816611  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105816815  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105816940  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105816954  ITGA5; integrin alpha-5 [KO:K06484]
105817042  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
105817130  WNT2; protein Wnt-2 [KO:K00182]
105817144  CAV1; caveolin-1 isoform X1 [KO:K06278]
105817145  CAV2; caveolin-2 isoform X1 [KO:K12958]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105817162  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
105817209  CD63; CD63 antigen [KO:K06497]
105817414  SDC1; syndecan-1 [KO:K06257]
105817589  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
105817598  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105817609  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105817666  GPC3; glypican-3 [KO:K08109]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818206  SHH; sonic hedgehog protein [KO:K11988]
105818410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105818818  FZD3; frizzled-3 [KO:K02329]
105818927  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105818928  ANK2; ankyrin-2 [KO:K09255]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819075  WNT9B; protein Wnt-9b [KO:K01064]
105819079  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105819095  ITGA2; integrin alpha-2 [KO:K06481]
105819255  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105819437  FZD7; frizzled-7 [KO:K02432]
105819655  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
105819671  ANK1; ankyrin-1 isoform X1 [KO:K10380]
105819837  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
105819944  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
105819999  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105820249  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820566  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820791  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105820952  ANK3; ankyrin-3 isoform X1 [KO:K09259]
105821032  FZD10; frizzled-10 [KO:K02842]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105821267  SDC4; syndecan-4 [KO:K16338]
105821522  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105822110  FZD2; frizzled-2 [KO:K02235]
105822251  HSPB2; heat shock protein beta-2 [KO:K09543]
105822404  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105822440  TWIST1; twist-related protein 1 [KO:K09069]
105822640  [KO:K06493]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105822719  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105822738  [KO:K00572]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823667  FZD8; frizzled-8 [KO:K02375]
105823715  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:3.6.4.13]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105823921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105823952  FZD5; frizzled-5 [KO:K02375]
105824021  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105824287  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
105824291  WNT8B; protein Wnt-8b [KO:K00714]
105824348  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105824525  FLNA; filamin-A isoform X1 [KO:K04437]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825335  CTNNB1; catenin beta-1 [KO:K02105]
105825452  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105825510  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
105825550  GPC1; glypican-1 [KO:K08107]
105825623  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105825663  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105825985  PDCD4; programmed cell death protein 4 [KO:K16865]
105826087  LUM; lumican [KO:K08122]
105826105  DCN; decorin [KO:K04660]
105826277  FZD1; frizzled-1 [KO:K02432]
105826455  TLR4; toll-like receptor 4 [KO:K10160]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826598  MRAS; ras-related protein M-Ras [KO:K07831]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826682  [KO:K05730]
105826774  SMO; smoothened homolog [KO:K06226]
105826841  WNT7A; protein Wnt-7a [KO:K00572]
105826908  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105827009  [KO:K02991]
105827360  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105827364  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105827422  CTTN; src substrate cortactin isoform X1 [KO:K06106]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
pcoq04010  MAPK signaling pathway
pcoq04020  Calcium signaling pathway
pcoq04066  HIF-1 signaling pathway
pcoq04150  mTOR signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04210  Apoptosis
pcoq04310  Wnt signaling pathway
pcoq04340  Hedgehog signaling pathway
pcoq04350  TGF-beta signaling pathway
pcoq04370  VEGF signaling pathway
pcoq04510  Focal adhesion
pcoq04520  Adherens junction
pcoq04810  Regulation of actin cytoskeleton
KO pathway
ko05205   

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