KEGG   PATHWAY: ppam04020
Entry
ppam04020                   Pathway                                
Name
Calcium signaling pathway - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ppam04020  Calcium signaling pathway
ppam04020

Other DBs
GO: 0019722
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129061280  [KO:K04809]
129061435  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129061441  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129061712  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
129061872  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
129061953  EDNRA; endothelin-1 receptor [KO:K04197]
129062040  CASQ1; calsequestrin-1 isoform X1 [KO:K23468]
129062211  AVPR1B; vasopressin V1b receptor [KO:K04227]
129062310  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129062408  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
129062544  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129062601  P2RX3; P2X purinoceptor 3 [KO:K05217]
129062638  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129062841  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129062855  [KO:K05863]
129063259  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129063834  CASQ2; calsequestrin-2 [KO:K23445]
129063964  NGF; beta-nerve growth factor [KO:K02582]
129064049  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
129064066  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
129064077  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
129064258  FGF7; fibroblast growth factor 7 [KO:K04358]
129064384  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
129064550  [KO:K05863]
129064682  ADRB3; beta-3 adrenergic receptor [KO:K04143]
129064694  FGF20; fibroblast growth factor 20 [KO:K04358]
129064788  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129064887  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129064900  VEGFC; vascular endothelial growth factor C [KO:K05449]
129064951  [KO:K06856]
129064979  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129064993  MCOLN1; mucolipin-1 [KO:K04992]
129065030  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129065324  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
129065350  FGF16; fibroblast growth factor 16 [KO:K04358]
129065398  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
129065572  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
129065582  MCOLN2; mucolipin-2 [KO:K04993]
129065583  MCOLN3; mucolipin-3 [KO:K04994]
129065634  CALM2; calmodulin-2 [KO:K02183]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129065693  BDKRB1; B1 bradykinin receptor [KO:K03915]
129065694  BDKRB2; B2 bradykinin receptor [KO:K03916]
129065835  CALM1; calmodulin-1 [KO:K02183]
129065929  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
129065939  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
129066345  FGF18; fibroblast growth factor 18 [KO:K04358]
129066457  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129066506  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
129066548  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129066549  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129066563  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
129066585  FGF1; fibroblast growth factor 1 [KO:K18496]
129066687  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129066765  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
129067084  [KO:K15040]
129067273  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129067386  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
129067445  TFEB; transcription factor EB [KO:K15590]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129067734  PLN; cardiac phospholamban [KO:K05852]
129067748  TRDN; triadin isoform X1 [KO:K23449]
129067827  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129068161  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
129068177  DRD1; D(1A) dopamine receptor [KO:K04144]
129068186  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
129068195  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
129068332  FGF4; fibroblast growth factor 4 [KO:K04358]
129068333  FGF19; fibroblast growth factor 19 [KO:K22603]
129068334  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
129068425  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129068458  FGF3; fibroblast growth factor 3 [KO:K04358]
129068613  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129068614  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129068779  ADORA2B; adenosine receptor A2b [KO:K04267]
129068893  PDE1C; LOW QUALITY PROTEIN: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129068928  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129068934  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129068954  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
129068975  HRH2; histamine H2 receptor [KO:K04150]
129069014  PTAFR; platelet-activating factor receptor [KO:K04279]
129069120  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
129069781  TACR2; substance-K receptor [KO:K04223]
129069819  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
129069841  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129069854  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129069869  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129069877  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129069891  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
129069951  [KO:K05863]
129069968  MRLN; myoregulin [KO:K22643]
129070029  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129070278  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
129070525  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
129070595  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
129070597  [KO:K04632]
129070613  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129070662  TNNC2; troponin C, skeletal muscle [KO:K12042]
129070698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129070789  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
129070855  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129070857  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129071050  [KO:K15040]
129071112  [KO:K05096] [EC:2.7.10.1]
129071404  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
129071473  HTR5A; 5-hydroxytryptamine receptor 5A isoform X1 [KO:K04161]
129071727  [KO:K04161]
129071824  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129071919  [KO:K10784]
129071926  [KO:K10784]
129071959  FGF10; fibroblast growth factor 10 [KO:K04358]
129072025  LHCGR; LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor [KO:K04248]
129072221  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
129072376  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129072378  P2RX1; P2X purinoceptor 1 [KO:K05215]
129072488  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
129072531  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
129072575  PDGFC; platelet-derived growth factor C [KO:K05450]
129072823  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
129072943  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129073011  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
129073176  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
129073492  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129073529  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129073839  NTSR1; neurotensin receptor type 1 [KO:K04211]
129073895  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
129074063  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
129074067  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
129074168  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
129074223  FGF23; fibroblast growth factor 23 [KO:K22428]
129074224  FGF6; fibroblast growth factor 6 [KO:K04358]
129074287  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
129074308  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
129074312  TBXA2R; thromboxane A2 receptor [KO:K04264]
129074353  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
129074539  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
129074626  F2R; proteinase-activated receptor 1 [KO:K03914]
129074873  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129074904  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
129075010  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129075160  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129075257  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129075491  [KO:K15041]
129075503  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
129075707  [KO:K15041]
129075763  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
129075841  AVPR1A; vasopressin V1a receptor [KO:K04226]
129075941  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
129076152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129076205  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
129076347  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
129076536  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
129076632  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
129076731  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129076926  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
129076969  VEGFD; vascular endothelial growth factor D [KO:K05449]
129076973  GRPR; gastrin-releasing peptide receptor [KO:K04169]
129077222  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129077291  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129077320  ADRB1; beta-1 adrenergic receptor [KO:K04141]
129077479  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129077568  STIM2; stromal interaction molecule 2 [KO:K18196]
129077631  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
129077642  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129077684  DRD5; D(1B) dopamine receptor [KO:K05840]
129077688  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129077699  CCKAR; cholecystokinin receptor type A [KO:K04194]
129077932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129077935  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
129078029  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
129078083  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129078120  ORAI3; protein orai-3 [KO:K16058]
129078231  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129078244  [KO:K04634]
129078245  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
129078752  CALML6; calmodulin-like protein 6 [KO:K02183]
129078786  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129079053  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129079149  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129079421  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
129079449  RYR2; ryanodine receptor 2 [KO:K04962]
129079505  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129079660  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
129079661  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129079754  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129079912  AGTR1; type-1 angiotensin II receptor [KO:K04166]
129080089  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129080142  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
129080346  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
129080370  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129080924  EDNRB; endothelin receptor type B [KO:K04198]
129081076  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
129081137  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
129081330  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129081363  TGFA; protransforming growth factor alpha [KO:K08774]
129081586  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
129081669  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
129081992  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
129082327  FGF9; fibroblast growth factor 9 [KO:K04358]
129082780  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
129082796  FGF21; fibroblast growth factor 21 [KO:K22429]
129082875  CALM3; calmodulin-3 [KO:K02183]
129082896  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129082904  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
129082916  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
129083234  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
129083353  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
129083503  [KO:K05863]
129083643  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129083674  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129083735  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
129083798  ORAI2; protein orai-2 isoform X1 [KO:K16057]
129083913  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
129084060  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
129084082  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129084108  FGF5; fibroblast growth factor 5 [KO:K04358]
129084161  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
129084540  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
129084580  [KO:K02183]
129084594  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
129084965  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129085005  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129085287  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129085325  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129085427  TACR3; neuromedin-K receptor [KO:K04224]
129085550  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
129085704  [KO:K05863]
129086014  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129086230  ADORA2A; adenosine receptor A2a [KO:K04266]
129086365  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
129086402  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
129086508  SMIM6; small integral membrane protein 6 [KO:K26468]
129086576  [KO:K02183]
129086629  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
129086684  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
129086753  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
129086834  TACR1; substance-P receptor [KO:K04222]
129086851  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
129087036  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129087147  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
129087287  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129087301  CALML3; calmodulin-like protein 3 [KO:K02183]
129087304  P2RX7; P2X purinoceptor 7 [KO:K05220]
129087305  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
129087355  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
129087436  TPCN1; two pore channel protein 1 [KO:K16896]
129087497  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
129087685  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129087758  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
129087801  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
129087828  HRH1; histamine H1 receptor [KO:K04149]
129087831  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
129087872  OXTR; oxytocin receptor [KO:K04229]
129088193  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129088299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129088427  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
129088521  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ppam04010  MAPK signaling pathway
ppam04070  Phosphatidylinositol signaling system
ppam04210  Apoptosis
ppam04720  Long-term potentiation
ppam04730  Long-term depression
KO pathway
ko04020   

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