KEGG   PATHWAY: pps04510
Entry
pps04510                    Pathway                                
Name
Focal adhesion - Pan paniscus (bonobo)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pps04510  Focal adhesion
pps04510

Other DBs
GO: 0005925
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967359  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
100967547  ITGA8; integrin alpha-8 isoform X2 [KO:K06584]
100967602  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100967866  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
100967906  COMP; cartilage oligomeric matrix protein [KO:K04659]
100967966  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100967996  LAMC2; laminin subunit gamma-2 isoform X2 [KO:K06246]
100968217  [KO:K06238]
100968295  ITGA5; integrin alpha-5 [KO:K06484]
100968361  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
100968935  LAMC1; laminin subunit gamma-1 [KO:K05635]
100969111  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100969442  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100969648  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100969934  PAK6; serine/threonine-protein kinase PAK 6 isoform X2 [KO:K05735] [EC:2.7.11.1]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100969999  VEGFD; vascular endothelial growth factor D [KO:K05449]
100970113  [KO:K04725] [EC:2.3.2.27]
100970217  VEGFA; vascular endothelial growth factor A, long form isoform X4 [KO:K05448]
100970244  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
100970296  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100970542  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100970548  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
100970636  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
100970723  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
100971139  [KO:K06276] [EC:2.7.11.1]
100971161  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100971253  [KO:K04725] [EC:2.3.2.27]
100971419  LAMA5; laminin subunit alpha-5 isoform X2 [KO:K06240]
100971429  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100971564  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
100971666  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100971729  MYL10; myosin regulatory light chain 10 isoform X3 [KO:K12756]
100971932  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100972192  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X11 [KO:K06277]
100972306  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100972364  PXN; paxillin isoform X1 [KO:K05760]
100972511  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
100972624  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
100972784  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100972868  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100972981  [KO:K12757]
100973169  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100973579  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
100973798  CRKL; crk-like protein [KO:K04438]
100973904  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100974497  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100974667  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100974798  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100974826  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100974889  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100975102  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100975341  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100975589  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100975632  EGF; pro-epidermal growth factor [KO:K04357]
100975853  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100976112  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100976232  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100976292  EMP2; epithelial membrane protein 2 [KO:K26256]
100976587  CRK; adapter molecule crk isoform X1 [KO:K04438]
100976833  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100976901  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100976973  [KO:K00889] [EC:2.7.1.68]
100977098  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100977227  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100977235  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100977352  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100977568  TNC; tenascin isoform X3 [KO:K06252]
100977893  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
100977910  MYL12B; myosin regulatory light chain 12B [KO:K12757]
100978062  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100978092  ITGA1; integrin alpha-1 [KO:K06480]
100978109  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
100978289  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100978326  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100978441  ITGA2; integrin alpha-2 [KO:K06481]
100978696  [KO:K12757]
100978891  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100979183  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
100979422  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100979524  MYL11; myosin regulatory light chain 11 [KO:K12758]
100979542  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100979758  ITGB5; integrin beta-5 [KO:K06588]
100979774  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100980038  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100980143  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X13 [KO:K05726]
100980229  TNN; tenascin-N isoform X2 [KO:K06252]
100980320  FLNA; filamin-A isoform X1 [KO:K04437]
100980616  VTN; vitronectin [KO:K06251]
100980738  LAMB3; laminin subunit beta-3 [KO:K06244]
100980841  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
100980908  JUN; transcription factor Jun [KO:K04448]
100980925  [KO:K06238]
100980934  RAP1A; ras-related protein Rap-1A [KO:K04353]
100981083  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100981220  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100981324  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100981352  TNR; tenascin-R isoform X1 [KO:K06252]
100981951  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
100982035  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100982337  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100982459  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100982480  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100982661  ZYX; zyxin isoform X1 [KO:K06273]
100982766  VAV1; proto-oncogene vav [KO:K05730]
100982914  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100982978  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100983117  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100983139  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
100983152  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100983460  ITGA4; integrin alpha-4 [KO:K06483]
100983653  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100983944  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
100984147  PGF; placenta growth factor isoform X1 [KO:K16859]
100984173  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100984583  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100984686  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100985072  PARVG; gamma-parvin [KO:K06275]
100985238  VWF; von Willebrand factor [KO:K03900]
100985400  VCL; vinculin isoform X1 [KO:K05700]
100985431  THBS3; thrombospondin-3 isoform X13 [KO:K04659]
100985635  PARVB; beta-parvin isoform X7 [KO:K06275]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100986193  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
100986423  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100986594  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100986603  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
100986884  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100987022  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100987158  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100987217  CHAD; chondroadherin [KO:K06248]
100987617  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
100987875  CAV3; caveolin-3 [KO:K12959]
100987964  [KO:K05692]
100988203  TLN1; talin-1 isoform X1 [KO:K06271]
100988375  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100988665  BAD; bcl2-associated agonist of cell death [KO:K02158]
100988790  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100988890  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100989051  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100989468  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100989733  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100989777  [KO:K04392]
100989804  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100989953  PTK2; focal adhesion kinase 1 isoform X7 [KO:K05725] [EC:2.7.10.2]
100990080  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990245  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100990246  CDC42; cell division control protein 42 homolog isoform X3 [KO:K04393]
100990579  [KO:K05692]
100990660  VEGFC; vascular endothelial growth factor C [KO:K05449]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990839  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100990850  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100990998  [KO:K00889] [EC:2.7.1.68]
100991042  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100991060  COL1A1; collagen alpha-1(I) chain isoform X2 [KO:K06236]
100991072  THBS2; thrombospondin-2 [KO:K04659]
100991197  ITGA2B; integrin alpha-IIb [KO:K06476]
100991389  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100991447  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100991777  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100991980  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
100992059  ITGB1; integrin beta-1 [KO:K05719]
100992465  CAV1; caveolin-1 isoform X1 [KO:K06278]
100992477  IBSP; bone sialoprotein 2 [KO:K06253]
100992486  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100992555  FN1; fibronectin isoform X2 [KO:K05717]
100992733  FLNB; filamin-B isoform X4 [KO:K27392]
100992738  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100992816  CAV2; caveolin-2 isoform X1 [KO:K12958]
100992951  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100992963  [KO:K06252]
100993131  [KO:K04393]
100993361  SHC1; SHC-transforming protein 1 isoform X9 [KO:K06279]
100993366  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100993709  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
100993738  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100993959  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100994106  SPP1; osteopontin isoform X3 [KO:K06250]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100994510  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
100994583  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100994588  TLN2; talin-2 isoform X1 [KO:K06271]
100994838  PARVA; alpha-parvin [KO:K06275]
100994889  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100994890  THBS1; thrombospondin-1 [KO:K16857]
100994899  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100995377  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100995578  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
100995605  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
100995642  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
100995666  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100995714  LAMA2; laminin subunit alpha-2 [KO:K05637]
100995715  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100995742  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100995906  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
103786698  [KO:K06250]
117974938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117980785  [KO:K12757]
129398212  ACTB; actin, cytoplasmic 1 [KO:K05692]
130540441  EMP1; epithelial membrane protein 1 isoform X2 [KO:K26255]
134730135  [KO:K06269] [EC:3.1.3.16]
134730136  [KO:K06269] [EC:3.1.3.16]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
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Lee JW, Juliano R.
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Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
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Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
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Danen EH, Yamada KM.
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Fibronectin, integrins, and growth control.
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J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
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Guo W, Giancotti FG.
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Integrin signalling during tumour progression.
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Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
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Petit V, Thiery JP.
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Focal adhesions: structure and dynamics.
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Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
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Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
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J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pps04010  MAPK signaling pathway
pps04060  Cytokine-cytokine receptor interaction
pps04070  Phosphatidylinositol signaling system
pps04110  Cell cycle
pps04151  PI3K-Akt signaling pathway
pps04310  Wnt signaling pathway
pps04512  ECM-receptor interaction
pps04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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