KEGG   PATHWAY: pps04151
Entry
pps04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Pan paniscus (bonobo)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pps04151  PI3K-Akt signaling pathway
pps04151

Other DBs
GO: 0043491
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967291  FGF19; fibroblast growth factor 19 [KO:K22603]
100967294  IL3; interleukin-3 [KO:K04736]
100967324  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100967359  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
100967426  [KO:K16197]
100967539  [KO:K05414]
100967547  ITGA8; integrin alpha-8 isoform X2 [KO:K06584]
100967602  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100967638  FGF4; fibroblast growth factor 4 [KO:K04358]
100967756  EIF4E; eukaryotic translation initiation factor 4E isoform X8 [KO:K03259]
100967770  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100967866  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
100967906  COMP; cartilage oligomeric matrix protein [KO:K04659]
100967915  NRTN; neurturin [KO:K25414]
100967980  FGF3; fibroblast growth factor 3 [KO:K04358]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100967996  LAMC2; laminin subunit gamma-2 isoform X2 [KO:K06246]
100968217  [KO:K06238]
100968231  [KO:K05414]
100968267  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100968295  ITGA5; integrin alpha-5 [KO:K06484]
100968316  [KO:K03259]
100968351  FGF2; fibroblast growth factor 2 [KO:K18497]
100968468  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
100968756  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100968779  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100968814  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100968847  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5 [KO:K05629]
100968935  LAMC1; laminin subunit gamma-1 [KO:K05635]
100968963  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100969001  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100969230  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100969253  [KO:K16339] [EC:3.1.2.2]
100969275  [KO:K05414]
100969352  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100969387  INS; insulin [KO:K04526]
100969442  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100969624  [KO:K05414]
100969648  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100969808  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100969822  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100969999  VEGFD; vascular endothelial growth factor D [KO:K05449]
100970008  FGF20; fibroblast growth factor 20 [KO:K04358]
100970085  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
100970217  VEGFA; vascular endothelial growth factor A, long form isoform X4 [KO:K05448]
100970249  [KO:K11583]
100970300  [KO:K05414]
100970360  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100970465  NRAS; GTPase NRas isoform X2 [KO:K07828]
100970547  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100970548  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
100970658  [KO:K05414]
100970723  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
100970743  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100970831  PRL; prolactin isoform X1 [KO:K05439]
100971050  TSC2; tuberin isoform X16 [KO:K07207]
100971119  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100971139  [KO:K06276] [EC:2.7.11.1]
100971419  LAMA5; laminin subunit alpha-5 isoform X2 [KO:K06240]
100971425  [KO:K05438]
100971596  IRS1; insulin receptor substrate 1 [KO:K16172]
100971653  OSM; oncostatin-M [KO:K05418]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100972005  [KO:K05414]
100972031  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100972035  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100972194  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
100972202  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100972246  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100972250  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100972306  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100972354  [KO:K05414]
100972365  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100972442  [KO:K05438]
100972511  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
100972676  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100972784  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100972785  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
100972797  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100972868  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100972885  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100973020  [KO:K05438]
100973049  [KO:K05414]
100973153  TGFA; protransforming growth factor alpha isoform X3 [KO:K08774]
100973232  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
100973241  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
100973292  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100973322  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100973372  KITLG; kit ligand isoform X1 [KO:K05461]
100973399  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100973549  BCL2L11; bcl-2-like protein 11 isoform X7 [KO:K16341]
100973869  EREG; proepiregulin [KO:K09784]
100973904  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100973941  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
100974292  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100974345  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100974407  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
100974494  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
100974497  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100974511  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100974638  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
100974672  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100974757  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
100974826  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100974840  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13 [KO:K05631]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100974967  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100975023  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100975327  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100975521  FGF21; fibroblast growth factor 21 [KO:K22429]
100975575  TSC1; hamartin isoform X2 [KO:K07206]
100975589  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100975618  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
100975632  EGF; pro-epidermal growth factor [KO:K04357]
100975853  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100976101  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100976112  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100976275  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100976294  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100976373  FOXO3; forkhead box protein O3 [KO:K09408]
100976440  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100976551  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100976569  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X4 [KO:K04465]
100976735  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100976740  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100976833  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100976901  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100976984  ARTN; artemin isoform X1 [KO:K25415]
100977025  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X3 [KO:K04369] [EC:2.7.12.2]
100977074  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100977227  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100977235  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100977352  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100977358  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
100977376  [KO:K03258]
100977477  YWHAZ; 14-3-3 protein zeta/delta isoform X2 [KO:K16197]
100977568  TNC; tenascin isoform X3 [KO:K06252]
100977804  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100977893  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100978062  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100978092  ITGA1; integrin alpha-1 [KO:K06480]
100978109  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
100978194  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100978197  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100978289  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100978441  ITGA2; integrin alpha-2 [KO:K06481]
100978515  [KO:K06630]
100978523  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100978647  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X2 [KO:K04545]
100978830  RBL2; retinoblastoma-like protein 2 [KO:K16332]
100979133  FGF5; fibroblast growth factor 5 isoform X3 [KO:K04358]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100979428  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100979542  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100979595  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100979613  EFNA2; ephrin-A2 [KO:K05462]
100979704  FGF9; fibroblast growth factor 9 [KO:K04358]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100979758  ITGB5; integrin beta-5 [KO:K06588]
100979779  [KO:K04079]
100979809  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
100980038  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100980204  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100980229  TNN; tenascin-N isoform X2 [KO:K06252]
100980274  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
100980367  GHR; growth hormone receptor isoform X2 [KO:K05080]
100980415  HSP90B1; endoplasmin isoform X2 [KO:K09487]
100980493  [KO:K03258]
100980556  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100980616  VTN; vitronectin [KO:K06251]
100980629  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100980644  TLR4; toll-like receptor 4 precursor [KO:K10160]
100980724  [KO:K04374]
100980738  LAMB3; laminin subunit beta-3 [KO:K06244]
100980790  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
100980807  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100980925  [KO:K06238]
100981063  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100981083  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100981139  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100981220  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100981222  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100981232  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100981258  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100981266  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100981352  TNR; tenascin-R isoform X1 [KO:K06252]
100981507  EPO; erythropoietin [KO:K05437]
100981626  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
100981656  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100981695  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100981855  EIF4B; eukaryotic translation initiation factor 4B isoform X5 [KO:K03258]
100981869  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100981987  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100982237  PRLR; prolactin receptor isoform X2 [KO:K05081]
100982337  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100982459  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100982462  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100982509  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100982572  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
100982783  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100982968  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100982978  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100983091  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100983117  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100983139  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
100983141  YWHAB; 14-3-3 protein beta/alpha isoform X4 [KO:K16197]
100983152  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100983460  ITGA4; integrin alpha-4 [KO:K06483]
100983575  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100983653  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100983866  BDNF; brain-derived neurotrophic factor isoform X3 [KO:K04355]
100983884  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
100983900  [KO:K05438]
100984147  PGF; placenta growth factor isoform X1 [KO:K16859]
100984489  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
100984583  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100984686  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100984695  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100984780  IL2; interleukin-2 [KO:K05429]
100984856  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100984960  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
100985238  VWF; von Willebrand factor [KO:K03900]
100985264  FGF16; fibroblast growth factor 16 [KO:K04358]
100985362  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100985431  THBS3; thrombospondin-3 isoform X13 [KO:K04659]
100985706  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100985711  F2R; proteinase-activated receptor 1 [KO:K03914]
100985907  NTF3; neurotrophin-3 [KO:K04356]
100985931  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100985935  KIT; mast/stem cell growth factor receptor Kit isoform X7 [KO:K05091] [EC:2.7.10.1]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100986193  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
100986194  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100986197  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
100986199  [KO:K12457]
100986540  IL7; interleukin-7 isoform X1 [KO:K05431]
100986594  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100986603  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
100986679  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100986739  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
100987022  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100987089  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
100987158  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100987217  CHAD; chondroadherin [KO:K06248]
100987323  [KO:K04382] [EC:3.1.3.16]
100987458  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100987536  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
100987617  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
100987712  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100987804  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100987951  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X14 [KO:K11584]
100988115  FGFR1; fibroblast growth factor receptor 1 isoform X8 [KO:K04362] [EC:2.7.10.1]
100988345  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100988354  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100988420  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100988437  [KO:K04369] [EC:2.7.12.2]
100988487  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100988665  BAD; bcl2-associated agonist of cell death [KO:K02158]
100988777  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
100988878  IL4; interleukin-4 isoform X1 [KO:K05430]
100989254  PSPN; persephin [KO:K25416]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100989491  FGF6; fibroblast growth factor 6 [KO:K04358]
100989601  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100989625  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
100989638  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100989680  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100989684  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100989777  [KO:K04392]
100989804  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100989835  FGF23; fibroblast growth factor 23 [KO:K22428]
100989942  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
100989953  PTK2; focal adhesion kinase 1 isoform X7 [KO:K05725] [EC:2.7.10.2]
100990010  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100990031  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
100990047  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990138  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X4 [KO:K11584]
100990236  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
100990660  VEGFC; vascular endothelial growth factor C [KO:K05449]
100990801  KRAS; GTPase KRas isoform X1 [KO:K07827]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990839  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100990850  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100991005  MTCP1; protein p13 MTCP-1 [KO:K16837]
100991060  COL1A1; collagen alpha-1(I) chain isoform X2 [KO:K06236]
100991072  THBS2; thrombospondin-2 [KO:K04659]
100991126  YWHAQ; 14-3-3 protein theta [KO:K16197]
100991197  ITGA2B; integrin alpha-IIb [KO:K06476]
100991308  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X6 [KO:K03456]
100991315  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100991389  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100991417  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100991777  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100991905  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100991998  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100992059  ITGB1; integrin beta-1 [KO:K05719]
100992216  YWHAH; 14-3-3 protein eta [KO:K16198]
100992242  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100992335  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100992375  MYB; transcriptional activator Myb isoform X4 [KO:K09420]
100992392  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100992438  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100992477  IBSP; bone sialoprotein 2 [KO:K06253]
100992555  FN1; fibronectin isoform X2 [KO:K05717]
100992567  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100992612  FGF10; fibroblast growth factor 10 [KO:K04358]
100992738  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100992814  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
100992951  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100992963  [KO:K06252]
100993144  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100993271  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
100993334  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100993366  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100993709  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
100994039  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100994102  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100994106  SPP1; osteopontin isoform X3 [KO:K06250]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100994439  YWHAG; 14-3-3 protein gamma [KO:K16198]
100994576  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100994583  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100994768  TLR2; toll-like receptor 2 precursor [KO:K10159]
100994887  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100994889  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100994890  THBS1; thrombospondin-1 [KO:K16857]
100995028  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100995177  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100995377  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100995408  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100995446  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100995605  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
100995667  NGF; beta-nerve growth factor [KO:K02582]
100995714  LAMA2; laminin subunit alpha-2 [KO:K05637]
100995715  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100995734  [KO:K05414]
100995792  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100995851  IFNB1; interferon beta [KO:K05415]
100995906  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
100995920  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100996186  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
103782638  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
103786410  MYC; myc proto-oncogene protein [KO:K04377]
103786698  [KO:K06250]
103786771  [KO:K16197]
112437196  [KO:K04545]
112437428  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
117974215  FGF7; fibroblast growth factor 7 [KO:K04358]
117974938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117975026  [KO:K04542]
117976254  [KO:K03259]
117976712  [KO:K05438]
117977099  [KO:K16197]
117977645  [KO:K07210]
117977740  [KO:K11583]
117980428  FGF18; fibroblast growth factor 18 [KO:K04358]
117981650  [KO:K05414]
117981652  [KO:K05414]
129392943  [KO:K05438]
129393206  [KO:K07208]
129394720  NTF4; neurotrophin-4 [KO:K12457]
129397852  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
134728514  [KO:K04358]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pps00010  Glycolysis / Gluconeogenesis
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04062  Chemokine signaling pathway
pps04064  NF-kappa B signaling pathway
pps04068  FoxO signaling pathway
pps04110  Cell cycle
pps04115  p53 signaling pathway
pps04150  mTOR signaling pathway
pps04210  Apoptosis
pps04370  VEGF signaling pathway
pps04510  Focal adhesion
pps04620  Toll-like receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04662  B cell receptor signaling pathway
pps04910  Insulin signaling pathway
KO pathway
ko04151   

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