KEGG   PATHWAY: shr05225
Entry
shr05225                    Pathway                                
Name
Hepatocellular carcinoma - Sarcophilus harrisii (Tasmanian devil)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
shr05225  Hepatocellular carcinoma
shr05225

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100928770  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100928068  IGF2; insulin-like growth factor II [KO:K13769]
100916673  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100923119  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100919206  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100914678  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100926921  SHC1; SHC-transforming protein 1 isoform X4 [KO:K06279]
100917745  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100914800  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
100927458  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100927199  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100935081  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100930707  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100915548  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100914196  RB1; retinoblastoma-associated protein [KO:K06618]
116421696  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
100921594  E2F2; transcription factor E2F2 [KO:K09389]
100934669  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100914433  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100926902  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100920439  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116423727  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100916731  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100916232  DDB2; DNA damage-binding protein 2 [KO:K10140]
100923657  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100932899  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100924154  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100932607  TGFB1; LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375]
100914910  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
100929617  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100913844  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100913352  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100914956  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100923201  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
100923569  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100928059  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100918306  WNT2; protein Wnt-2 isoform X3 [KO:K00182]
100918389  WNT2B; protein Wnt-2b [KO:K00182]
100914628  WNT3A; protein Wnt-3a [KO:K00312]
100935307  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100925510  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100917926  WNT5A; protein Wnt-5a [KO:K00444]
100924415  WNT5B; protein Wnt-5b [KO:K00444]
100933826  WNT6; protein Wnt-6 [KO:K00445]
100925362  WNT7B; protein Wnt-7b [KO:K00572]
100931119  WNT7A; protein Wnt-7a [KO:K00572]
100934290  WNT8B; protein Wnt-8b [KO:K00714]
100923381  WNT8A; protein Wnt-8a [KO:K00714]
100914365  WNT9A; protein Wnt-9a [KO:K01064]
100919162  WNT9B; LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
100917765  WNT10A; protein Wnt-10a [KO:K01357]
100932979  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
100913767  WNT11; protein Wnt-11 [KO:K01384]
100921973  WNT16; protein Wnt-16 [KO:K01558]
100921540  FZD1; frizzled-1 [KO:K02432]
100923425  FZD7; frizzled-7 [KO:K02432]
100932536  FZD2; frizzled-2 [KO:K02235]
100919821  FZD3; frizzled-3 isoform X1 [KO:K02329]
100919498  FZD4; frizzled-4 [KO:K02354]
100916636  FZD5; frizzled-5 [KO:K02375]
111721152  FZD8; frizzled-8 [KO:K02375]
100919476  FZD6; frizzled-6 isoform X1 [KO:K02376]
100914963  FZD10; frizzled-10 [KO:K02842]
100930633  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100916936  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100932600  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
100932119  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100931932  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
105749059  proto-oncogene FRAT1 [KO:K03069]
100930993  GSK-3-binding protein FRAT2 [KO:K03096]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100923576  AXIN1; axin-1 isoform X1 [KO:K02157]
100933740  AXIN2; axin-2 isoform X1 [KO:K04385]
100925931  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100915224  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100930636  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100915381  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100924173  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
100919354  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
105751130  LOW QUALITY PROTEIN: casein kinase I [KO:K08957] [EC:2.7.11.1]
100930141  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100922609  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100922675  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100934638  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100927230  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100915496  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
100925365  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100916256  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
100928482  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100929215  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100924507  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100926836  LOW QUALITY PROTEIN: glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100935165  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100913363  glutathione S-transferase omega-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
100927430  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100927692  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
100927944  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100929408  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100926310  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100926572  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100927091  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
100917755  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100933898  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
100921449  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X2 [KO:K22182] [EC:1.8.1.9]
100922886  TXNRD3; thioredoxin reductase 3 isoform X2 [KO:K22182] [EC:1.8.1.9]
100915696  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100917007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100925463  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
100928302  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100923807  actin, cytoplasmic type 5 [KO:K05692]
100919051  ACTB; actin, cytoplasmic 1 [KO:K05692]
100916712  LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
100934515  ACTL6A; actin-like protein 6A [KO:K11340]
100917773  ACTL6B; actin-like protein 6B [KO:K11652]
100934618  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X1 [KO:K11650]
100917447  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
100928991  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
100919340  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
100920160  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
100923422  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
100920389  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
100934187  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
100926029  SMARCB1; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [KO:K11648]
100930330  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
100923534  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
100926980  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
100924016  SMARCA4; transcription activator BRG1 isoform X4 [KO:K11647] [EC:5.6.2.-]
100934894  ARID2; AT-rich interactive domain-containing protein 2 isoform X1 [KO:K11765]
100926727  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
100924348  BRD7; bromodomain-containing protein 7 isoform X1 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
shr04010  MAPK signaling pathway
shr04020  Calcium signaling pathway
shr04110  Cell cycle
shr04115  p53 signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04310  Wnt signaling pathway
shr04350  TGF-beta signaling pathway
shr04932  Non-alcoholic fatty liver disease
shr04936  Alcoholic liver disease
shr05160  Hepatitis C
shr05161  Hepatitis B
KO pathway
ko05225   
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