KEGG   PATHWAY: zvi04510
Entry
zvi04510                    Pathway                                
Name
Focal adhesion - Zootoca vivipara (common lizard)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
zvi04510  Focal adhesion
zvi04510

Other DBs
GO: 0005925
Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118075192  ZYX; zyxin isoform X1 [KO:K06273]
118075210  FLNA; filamin-A isoform X1 [KO:K04437]
118075261  MYL5; myosin light chain 5 [KO:K12753]
118075410  SOS2; son of sevenless homolog 2 [KO:K03099]
118075486  [KO:K12958]
118075494  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
118075732  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118075832  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118076040  THBS3; thrombospondin-3 [KO:K04659]
118076054  PXN; paxillin isoform X1 [KO:K05760]
118076259  [KO:K00889] [EC:2.7.1.68]
118076282  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
118076311  VEGFB; vascular endothelial growth factor B [KO:K16858]
118076378  BAD; bcl2-associated agonist of cell death [KO:K02158]
118076480  CRKL; crk-like protein [KO:K04438]
118076723  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118076742  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
118076890  THBS4; thrombospondin-4 [KO:K04659]
118076970  SHC3; SHC-transforming protein 3 [KO:K17448]
118077038  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118077109  ITGA1; integrin alpha-1 [KO:K06480]
118077115  TLN1; talin-1 isoform X1 [KO:K06271]
118077139  ITGA2; integrin alpha-2 [KO:K06481]
118077665  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118077849  [KO:K05692]
118078121  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118078194  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
118078195  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118079192  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
118079381  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
118079581  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118079639  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118079682  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118079760  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
118079792  CHAD; chondroadherin [KO:K06248]
118079827  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118079839  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118079987  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118080395  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118080415  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118080419  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118080560  RHOA; transforming protein RhoA [KO:K04513]
118080671  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118080725  FLNB; filamin-B isoform X1 [KO:K27392]
118080881  LAMB2; laminin subunit beta-2 [KO:K06243]
118080882  [KO:K06243]
118081109  TNXB; tenascin-X isoform X1 [KO:K06252]
118081774  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118081845  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118081879  PGF; placenta growth factor [KO:K16859]
118081924  THBS2; thrombospondin-2 [KO:K04659]
118082107  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
118082130  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
118082132  LAMA4; laminin subunit alpha-4 [KO:K06241]
118082338  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
118082356  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
118082382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118082493  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118082616  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
118082618  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
118082777  [KO:K04364]
118082968  THBS1; thrombospondin-1 [KO:K16857]
118083024  [KO:K05735] [EC:2.7.11.1]
118083028  SOS1; son of sevenless homolog 1 [KO:K03099]
118083208  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118083253  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118083339  PDGFC; platelet-derived growth factor C [KO:K05450]
118083408  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118083576  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118083687  [KO:K05692]
118083713  EGF; pro-epidermal growth factor [KO:K04357]
118083754  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118083789  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
118083847  TNC; tenascin isoform X1 [KO:K06252]
118083955  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
118083993  SPP1; osteopontin [KO:K06250]
118084127  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
118084151  [KO:K05096] [EC:2.7.10.1]
118084167  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
118084202  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
118084234  LAMC3; laminin subunit gamma-3 [KO:K06247]
118084339  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
118084365  [KO:K05692]
118084499  IBSP; bone sialoprotein 2 [KO:K06253]
118084634  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118084895  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
118084907  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118084973  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118085150  [KO:K05692]
118085232  PDGFD; platelet-derived growth factor D [KO:K05450]
118085281  VEGFD; vascular endothelial growth factor D [KO:K05449]
118085897  COMP; cartilage oligomeric matrix protein [KO:K04659]
118085906  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118085960  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118086264  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
118086273  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
118086298  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
118086401  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
118086452  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
118086712  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118086713  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
118086864  PARVA; alpha-parvin isoform X1 [KO:K06275]
118086883  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118087137  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118087296  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118087797  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
118087852  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
118087871  SHC2; SHC-transforming protein 2 [KO:K17447]
118088013  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118088329  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118088425  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118088466  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118088586  HRAS; GTPase HRas [KO:K02833]
118088701  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
118088799  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118088813  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
118088978  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118088990  [KO:K02649]
118089100  JUN; transcription factor AP-1 [KO:K04448]
118089159  TNN; tenascin-N [KO:K06252]
118089160  TNR; tenascin-R [KO:K06252]
118089199  LAMC2; laminin subunit gamma-2 [KO:K06246]
118089318  LAMC1; laminin subunit gamma-1 [KO:K05635]
118089375  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
118089490  RAP1A; ras-related protein Rap-1A [KO:K04353]
118089557  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
118089643  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
118089797  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118089983  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
118090037  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118090072  [KO:K00907] [EC:2.7.11.18]
118090240  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
118090295  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118090513  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118090599  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
118090600  LAMB1; laminin subunit beta-1 [KO:K05636]
118090617  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118090625  RAP1B; ras-related protein Rap-1b [KO:K07836]
118090716  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118090738  CAV1; caveolin-1 isoform X1 [KO:K06278]
118090739  CAV2; caveolin-2 [KO:K12958]
118090956  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
118090974  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118091008  EMP1; epithelial membrane protein 1 [KO:K26255]
118091269  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118091334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118091403  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118091493  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
118091641  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
118091663  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118091757  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118091777  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118091799  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118091844  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
118091883  [KO:K06238]
118091929  [KO:K06238]
118091932  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118091991  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
118092163  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
118092483  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118092538  ACTB; actin, cytoplasmic 1 [KO:K05692]
118092551  EMP2; epithelial membrane protein 2 [KO:K26256]
118092573  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118092637  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118092682  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118092724  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118092754  TLN2; talin-2 isoform X1 [KO:K06271]
118092785  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118092793  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
118092862  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
118093123  ITGA11; integrin alpha-11 [KO:K06587]
118093376  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118093405  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118093522  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118093528  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118093552  [KO:K06237]
118093553  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
118093773  ITGAV; integrin alpha-V [KO:K06487]
118093906  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
118094199  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118094316  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
118094322  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
118094387  [KO:K04438]
118094604  ITGA3; integrin alpha-3 [KO:K06482]
118094664  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118094794  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118094978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118095035  [KO:K00922] [EC:2.7.1.153]
118095102  ITGB3; integrin beta-3 [KO:K06493]
118095213  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
118095316  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
118096089  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118096231  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118096285  PARVB; beta-parvin isoform X1 [KO:K06275]
118096593  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
118096600  PARVG; gamma-parvin isoform X1 [KO:K06275]
118096635  VCL; vinculin isoform X1 [KO:K05700]
118096643  VWF; von Willebrand factor isoform X1 [KO:K03900]
118096728  CRK; adapter molecule crk isoform X1 [KO:K04438]
118096795  FN1; fibronectin isoform X1 [KO:K05717]
118096892  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118096921  VTN; vitronectin [KO:K06251]
118096988  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
118097001  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118097009  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118097179  MYL10; myosin regulatory light chain 10 [KO:K12756]
118097518  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118097693  [KO:K12959]
118097793  [KO:K04513]
118097847  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
zvi04010  MAPK signaling pathway
zvi04060  Cytokine-cytokine receptor interaction
zvi04070  Phosphatidylinositol signaling system
zvi04110  Cell cycle
zvi04310  Wnt signaling pathway
zvi04512  ECM-receptor interaction
zvi04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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