KEGG   PATHWAY: afb04514
Entry
afb04514                    Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Anoplopoma fimbria (sablefish)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
afb04514  Cell adhesion molecule (CAM) interaction
afb04514

Other DBs
GO: 0050839
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129088811  [KO:K06087]
129089019  [KO:K05695] [EC:3.1.3.48]
129089113  cldn15la; claudin 15-like a [KO:K06087]
129089155  cldn1; claudin-1 [KO:K06087]
129089170  ptprfa; protein tyrosine phosphatase receptor type Fa [KO:K05695] [EC:3.1.3.48]
129089172  cldn18; claudin-18 [KO:K06087]
129089209  [KO:K07522]
129089218  mpz; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
129089347  [KO:K06778] [EC:3.1.3.48]
129089414  cadm3; LOW QUALITY PROTEIN: cell adhesion molecule 3 [KO:K06780]
129089429  slitrk3a; SLIT and NTRK-like protein 3 [KO:K25834]
129089799  nlgn3a; neuroligin-3a [KO:K07378]
129089884  slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
129090209  nectin3a; nectin-3-like protein isoform X1 [KO:K06592]
129090288  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
129090979  nrxn1a; neurexin 1a isoform X1 [KO:K07377]
129091023  [KO:K06461]
129091534  [KO:K16360]
129091898  [KO:K07377]
129091988  [KO:K05413]
129092000  vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
129092024  [KO:K05689]
129092235  itga9; integrin alpha-9 [KO:K06585]
129092327  cldnf; claudin f [KO:K06087]
129092335  [KO:K06087]
129092343  [KO:K06087]
129092478  cdh5; cadherin-5 [KO:K06533]
129093030  cadm1b; cell adhesion molecule 1b [KO:K06781]
129093062  nrxn2b; LOW QUALITY PROTEIN: neurexin 2b [KO:K07377]
129093075  cd99l2; CD99 antigen-like protein 2 [KO:K06520]
129093545  cldn15a; claudin-15a [KO:K06087]
129093562  [KO:K06777] [EC:3.1.3.48]
129093662  cldn8.1; claudin-8 [KO:K06087]
129093666  cldn7a; claudin-7-A [KO:K06087]
129093689  [KO:K06752]
129093728  nlgn2a; neuroligin-2a isoform X1 [KO:K07378]
129094061  [KO:K06710]
129094205  negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
129094209  [KO:K06088]
129094351  selp; P-selectin isoform X1 [KO:K06496]
129094355  nectin1b; LOW QUALITY PROTEIN: nectin cell adhesion molecule 1b [KO:K06081]
129094419  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
129094438  sele; E-selectin [KO:K06496]
129094526  esamb; endothelial cell-selective adhesion molecule [KO:K06787]
129094527  vcam1b; vascular cell adhesion protein 1b [KO:K06527]
129094645  jam3a; LOW QUALITY PROTEIN: junctional adhesion molecule 3B [KO:K06785]
129094697  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
129094715  ptprsa; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
129094819  [KO:K06087]
129094975  [KO:K06087]
129095048  [KO:K06087]
129095081  [KO:K06495]
129095102  [KO:K06087]
129095167  cldn34a; claudin-34 [KO:K06087]
129095238  [KO:K06087]
129095276  [KO:K06467]
129095302  [KO:K06467]
129095304  [KO:K06467]
129095310  [KO:K06467]
129095317  [KO:K06467]
129095324  cldnj; claudin j [KO:K06087]
129095445  [KO:K06087]
129095545  ptprdb; LOW QUALITY PROTEIN: protein tyrosine phosphatase receptor type Db [KO:K06777] [EC:3.1.3.48]
129095673  [KO:K06087]
129095973  zmp:0000001082; integrin alpha-D [KO:K05718]
129096030  [KO:K06467]
129096255  pecam1b; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
129096405  [KO:K06087]
129096886  [KO:K06751]
129096897  [KO:K06751]
129096898  [KO:K06751]
129096899  [KO:K06751]
129096901  [KO:K06751]
129096902  [KO:K06751]
129096977  [KO:K06751]
129097256  sdc3; putative uncharacterized protein DDB_G0271982 [KO:K16337]
129097327  [KO:K06751]
129097328  [KO:K06751]
129097341  [KO:K06456]
129097407  itgb8; integrin beta-8 [KO:K06591]
129097525  cldn35; claudin-4 isoform X1 [KO:K06087]
129097556  sdc2; syndecan-2 [KO:K16336]
129097697  ncam1b; neural cell adhesion molecule 1b isoform X1 [KO:K06491]
129097860  cldnk; LOW QUALITY PROTEIN: claudin k [KO:K06087]
129097936  cldni; claudin i [KO:K06087]
129098057  cntnap1; contactin-associated protein 1 [KO:K07379]
129098281  pecam1a; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
129098942  lrrc4ba; leucine-rich repeat-containing protein 4B isoform X1 [KO:K16360]
129099032  [KO:K06816]
129099234  l1cama; neural cell adhesion molecule L1.2 [KO:K06550]
129099459  [KO:K06550]
129099503  [KO:K06797]
129099757  nfascb; neurofascin [KO:K06757]
129099789  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
129100034  cd34; uncharacterized protein cd34 [KO:K06474]
129100661  cldn5a; claudin 5a [KO:K06087]
129101007  neo1a; LOW QUALITY PROTEIN: neogenin 1a [KO:K06766]
129101633  vsig8b; V-set and immunoglobulin domain-containing protein 8b [KO:K06788]
129101757  cldn26; putative claudin-24 [KO:K06087]
129102002  cldn5b; claudin-5b [KO:K06087]
129102243  ntng2b; netrin-G2 [KO:K16359]
129102261  oclna; LOW QUALITY PROTEIN: occludin [KO:K06088]
129102416  [KO:K06745]
129102833  vsig8a; V-set and immunoglobulin domain-containing protein 8a [KO:K06788]
129102867  cldn23.1; claudin 23a [KO:K06087]
129102999  nrxn3a; neurexin 3a [KO:K07377]
129103348  [KO:K06087]
129103784  [KO:K25834]
129103787  cldn11a; claudin-11a [KO:K06087]
129103889  [KO:K06087]
129104002  cldn23l; claudin-23 [KO:K06087]
129104167  [KO:K06087]
129104168  [KO:K06087]
129104169  [KO:K06087]
129104281  itgav; integrin alpha-V [KO:K06487]
129104290  cd276; CD276 antigen [KO:K06746]
129104366  itga4; integrin alpha-4 [KO:K06483]
129104423  [KO:K07378]
129104806  [KO:K06087]
129104911  jam2b; junctional adhesion molecule 2b [KO:K06735]
129104913  slitrk5b; SLIT and NTRK-like protein 5 [KO:K25836]
129104919  cldn10c; claudin-10 [KO:K06087]
129104994  vtcn1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
129105039  cd28; cytotoxic T-lymphocyte protein 4 [KO:K06538]
129105058  si:ch211-141e20.2; nectin-3-like protein isoform X1 [KO:K06081]
129105063  [KO:K06467]
129105074  itgb2; integrin beta-2 [KO:K06464]
129105118  itga6a; integrin alpha-6 [KO:K06485]
129105141  [KO:K06467]
129105153  [KO:K06467]
129105172  nfasca; neurofascin homolog (chicken) a [KO:K06757]
129105433  sdc4; syndecan-4 isoform X1 [KO:K16338]
129105445  cdh4; cadherin-4 [KO:K06797]
129105569  [KO:K06752]
129105802  cntn2; contactin-2 [KO:K06760]
129105972  [KO:K06752]
129105994  cd8a; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
129106002  cldn19; claudin-19 [KO:K06087]
129106013  cd8b; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
129106219  si:ch211-286o17.1; hematopoietic progenitor cell antigen CD34 [KO:K06474]
129106751  [KO:K07377]
129107363  [KO:K16338]
129107716  [KO:K06759]
129107802  glg1a; Golgi apparatus protein 1 isoform X1 [KO:K06816]
129107906  [KO:K05689]
129108024  lrrc4cb; leucine-rich repeat-containing protein 4C [KO:K07523]
129108051  cdh15; cadherin-15 [KO:K06809]
129108118  lrrc4.2; leucine-rich repeat-containing protein 4.2 [KO:K16351]
129108409  [KO:K06756]
129108774  [KO:K06449]
129108819  lrrc4ca; leucine rich repeat containing 4C, genome duplicate a [KO:K07523]
129109051  cldn12; claudin-12 [KO:K06087]
129109112  ncam3; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
129109113  si:dkey-33i11.1; sialoadhesin [KO:K06467]
129109114  [KO:K06467]
129109174  si:dkey-24p1.1; B-cell receptor CD22 [KO:K06467]
129109193  itga8; integrin alpha-8 [KO:K06584]
129109336  [KO:K06771]
129109359  [KO:K06752]
129109360  [KO:K06752]
129109390  [KO:K06752]
129109531  [KO:K06531]
129109537  [KO:K06454]
129109556  [KO:K03160]
129109632  [KO:K16336]
129109649  [KO:K06467]
129109749  [KO:K06771]
129109813  [KO:K06547]
129109978  [KO:K06771]
129110128  [KO:K06771]
129110247  [KO:K06752]
129110494  cntnap2a; contactin-associated protein-like 2a [KO:K07380]
129110532  itgb1a; integrin beta-1a [KO:K05719]
129110611  [KO:K05693] [EC:3.1.3.48]
129110719  ntng1a; netrin-G1 isoform X1 [KO:K07522]
129110870  cd226; CD226 antigen [KO:K06567]
129110897  [KO:K05693] [EC:3.1.3.48]
129110948  cldn11b; claudin-11b [KO:K06087]
129111483  [KO:K06491]
129111526  [KO:K06087]
129111550  cdh2; LOW QUALITY PROTEIN: cadherin-2 [KO:K06736]
129111555  [KO:K05719]
129111659  [KO:K06087]
129111752  nlgn4xa; LOW QUALITY PROTEIN: neuroligin 4 X-linked a [KO:K07378]
129111773  si:ch211-132g1.1; T-cell surface antigen CD2 isoform X1 [KO:K06449]
129111848  [KO:K25836]
129111916  cntnap2b; contactin-associated protein-like 2b [KO:K07380]
129111925  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
129111926  [KO:K06736]
129111927  cldn10e; claudin-10 [KO:K06087]
129111928  [KO:K06087]
129111933  [KO:K06087]
129111944  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
129111952  [KO:K25832]
129111962  cd99; CD99 molecule isoform X1 [KO:K06520]
129112026  nlgn1; neuroligin-1 isoform X1 [KO:K07378]
129112228  nrcama; neuronal cell adhesion molecule a isoform X1 [KO:K06756]
129112247  lrrc4.1; leucine-rich repeat-containing protein 4 [KO:K16351]
129112253  itga6b; integrin alpha-6b isoform X1 [KO:K06485]
129112339  cntn1b; contactin 1b [KO:K06759]
129113048  [KO:K06087]
129113049  [KO:K06087]
129113051  [KO:K06087]
129113186  nlgn2b; neuroligin-2b [KO:K07378]
129113191  [KO:K06087]
129113402  nlgn3b; neuroligin-3b isoform X1 [KO:K07378]
129113407  jam3b; junctional adhesion molecule 3B [KO:K06785]
129113531  nectin3b; nectin-3-like protein isoform X1 [KO:K06592]
129113556  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
129113609  [KO:K06087]
129113626  cadm1a; cell adhesion molecule 1a isoform X1 [KO:K06781]
129113643  alcama; CD166 antigen homolog A [KO:K06547]
129113773  cxadr; coxsackievirus and adenovirus receptor homolog [KO:K06788]
129113855  [KO:K06087]
129113938  nectin1a; nectin cell adhesion molecule 1a [KO:K06081]
129113949  cldn2; claudin-2 [KO:K06087]
129114037  esama; endothelial cell adhesion molecule a [KO:K06787]
129114040  ncam1a; neural cell adhesion molecule 1a [KO:K06491]
129114062  zgc:165604; immunoglobulin superfamily member 11 [KO:K06791]
129114903  [KO:K06467]
129115698  [KO:K06771]
129116152  [KO:K06087]
129116156  [KO:K06087]
129116783  [KO:K06751]
129116801  [KO:K06467]
129116804  [KO:K06467]
129116835  [KO:K06751]
129116874  [KO:K06752]
129116877  [KO:K06752]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
afb04520  Adherens junction
afb04530  Tight junction
KO pathway
ko04514   

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