KEGG   PATHWAY: hsa04145
Entry
hsa04145                    Pathway                                
Name
Phagosome - Homo sapiens (human)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsa04145  Phagosome
hsa04145

Network
nt06181  Salmonella
  Element
N01295  Rab7-regulated microtubule minus-end directed transport
N01302  Early endosomal fusion
Drug
D00570  Colchicine (JP18/USP)
D10028  Valategrast hydrochloride (USAN)
D11525  Enfortumab vedotin (USAN)
D11684  Verdiperstat (USAN/INN)
D11812  Pabinafusp alfa (genetical recombination) (JAN)
D12333  Zelpultide alfa (USAN/INN)
D12509  Trontinemab (USAN/INN)
D12624  Paridiprubart (USAN/INN)
D12647  Mitiperstat (USAN/INN)
D12777  Olgotrelvir (USAN)
D12778  Olgotrelvir sodium (USAN)
D12806  Tividenofusp alfa (USAN/INN)
D13225  Delpacibart (USAN/INN)
Other DBs
GO: 0045335
Organism
Homo sapiens (human) [GN:hsa]
Gene
101927180  ATP6V1FP2; V-type proton ATPase subunit F-like [KO:K02151]
102723407  [KO:K06856]
10312  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform a [KO:K02154]
10332  CLEC4M; C-type lectin domain family 4 member M isoform 1 [KO:K06563]
10333  TLR6; toll-like receptor 6 precursor [KO:K10169]
10376  TUBA1B; tubulin alpha-1B chain [KO:K07374]
10381  TUBB3; tubulin beta-3 chain isoform 1 [KO:K07375]
10382  TUBB4A; tubulin beta-4A chain isoform 3 [KO:K07375]
10383  TUBB4B; tubulin beta-4B chain [KO:K07375]
10952  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
11151  CORO1A; coronin-1A [KO:K13882]
112714  TUBA3E; tubulin alpha-3E chain [KO:K07374]
113457  TUBA3D; tubulin alpha-3D chain [KO:K07374]
127124  ATP6V1G3; V-type proton ATPase subunit G 3 isoform a [KO:K02152]
1311  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
1514  CTSL; procathepsin L isoform 1 preproprotein [KO:K01365] [EC:3.4.22.15]
1520  CTSS; cathepsin S isoform 1 preproprotein [KO:K01368] [EC:3.4.22.27]
1535  CYBA; cytochrome b-245 light chain [KO:K08009]
1536  CYBB; NADPH oxidase 2 [KO:K21421] [EC:1.-.-.-]
155066  ATP6V0E2; V-type proton ATPase subunit e 2 isoform 1 [KO:K02153]
1778  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
1780  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform a [KO:K10415]
1781  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform 1 [KO:K10415]
1783  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform 1 [KO:K10416]
200576  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2 [KO:K00921] [EC:2.7.1.150]
203068  TUBB; tubulin beta chain isoform b [KO:K07375]
2204  FCAR; immunoglobulin alpha Fc receptor isoform a precursor [KO:K06513]
2209  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor [KO:K06498]
2212  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor [KO:K06472]
2213  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [KO:K12560]
2214  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor [KO:K06463]
2215  FCGR3B; low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor [KO:K06463]
22925  PLA2R1; secretory phospholipase A2 receptor isoform 1 precursor [KO:K06560]
23480  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
23545  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
23673  STX12; syntaxin-12 [KO:K13813]
245972  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
245973  ATP6V1C2; V-type proton ATPase subunit C 2 isoform a [KO:K02148]
260334  TUBB8B; tubulin beta 8B isoform 1 [KO:K07375]
29927  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 isoform 1 [KO:K10956]
30835  CD209; CD209 antigen isoform 1 [KO:K06563]
3105  HLA-A; HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B precursor [KO:K06751]
3107  HLA-C; HLA class I histocompatibility antigen, C alpha chain precursor [KO:K06751]
3108  HLA-DMA; HLA class II histocompatibility antigen, DM alpha chain precursor [KO:K06752]
3109  HLA-DMB; HLA class II histocompatibility antigen, DM beta chain precursor [KO:K06752]
3111  HLA-DOA; HLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
3112  HLA-DOB; HLA class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
3113  HLA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain precursor [KO:K06752]
3115  HLA-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain precursor [KO:K06752]
3117  HLA-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain precursor [KO:K06752]
3118  HLA-DQA2; HLA class II histocompatibility antigen, DQ alpha 2 chain precursor [KO:K06752]
3119  HLA-DQB1; HLA class II histocompatibility antigen, DQ beta 1 chain isoform 2 precursor [KO:K06752]
3120  HLA-DQB2; HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor [KO:K06752]
3122  HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 precursor [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 precursor [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 precursor [KO:K06752]
3133  HLA-E; HLA class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
3134  HLA-F; HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor [KO:K06751]
3135  HLA-G; HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor [KO:K06751]
338382  RAB7B; ras-related protein Rab-7b isoform a [KO:K07898]
347688  TUBB8; tubulin beta-8 chain isoform 1 [KO:K07375]
347733  TUBB2B; tubulin beta-2B chain [KO:K07375]
3673  ITGA2; integrin alpha-2 precursor [KO:K06481]
3678  ITGA5; integrin alpha-5 precursor [KO:K06484]
3684  ITGAM; integrin alpha-M isoform 2 precursor [KO:K06461]
3685  ITGAV; integrin alpha-V isoform 1 preproprotein [KO:K06487]
3688  ITGB1; integrin beta-1 isoform 1A precursor [KO:K05719]
3689  ITGB2; integrin beta-2 isoform 1 precursor [KO:K06464]
3690  ITGB3; integrin beta-3 precursor [KO:K06493]
3693  ITGB5; integrin beta-5 isoform a precursor [KO:K06588]
3916  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
3920  LAMP2; lysosome-associated membrane glycoprotein 2 isoform A precursor [KO:K06528]
4074  M6PR; cation-dependent mannose-6-phosphate receptor isoform 1 precursor [KO:K10089]
4153  MBL2; mannose-binding protein C precursor [KO:K03991]
4353  MPO; myeloperoxidase precursor [KO:K10789] [EC:1.11.2.2]
4360  MRC1; macrophage mannose receptor 1 precursor [KO:K06560]
4481  MSR1; macrophage scavenger receptor types I and II isoform type 1 [KO:K06558]
4688  NCF2; neutrophil cytosol factor 2 isoform 1 [KO:K08010]
4689  NCF4; neutrophil cytosol factor 4 isoform 1 [KO:K08012]
4842  NOS1; nitric oxide synthase 1 isoform 1 [KO:K13240] [EC:1.14.13.39]
4973  OLR1; oxidized low-density lipoprotein receptor 1 isoform 1 [KO:K08763]
50617  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
51143  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform 1 [KO:K10416]
51382  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
51606  ATP6V1H; V-type proton ATPase subunit H isoform 1 [KO:K02144]
51807  TUBA8; tubulin alpha-8 chain isoform 1 [KO:K07374]
523  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
525  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
526  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
527  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
528  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1 [KO:K00914] [EC:2.7.1.137]
529  ATP6V1E1; V-type proton ATPase subunit E 1 isoform a [KO:K02150]
533  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1 [KO:K03661]
534  ATP6V1G2; V-type proton ATPase subunit G 2 isoform a [KO:K02152]
53407  STX18; syntaxin-18 isoform 1 [KO:K08492]
535  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform 1 [KO:K02154]
537  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
55176  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 isoform a [KO:K10956]
5868  RAB5A; ras-related protein Rab-5A isoform 1 [KO:K07887]
5869  RAB5B; ras-related protein Rab-5B isoform 1 [KO:K07888]
5878  RAB5C; ras-related protein Rab-5C isoform a [KO:K07889]
5879  RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392]
60  ACTB; actin, cytoplasmic 1 [KO:K05692]
6441  SFTPD; pulmonary surfactant-associated protein D precursor [KO:K10068]
64581  CLEC7A; C-type lectin domain family 7 member A isoform a [KO:K10074]
653361  NCF1; neutrophil cytosol factor 1 [KO:K08011]
653509  SFTPA1; pulmonary surfactant-associated protein A1 isoform 1 precursor [KO:K10067]
6890  TAP1; antigen peptide transporter 1 isoform 1 [KO:K05653] [EC:7.4.2.14]
6891  TAP2; antigen peptide transporter 2 isoform 3 [KO:K05654] [EC:7.4.2.14]
7037  TFRC; transferrin receptor protein 1 isoform 1 [KO:K06503]
7057  THBS1; thrombospondin-1 precursor [KO:K16857]
7058  THBS2; thrombospondin-2 isoform 1 precursor [KO:K04659]
7059  THBS3; thrombospondin-3 isoform 1 precursor [KO:K04659]
7060  THBS4; thrombospondin-4 isoform a precursor [KO:K04659]
7097  TLR2; toll-like receptor 2 precursor [KO:K10159]
7099  TLR4; toll-like receptor 4 isoform A precursor [KO:K10160]
71  ACTG1; actin, cytoplasmic 2 [KO:K05692]
715  C1R; complement C1r subcomponent isoform 1 preproprotein [KO:K01330] [EC:3.4.21.41]
718  C3; complement C3 preproprotein [KO:K03990]
7277  TUBA4A; tubulin alpha-4A chain isoform 1 [KO:K07374]
7278  TUBA3C; tubulin alpha-3C chain [KO:K07374]
7280  TUBB2A; tubulin beta-2A chain isoform 1 [KO:K07375]
729238  SFTPA2; pulmonary surfactant-associated protein A2 isoform 1 precursor [KO:K10067]
7846  TUBA1A; tubulin alpha-1A chain isoform 1 [KO:K07374]
7879  RAB7A; ras-related protein Rab-7a [KO:K07897]
78989  COLEC11; collectin-11 isoform a precursor [KO:K10066]
79659  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform 1 [KO:K10414]
79861  TUBAL3; tubulin alpha chain-like 3 isoform 1 [KO:K07374]
81027  TUBB1; tubulin beta-1 chain [KO:K07375]
81035  COLEC12; collectin-12 [KO:K10062]
811  CALR; calreticulin precursor [KO:K08057]
821  CANX; calnexin isoform d precursor [KO:K08054]
83547  RILP; rab-interacting lysosomal protein [KO:K13883]
8411  EEA1; early endosome antigen 1 [KO:K12478]
8417  STX7; syntaxin-7 isoform a [KO:K08488]
84617  TUBB6; tubulin beta-6 chain isoform 1 [KO:K07375]
84790  TUBA1C; tubulin alpha-1C chain isoform c [KO:K07374]
8685  MARCO; macrophage receptor MARCO [KO:K13884]
8992  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
90423  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
9103  FCGR2C; Fc gamma receptor IIc (gene/pseudogene) [KO:K16824]
9114  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
9146  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
929  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
9296  ATP6V1F; V-type proton ATPase subunit F isoform 1 [KO:K02151]
9341  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
948  CD36; platelet glycoprotein 4 isoform 1 [KO:K06259]
949  SCARB1; scavenger receptor class B member 1 isoform 3 [KO:K13885]
9550  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
9554  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
9902  MRC2; C-type mannose receptor 2 precursor [KO:K06560]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
hsa04142  Lysosome
hsa04144  Endocytosis
hsa04610  Complement and coagulation cascades
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

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