KEGG   PATHWAY: hsa04145
Entry
hsa04145                    Pathway                                
Name
Phagosome - Homo sapiens (human)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsa04145  Phagosome
hsa04145

Network
  Element
N01295  Rab7-regulated microtubule minus-end directed transport
N01302  Early endosomal fusion
Drug
D00570  Colchicine (JP18/USP)
D10028  Valategrast hydrochloride (USAN)
D11525  Enfortumab vedotin (USAN)
D11684  Verdiperstat (USAN/INN)
D11812  Pabinafusp alfa (genetical recombination) (JAN)
D12333  Zelpultide alfa (USAN/INN)
D12509  Trontinemab (USAN/INN)
D12624  Paridiprubart (USAN/INN)
D12647  Mitiperstat (USAN/INN)
D12777  Olgotrelvir (USAN)
D12778  Olgotrelvir sodium (USAN)
D12806  Tividenofusp alfa (USAN/INN)
Other DBs
GO: 0045335
Organism
Homo sapiens (human) [GN:hsa]
Gene
9341  VAMP3; vesicle associated membrane protein 3 [KO:K13505]
23673  STX12; syntaxin 12 [KO:K13813]
8417  STX7; syntaxin 7 [KO:K08488]
71  ACTG1; actin gamma 1 [KO:K05692]
60  ACTB; actin beta [KO:K05692]
11151  CORO1A; coronin 1A [KO:K13882]
53407  STX18; syntaxin 18 [KO:K08492]
9554  SEC22B; SEC22 homolog B, vesicle trafficking protein [KO:K08517]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3108  HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
5868  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
8411  EEA1; early endosome antigen 1 [KO:K12478]
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
7037  TFRC; transferrin receptor [KO:K06503]
9146  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
523  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
525  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
526  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
245973  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
528  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
51382  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
90423  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
529  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
9296  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
101927180  ATP6V1FP2; V-type proton ATPase subunit F-like [KO:K02151]
9550  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
127124  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
534  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
8992  ATP6V0E1; ATPase H+ transporting V0 subunit e1 [KO:K02153]
155066  ATP6V0E2; ATPase H+ transporting V0 subunit e2 [KO:K02153]
10312  TCIRG1; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
23545  ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
50617  ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
535  ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
9114  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
245972  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
51606  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
527  ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
533  ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
537  ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
7879  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
338382  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
83547  RILP; Rab interacting lysosomal protein [KO:K13883]
1778  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
79659  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
1780  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
1781  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
1783  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
51143  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
10376  TUBA1B; tubulin alpha 1b [KO:K07374]
7277  TUBA4A; tubulin alpha 4a [KO:K07374]
7278  TUBA3C; tubulin alpha 3c [KO:K07374]
7846  TUBA1A; tubulin alpha 1a [KO:K07374]
84790  TUBA1C; tubulin alpha 1c [KO:K07374]
51807  TUBA8; tubulin alpha 8 [KO:K07374]
112714  TUBA3E; tubulin alpha 3e [KO:K07374]
113457  TUBA3D; tubulin alpha 3d [KO:K07374]
79861  TUBAL3; tubulin alpha like 3 [KO:K07374]
84617  TUBB6; tubulin beta 6 class V [KO:K07375]
203068  TUBB; tubulin beta class I [KO:K07375]
81027  TUBB1; tubulin beta 1 class VI [KO:K07375]
7280  TUBB2A; tubulin beta 2A class IIa [KO:K07375]
10381  TUBB3; tubulin beta 3 class III [KO:K07375]
10382  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
347688  TUBB8; tubulin beta 8 class VIII [KO:K07375]
347733  TUBB2B; tubulin beta 2B class IIb [KO:K07375]
10383  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
124908013  tubulin beta 8B [KO:K07375]
124908015  tubulin beta 8B [KO:K07375]
124908041  tubulin beta 8B [KO:K07375]
260334  TUBB8B; tubulin beta 8B [KO:K07375]
3916  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
3920  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
200576  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
4074  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
4842  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
4353  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
1514  CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
1520  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
29927  SEC61A1; SEC61 translocon subunit alpha 1 [KO:K10956]
55176  SEC61A2; SEC61 translocon subunit alpha 2 [KO:K10956]
10952  SEC61B; SEC61 translocon subunit beta [KO:K09481]
23480  SEC61G; SEC61 translocon subunit gamma [KO:K07342]
6890  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653] [EC:7.4.2.14]
6891  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654] [EC:7.4.2.14]
811  CALR; calreticulin [KO:K08057]
821  CANX; calnexin [KO:K08054]
2204  FCAR; Fc alpha receptor [KO:K06513]
2209  FCGR1A; Fc gamma receptor Ia [KO:K06498]
2212  FCGR2A; Fc gamma receptor IIa [KO:K06472]
2213  FCGR2B; Fc gamma receptor IIb [KO:K12560]
9103  FCGR2C; Fc gamma receptor IIc (gene/pseudogene) [KO:K16824]
2214  FCGR3A; Fc gamma receptor IIIa [KO:K06463]
2215  FCGR3B; Fc gamma receptor IIIb [KO:K06463]
102723407  IGH; immunoglobulin heavy variable 4-38-2-like [KO:K06856]
715  C1R; complement C1r [KO:K01330] [EC:3.4.21.41]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
3689  ITGB2; integrin subunit beta 2 [KO:K06464]
718  C3; complement C3 [KO:K03990]
78989  COLEC11; collectin subfamily member 11 [KO:K10066]
81035  COLEC12; collectin subfamily member 12 [KO:K10062]
4153  MBL2; mannose binding lectin 2 [KO:K03991]
653509  SFTPA1; surfactant protein A1 [KO:K10067]
729238  SFTPA2; surfactant protein A2 [KO:K10067]
6441  SFTPD; surfactant protein D [KO:K10068]
3685  ITGAV; integrin subunit alpha V [KO:K06487]
3673  ITGA2; integrin subunit alpha 2 [KO:K06481]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
3690  ITGB3; integrin subunit beta 3 [KO:K06493]
3693  ITGB5; integrin subunit beta 5 [KO:K06588]
7057  THBS1; thrombospondin 1 [KO:K16857]
1311  COMP; cartilage oligomeric matrix protein [KO:K04659]
7058  THBS2; thrombospondin 2 [KO:K04659]
7059  THBS3; thrombospondin 3 [KO:K04659]
7060  THBS4; thrombospondin 4 [KO:K04659]
7097  TLR2; toll like receptor 2 [KO:K10159]
10333  TLR6; toll like receptor 6 [KO:K10169]
7099  TLR4; toll like receptor 4 [KO:K10160]
929  CD14; CD14 molecule [KO:K04391]
22925  PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
4360  MRC1; mannose receptor C-type 1 [KO:K06560]
9902  MRC2; mannose receptor C-type 2 [KO:K06560]
10332  CLEC4M; C-type lectin domain family 4 member M [KO:K06563]
30835  CD209; CD209 molecule [KO:K06563]
64581  CLEC7A; C-type lectin domain containing 7A [KO:K10074]
4481  MSR1; macrophage scavenger receptor 1 [KO:K06558]
8685  MARCO; macrophage receptor with collagenous structure [KO:K13884]
4973  OLR1; oxidized low density lipoprotein receptor 1 [KO:K08763]
949  SCARB1; scavenger receptor class B member 1 [KO:K13885]
948  CD36; CD36 molecule (CD36 blood group) [KO:K06259]
1535  CYBA; cytochrome b-245 alpha chain [KO:K08009]
1536  CYBB; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
653361  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
4688  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
4689  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
hsa04142  Lysosome
hsa04144  Endocytosis
hsa04610  Complement and coagulation cascades
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
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