KEGG   PATHWAY: iti04062
Entry
iti04062                    Pathway                                
Name
Chemokine signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
iti04062  Chemokine signaling pathway
iti04062

Other DBs
GO: 0070098
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954372  [KO:K05505]
101954421  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101954516  [KO:K11224]
101954637  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101954665  [KO:K05407]
101954767  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101954821  Ccl27; C-C motif chemokine 27 [KO:K16598]
101954847  [KO:K04545]
101954938  [KO:K05506]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955043  Gsk3a; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101955089  Ccl19; C-C motif chemokine 19 [KO:K05512]
101955103  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101955124  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101955142  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
101955160  Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
101955252  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101955264  Ikbkg; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101955316  Rela; transcription factor p65 [KO:K04735]
101955440  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955681  Crk; adapter molecule crk isoform X1 [KO:K04438]
101956013  Pxn; paxillin isoform X7 [KO:K05760]
101956095  [KO:K05050]
101956113  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
101956155  Arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
101956315  Prkcd; protein kinase C delta type isoform X4 [KO:K06068] [EC:2.7.11.13]
101956319  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101956323  Cx3cl1; fractalkine isoform X2 [KO:K05508]
101956398  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101956611  Ccl17; C-C motif chemokine 17 [KO:K21083]
101956621  Ccl28; C-C motif chemokine 28 [KO:K05513]
101956770  Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175]
101957195  Ccl22; C-C motif chemokine 22 [KO:K21095]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957398  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101957457  Dock2; dedicator of cytokinesis protein 2 [KO:K12367]
101957854  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
101957921  Foxo3; forkhead box protein O3 [KO:K09408]
101958021  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
101958138  Ptk2b; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101958226  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
101958232  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101958429  Vav2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
101958549  Hck; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
101958796  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
101959100  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
101959358  [KO:K04513]
101959359  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101959496  Ccr6; C-C chemokine receptor type 6 [KO:K04181]
101959567  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101959882  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101960012  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101960401  Shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101960404  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101960436  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101960598  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
101960649  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101960769  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101960867  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101961077  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101961195  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961917  Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
101962014  Src; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101962074  [KO:K07836]
101962115  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101962140  Cxcl9; C-X-C motif chemokine 9 [KO:K05416]
101962360  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101962431  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
101962660  [KO:K00922] [EC:2.7.1.153]
101962695  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101962777  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101962801  Fgr; tyrosine-protein kinase Fgr isoform X2 [KO:K08891] [EC:2.7.10.2]
101962974  Vav1; proto-oncogene vav [KO:K05730]
101963124  Sos2; son of sevenless homolog 2 [KO:K03099]
101963155  Ccl25; C-C motif chemokine 25 [KO:K13072]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963326  Ccl20; C-C motif chemokine 20 [KO:K14625]
101963347  Cxcr6; C-X-C chemokine receptor type 6 [KO:K04191]
101963674  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101963760  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963928  Xcr1; LOW QUALITY PROTEIN: chemokine XC receptor 1 [KO:K04193]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964209  [KO:K04176]
101964412  [KO:K05505]
101964482  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
101964645  [KO:K04545]
101964684  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101964687  [KO:K10029]
101964713  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101964770  [KO:K04177]
101964920  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101964975  [KO:K10030]
101965040  Pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101965069  [KO:K04180]
101965569  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101965805  Ccl5; C-C motif chemokine 5 [KO:K12499]
101965906  [KO:K00922] [EC:2.7.1.153]
101966082  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101966092  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101966104  Ccl16; C-C motif chemokine 16 [KO:K21093]
101966144  [KO:K04393]
101966388  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
101966401  Ccl14; C-C motif chemokine 14 [KO:K21092]
101966426  Rhoa; transforming protein RhoA [KO:K04513]
101966508  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
101966535  Ccl26; C-C motif chemokine 26 [KO:K21096]
101966622  Ccl24; C-C motif chemokine 24 [KO:K21097]
101966689  Ccl15; C-C motif chemokine 15 [KO:K05511]
101966799  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
101966810  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101966975  [KO:K05511]
101967139  Was; wiskott-Aldrich syndrome protein [KO:K05747]
101967687  Grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101967830  [KO:K05408]
101967940  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101968159  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101968303  [KO:K05408]
101968339  Ccl1; C-C motif chemokine 1 [KO:K05514]
101968416  [KO:K05871] [EC:2.7.10.2]
101968522  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101968597  [KO:K12964]
101968658  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
101968846  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101968896  [KO:K00922] [EC:2.7.1.153]
101968920  [KO:K16596]
101968931  Pard3; partitioning defective 3 homolog isoform X2 [KO:K04237]
101969207  [KO:K14624]
101969248  Cxcl11; C-X-C motif chemokine 11 [KO:K12672]
101969446  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101969595  Rap1b; ras-related protein Rap-1b [KO:K07836]
101969825  Ccr9; C-C chemokine receptor type 9 [KO:K04184]
101969979  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101970437  Ccr10; C-C chemokine receptor type 10 [KO:K04185]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101970694  Cxcl13; C-X-C motif chemokine 13 [KO:K10032]
101970725  Ccr7; C-C chemokine receptor type 7 [KO:K04182]
101970750  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101970775  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101970818  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101970885  [KO:K05507]
101971023  [KO:K16598]
101971155  Cxcl16; C-X-C motif chemokine 16 [KO:K10035]
101971159  [KO:K04513]
101971244  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101971318  Ccl21; C-C motif chemokine 21 [KO:K16062]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971563  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101971945  Arrb2; beta-arrestin-2 [KO:K04439]
101971998  [KO:K04634]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972339  Elmo1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
101972410  Crkl; crk-like protein isoform X1 [KO:K04438]
101972573  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101972729  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101972773  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.39]
101972903  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101972980  Cxcl14; C-X-C motif chemokine 14 [KO:K10033]
101973091  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101973095  Shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101973111  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101973444  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
101973456  Grk2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
101973726  Ccl8; C-C motif chemokine 8 [KO:K16596]
101973902  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101974200  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101974517  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101975039  Grk7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
101975134  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101975241  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101975906  Nras; GTPase NRas [KO:K07828]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976232  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101976353  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101976552  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101977091  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101977647  Itk; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
101977694  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101977737  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101977788  Adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101978230  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101978298  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101978426  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
101978560  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106145241  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
110598919  [KO:K05407]
120892254  [KO:K10030]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
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J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
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Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
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Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
iti04010  MAPK signaling pathway
iti04060  Cytokine-cytokine receptor interaction
iti04120  Ubiquitin mediated proteolysis
iti04630  JAK-STAT signaling pathway
iti04670  Leukocyte transendothelial migration
iti04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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