Entry Name Measles
Description Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover, H protein expressed on viral particles and binding to SLAM or CD46, as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Disease Drug Orthology K19378 Morbillivirus hemagglutinin glycoprotein
K04007 membrane cofactor protein
K06536 signaling lymphocytic activation molecule family member 1
K19379 Morbillivirus fusion glycoprotein F0
K06563 C-type lectin domain family 4 member L/M
K12647 interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13 ]
K22281 measles non-structural protein V
K12648 mitochondrial antiviral-signaling protein
K03174 TNF receptor-associated factor 3
K07211 inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K05411 interferon regulatory factor 3
K19380 Morbillivirus nucleoprotein
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K02581 NF-kappa-B inhibitor beta
K04734 NF-kappa-B inhibitor alpha
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K19377 Morbillivirus phosphoprotein
K04729 myeloid differentiation primary response protein MyD88
K09447 interferon regulatory factor 7
K03115 casein kinase II subunit beta
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 transcription factor AP-1
K04379 proto-oncogene protein c-fos
K14753 guanine nucleotide-binding protein subunit beta-2-like 1 protein
K11220 signal transducer and activator of transcription 1
K11221 signal transducer and activator of transcription 2
K04693 interferon regulatory factor 9
K14754 interferon-induced GTP-binding protein Mx
K16194 eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1 ]
K16195 eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1 ]
K08860 eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1 ]
K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1 ]
K19381 Morbillivirus matrix protein
K07899 Ras-related protein Rab-9A
K07900 Ras-related protein Rab-9B
K03283 heat shock 70kDa protein 1/6/8
K03247 translation initiation factor 3 subunit H
K03237 translation initiation factor 2 subunit 1
K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27 ]
K10132 Bcl-2-binding component 3
K04389 tumor necrosis factor ligand superfamily member 6
K04390 tumor necrosis factor receptor superfamily member 6
K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373 FAS-associated death domain protein
K04726 BH3 interacting domain death agonist
K02159 apoptosis regulator BAX
K14021 Bcl-2 homologous antagonist/killer
K02161 apoptosis regulator Bcl-2
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02158 Bcl-2-antagonist of cell death
K02084 apoptotic protease-activating factor
K06624 cyclin-dependent kinase inhibitor 1B
K04503 G1/S-specific cyclin-D1
K10151 G1/S-specific cyclin-D2
K10152 G1/S-specific cyclin-D3
K06626 G1/S-specific cyclin-E1
K10784 T cell receptor alpha chain V region
K10785 T-cell receptor beta chain V region
K06450 T-cell surface glycoprotein CD3 delta chain
K06451 T-cell surface glycoprotein CD3 epsilon chain
K06452 T-cell surface glycoprotein CD3 gamma chain
K05068 interleukin 2 receptor alpha
K05069 interleukin 2 receptor beta
K05070 interleukin 2 receptor gamma
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K04692 signal transducer and activator of transcription 3
K11223 signal transducer and activator of transcription 5A
K11224 signal transducer and activator of transcription 5B
K12560 low affinity immunoglobulin gamma Fc receptor II-b
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Schneider-Schaulies S, Schneider-Schaulies J
Title Measles virus-induced immunosuppression.
Journal Reference Authors Hahm B
Title Hostile communication of measles virus with host innate immunity and dendritic cells.
Journal Reference Authors Gerlier D, Valentin H
Title Measles virus interaction with host cells and impact on innate immunity.
Journal Reference Authors Schneider-Schaulies S, Dittmer U
Title Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
Journal Reference Authors Avota E, Gassert E, Schneider-Schaulies S
Title Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
Journal Reference Authors Jiang Y, Qin Y, Chen M
Title Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
Journal Reference Authors Pfaller CK, Conzelmann KK
Title Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Journal Reference Authors Yokota S, Okabayashi T, Yokosawa N, Fujii N
Title Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
Journal Reference Authors Delpeut S, Noyce RS, Siu RW, Richardson CD
Title Host factors and measles virus replication.
Journal Reference Authors Shah M, Anwar MA, Kim JH, Choi S
Title Advances in Antiviral Therapies Targeting Toll-like Receptors.
Journal Reference Authors Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
Title Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
Journal Reference Authors Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
Title Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
Journal Reference Authors Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
Title STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
Journal Reference Authors Shaffer JA, Bellini WJ, Rota PA
Title The C protein of measles virus inhibits the type I interferon response.
Journal Reference Authors Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
Title hsp72, a host determinant of measles virus neurovirulence.
Journal Reference Authors Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
Title Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
Journal Reference Authors Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
Title Promotion of virus assembly and organization by the measles virus matrix protein.
Journal Reference Authors Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
Title Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
Journal Reference Authors Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
Title Measles virus N protein inhibits host translation by binding to eIF3-p40.
Journal Reference Authors Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
Title Measles virus: evidence for association with lung cancer.
Journal Reference Authors Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
Title Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
Journal Reference Authors Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
Title Measles virus V protein inhibits p53 family member p73.
Journal Reference Authors Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
Title Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
Journal Reference Authors Kushwah R, Hu J
Title Dendritic cell apoptosis: regulation of tolerance versus immunity.
Journal Reference Authors Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
Title Measles virus induces functional TRAIL production by human dendritic cells.
Journal Reference Authors Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
Title Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
Journal Reference Authors Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
Title Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Griffin DE
Title Measles virus-induced suppression of immune responses.
Journal Reference Authors Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
Title Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
Journal Reference Authors Avota E, Muller N, Klett M, Schneider-Schaulies S
Title Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
Journal Reference Authors Yanagi Y, Takeda M, Ohno S
Title Measles virus: cellular receptors, tropism and pathogenesis.
Journal Reference Authors Kerdiles YM, Sellin CI, Druelle J, Horvat B
Title Immunosuppression caused by measles virus: role of viral proteins.
Journal Related ko04120 Ubiquitin mediated proteolysis
ko04620 Toll-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04658 Th1 and Th2 cell differentiation
ko04660 T cell receptor signaling pathway
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