Entry Name Measles
Description Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover, H protein expressed on viral particles and binding to SLAM or CD46, as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease Drug Orthology K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02084 APAF1; apoptotic protease-activating factor
K02158 BAD; Bcl-2-antagonist of cell death
K02159 BAX; apoptosis regulator BAX
K02161 BCL2; apoptosis regulator Bcl-2
K02373 FADD; FAS-associated death domain protein
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K03115 CSNK2B; casein kinase II subunit beta
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03174 TRAF3; TNF receptor-associated factor 3
K03237 EIF2S1; translation initiation factor 2 subunit 1
K03247 EIF3H; translation initiation factor 3 subunit H
K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
K04007 CD46, MCP; membrane cofactor protein
K04379 FOS; proto-oncogene protein c-fos
K04383 IL1A; interleukin 1 alpha
K04389 TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 JUN; transcription factor AP-1
K04451 TP53, P53; tumor protein p53
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04503 CCND1; G1/S-specific cyclin-D1
K04519 IL1B; interleukin 1 beta
K04570 BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04692 STAT3; signal transducer and activator of transcription 3
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04726 BID; BH3 interacting domain death agonist
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1 ]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05069 IL2RB, CD122; interleukin 2 receptor beta
K05070 IL2RG, CD132; interleukin 2 receptor gamma
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05404 TLR7; toll-like receptor 7
K05411 IRF3; interferon regulatory factor 3
K06450 CD3D; T-cell surface glycoprotein CD3 delta chain
K06451 CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452 CD3G; T-cell surface glycoprotein CD3 gamma chain
K06536 SLAMF1, CD150; signaling lymphocytic activation molecule family member 1
K06563 CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06626 CCNE; G1/S-specific cyclin-E1
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K07899 RAB9A, RAB9; Ras-related protein Rab-9A
K07900 RAB9B; Ras-related protein Rab-9B
K08860 EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1 ]
K09447 IRF7; interferon regulatory factor 7
K10132 BBC3, PUMA; Bcl-2-binding component 3
K10144 RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27 ]
K10148 TP73; tumor protein p73
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K10159 TLR2, CD282; toll-like receptor 2
K10160 TLR4, CD284; toll-like receptor 4
K10161 TLR9, CD289; toll-like receptor 9
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K11859 TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12 ]
K12560 FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
K12646 RIGI, DDX58; ATP-dependent RNA helicase DDX58 [EC:5.6.2.6 ]
K12647 IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:5.6.2.6 ]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K12968 ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37 ]
K14021 BAK, BAK1; Bcl-2 homologous antagonist/killer
K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
K14754 MX; interferon-induced GTP-binding protein Mx
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1 ]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1 ]
K16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1 ]
K19377 P, P/V/C; Morbillivirus phosphoprotein
K19378 H; Morbillivirus hemagglutinin glycoprotein
K19379 F; Morbillivirus fusion glycoprotein F0
K19380 N; Morbillivirus nucleoprotein
K19381 M; Morbillivirus matrix protein
K22281 V; measles non-structural protein V
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Schneider-Schaulies S, Schneider-Schaulies J
Title Measles virus-induced immunosuppression.
Journal Reference Authors Hahm B
Title Hostile communication of measles virus with host innate immunity and dendritic cells.
Journal Reference Authors Gerlier D, Valentin H
Title Measles virus interaction with host cells and impact on innate immunity.
Journal Reference Authors Schneider-Schaulies S, Dittmer U
Title Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
Journal Reference Authors Avota E, Gassert E, Schneider-Schaulies S
Title Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
Journal Reference Authors Jiang Y, Qin Y, Chen M
Title Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
Journal Reference Authors Pfaller CK, Conzelmann KK
Title Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Journal Reference Authors Yokota S, Okabayashi T, Yokosawa N, Fujii N
Title Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
Journal Reference Authors Delpeut S, Noyce RS, Siu RW, Richardson CD
Title Host factors and measles virus replication.
Journal Reference Authors Shah M, Anwar MA, Kim JH, Choi S
Title Advances in Antiviral Therapies Targeting Toll-like Receptors.
Journal Reference Authors Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
Title Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
Journal Reference Authors Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
Title Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
Journal Reference Authors Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
Title STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
Journal Reference Authors Shaffer JA, Bellini WJ, Rota PA
Title The C protein of measles virus inhibits the type I interferon response.
Journal Reference Authors Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
Title hsp72, a host determinant of measles virus neurovirulence.
Journal Reference Authors Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
Title Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
Journal Reference Authors Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
Title Promotion of virus assembly and organization by the measles virus matrix protein.
Journal Reference Authors Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
Title Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
Journal Reference Authors Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
Title Measles virus N protein inhibits host translation by binding to eIF3-p40.
Journal Reference Authors Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
Title Measles virus: evidence for association with lung cancer.
Journal Reference Authors Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
Title Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
Journal Reference Authors Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
Title Measles virus V protein inhibits p53 family member p73.
Journal Reference Authors Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
Title Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
Journal Reference Authors Kushwah R, Hu J
Title Dendritic cell apoptosis: regulation of tolerance versus immunity.
Journal Reference Authors Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
Title Measles virus induces functional TRAIL production by human dendritic cells.
Journal Reference Authors Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
Title Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
Journal Reference Authors Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
Title Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Griffin DE
Title Measles virus-induced suppression of immune responses.
Journal Reference Authors Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
Title Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
Journal Reference Authors Avota E, Muller N, Klett M, Schneider-Schaulies S
Title Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
Journal Reference Authors Yanagi Y, Takeda M, Ohno S
Title Measles virus: cellular receptors, tropism and pathogenesis.
Journal Reference Authors Kerdiles YM, Sellin CI, Druelle J, Horvat B
Title Immunosuppression caused by measles virus: role of viral proteins.
Journal Related ko04120 Ubiquitin mediated proteolysis
ko04620 Toll-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04658 Th1 and Th2 cell differentiation
ko04660 T cell receptor signaling pathway
