Entry Name Yersinia infection - Lemur catta (Ring-tailed lemur)
Description Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a type three secretion system (T3SS) to express its pathogenicity. Through inactivation of small GTPases by YopT protease, YopE GTPase-activating protein, and YpkA/YopO sequestration of GDP-bound small GTPases, Yersinia prevents its uptake by phagocytic cells and disrupts the actin cytoskeleton. YopH phosphatase shuts down phagocytosis by dephosphorylating key host proteins as well as suppresses T cell activation. Yersinia induces macrophage pyroptosis via YopB/YopD activation of canonical and noncanonical inflammasomes and YopT/YopE-mediated activation of pyrin. These effects are counteracted by YopK and YopM. YopP/J is a member of an ubiquitin-like protein cysteine protease family and simultaneously targets signaling components of the MAPK and NF-kappaB signaling pathways following activation of Toll-like receptor4 to inhibit production of proinflammatory cytokines.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Disease Organism Lemur catta (Ring-tailed lemur) [GN:
lcat ]
Gene 123620864 WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475 ]
123621580 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
123622664 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
123622732 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
123622735 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
123623074 ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755 ]
123624056 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330 ]
123625176 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
123625428 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
123627174 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
123627206 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
123629856 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123630278 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
123632516 LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362 ]
123632689 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
123633357 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
123634333 WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
123634506 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
123637147 CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458 ]
123637150 CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459 ]
123639294 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
123639706 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
123640344 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
123641456 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
123643412 WIPF1; LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1 [KO:K19475 ]
123646053 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754 ]
123646308 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
123647223 SKAP2; src kinase-associated phosphoprotein 2 isoform X1 [KO:K23471 ]
123648378 ARHGEF28; rho guanine nucleotide exchange factor 28 isoform X1 [KO:K21072 ]
123648578 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
123649353 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
123649372 ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710 ]
123650678 BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627 ]
123650723 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Pha K, Navarro L
Title Yersinia type III effectors perturb host innate immune responses.
Journal Reference Authors Pinaud L, Sansonetti PJ, Phalipon A
Title Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal Reference Authors Huveneers S, Danen EH
Title Adhesion signaling - crosstalk between integrins, Src and Rho.
Journal Reference Authors Angot A, Vergunst A, Genin S, Peeters N
Title Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems.
Journal Reference Authors Bliska JB
Title Yop effectors of Yersinia spp. and actin rearrangements.
Journal Reference Authors Gustavsson A, Yuan M, Fallman M
Title Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation.
Journal Reference Authors Bruce-Staskal PJ, Weidow CL, Gibson JJ, Bouton AH
Title Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake.
Journal J Cell Sci 115:2689-700 (2002)
Reference Authors McGee K, Zettl M, Way M, Fallman M
Title A role for N-WASP in invasin-promoted internalisation.
Journal Reference Authors Pizarro-Cerda J, Cossart P
Title Subversion of phosphoinositide metabolism by intracellular bacterial pathogens.
Journal Reference Authors Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB
Title The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
Journal Reference Authors Schotte P, Denecker G, Van Den Broeke A, Vandenabeele P, Cornelis GR, Beyaert R
Title Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.
Journal Reference Authors Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE
Title Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.
Journal Reference Authors Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM
Title Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
Journal Reference Authors Haase R, Richter K, Pfaffinger G, Courtois G, Ruckdeschel K
Title Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells.
Journal Reference Authors Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M
Title The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
Journal Reference Authors Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC
Title A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.
Journal Reference Authors Rolan HG, Durand EA, Mecsas J
Title Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
Journal Reference Authors Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T
Title Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
Journal Related lcat04620 Toll-like receptor signaling pathway
lcat04621 NOD-like receptor signaling pathway
KO pathway
