KEGG   PATHWAY: mlk04020
Entry
mlk04020                    Pathway                                
Name
Calcium signaling pathway - Mustela lutreola (European mink)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mlk04020  Calcium signaling pathway
mlk04020

Other DBs
GO: 0019722
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131836744  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
131840489  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
131818324  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
131839245  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
131820828  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
131815259  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
131824222  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
131814284  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
131829017  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
131836062  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
131811475  ADORA2A; adenosine receptor A2a [KO:K04266]
131816857  ADORA2B; adenosine receptor A2b [KO:K04267]
131830672  ADRB1; beta-1 adrenergic receptor [KO:K04141]
131831743  ADRB2; beta-2 adrenergic receptor [KO:K04142]
131820474  ADRB3; beta-3 adrenergic receptor [KO:K04143]
131831933  DRD1; D(1A) dopamine receptor [KO:K04144]
131819381  DRD5; D(1B) dopamine receptor [KO:K05840]
131831936  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
131831742  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
131826933  5-hydroxytryptamine receptor 5B [KO:K04161]
131829979  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
131809910  HTR6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
131828667  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
131840487  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
131840488  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
131807579  neuroendocrine secretory protein 55 [KO:K04632]
131810915  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
131829179  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
131831568  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
131807291  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131836404  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
131818734  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
131826395  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
131819927  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
131823635  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131808844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
131833864  PLN; cardiac phospholamban [KO:K05852]
131820192  SLN; sarcolipin [KO:K22642]
131828943  MRLN; myoregulin isoform X1 [KO:K22643]
131828664  C1H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
131815882  SMIM6; small integral membrane protein 6 [KO:K26468]
131811510  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
131819241  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
131816947  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
131818368  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
131808228  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
131825106  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
131811031  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
131819349  ORAI2; protein orai-2 isoform X1 [KO:K16057]
131819365  ORAI3; protein orai-3 [KO:K16058]
131838359  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
131824037  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131821118  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
131814910  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
131823608  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
131812571  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
131814383  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
131816125  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
131819432  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
131839502  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
131835715  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
131812507  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
131819881  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
131839014  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
131816519  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
131817984  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
131812693  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
131823175  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
131816948  P2RX1; P2X purinoceptor 1 [KO:K05215]
131811673  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
131812735  P2RX3; P2X purinoceptor 3 [KO:K05217]
131811888  P2RX4; P2X purinoceptor 4 [KO:K05218]
131815714  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
131811242  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
131811887  P2RX7; P2X purinoceptor 7 [KO:K05220]
131818258  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
131829015  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
131837162  RYR3; ryanodine receptor 3 [KO:K04963]
131833842  TRDN; triadin isoform X1 [KO:K23449]
131815009  CASQ1; calsequestrin-1 [KO:K23468]
131809611  CASQ2; calsequestrin-2 [KO:K23445]
131826785  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
131821524  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
131813910  LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2-like [KO:K04323]
131813921  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
131829812  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
131833152  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
131831852  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
131808003  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
131825026  AGTR1; type-1 angiotensin II receptor [KO:K04166]
131832630  EDNRA; endothelin-1 receptor [KO:K04197]
131813761  EDNRB; endothelin receptor type B [KO:K04198]
131832374  F2R; proteinase-activated receptor 1 [KO:K03914]
131833708  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
131839461  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
131821560  GRPR; gastrin-releasing peptide receptor [KO:K04169]
131824225  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
131827347  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
131821035  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
131813965  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
131808606  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
131807942  NTSR1; neurotensin receptor type 1 [KO:K04211]
131824180  OXTR; oxytocin receptor [KO:K04229]
131838500  AVPR1A; vasopressin V1a receptor [KO:K04226]
131814976  AVPR1B; vasopressin V1b receptor [KO:K04227]
131836409  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
131809347  PTAFR; platelet-activating factor receptor [KO:K04279]
131823646  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
131809169  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
131809798  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
131836961  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
131840349  TACR1; substance-P receptor isoform X1 [KO:K04222]
131828883  TACR2; substance-K receptor isoform X1 [KO:K04223]
131829715  TACR3; neuromedin-K receptor [KO:K04224]
131823293  TBXA2R; thromboxane A2 receptor [KO:K04264]
131828017  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
131808006  thyrotropin-releasing hormone receptor-like [KO:K04282]
131825148  CCKAR; cholecystokinin receptor type A [KO:K04194]
131808535  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
131826966  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
131812467  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
131823276  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
131812472  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
131823279  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131840269  TGFA; protransforming growth factor alpha [KO:K08774]
131819467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
131839489  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
131834784  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
131831691  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
131832196  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
131828225  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
131836265  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131839915  FGF6; fibroblast growth factor 6 [KO:K04358]
131834291  FGF17; fibroblast growth factor 17 [KO:K04358]
131819956  FGF5; fibroblast growth factor 5 [KO:K04358]
131820615  FGF20; fibroblast growth factor 20 [KO:K04358]
131813822  FGF9; fibroblast growth factor 9 [KO:K04358]
131821509  FGF16; fibroblast growth factor 16 [KO:K04358]
131822740  FGF4; fibroblast growth factor 4 [KO:K04358]
131822741  FGF3; fibroblast growth factor 3 [KO:K04358]
131823154  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
131830281  FGF8; fibroblast growth factor 8 [KO:K04358]
131831722  FGF10; fibroblast growth factor 10 [KO:K04358]
131831909  FGF18; fibroblast growth factor 18 [KO:K04358]
131822739  FGF19; fibroblast growth factor 19 [KO:K22603]
131818352  FGF21; fibroblast growth factor 21 [KO:K22429]
131838416  FGF23; fibroblast growth factor 23 [KO:K22428]
131834629  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
131814601  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
131820340  VEGFC; vascular endothelial growth factor C [KO:K05449]
131821520  VEGFD; vascular endothelial growth factor D [KO:K05449]
131810037  NGF; beta-nerve growth factor [KO:K02582]
131829310  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
131823936  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
131831673  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131838613  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
131827495  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131831763  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131820646  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
131830605  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
131827098  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131831964  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
131814136  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131832669  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131824009  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131814908  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
131812441  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
131835632  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
131829655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131823947  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
131828679  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
131827452  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
131815973  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
131824372  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
131836105  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
131814631  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131808069  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
131808080  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
131807620  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
131818792  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
131828627  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
131837967  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
131824160  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
131838936  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
131834230  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
131825764  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
131811195  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
131816932  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
131823450  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
131809112  MCOLN2; mucolipin-2 [KO:K04993]
131809111  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
131816984  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
131817451  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
131828840  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
131836545  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
131832037  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
131828797  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
131820455  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
131832988  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
131820320  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
131828020  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
131821117  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
131821316  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
131828775  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
131824011  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
131808040  TNNC2; troponin C, skeletal muscle [KO:K12042]
131835976  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
131836771  CALM1; calmodulin-1 isoform X1 [KO:K02183]
131838058  calmodulin-like protein 3 [KO:K02183]
131839863  calmodulin-like [KO:K02183]
131808503  CALM2; calmodulin-2 [KO:K02183]
131817928  CALM3; calmodulin-3 [KO:K02183]
131810396  CALML6; calmodulin-like protein 6 [KO:K02183]
131819361  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
131819626  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
131821114  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
131818013  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
131834448  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
131808024  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
131824634  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
131817477  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
131838282  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
131815310  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
131824196  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
131828816  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
131828862  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
131829200  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
131831765  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
131832524  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
131834170  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131828824  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131829901  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
131812695  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
131833958  TFEB; transcription factor EB [KO:K15590]
131810821  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
131807426  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
131838931  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
131818512  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
131836414  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
131811917  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
131816344  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
131829935  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
131838653  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
131827015  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
131829591  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
131833269  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
131836144  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
131818590  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
131815195  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
131815964  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
131819600  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131818861  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mlk04010  MAPK signaling pathway
mlk04070  Phosphatidylinositol signaling system
mlk04210  Apoptosis
mlk04720  Long-term potentiation
mlk04730  Long-term depression
KO pathway
ko04020   
LinkDB

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