KEGG   PATHWAY: mpah05012
Entry
mpah05012                   Pathway                                
Name
Parkinson disease - Mus pahari (shrew mouse)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mpah05012  Parkinson disease
mpah05012

Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110326786  Adora2a; adenosine receptor A2a [KO:K04266]
110332897  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110317699  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110317700  neuroendocrine secretory protein 55 [KO:K04632]
110327760  Drd2; D(2) dopamine receptor [KO:K04145]
110314435  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
110327202  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
110319821  Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
110329393  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110334152  Drd1; D(1A) dopamine receptor [KO:K04144]
110314052  Uba1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
110328537  Uba7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
110322831  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
110323225  ubiquitin-like isoform X1 [KO:K02927]
110328299  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
110331531  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
110331651  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
110336738  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
110330576  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
110318389  ubiquitin-40S ribosomal protein S27a [KO:K02977]
110318483  ubiquitin-40S ribosomal protein S27a [KO:K02977]
110329647  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
110318922  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
110323130  Ube2j2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
110338773  Ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
110326535  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
110331669  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
110338080  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
110316447  Snca; alpha-synuclein [KO:K04528]
110316559  Gpr37; prosaposin receptor GPR37 [KO:K04243]
110329492  Sept5; septin-5 isoform X1 [KO:K04557]
110333087  Sncaip; synphilin-1 isoform X1 [KO:K04558]
110324196  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
110333899  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
110327417  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
110319566  Psma7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
110333269  Psma8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
110320113  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
110321258  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
110324319  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
110331969  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
110317854  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
110332263  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
110323478  Psmb2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
110325463  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
110338158  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
110320096  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
110317419  Psmc2; 26S protease regulatory subunit 7 [KO:K03061]
110324155  Psmc1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
110317526  Psmc4; 26S protease regulatory subunit 6B isoform X1 [KO:K03063]
110325226  Psmc6; 26S protease regulatory subunit 10B [KO:K03064]
110317665  Psmc3; 26S protease regulatory subunit 6A [KO:K03065]
110331458  Psmc5; 26S protease regulatory subunit 8 [KO:K03066]
110329924  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
110321309  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
110332775  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
110312964  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
110331343  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
110331208  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
110325295  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
110337398  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
110319108  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
110318110  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
110323088  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
110318228  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
110319004  proteasomal ubiquitin receptor ADRM1-like [KO:K06691]
110317098  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
110330551  Uchl1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
110328293  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110334170  Calml3; calmodulin-like protein 3 [KO:K02183]
110334182  calmodulin-4 [KO:K02183]
110336102  Calm2; calmodulin isoform X1 [KO:K02183]
110324261  Calm1; calmodulin [KO:K02183]
110336466  Calm3; calmodulin [KO:K02183]
110331006  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110320932  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110332832  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110325574  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110331493  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
110319080  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
110317210  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110317251  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110338229  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110319649  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110319438  Hspa5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
110321899  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
110326609  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
110331346  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
110330475  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
110324429  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
110334651  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110327669  Th; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
110313452  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
110313782  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
110328936  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
110336763  Slc18a1; chromaffin granule amine transporter [KO:K08155]
110333946  Slc18a2; synaptic vesicular amine transporter [KO:K08155]
110334498  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
110326925  Slc39a3; zinc transporter ZIP3 [KO:K14709]
110325864  Slc39a2; zinc transporter ZIP2 isoform X1 [KO:K14709]
110320369  Slc39a1; zinc transporter ZIP1 [KO:K14709]
110335067  Slc39a4; zinc transporter ZIP4 [KO:K14710]
110326807  Slc39a5; zinc transporter ZIP5 [KO:K14711]
110333255  Slc39a6; zinc transporter ZIP6 [KO:K14712]
110335563  Slc39a7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
110320285  Slc39a8; zinc transporter ZIP8 [KO:K14714]
110324284  Slc39a9; zinc transporter ZIP9 isoform X1 [KO:K14715]
110322097  Slc39a10; zinc transporter ZIP10 [KO:K14716]
110332687  Slc39a11; zinc transporter ZIP11 [KO:K14717]
110319120  Slc39a12; zinc transporter ZIP12 isoform X1 [KO:K14718]
110318319  Slc39a13; zinc transporter ZIP13 isoform X1 [KO:K14719]
110325482  Slc39a14; zinc transporter ZIP14 isoform X1 [KO:K14720]
36165356  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36165352  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36165337  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36165334  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36165335  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36165330  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36165329  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
110316888  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
110335628  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
110338235  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110313685  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110333203  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
110337062  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
110326234  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
110317006  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
110316386  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
110335084  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
110335777  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
110318772  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110316704  Ndufa9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
110321748  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
110328243  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
110335867  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
110326784  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
110336643  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110324555  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
110317149  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
110322308  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
110326037  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
110329959  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110320492  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
110338914  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
110333533  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
110337650  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
110331668  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
110334970  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
110338345  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
110314570  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
110321204  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
110321406  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
110318572  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
110329019  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
110323693  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
110329167  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
110326881  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
110327359  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
110320722  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
110332408  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
110328746  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
110323139  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
110322178  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
110324197  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237]
110328112  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
110333870  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
36165327  CYTB; cytochrome b [KO:K00412]
110334724  cytochrome c1, heme protein, mitochondrial [KO:K00413]
110327331  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
110318232  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
110323660  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
110334014  cytochrome b-c1 complex subunit 7 [KO:K00417]
110332489  cytochrome b-c1 complex subunit 8 [KO:K00418]
110330872  cytochrome b-c1 complex subunit 9 [KO:K00419]
110326979  cytochrome b-c1 complex subunit 10 [KO:K00420]
36165339  COX3; cytochrome c oxidase subunit III [KO:K02262]
36165346  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36165343  COX2; cytochrome c oxidase subunit II [KO:K02261]
110319299  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
110337554  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
110328046  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
110322258  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
110313018  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110325548  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
110332943  cytochrome c oxidase subunit 6B1 [KO:K02267]
110336798  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
110335202  cytochrome c oxidase subunit 6C [KO:K02268]
110328169  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
110338814  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
110335711  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
110313979  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
110330226  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110329085  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
110332346  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
110324960  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
110339130  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
110333376  Atp5a1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
110324657  ATP synthase subunit beta, mitochondrial-like [KO:K02133] [EC:7.1.2.2]
110326266  Atp5b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
110333647  Atp5c1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
110326670  Atp5d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
110319359  Atp5e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
36165340  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
110320209  Atp5f1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
110318554  Atp5g3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
110331847  Atp5g1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
110334965  Atp5g2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
110320480  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
110332361  Atp5h; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
110329905  Atp5o; ATP synthase subunit O, mitochondrial [KO:K02137]
110329594  Atp5j; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
36165341  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
110323093  Pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
110326646  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
110334545  Lrrk2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
110317283  Htra2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
110329522  Trap1; heat shock protein 75 kDa, mitochondrial isoform X1 [KO:K09488]
110331342  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
110325370  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110336305  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110313362  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110336417  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110320569  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110325751  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110332378  cytochrome c-like [KO:K08738]
110316223  cytochrome c, somatic [KO:K08738]
110317786  cytochrome c, testis-specific [KO:K08738]
110326877  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
110323338  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
110336608  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110323526  Park7; protein DJ-1 [KO:K05687] [EC:3.5.1.124]
110318630  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110320030  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110319885  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
110337969  LOW QUALITY PROTEIN: mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
110322845  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
110332910  Kif5b; kinesin-1 heavy chain [KO:K10396]
110326230  Kif5a; kinesin heavy chain [KO:K10396]
110318104  Kif5c; kinesin heavy chain [KO:K10396]
110319541  Klc2; kinesin light chain 2 [KO:K10407]
110336348  Klc3; kinesin light chain 3 isoform X1 [KO:K10407]
110324984  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
110335434  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
110316306  tubulin alpha-3 chain isoform X1 [KO:K07374]
110321284  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
110334563  tubulin alpha-1C chain-like [KO:K07374]
110316395  Tuba8; tubulin alpha-8 chain isoform X1 [KO:K07374]
110316417  tubulin alpha-3 chain isoform X1 [KO:K07374]
110334627  tubulin alpha-1A chain-like [KO:K07374]
110325235  tubulin alpha chain-like [KO:K07374]
110334021  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
110319104  Tubb1; tubulin beta-1 chain [KO:K07375]
110333011  Tubb6; tubulin beta-6 chain isoform X1 [KO:K07375]
110335873  Tubb; tubulin beta chain isoform X1 [KO:K07375]
110335384  Tubb4a; tubulin beta-4A chain isoform X1 [KO:K07375]
110337799  Tubb3; tubulin beta-3 chain isoform X1 [KO:K07375]
110333774  tubulin beta-2A chain-like [KO:K07375]
110319452  Tubb4b; tubulin beta-4B chain isoform X1 [KO:K07375]
110333829  LOW QUALITY PROTEIN: tubulin beta-2B chain-like [KO:K07375]
110331731  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110337954  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
110318263  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
110335007  Txn2; thioredoxin, mitochondrial [KO:K03671]
110323466  thioredoxin isoform X1 [KO:K03671]
110335556  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
110337870  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110329810  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
110327787  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
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Expanding insights of mitochondrial dysfunction in Parkinson's disease.
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Nat Rev Neurosci 7:207-19 (2006)
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PMID:12938733
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PMID:26501339
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Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
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Biomolecules 5:2675-700 (2015)
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PMID:15767499
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Mov Disord 21:1806-23 (2006)
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BMC Biochem 8 Suppl 1:S13 (2007)
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PMID:29090092
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Neuropharmacology 45:1-13 (2003)
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PMID:20495568
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Nat Med 16:653-61 (2010)
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Calcium signaling in Parkinson's disease.
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PMID:19230774
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Trends Mol Med 15:89-100 (2009)
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PMID:28468938
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The role of Ca(2+) signaling in Parkinson's disease.
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Dis Model Mech 10:519-535 (2017)
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PMID:28838811
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Mitochondrial calcium imbalance in Parkinson's disease.
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Neurosci Lett 663:86-90 (2018)
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PMID:19663908
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Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
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FEBS J 276:5041-52 (2009)
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Trends Mol Med 19:165-75 (2013)
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ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
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Brain Res 1648:626-632 (2016)
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Eur J Pharmacol 765:154-6 (2015)
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Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
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Nutr Neurosci 1-16 (2019)
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Protective and toxic roles of dopamine in Parkinson's disease.
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J Neurochem 129:898-915 (2014)
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The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
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Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
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A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
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Neural Regen Res 10:1225-7 (2015)
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Biochim Biophys Acta 1813:623-33 (2011)
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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
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Neurobiol Dis 108:65-72 (2017)
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J Bioenerg Biomembr 51:175-188 (2019)
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Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
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Related
pathway
mpah00190  Oxidative phosphorylation
mpah00350  Tyrosine metabolism
mpah03050  Proteasome
mpah04020  Calcium signaling pathway
mpah04120  Ubiquitin mediated proteolysis
mpah04137  Mitophagy - animal
mpah04141  Protein processing in endoplasmic reticulum
mpah04210  Apoptosis
mpah04728  Dopaminergic synapse
KO pathway
ko05012   
LinkDB

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