Entry Name Hepatocellular carcinoma - Oryctolagus cuniculus (rabbit)
Description Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Disease H00048 Hepatocellular carcinoma
Organism Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene 100009371 TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Whittaker S, Marais R, Zhu AX
Title The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
Journal Reference Authors Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
Title Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
Journal Reference Authors Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
Title Genomics and signaling pathways in hepatocellular carcinoma.
Journal Reference Authors Breuhahn K, Longerich T, Schirmacher P
Title Dysregulation of growth factor signaling in human hepatocellular carcinoma.
Journal Reference Authors Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
Title Pathogenesis of hepatocellular carcinoma and molecular therapies.
Journal Reference Authors Kudo M
Title Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
Journal Reference Authors Nault JC, Zucman-Rossi J
Title Genetics of hepatocellular carcinoma: the next generation.
Journal Reference Authors Rocken C, Carl-McGrath S.
Title Pathology and pathogenesis of hepatocellular carcinoma.
Journal Reference Authors Cornella H, Alsinet C, Villanueva A
Title Molecular pathogenesis of hepatocellular carcinoma.
Journal Reference Authors Niu ZS, Niu XJ, Wang WH
Title Genetic alterations in hepatocellular carcinoma: An update.
Journal Reference Authors Tannapfel A, Wittekind C
Title Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
Journal Reference Authors Shiraha H, Yamamoto K, Namba M
Title Human hepatocyte carcinogenesis (review).
Journal Reference Authors Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
Title High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Journal Reference Authors Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
Title Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
Journal Reference Authors Praslicka BJ, Kerins MJ, Ooi A
Title The complex role of NRF2 in cancer: a genomic view
Journal Reference Authors Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
Title The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
Journal Reference Authors Taguchi K, Motohashi H, Yamamoto M
Title Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
Journal Reference Authors Klaunig JE, Kamendulis LM, Hocevar BA
Title Oxidative stress and oxidative damage in carcinogenesis.
Journal Reference Authors Krupp G, Bonatz G, Parwaresch R
Title Telomerase, immortality and cancer.
Journal Reference Authors Jafri MA, Ansari SA, Alqahtani MH, Shay JW
Title Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
Journal Reference Authors Shay JW
Title Role of Telomeres and Telomerase in Aging and Cancer.
Journal Reference Authors Granito A, Guidetti E, Gramantieri L
Title c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
Journal Reference Authors Vita M, Henriksson M
Title The Myc oncoprotein as a therapeutic target for human cancer.
Journal Reference Authors Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
Title Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
Journal Related ocu04932 Non-alcoholic fatty liver disease
KO pathway
