KEGG   PATHWAY: ocu04151
Entry
ocu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Oryctolagus cuniculus (rabbit)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ocu04151  PI3K-Akt signaling pathway
ocu04151

Other DBs
GO: 0043491
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008808  pro-epidermal growth factor [KO:K04357]
100009482  protransforming growth factor alpha isoform X2 [KO:K08774]
100343410  proepiregulin [KO:K09784]
100354550  amphiregulin [KO:K09782]
100328898  FGF1; fibroblast growth factor 1 [KO:K18496]
100009068  fibroblast growth factor 2 [KO:K18497]
100008681  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100008834  fibroblast growth factor 8 isoform X1 [KO:K04358]
100316906  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100340478  fibroblast growth factor 18 [KO:K04358]
100342742  fibroblast growth factor 16 [KO:K04358]
100342802  fibroblast growth factor 10 [KO:K04358]
100346367  fibroblast growth factor 6 [KO:K04358]
100355861  fibroblast growth factor 9 [KO:K04358]
103345488  fibroblast growth factor 17 isoform X1 [KO:K04358]
100356340  fibroblast growth factor 21 [KO:K22429]
100343050  fibroblast growth factor 23 [KO:K22428]
103350089  beta-nerve growth factor isoform X1 [KO:K02582]
100356949  LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
100345073  neurotrophin-3 [KO:K04356]
100355175  neurotrophin-4 [KO:K12457]
100008668  IGF1; insulin-like growth factor I precursor [KO:K05459]
100328792  IGF2; insulin-like growth factor II precursor [KO:K13769]
100352388  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100358772  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100008912  PDGFD; platelet-derived growth factor D [KO:K05450]
100350272  platelet-derived growth factor C [KO:K05450]
100338577  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100009028  KITLG; kit ligand precursor [KO:K05461]
103346567  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100008899  vascular endothelial growth factor A [KO:K05448]
127487461  vascular endothelial growth factor B isoform X1 [KO:K16858]
100339515  placenta growth factor isoform X1 [KO:K16859]
100338090  vascular endothelial growth factor D isoform X1 [KO:K05449]
100338211  vascular endothelial growth factor C isoform X1 [KO:K05449]
100316908  HGF; hepatocyte growth factor precursor [KO:K05460]
100342781  angiopoietin-1 isoform X1 [KO:K05465]
100353377  angiopoietin-2 isoform X1 [KO:K05466]
100348305  angiopoietin-4 [KO:K05467]
100344921  ephrin-A1 [KO:K05462]
100358004  ephrin-A5 isoform X1 [KO:K05462]
100358959  ephrin-A3 isoform X1 [KO:K05462]
103350046  ephrin-A4 [KO:K05462]
127489207  ephrin-A2 [KO:K05462]
100355129  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100352677  artemin [KO:K25415]
100008806  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100009554  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100008807  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
127491144  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
100009328  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100351861  fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100009417  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
127485863  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100355275  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100349095  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100354292  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100352548  BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
100008911  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100144342  insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100343006  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100342872  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100340992  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100327263  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
108175474  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100343352  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100358984  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100008829  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100008607  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
100126565  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100356675  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100343518  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100340710  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100342500  growth factor receptor-bound protein 2 [KO:K04364]
100346391  son of sevenless homolog 2 isoform X1 [KO:K03099]
100356615  son of sevenless homolog 1 isoform X1 [KO:K03099]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100339981  insulin receptor substrate 1 [KO:K16172]
100009578  TLR2; toll-like receptor 2 precursor [KO:K10159]
100009497  TLR4; toll-like receptor 4 [KO:K10160]
100339873  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100009097  Ig gamma chain C region [KO:K06856]
100352996  immunoglobulin heavy variable 3-66 [KO:K06856]
100353328  immunoglobulin heavy variable 3-11 [KO:K06856]
103347220  immunoglobulin heavy variable 3-66 [KO:K06856]
100345556  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100345233  B-lymphocyte antigen CD19 [KO:K06465]
103351397  phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100356068  somatotropin precursor [KO:K05438]
100009394  PRL; prolactin precursor [KO:K05439]
100342491  oncostatin-M [KO:K05418]
100302458  IL2; interleukin-2 isoform 1 precursor [KO:K05429]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100302454  IL4; interleukin-4 isoform 1 precursor [KO:K05430]
100345409  interleukin-7 isoform X1 [KO:K05431]
100353390  interferon alpha-21-like [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100356678  interferon alpha-1/13 [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100357708  interferon alpha-21-like isoform X2 [KO:K05414]
100342931  interferon beta [KO:K05415]
100008786  EPO; erythropoietin precursor [KO:K05437]
100356652  granulocyte colony-stimulating factor [KO:K05423]
100009325  GHR; growth hormone receptor precursor [KO:K05080]
100009046  PRLR; prolactin receptor precursor [KO:K05081]
100356631  oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
100338113  interleukin-2 receptor subunit alpha [KO:K05068]
100358489  interleukin-2 receptor subunit alpha [KO:K05068]
103346218  interleukin-2 receptor subunit beta [KO:K05069]
103351862  cytokine receptor common subunit gamma [KO:K05070]
103345135  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
100347752  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100337721  interleukin-4 receptor subunit alpha [KO:K05071]
100343726  interleukin-7 receptor subunit alpha [KO:K05072]
100338604  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100338097  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100355350  erythropoietin receptor [KO:K05079]
100342746  LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061]
100352594  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100358134  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
127486194  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100008997  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
100347598  collagen alpha-1(I) chain isoform X1 [KO:K06236]
100009005  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
100338437  collagen alpha-6(IV) chain [KO:K06237]
100357427  collagen alpha-5(IV) chain [KO:K06237]
100357900  collagen alpha-4(IV) chain isoform X2 [KO:K06237]
100358256  collagen alpha-1(IV) chain [KO:K06237]
100358522  LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
108176892  collagen alpha-3(IV) chain isoform X1 [KO:K06237]
100339915  collagen alpha-6(VI) chain [KO:K06238]
100340417  collagen alpha-5(VI) chain [KO:K06238]
100343947  collagen alpha-1(VI) chain [KO:K06238]
100356474  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103345754  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100338915  collagen alpha-2(IX) chain [KO:K08131]
100340815  collagen alpha-3(IX) chain [KO:K08131]
103349793  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100350500  laminin subunit alpha-2 isoform X1 [KO:K05637]
100357482  laminin subunit alpha-1 isoform X1 [KO:K05637]
100346886  laminin subunit alpha-3 isoform X1 [KO:K06240]
103347398  laminin subunit alpha-5 [KO:K06240]
108177458  laminin subunit alpha-4 [KO:K06241]
100358679  laminin subunit beta-1 isoform X1 [KO:K05636]
100009388  laminin subunit beta-2 [KO:K06243]
100342905  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
100351387  laminin subunit gamma-1 [KO:K05635]
103345292  laminin subunit gamma-3 [KO:K06247]
100347341  chondroadherin [KO:K06248]
100341603  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100350430  thrombospondin-1 [KO:K16857]
100343910  thrombospondin-3 [KO:K04659]
100357137  thrombospondin-4 [KO:K04659]
100357972  thrombospondin-2 isoform X1 [KO:K04659]
100328589  FN1; fibronectin isoform X1 [KO:K05717]
100008982  SPP1; osteopontin precursor [KO:K06250]
100009128  VTN; vitronectin precursor [KO:K06251]
100301551  TNC; tenascin isoform X1 [KO:K06252]
100347324  tenascin-R [KO:K06252]
100356305  tenascin-N isoform X1 [KO:K06252]
100357231  LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
127488898  LOW QUALITY PROTEIN: tenascin-X-like [KO:K06252]
100009165  VWF; von Willebrand factor precursor [KO:K03900]
100344425  bone sialoprotein 2 [KO:K06253]
100342711  integrin alpha-1 [KO:K06480]
100101621  integrin alpha-2 [KO:K06481]
100008734  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100348594  integrin alpha-3 [KO:K06482]
100346103  integrin alpha-4 isoform X1 [KO:K06483]
100009172  integrin alpha-5 [KO:K06484]
100008642  integrin alpha-6 isoform X1 [KO:K06485]
100346005  integrin alpha-7 isoform X6 [KO:K06583]
127487418  integrin alpha-7 isoform X1 [KO:K06583]
100351181  integrin alpha-8 [KO:K06584]
100339625  integrin alpha-9 [KO:K06585]
103350383  integrin alpha-9 [KO:K06585]
100340248  integrin alpha-10 isoform X1 [KO:K06586]
100344251  integrin alpha-11 [KO:K06587]
100008956  integrin alpha-V isoform X1 [KO:K06487]
100008898  integrin beta-1 isoform X2 [KO:K05719]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100101587  LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100353546  integrin beta-5 [KO:K06588]
100338232  integrin beta-6 isoform X1 [KO:K06589]
100350557  integrin beta-7 isoform X1 [KO:K06590]
100009141  ITGB8; integrin beta-8 precursor [KO:K06591]
100347455  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100351711  proteinase-activated receptor 1 [KO:K03914]
100346573  muscarinic acetylcholine receptor M1 [KO:K04129]
100342878  muscarinic acetylcholine receptor M2 [KO:K04130]
100355169  lysophosphatidic acid receptor 1 [KO:K04289]
100343700  lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
100009484  lysophosphatidic acid receptor 3 [KO:K04294]
100344512  lysophosphatidic acid receptor 4 [KO:K04275]
100347657  lysophosphatidic acid receptor 5 [KO:K08390]
103352130  lysophosphatidic acid receptor 6 [KO:K04273]
100337783  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127489280  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100356799  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100346625  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100338332  guanine nucleotide-binding protein subunit beta-4 isoform X2 [KO:K04538]
100008941  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100352954  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100348350  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
103350926  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108178480  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100355417  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108177128  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100342201  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103350153  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108176185  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
127489712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100342450  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108178552  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100344144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100337757  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100340526  LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100347954  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
127489204  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100340670  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
100358166  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100341887  DNA damage-inducible transcript 4 protein [KO:K08270]
100338695  hamartin [KO:K07206]
100351640  tuberin isoform X1 [KO:K07207]
100348492  GTP-binding protein Rheb [KO:K07208]
100359276  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100356164  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103346553  regulatory-associated protein of mTOR [KO:K07204]
127482734  regulatory-associated protein of mTOR [KO:K07204]
100338850  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100009338  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100348102  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100354512  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100009260  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
127484730  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100354421  eukaryotic translation initiation factor 4B isoform X4 [KO:K03258]
100338367  40S ribosomal protein S6 [KO:K02991]
100339133  40S ribosomal protein S6 [KO:K02991]
100339973  40S ribosomal protein S6-like [KO:K02991]
100343251  40S ribosomal protein S6-like [KO:K02991]
100346495  40S ribosomal protein S6-like [KO:K02991]
100348810  40S ribosomal protein S6-like [KO:K02991]
108175483  40S ribosomal protein S6-like [KO:K02991]
108178879  40S ribosomal protein S6 [KO:K02991]
127487210  40S ribosomal protein S6-like [KO:K02991]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127488115  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
100350018  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100354906  serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
100008723  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
100352204  serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
100343709  serine/threonine-protein kinase Sgk3 isoform X2 [KO:K13304] [EC:2.7.11.1]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100339815  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5 [KO:K05631]
100350077  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100358716  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100339997  acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
103348628  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
100009252  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100009300  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100355092  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100355758  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100009139  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100328616  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100328617  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100348286  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100353545  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2 [KO:K11583]
100355159  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [KO:K11583]
100356580  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100009215  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100009216  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100009434  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100009533  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100346997  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100338694  heat shock protein HSP 90-alpha [KO:K04079]
100358690  heat shock protein HSP 90-beta [KO:K04079]
100009456  endoplasmin [KO:K09487]
100344117  hsp90 co-chaperone Cdc37 [KO:K09554]
100358960  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100356030  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 [KO:K16340] [EC:3.1.3.16]
100359297  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100339526  protein p13 MTCP-1 [KO:K16837]
100009498  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
127493711  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100347269  breast cancer type 1 susceptibility protein isoform X2 [KO:K10605] [EC:2.3.2.27]
100348842  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100008660  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100352840  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100144341  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
100303766  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
100345755  glucose-6-phosphatase 2 isoform X2 [KO:K01084] [EC:3.1.3.9]
100358721  glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100348489  cyclin-dependent kinase inhibitor 1 [KO:K06625]
100009037  cyclin-dependent kinase inhibitor 1B [KO:K06624]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100009039  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100009040  cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100009036  G1/S-specific cyclin-D2 [KO:K10151]
100009038  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100134864  G1/S-specific cyclin-E1 [KO:K06626]
100134867  G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100343573  forkhead box protein O3 [KO:K09408]
100339977  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100344073  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100345483  bcl-2-like protein 11 isoform X1 [KO:K16341]
100008930  YWHAQ; 14-3-3 protein theta [KO:K16197]
100342694  14-3-3 protein zeta/delta [KO:K16197]
100358299  14-3-3 protein beta/alpha [KO:K16197]
100358813  14-3-3 protein epsilon isoform X4 [KO:K06630]
100328734  YWHAH; 14-3-3 protein eta [KO:K16198]
100354276  14-3-3 protein gamma [KO:K16198]
127488492  14-3-3 protein gamma [KO:K16198]
100358587  bcl2-associated agonist of cell death [KO:K02158]
100008875  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103349397  apoptosis regulator Bcl-2 [KO:K02161]
100101592  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100339383  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100357489  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127493063  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
100359222  induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100349994  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100355888  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100356401  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100347664  transcriptional activator Myb isoform X1 [KO:K09420]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ocu00010  Glycolysis / Gluconeogenesis
ocu04010  MAPK signaling pathway
ocu04012  ErbB signaling pathway
ocu04062  Chemokine signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04068  FoxO signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04150  mTOR signaling pathway
ocu04210  Apoptosis
ocu04370  VEGF signaling pathway
ocu04510  Focal adhesion
ocu04620  Toll-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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