KEGG   PATHWAY: ocu04151
Entry
ocu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Oryctolagus cuniculus (rabbit)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ocu04151  PI3K-Akt signaling pathway
ocu04151

Other DBs
GO: 0043491
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008607  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
100008642  [KO:K06485]
100008660  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100008668  IGF1; insulin-like growth factor I precursor [KO:K05459]
100008681  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100008723  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100008734  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100008786  EPO; erythropoietin precursor [KO:K05437]
100008806  [KO:K04361] [EC:2.7.10.1]
100008807  [KO:K05084] [EC:2.7.10.1]
100008808  [KO:K04357]
100008829  [KO:K05097] [EC:2.7.10.1]
100008834  [KO:K04358]
100008875  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100008898  [KO:K05719]
100008899  [KO:K05448]
100008911  [KO:K04527] [EC:2.7.10.1]
100008912  PDGFD; platelet-derived growth factor D [KO:K05450]
100008930  YWHAQ; 14-3-3 protein theta [KO:K16197]
100008941  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100008956  [KO:K06487]
100008982  SPP1; osteopontin precursor [KO:K06250]
100008997  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
100009005  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
100009028  KITLG; kit ligand precursor [KO:K05461]
100009036  [KO:K10151]
100009037  [KO:K06624]
100009038  [KO:K10152]
100009039  [KO:K02089] [EC:2.7.11.22]
100009040  [KO:K02091] [EC:2.7.11.22]
100009046  PRLR; prolactin receptor precursor [KO:K05081]
100009068  [KO:K18497]
100009097  [KO:K06856]
100009128  VTN; vitronectin precursor [KO:K06251]
100009139  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100009141  ITGB8; integrin beta-8 precursor [KO:K06591]
100009165  VWF; von Willebrand factor precursor [KO:K03900]
100009172  [KO:K06484]
100009215  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100009216  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100009252  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100009260  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100009300  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009325  GHR; growth hormone receptor precursor [KO:K05080]
100009328  [KO:K05085] [EC:2.7.10.1]
100009338  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100009388  [KO:K06243]
100009394  PRL; prolactin precursor [KO:K05439]
100009417  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100009434  [KO:K11584]
100009456  [KO:K09487]
100009482  [KO:K08774]
100009484  [KO:K04294]
100009497  TLR4; toll-like receptor 4 [KO:K10160]
100009498  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100009533  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100009554  [KO:K05083] [EC:2.7.10.1]
100009578  TLR2; toll-like receptor 2 precursor [KO:K10159]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100101587  [KO:K06525]
100101592  [KO:K04399] [EC:3.4.22.62]
100101621  [KO:K06481]
100126565  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100134864  [KO:K06626]
100134865  [KO:K02206] [EC:2.7.11.22]
100134867  [KO:K06626]
100144341  [KO:K01596] [EC:4.1.1.32]
100144342  [KO:K05087] [EC:2.7.10.1]
100301551  TNC; tenascin isoform X1 [KO:K06252]
100302454  IL4; interleukin-4 isoform 1 precursor [KO:K05430]
100302458  IL2; interleukin-2 isoform 1 precursor [KO:K05429]
100303766  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
100316906  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100316908  HGF; hepatocyte growth factor precursor [KO:K05460]
100327263  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100328589  FN1; fibronectin isoform X1 [KO:K05717]
100328616  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
100328617  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
100328734  YWHAH; 14-3-3 protein eta [KO:K16198]
100328792  IGF2; insulin-like growth factor II precursor [KO:K13769]
100328898  FGF1; fibroblast growth factor 1 [KO:K18496]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100337721  [KO:K05071]
100337757  [KO:K21290]
100337783  [KO:K04536]
100337822  [KO:K00922] [EC:2.7.1.153]
100338090  [KO:K05449]
100338097  [KO:K05131]
100338113  [KO:K05068]
100338211  [KO:K05449]
100338232  [KO:K06589]
100338332  [KO:K04538]
100338367  [KO:K02991]
100338437  [KO:K06237]
100338577  [KO:K05453]
100338604  [KO:K05130]
100338694  [KO:K04079]
100338695  [KO:K07206]
100338850  [KO:K07205]
100338915  [KO:K08131]
100339133  [KO:K02991]
100339383  [KO:K04374]
100339515  [KO:K16859]
100339526  [KO:K16837]
100339625  [KO:K06585]
100339815  [KO:K05631]
100339873  [KO:K04392]
100339915  [KO:K06238]
100339973  [KO:K02991]
100339977  [KO:K16332]
100339981  [KO:K16172]
100339997  [KO:K16339] [EC:3.1.2.2]
100340248  [KO:K06586]
100340417  [KO:K06238]
100340478  [KO:K04358]
100340526  [KO:K21290]
100340670  [KO:K07198] [EC:2.7.11.31]
100340710  [KO:K05126] [EC:2.7.10.1]
100340815  [KO:K08131]
100340992  [KO:K05090] [EC:2.7.10.1]
100341603  [KO:K06249] [EC:3.4.21.-]
100341887  [KO:K08270]
100342201  [KO:K04546]
100342450  [KO:K04548]
100342491  [KO:K05418]
100342500  [KO:K04364]
100342694  [KO:K16197]
100342711  [KO:K06480]
100342742  [KO:K04358]
100342746  [KO:K05061]
100342781  [KO:K05465]
100342802  [KO:K04358]
100342852  [KO:K04456] [EC:2.7.11.1]
100342872  [KO:K05089] [EC:2.7.10.1]
100342878  [KO:K04130]
100342905  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
100342931  [KO:K05415]
100343006  [KO:K04363] [EC:2.7.10.1]
100343050  [KO:K22428]
100343130  [KO:K09048]
100343251  [KO:K02991]
100343352  [KO:K05096] [EC:2.7.10.1]
100343410  [KO:K09784]
100343518  [KO:K05103] [EC:2.7.10.1]
100343573  [KO:K09408]
100343700  [KO:K04291]
100343709  [KO:K13304] [EC:2.7.11.1]
100343726  [KO:K05072]
100343910  [KO:K04659]
100343947  [KO:K06238]
100344073  [KO:K04389]
100344117  [KO:K09554]
100344144  [KO:K21289] [EC:2.7.1.153]
100344241  [KO:K07828]
100344251  [KO:K06587]
100344425  [KO:K06253]
100344512  [KO:K04275]
100344921  [KO:K05462]
100345073  [KO:K04356]
100345181  [KO:K00922] [EC:2.7.1.153]
100345233  [KO:K06465]
100345250  [KO:K02649]
100345409  [KO:K05431]
100345475  [KO:K09048]
100345483  [KO:K16341]
100345556  [KO:K05855] [EC:2.7.10.2]
100345755  [KO:K01084] [EC:3.1.3.9]
100346005  [KO:K06583]
100346103  [KO:K06483]
100346367  [KO:K04358]
100346391  [KO:K03099]
100346495  [KO:K02991]
100346573  [KO:K04129]
100346625  [KO:K07825]
100346886  [KO:K06240]
100346997  [KO:K11584]
100347269  [KO:K10605] [EC:2.3.2.27]
100347324  [KO:K06252]
100347341  [KO:K06248]
100347345  [KO:K04371] [EC:2.7.11.24]
100347407  [KO:K04366] [EC:2.7.11.1]
100347455  [KO:K05725] [EC:2.7.10.2]
100347487  [KO:K07827]
100347598  [KO:K06236]
100347657  [KO:K08390]
100347664  [KO:K09420]
100347752  [KO:K05055]
100347954  [KO:K06276] [EC:2.7.11.1]
100348102  [KO:K03259]
100348286  [KO:K04354]
100348305  [KO:K05467]
100348350  [KO:K04540]
100348489  [KO:K06625]
100348492  [KO:K07208]
100348561  [KO:K04371] [EC:2.7.11.24]
100348594  [KO:K06482]
100348663  [KO:K00922] [EC:2.7.1.153]
100348810  [KO:K02991]
100348842  [KO:K03083] [EC:2.7.11.26]
100349095  [KO:K02583]
100349426  [KO:K02580]
100349994  [KO:K04465]
100350018  [KO:K23691]
100350077  [KO:K05629]
100350272  [KO:K05450]
100350430  [KO:K16857]
100350500  [KO:K05637]
100350557  [KO:K06590]
100351181  [KO:K06584]
100351387  [KO:K05635]
100351640  [KO:K07207]
100351711  [KO:K03914]
100351861  [KO:K04362] [EC:2.7.10.1]
100351999  [KO:K05870]
100352204  [KO:K13303] [EC:2.7.11.1]
100352388  [KO:K04359]
100352548  [KO:K04360] [EC:2.7.10.1]
100352594  [KO:K11217] [EC:2.7.10.2]
100352677  [KO:K25415]
100352840  [KO:K00693] [EC:2.4.1.11]
100352954  [KO:K07826]
100352996  [KO:K06856]
100353328  [KO:K06856]
100353377  [KO:K05466]
100353390  [KO:K05414]
100353545  [KO:K11583]
100353546  [KO:K06588]
100353706  [KO:K04456] [EC:2.7.11.1]
100354276  [KO:K16198]
100354292  [KO:K03176] [EC:2.7.10.1]
100354421  [KO:K03258]
100354512  [KO:K03259]
100354550  [KO:K09782]
100354654  [KO:K05414]
100354906  [KO:K23692]
100355092  [KO:K03456]
100355129  [KO:K05452]
100355159  [KO:K11583]
100355169  [KO:K04289]
100355175  [KO:K12457]
100355275  [KO:K05095] [EC:2.7.10.1]
100355350  [KO:K05079]
100355367  [KO:K04450]
100355417  [KO:K04544]
100355669  [KO:K05414]
100355758  [KO:K03456]
100355861  [KO:K04358]
100355888  [KO:K04467] [EC:2.7.11.10]
100355912  [KO:K05414]
100356030  [KO:K16340] [EC:3.1.3.16]
100356068  [KO:K05438]
100356164  [KO:K07203] [EC:2.7.11.1]
100356305  [KO:K06252]
100356340  [KO:K22429]
100356401  [KO:K07209] [EC:2.7.11.10]
100356419  [KO:K05414]
100356474  [KO:K06238]
100356580  [KO:K11583]
100356615  [KO:K03099]
100356631  [KO:K05057]
100356652  [KO:K05423]
100356675  [KO:K05121] [EC:2.7.10.1]
100356678  [KO:K05414]
100356799  [KO:K04537]
100356949  [KO:K04355]
100357137  [KO:K04659]
100357194  [KO:K05414]
100357231  [KO:K06252]
100357427  [KO:K06237]
100357482  [KO:K05637]
100357483  [KO:K09047]
100357489  [KO:K09049]
100357708  [KO:K05414]
100357841  [KO:K02649]
100357876  [KO:K09048]
100357900  [KO:K06237]
100357972  [KO:K04659]
100358004  [KO:K05462]
100358134  [KO:K04447] [EC:2.7.10.2]
100358166  [KO:K07198] [EC:2.7.11.31]
100358175  [KO:K09048]
100358256  [KO:K06237]
100358299  [KO:K16197]
100358489  [KO:K05068]
100358522  [KO:K06237]
100358587  [KO:K02158]
100358679  [KO:K05636]
100358690  [KO:K04079]
100358716  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100358721  [KO:K01084] [EC:3.1.3.9]
100358772  [KO:K17386]
100358813  [KO:K06630]
100358959  [KO:K05462]
100358960  [KO:K16333]
100358984  [KO:K05096] [EC:2.7.10.1]
100359222  [KO:K02539]
100359276  [KO:K08266]
100359297  [KO:K16340] [EC:3.1.3.16]
103345135  [KO:K04737]
103345292  [KO:K06247]
103345488  [KO:K04358]
103345754  [KO:K06238]
103346218  [KO:K05069]
103346553  [KO:K07204]
103346567  [KO:K05454]
103347220  [KO:K06856]
103347398  [KO:K06240]
103348628  [KO:K16339] [EC:3.1.2.2]
103349397  [KO:K02161]
103349793  [KO:K08131]
103350046  [KO:K05462]
103350089  [KO:K02582]
103350153  [KO:K04347]
103350383  [KO:K06585]
103350926  [KO:K04541]
103351397  [KO:K12230]
103351862  [KO:K05070]
103352130  [KO:K04273]
108175474  [KO:K05092] [EC:2.7.10.1]
108175483  [KO:K02991]
108176185  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108176892  [KO:K06237]
108177128  [KO:K04545]
108177458  [KO:K06241]
108178480  [KO:K04542]
108178552  [KO:K04549]
108178879  [KO:K02991]
127482734  [KO:K07204]
127484730  [KO:K04688] [EC:2.7.11.1]
127485184  [KO:K04735]
127485863  [KO:K05094] [EC:2.7.10.1]
127486116  [KO:K04456] [EC:2.7.11.1]
127486194  [KO:K11218] [EC:2.7.10.2]
127486605  [KO:K02833]
127487210  [KO:K02991]
127487418  [KO:K06583]
127487420  [KO:K02206] [EC:2.7.11.22]
127487461  [KO:K16858]
127488115  [KO:K06071] [EC:2.7.11.13]
127488492  [KO:K16198]
127488898  [KO:K06252]
127489204  [KO:K07298] [EC:2.7.11.1]
127489207  [KO:K05462]
127489236  [KO:K07827]
127489280  [KO:K04536]
127489461  [KO:K04368] [EC:2.7.12.2]
127489712  [KO:K04547]
127491144  [KO:K05084] [EC:2.7.10.1]
127493063  [KO:K09049]
127493711  [KO:K13242] [EC:1.14.13.39]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ocu00010  Glycolysis / Gluconeogenesis
ocu04010  MAPK signaling pathway
ocu04012  ErbB signaling pathway
ocu04062  Chemokine signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04068  FoxO signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04150  mTOR signaling pathway
ocu04210  Apoptosis
ocu04370  VEGF signaling pathway
ocu04510  Focal adhesion
ocu04620  Toll-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04910  Insulin signaling pathway
KO pathway
ko04151   

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