Entry
Name
Cytokine-cytokine receptor interaction - Otolemur garnettii (small-eared galago)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
oga04060 Cytokine-cytokine receptor interaction
Organism
Otolemur garnettii (small-eared galago) [GN:
oga ]
Gene
100942743 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
100943286 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100943964 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
100944437 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100944619 IL20RB; interleukin-20 receptor subunit beta isoform X3 [KO:K05137 ]
100945167 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
100945609 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
100945905 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
100946521 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
100946600 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
100948280 NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583 ]
100948400 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
100950116 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
100950692 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
100951008 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
100951748 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
100951885 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
100952305 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
100952571 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
100953825 IL11RA; interleukin-11 receptor subunit alpha isoform X2 [KO:K05056 ]
100954061 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
100954367 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
100954390 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100955576 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
100955892 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100956432 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
100957062 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100957582 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
100958191 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
100958277 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
100958428 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
100958512 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
100958832 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
100959043 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
100960008 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
100960645 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
100961220 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
100962064 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
100962082 IL10RA; LOW QUALITY PROTEIN: interleukin-10 receptor subunit alpha [KO:K05134 ]
100963314 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
100963581 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
100964358 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
100964778 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100964994 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
100965968 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
100966247 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100966364 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
100966595 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
100966792 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
105886771 TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
105887106 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
111722870 BMP15; LOW QUALITY PROTEIN: bone morphogenetic protein 15 [KO:K05498 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway