KEGG   PATHWAY: panu04062
Entry
panu04062                   Pathway                                
Name
Chemokine signaling pathway - Papio anubis (olive baboon)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
panu04062  Chemokine signaling pathway
panu04062

Other DBs
GO: 0070098
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126710  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100126711  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100137599  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100381196  CXCL8; interleukin-8 precursor [KO:K10030]
100381197  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100510871  [KO:K05408]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997333  [KO:K05506]
100997425  CCL15; C-C motif chemokine 15 [KO:K05511]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997643  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100997671  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.39]
100997846  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100997854  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100998012  CCL14; C-C motif chemokine 14 [KO:K21092]
100998237  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100998698  CCL18; C-C motif chemokine 18 [KO:K21094]
100998763  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100998839  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100998929  STAT3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
100999120  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
100999299  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101000002  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101000030  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101000328  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000692  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101000831  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101000833  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101000991  [KO:K04542]
101001002  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
101001096  [KO:K10031]
101001106  GRK4; G protein-coupled receptor kinase 4 isoform X13 [KO:K08291] [EC:2.7.11.16]
101001384  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101001420  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
101001939  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101002054  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002309  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101002577  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101003010  CCL21; C-C motif chemokine 21 [KO:K16062]
101003099  ROCK2; rho-associated protein kinase 2 isoform X5 [KO:K17388] [EC:2.7.11.39]
101003176  [KO:K12964]
101003196  PXN; paxillin isoform X6 [KO:K05760]
101003424  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
101003583  CCL19; C-C motif chemokine 19 [KO:K05512]
101003680  [KO:K05507]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101003812  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101003920  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101004091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101004170  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101004203  CX3CL1; fractalkine [KO:K05508]
101004325  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101004338  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101004383  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
101004755  [KO:K16598]
101004833  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101004984  CCL24; C-C motif chemokine 24 [KO:K21097]
101005025  CCL22; C-C motif chemokine 22 [KO:K21095]
101005107  CCL27; C-C motif chemokine 27 [KO:K16598]
101005212  [KO:K04177]
101005377  CCL17; C-C motif chemokine 17 [KO:K21083]
101005797  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101006054  [KO:K17447]
101006469  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101006603  CCL26; C-C motif chemokine 26 [KO:K21096]
101006754  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101006842  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
101006936  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101007115  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
101007122  CRKL; crk-like protein [KO:K04438]
101007171  JAK2; tyrosine-protein kinase JAK2 isoform X4 [KO:K04447] [EC:2.7.10.2]
101007578  PARD3; partitioning defective 3 homolog isoform X9 [KO:K04237]
101007735  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101007758  CCL11; eotaxin [KO:K16597]
101008087  XCR1; chemokine XC receptor 1 [KO:K04193]
101008105  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101008110  CCL7; C-C motif chemokine 7 isoform X1 [KO:K05509]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008476  CCL8; C-C motif chemokine 8 [KO:K16596]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008785  ADCY6; adenylate cyclase type 6 isoform X3 [KO:K08046] [EC:4.6.1.1]
101008827  CCL13; C-C motif chemokine 13 [KO:K16595]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101009030  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101009143  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101009167  CCL1; C-C motif chemokine 1 [KO:K05514]
101009331  CCL25; C-C motif chemokine 25 isoform X3 [KO:K13072]
101009394  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101009516  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101009748  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010000  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101010100  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
101010543  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101010826  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101011013  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
101011160  CRK; adapter molecule crk isoform X1 [KO:K04438]
101011251  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101011441  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101011726  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101011983  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012165  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101012463  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101012903  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101013495  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101013590  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
101013600  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101013880  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101014651  [KO:K17449]
101014828  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101014965  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
101014985  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
101015005  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101015074  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101015176  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101015366  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
101016095  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101016465  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101016713  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101016756  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101017180  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101017434  GRK2; beta-adrenergic receptor kinase 1 isoform X3 [KO:K00910] [EC:2.7.11.15]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101017773  CXCR1; C-X-C chemokine receptor type 1 isoform X1 [KO:K04175]
101017982  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101018542  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101018963  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
101019032  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101019414  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
101020378  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101020528  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
101020553  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101020657  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101021139  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101021341  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101022542  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
101022550  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
101022757  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101022800  [KO:K05505]
101022936  PTK2; focal adhesion kinase 1 isoform X25 [KO:K05725] [EC:2.7.10.2]
101022961  VAV3; guanine nucleotide exchange factor VAV3 isoform X6 [KO:K05730]
101023149  CXCL5; C-X-C motif chemokine 5 [KO:K05506]
101023496  CCR6; C-C chemokine receptor type 6 isoform X2 [KO:K04181]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101023887  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101024158  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101024177  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101024393  SHC3; SHC-transforming protein 3 [KO:K17448]
101024554  [KO:K05505]
101025057  GRK5; G protein-coupled receptor kinase 5 isoform X3 [KO:K08291] [EC:2.7.11.16]
101025236  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101025271  PPBP; platelet basic protein [KO:K10029]
101025455  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101025874  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101026251  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X15 [KO:K04345] [EC:2.7.11.11]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101026282  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101026520  CCL16; C-C motif chemokine 16 isoform X1 [KO:K21093]
101026663  CXCL1; growth-regulated alpha protein [KO:K05505]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101026878  [KO:K05511]
101026988  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101027022  PF4V1; platelet factor 4 variant isoform X2 [KO:K05407]
103876540  [KO:K05050]
103884403  [KO:K05505]
108583299  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116272720  [KO:K17449]
116272724  [KO:K17449]
116272729  [KO:K17449]
116272733  [KO:K17449]
116272789  [KO:K17449]
116274104  [KO:K05506]
116275838  [KO:K04539]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
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J Biol Chem 271:2832-8 (1996)
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Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
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Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
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Immunol Res 21:293-303 (2000)
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Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
panu04010  MAPK signaling pathway
panu04060  Cytokine-cytokine receptor interaction
panu04120  Ubiquitin mediated proteolysis
panu04630  JAK-STAT signaling pathway
panu04670  Leukocyte transendothelial migration
panu04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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