KEGG   PATHWAY: achl04010
Entry
achl04010                   Pathway                                
Name
MAPK signaling pathway - Acanthisitta chloris (rifleman)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
achl04010  MAPK signaling pathway
achl04010

Other DBs
GO: 0000165
Organism
Acanthisitta chloris (rifleman) [GN:achl]
Gene
103806638  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103802711  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103803517  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
103808937  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
103806068  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103803390  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103797159  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103797268  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
103799219  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
103805875  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103805859  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
103798265  CACNG3; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103805876  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103800423  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103804251  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103804704  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103803878  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103805475  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103797261  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103797355  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
103802447  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103802795  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
103797134  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103801123  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103803058  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
103808255  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103807681  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
103811180  NF1; neurofibromin [KO:K08052]
103807589  RASA1; ras GTPase-activating protein 1 [KO:K04352]
103797572  RASA2; ras GTPase-activating protein 2 [KO:K08053]
103805174  RAP1A; ras-related protein Rap-1A [KO:K04353]
103797087  RAP1B; ras-related protein Rap-1b [KO:K07836]
103797310  pro-epidermal growth factor-like [KO:K04357]
103800957  pro-epidermal growth factor-like [KO:K04357]
103808491  TGFA; protransforming growth factor alpha [KO:K08774]
103811907  EREG; proepiregulin [KO:K09784]
103799837  AREG; amphiregulin [KO:K09782]
103805303  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103798142  FGF8; fibroblast growth factor 8 [KO:K04358]
103805372  fibroblast growth factor 4-like [KO:K04358]
103805578  FGF18; fibroblast growth factor 18 [KO:K04358]
103806448  FGF20; fibroblast growth factor 20 [KO:K04358]
103806783  fibroblast growth factor 9 [KO:K04358]
103801481  FGF6; fibroblast growth factor 6 [KO:K04358]
103802342  FGF16; fibroblast growth factor 16 [KO:K04358]
103799123  FGF19; fibroblast growth factor 19 [KO:K22603]
103801482  fibroblast growth factor 23-like [KO:K22428]
103799597  NGF; beta-nerve growth factor [KO:K02582]
103811115  BDNF; brain-derived neurotrophic factor [KO:K04355]
103801841  NTF3; neurotrophin-3 [KO:K04356]
103802297  INS; insulin [KO:K04526]
103804378  IGF1; insulin-like growth factor I [KO:K05459]
103805251  IGF2; insulin-like growth factor II [KO:K13769]
103808525  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103809800  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103806982  PDGFC; platelet-derived growth factor C [KO:K05450]
103811172  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
103799074  KITLG; kit ligand [KO:K05461]
103799237  VEGFA; vascular endothelial growth factor A [KO:K05448]
103807687  PGF; placenta growth factor [KO:K16859]
103808049  VEGFC; vascular endothelial growth factor C [KO:K05449]
103803238  FIGF; vascular endothelial growth factor D [KO:K05449]
103799327  ANGPT1; angiopoietin-1 [KO:K05465]
103812241  ANGPT2; angiopoietin-2 [KO:K05466]
103801950  angiopoietin-4-like [KO:K05467]
103810570  ephrin-A5-like [KO:K05462]
103800891  EFNA2; ephrin-A2 [KO:K05462]
103801198  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103800008  artemin-like [KO:K25415]
103797002  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
103806071  fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103800822  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103801282  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103800983  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
103798238  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103803982  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103802359  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103802358  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103802033  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103806192  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103802127  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103802422  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
103797706  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103802034  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103812167  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103803817  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103805024  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103802434  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103810188  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103810694  SOS2; son of sevenless homolog 2 [KO:K03099]
103808944  SOS1; son of sevenless homolog 1 [KO:K03099]
103801883  HRAS; GTPase HRas [KO:K02833]
103804109  KRAS; GTPase KRas isoform X1 [KO:K07827]
103811226  GTPase NRas [KO:K07828]
103798509  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103810142  MRAS; ras-related protein M-Ras [KO:K07831]
103807473  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103811193  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103809856  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103811684  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103802868  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
103797961  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
103798104  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103810766  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
103799138  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103807514  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103804193  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103811944  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
103800989  SRF; serum response factor [KO:K04378]
103799376  STMN1; stathmin [KO:K04381]
103804138  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103805177  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103800283  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103801365  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103801366  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103801367  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103801370  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103811428  IL1B; interleukin-1 beta [KO:K04519]
103811139  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103807798  TGFB3; transforming growth factor beta-3 [KO:K13377]
103799439  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103810120  interleukin-1 receptor type 1-like [KO:K04386]
103809529  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
103800140  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103805135  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103811946  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103803923  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103811676  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103798433  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103797226  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103804054  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103802159  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103797011  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103808775  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103804051  DAXX; death domain-associated protein 6 [KO:K02308]
103811144  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103805791  LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4-like [KO:K04733] [EC:2.7.11.1]
103802335  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103806780  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103801279  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103804172  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103806036  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
103809621  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
103798268  serine/threonine-protein kinase PAK 3-like [KO:K04409] [EC:2.7.11.1]
103809948  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103802165  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103804870  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103810726  STK3; serine/threonine-protein kinase 3 [KO:K04412]
103804394  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103802285  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103810253  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103803986  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
103802063  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103803769  mitogen-activated protein kinase kinase kinase 9-like [KO:K04417] [EC:2.7.11.25]
103806140  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
103811889  mitogen-activated protein kinase kinase kinase 13-like [KO:K04422] [EC:2.7.11.25]
103804281  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
103801419  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103805164  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103812175  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103801355  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
103806832  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
103807200  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103799486  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
103800454  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
103803907  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
103805882  CRK; adapter molecule crk [KO:K04438]
103808074  CRKL; crk-like protein [KO:K04438]
103806632  beta-arrestin-1 isoform X1 [KO:K04439]
103811480  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103812215  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103806889  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103797444  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103797445  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103807808  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103808070  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
103801196  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
103811596  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103805527  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
103811588  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103809612  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
103812220  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103797936  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103808275  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103810858  protein max-like [KO:K04453]
103806508  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
103801923  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103801373  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
103810195  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
103805604  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103807067  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103803993  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103811543  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103799604  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103799646  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103803202  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103809496  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103798628  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103806994  DUSP3; LOW QUALITY PROTEIN: dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103808267  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
103808344  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
103804100  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
103811152  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
103811582  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103805825  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103798520  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103807978  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103807532  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103806362  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
achl04070  Phosphatidylinositol signaling system
achl04110  Cell cycle
achl04115  p53 signaling pathway
achl04210  Apoptosis
achl04310  Wnt signaling pathway
KO pathway
ko04010   
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