KEGG   PATHWAY: alat05168
Entry
alat05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Acanthopagrus latus (yellowfin seabream)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
alat05168  Herpes simplex virus 1 infection
alat05168

Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119005615  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
119030139  uncharacterized protein LOC119030139 [KO:K05468]
119030560  tumor necrosis factor-like [KO:K05468]
119029745  tumor necrosis factor ligand superfamily member 14 [KO:K05477]
119024560  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
119013261  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
119022866  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
119022867  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
119029609  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
119030239  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
119019943  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119023819  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119019038  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119010013  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119033964  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119022646  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119034409  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
119013032  NF-kappa-B inhibitor alpha-like [KO:K04734]
119007232  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119027261  rela; transcription factor p65 isoform X1 [KO:K04735]
119030723  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
119030747  nectin-1-like [KO:K06081]
119033202  nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081]
119026407  nectin-1-like isoform X1 [KO:K06081]
119006336  nectin-2-like isoform X1 [KO:K06531]
119029794  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
119023340  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
119021715  integrin alpha-5-like [KO:K06484]
119022620  itga5; integrin alpha-5 [KO:K06484]
119009414  itgb3b; integrin beta-3b [KO:K06493]
119013406  itgb3a; integrin beta-3a [KO:K06493]
119023170  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119020663  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
119030317  syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
119020319  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
119009595  irf3; interferon regulatory factor 3 [KO:K05411]
119027521  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
119028201  complement C3-like isoform X1 [KO:K03990]
119021685  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
119019512  complement C3-like [KO:K03990]
119021043  complement C3-like [KO:K03990]
119019238  c5; complement C5 [KO:K03994]
119013520  properdin-like [KO:K15412]
119007510  monocyte differentiation antigen CD14-like [KO:K10159]
119005747  tlr18; toll-like receptor 18 [KO:K10159]
119020799  toll-like receptor 2 [KO:K10159]
119027456  toll-like receptor 2 type-2 [KO:K10159]
119008972  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119024096  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
119028930  tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
119011883  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
119024075  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119023059  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119017781  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119034485  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
119012374  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119020932  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119012337  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119019748  interleukin-1 beta-like [KO:K04519]
119017429  interleukin-6 [KO:K05405]
119016898  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119008508  il12a; interleukin-12 subunit alpha isoform X1 [KO:K05406]
119011350  uncharacterized protein LOC119011350 [KO:K05406]
119007358  il12ba; interleukin 12Ba [KO:K05425]
119031730  il12bb; interleukin-12 subunit beta [KO:K05425]
119020042  si:dkey-88e18.2; interleukin-12 subunit beta isoform X1 [KO:K05425]
119026164  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
119004944  mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
119004867  traf3; TNF receptor-associated factor 3 [KO:K03174]
119021441  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
119032484  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119014327  interferon a3-like isoform X1 [KO:K05414]
119009736  interferon a3-like isoform X1 [KO:K05414]
119009740  interferon a3-like [KO:K05414]
119013828  interferon a3-like [KO:K05414]
119015120  cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
119033773  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
119008127  sting1; stimulator of interferon genes protein [KO:K12654]
119004845  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
119009696  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
119012369  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
119013270  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
119020238  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
119027263  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
119009931  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
119033620  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
119033621  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
119034474  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119005034  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
119012020  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
119029807  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
119013143  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
119011645  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
119013073  eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680]
119011076  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
119023057  host cell factor 1-like [KO:K14966]
119020508  hcfc1a; host cell factor 1a [KO:K14966]
119032608  hcfc2; host cell factor 2 isoform X1 [KO:K27390]
119006312  pou2f2a; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
119016699  POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
119031100  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
119025315  pou2f1b; POU domain, class 2, transcription factor 1b isoform X1 [KO:K09364]
119009445  suppressor of cytokine signaling 3-like [KO:K04696]
119013904  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
119028104  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119014355  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119015223  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
119025600  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
119020489  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
119008575  irf9; interferon regulatory factor 9 [KO:K04693]
119008415  zinc finger protein 708-like [KO:K09228]
119006204  zinc finger protein Xfin-like [KO:K09228]
119006553  gastrula zinc finger protein XlCGF57.1 [KO:K09228]
119005521  oocyte zinc finger protein XlCOF6-like [KO:K09228]
119005555  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
119005811  im:7147486; zinc finger protein 865 [KO:K09228]
119005819  si:dkeyp-84f3.5; zinc finger protein 135 [KO:K09228]
119028273  zinc finger protein 239-like [KO:K09228]
119032246  zinc finger protein 345-like [KO:K09228]
119015026  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
119015129  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119029390  zinc finger protein 345-like isoform X1 [KO:K09228]
119029395  zinc finger protein OZF-like isoform X1 [KO:K09228]
119029396  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119029399  zinc finger protein 782-like [KO:K09228]
119029701  zinc finger protein OZF-like isoform X1 [KO:K09228]
119029703  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119029704  zinc finger protein OZF-like [KO:K09228]
119029707  zinc finger protein OZF-like [KO:K09228]
119029868  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
119009428  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
119009430  zinc finger protein OZF-like isoform X1 [KO:K09228]
119009431  zinc finger protein OZF-like [KO:K09228]
119009453  zinc finger protein 135-like isoform X1 [KO:K09228]
119009454  zinc finger protein 93-like isoform X1 [KO:K09228]
119009460  zinc finger protein 260-like [KO:K09228]
119009463  oocyte zinc finger protein XlCOF6-like [KO:K09228]
119009465  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
119009882  zinc finger protein 93-like isoform X1 [KO:K09228]
119016998  zinc finger protein 79-like [KO:K09228]
119017249  zinc finger protein 664-like isoform X1 [KO:K09228]
119017262  zinc finger protein 791-like [KO:K09228]
119017270  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119017273  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119017277  zinc finger protein 501-like isoform X1 [KO:K09228]
119017278  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119017279  zinc finger protein 436-like [KO:K09228]
119017280  zinc finger protein OZF-like isoform X1 [KO:K09228]
119017281  zinc finger protein 260-like [KO:K09228]
119017284  zinc finger protein OZF-like isoform X1 [KO:K09228]
119017285  zinc finger protein 771-like isoform X1 [KO:K09228]
119017287  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
119017288  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119017290  zinc finger protein 502-like isoform X1 [KO:K09228]
119017293  zinc finger protein 239-like [KO:K09228]
119017295  zinc finger protein 691-like [KO:K09228]
119017296  zinc finger protein 771-like isoform X1 [KO:K09228]
119017297  zinc finger protein 771-like isoform X1 [KO:K09228]
119017299  zinc finger protein 135-like isoform X1 [KO:K09228]
119017301  zinc finger protein 501-like isoform X1 [KO:K09228]
119017305  zinc finger protein OZF-like [KO:K09228]
119017306  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
119017304  zinc finger protein 239-like [KO:K09228]
119017309  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
119010293  zinc finger protein 572-like [KO:K09228]
119017331  zinc finger protein 664-like [KO:K09228]
119010661  si:dkey-7l6.3; zinc finger protein with KRAB and SCAN domains 1 [KO:K09228]
119011074  zinc finger protein 665-like isoform X1 [KO:K09228]
119011075  zinc finger protein ZFMSA12A-like [KO:K09228]
119011212  zinc finger protein 569-like [KO:K09228]
119018150  zinc finger protein 436-like isoform X1 [KO:K09228]
119011364  zinc finger and BTB domain-containing protein 24-like [KO:K09228]
119032169  zinc finger protein 14-like isoform X1 [KO:K09228]
119032245  zinc finger protein 132-like [KO:K09228]
119032306  zinc finger protein 2 homolog [KO:K09228]
119011913  uncharacterized protein LOC119011913 isoform X1 [KO:K09228]
119011914  zinc finger protein 658B-like isoform X1 [KO:K09228]
119011915  zinc finger and SCAN domain-containing protein 30-like [KO:K09228]
119018989  zinc finger protein 37-like isoform X1 [KO:K09228]
119018992  zinc finger protein 79-like [KO:K09228]
119018993  zinc finger protein 135-like [KO:K09228]
119018995  gastrula zinc finger protein XlCGF42.1-like [KO:K09228]
119019118  zinc finger and SCAN domain-containing protein 2-like isoform X1 [KO:K09228]
119019119  zinc finger and SCAN domain-containing protein 21-like [KO:K09228]
119019120  zinc finger protein 436-like [KO:K09228]
119019122  zinc finger protein 181-like isoform X1 [KO:K09228]
119019292  zinc finger protein 835-like [KO:K09228]
119025850  zinc finger protein Xfin-like [KO:K09228]
119032725  uncharacterized protein LOC119032725 isoform X1 [KO:K09228]
119032757  zinc finger protein 708-like isoform X1 [KO:K09228]
119033015  oocyte zinc finger protein XlCOF6-like [KO:K09228]
119019730  zinc finger protein OZF-like [KO:K09228]
119026705  zinc finger protein 260-like [KO:K09228]
119027148  zinc finger protein 665-like [KO:K09228]
119027300  zinc finger protein 664-like [KO:K09228]
119013444  zinc finger protein OZF-like [KO:K09228]
119013445  zinc finger protein 664-like [KO:K09228]
119013446  zinc finger and SCAN domain-containing protein 21-like [KO:K09228]
119027750  LOW QUALITY PROTEIN: zinc finger protein 26-like [KO:K09228]
119034149  zinc finger protein 253-like [KO:K09228]
119013743  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
119033918  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
119019458  ifngr1; interferon gamma receptor 1 [KO:K05132]
119029452  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
119019840  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
119014340  daxx; death domain-associated protein 6 [KO:K02308]
119005680  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
119014351  tap2a; antigen peptide transporter 2a [KO:K05654] [EC:7.4.2.14]
119010276  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
119014417  tapbp.1; TAP binding protein (tapasin), tandem duplicate 1 [KO:K08058]
119017286  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
119024064  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119028578  calr; calreticulin [KO:K08057]
119029068  calreticulin-like isoform X1 [KO:K08057]
119011663  calr3b; calreticulin 3b isoform X1 [KO:K08057]
119008296  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014423  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119014430  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014448  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014456  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014462  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014469  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014475  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014490  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
119014502  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
119014509  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014515  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014523  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014534  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014545  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
119014566  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014574  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
119014603  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119014607  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014619  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014687  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014742  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119016705  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
119016882  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119017020  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119017303  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119014231  major histocompatibility complex class I-related gene protein-like [KO:K06751]
119032729  beta-2-microglobulin-like [KO:K08055]
119032730  beta-2-microglobulin-like [KO:K08055]
119005459  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
119005460  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119005461  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
119005681  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
119005682  si:ch73-31d8.2; H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
119026733  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
119026734  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
119027806  H-2 class II histocompatibility antigen, A-K beta chain-like [KO:K06752]
119027807  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
119014239  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
119014240  H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752]
119007745  cd74a; CD74 molecule, major histocompatibility complex, class II invariant chain a [KO:K06505]
119028004  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119023218  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119011374  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119033526  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
119027583  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
119028110  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119028425  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
119029893  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119011069  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119011087  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119019184  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
119004679  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119005804  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119030658  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119030830  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
119033152  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119029532  tsc1b; TSC complex subunit 1b [KO:K07206]
119019368  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
119024301  tsc2; tuberin isoform X1 [KO:K07207]
119008519  rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
119011888  GTP-binding protein Rheb [KO:K07208]
119020487  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
119022895  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
119030521  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
119019606  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
119021964  srpk1b; SRSF protein kinase 1b isoform X1 [KO:K15409] [EC:2.7.11.1]
119023049  srpk1a; SRSF protein kinase 1a isoform X1 [KO:K15409] [EC:2.7.11.1]
119030981  serine/arginine-rich splicing factor 1B [KO:K12890]
119030982  serine/arginine-rich splicing factor 1-like isoform X1 [KO:K12890]
119033795  srsf1a; serine/arginine-rich splicing factor 1A [KO:K12890]
119009482  srsf2a; serine and arginine rich splicing factor 2a isoform X1 [KO:K12891]
119013570  srsf2b; serine/arginine-rich splicing factor 2b isoform X1 [KO:K12891]
119021526  srsf3b; serine/arginine-rich splicing factor 3b isoform X1 [KO:K12892]
119021615  srsf3a; serine/arginine-rich splicing factor 3a [KO:K12892]
119034499  srsf5a; serine and arginine rich splicing factor 5a isoform X1 [KO:K12893]
119022744  serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893]
119016747  srsf4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
119012462  srsf5b; serine and arginine rich splicing factor 5b [KO:K12893]
119032433  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
119030319  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
119008095  zgc:153681; nuclear RNA export factor 1 isoform X1 [KO:K14284]
119027525  THO complex subunit 4-like [KO:K12881]
119013876  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
119007260  cd40lg; CD40 ligand [KO:K04389]
119029123  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119034075  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119006356  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119018316  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119017669  fadd; protein FADD [KO:K02373]
119010726  caspase-8-like [KO:K04398] [EC:3.4.22.61]
119011511  caspase-8-like [KO:K04398] [EC:3.4.22.61]
119026092  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
119024241  bida; BH3 interacting domain death agonist isoform X1 [KO:K04726]
119013666  apoptosis regulator BAX-like [KO:K02159]
119017934  zgc:153993; apoptosis regulator BAX [KO:K02159]
119014265  apoptosis regulator BAX-like [KO:K02159]
119027095  badb; BCL2 associated agonist of cell death b [KO:K02158]
119011053  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
119022663  bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
119021192  bcl-2-like protein 1 [KO:K04570]
119016417  cytochrome c-like [KO:K08738]
119026341  cytochrome c-b-like [KO:K08738]
119033999  cytochrome c [KO:K08738]
119032660  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
119023405  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119007045  caspase-3-like [KO:K02187] [EC:3.4.22.56]
119010646  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
alat03040  Spliceosome
alat03050  Proteasome
alat04115  p53 signaling pathway
alat04210  Apoptosis
alat04620  Toll-like receptor signaling pathway
alat04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

DBGET integrated database retrieval system