KEGG   PATHWAY: cdk05168
Entry
cdk05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Camelus dromedarius (Arabian camel)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
cdk05168  Herpes simplex virus 1 infection
cdk05168

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105087474  LTA; lymphotoxin-alpha [KO:K05468]
105104551  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
105106196  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105099319  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105084316  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105106603  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105092140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105087177  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105087178  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105088228  C-C motif chemokine 2 [KO:K14624]
105090202  NECTIN1; nectin-1 [KO:K06081]
105095468  NECTIN2; nectin-2 isoform X1 [KO:K06531]
105106097  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
105102551  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
105105612  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
105101003  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105084996  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116149854  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
105106413  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105105766  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105106036  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
105100198  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105095933  IFNB1; interferon beta [KO:K05415]
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105104550  C3; complement C3 [KO:K03990]
105104667  C5; complement C5 [KO:K03994]
105102847  CFP; properdin [KO:K15412]
105099662  TLR2; toll-like receptor 2 [KO:K10159]
105090692  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105105431  IRF7; interferon regulatory factor 7 [KO:K09447]
105102386  TLR3; toll-like receptor 3 [KO:K05401]
105091750  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105097094  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105098727  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105106823  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105095522  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105091931  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105100906  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105093155  IL1B; interleukin-1 beta [KO:K04519]
105097869  CCL5; C-C motif chemokine 5 [KO:K12499]
105095065  IL6; interleukin-6 [KO:K05405]
105087473  TNF; tumor necrosis factor [KO:K03156]
105094260  IL12A; interleukin-12 subunit alpha isoform X2 [KO:K05406]
105099900  IL12B; interleukin-12 subunit beta [KO:K05425]
105085563  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105093686  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
105096015  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
105103454  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105098613  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105089261  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105105541  interferon alpha-1-like [KO:K05414]
105105457  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
105105461  LOW QUALITY PROTEIN: interferon alpha-14-like [KO:K05414]
105095932  interferon alpha-14-like [KO:K05414]
116152603  interferon alpha-14-like [KO:K05414]
116152604  interferon alpha-14-like [KO:K05414]
105099837  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
105098117  STING1; stimulator of interferon response cGAMP interactor 1 [KO:K12654]
105098564  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105104430  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105102484  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105099377  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X5 [KO:K16194] [EC:2.7.11.1]
105105818  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105104181  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105096892  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
105086172  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105094331  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
105086093  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
105090881  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
105098543  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X3 [KO:K03680]
105085890  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
105101979  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105096236  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105098726  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
105097479  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
105090222  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
105092724  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
105090129  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
105089868  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
105089871  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105092151  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105107124  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105087637  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105088783  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
105086362  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105102416  IRF9; interferon regulatory factor 9 [KO:K04693]
105099396  zinc finger protein 501-like [KO:K09228]
105087655  ZNF846; zinc finger protein 846 isoform X1 [KO:K09228]
105087694  zinc finger protein 699-like [KO:K09228]
105088081  zinc finger protein 565 [KO:K09228]
105088085  ZNF567; zinc finger protein 567 isoform X2 [KO:K09228]
105089712  ZNF713; zinc finger protein 713 [KO:K09228]
105086875  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
105084396  ZNF596; zinc finger protein 596 isoform X3 [KO:K09228]
105084409  zinc finger protein 596-like isoform X1 [KO:K09228]
105084605  ZNF662; zinc finger protein 662 isoform X2 [KO:K09228]
105090249  ZNF45; zinc finger protein 45 [KO:K09228]
105090250  zinc finger protein 234-like isoform X2 [KO:K09228]
105090255  ZNF227; zinc finger protein 227 [KO:K09228]
105084624  ZNF619; LOW QUALITY PROTEIN: zinc finger protein 619 [KO:K09228]
105084658  ZNF484; zinc finger protein 484 isoform X1 [KO:K09228]
105085075  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
105085201  ZNF212; zinc finger protein 212 isoform X4 [KO:K09228]
105087590  ZNF558; zinc finger protein 558 isoform X1 [KO:K09228]
105087592  zinc finger protein 709-like isoform X1 [KO:K09228]
105088026  ZNF792; zinc finger protein 792 isoform X4 [KO:K09228]
105088883  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
105091273  zinc finger protein 347-like [KO:K09228]
105091277  zinc finger protein 665-like isoform X1 [KO:K09228]
105092000  zinc finger protein 347-like [KO:K09228]
105092010  zinc finger protein 845-like [KO:K09228]
105092611  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
105091264  zinc finger protein 665-like isoform X1 [KO:K09228]
105091265  zinc finger protein 677-like isoform X1 [KO:K09228]
105091267  zinc finger protein 677-like [KO:K09228]
105092924  ZNF514; zinc finger protein 514 [KO:K09228]
105093332  ZNF546; zinc finger protein 546 isoform X1 [KO:K09228]
105094128  ZNF133; zinc finger protein 133 isoform X2 [KO:K09228]
105101144  ZFP57; LOW QUALITY PROTEIN: zinc finger protein 57 homolog [KO:K09228]
105096801  ZNF132; zinc finger protein 132 [KO:K09228]
105099682  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
105096808  ZNF8; zinc finger protein 8 [KO:K09228]
105096812  ZNF135; zinc finger protein 135 isoform X1 [KO:K09228]
105098470  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
105104799  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
105099409  ZNF316; LOW QUALITY PROTEIN: zinc finger protein 316 [KO:K09228]
116147233  zinc finger protein 665-like [KO:K09228]
105099408  ZNF853; LOW QUALITY PROTEIN: zinc finger protein 853 [KO:K09228]
105099390  ZNF12; zinc finger protein 12 [KO:K09228]
105099412  zinc finger protein 300-like isoform X1 [KO:K09228]
105098956  ZNF114; zinc finger protein 114 [KO:K09228]
105096046  ZNF343; LOW QUALITY PROTEIN: zinc finger protein 343 [KO:K09228]
105096802  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
105101189  zinc finger protein 829 isoform X1 [KO:K09228]
105101194  ZNF529; zinc finger protein 529 isoform X6 [KO:K09228]
105101197  LOW QUALITY PROTEIN: zinc finger protein 420 [KO:K09228]
105097210  ZNF169; zinc finger protein 169 isoform X7 [KO:K09228]
105104071  zinc finger protein 709-like [KO:K09228]
105100637  ZNF354C; zinc finger protein 354C [KO:K09228]
105100638  ZNF879; zinc finger protein 879 isoform X1 [KO:K09228]
105100639  ZNF454; zinc finger protein 454 [KO:K09228]
105104973  ZNF250; zinc finger protein 250 isoform X2 [KO:K09228]
105104976  ZNF7; zinc finger protein 7 isoform X2 [KO:K09228]
105105033  ZNF772; zinc finger protein 772 isoform X1 [KO:K09228]
105105038  zinc finger protein 256-like [KO:K09228]
105084543  ZNF311; zinc finger protein 311 [KO:K09228]
105101943  ZNF41; zinc finger protein 41 isoform X1 [KO:K09228]
105101944  ZNF157; zinc finger protein 157 isoform X1 [KO:K09228]
105101960  ZNF674; zinc finger protein 674 [KO:K09228]
105096813  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
105102735  ZNF768; zinc finger protein 768 [KO:K09228]
105105683  ZNF623; zinc finger protein 623 [KO:K09228]
105105397  ZNF317; zinc finger protein 317 [KO:K09228]
105105402  ZNF699; zinc finger protein 699 [KO:K09228]
105096933  ZFP30; zinc finger protein 30 homolog [KO:K09228]
105096934  zinc finger protein 790 isoform X1 [KO:K09228]
105096935  zinc finger protein 420 isoform X1 [KO:K09228]
105096938  ZNF570; zinc finger protein 570 [KO:K09228]
105096940  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
105096943  ZNF875; LOW QUALITY PROTEIN: uncharacterized protein ZNF875 [KO:K09228]
105096945  zinc finger protein 585A isoform X1 [KO:K09228]
105096958  zinc finger protein 436-like isoform X2 [KO:K09228]
105098766  ZNF582; zinc finger protein 582 isoform X2 [KO:K09228]
105098767  zinc finger protein 471 isoform X1 [KO:K09228]
105098768  ZNF470; zinc finger protein 470 isoform X1 [KO:K09228]
105102845  ZNF81; zinc finger protein 81 [KO:K09228]
105102566  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
105096730  ZNF181; zinc finger protein 181 isoform X2 [KO:K09228]
105100178  zinc finger protein 883 isoform X1 [KO:K09228]
105100179  ZNF473; zinc finger protein 473 [KO:K09228]
116149966  ZNF268; zinc finger protein 268 [KO:K09228]
116149967  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
105101624  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
105101626  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
105106047  zinc finger protein 77-like isoform X1 [KO:K09228]
105106048  zinc finger protein 77 [KO:K09228]
105105976  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
105106107  ZNF354A; zinc finger protein 354A isoform X1 [KO:K09228]
105100647  zinc finger protein 354B [KO:K09228]
105106051  ZNF554; zinc finger protein 554 [KO:K09228]
105096795  zinc finger protein 324A-like isoform X1 [KO:K09228]
105097399  ZNF248; zinc finger protein 248 isoform X1 [KO:K09228]
105097401  zinc finger protein 33B [KO:K09228]
105099391  RBAK; RB-associated KRAB zinc finger protein [KO:K09228]
105103376  ZFP69; zinc finger protein 69 homolog isoform X2 [KO:K09228]
105103377  ZFP69B; zinc finger protein 69 homolog B isoform X1 [KO:K09228]
105103378  zinc finger protein 684-like isoform X1 [KO:K09228]
105106050  ZNF555; zinc finger protein 555 [KO:K09228]
105106076  zinc finger protein 260-like isoform X1 [KO:K09228]
105106210  ZNF184; zinc finger protein 184 isoform X1 [KO:K09228]
105102792  zinc finger protein 764-like isoform X1 [KO:K09228]
105096807  ZNF544; zinc finger protein 544 isoform X1 [KO:K09228]
105104704  ZNF285; zinc finger protein 285 [KO:K09228]
105104708  ZNF112; zinc finger protein 112 [KO:K09228]
105104709  ZNF180; zinc finger protein 180 isoform X1 [KO:K09228]
105095233  ZNF74; zinc finger protein 74 isoform X1 [KO:K09228]
116149250  zinc finger protein 705A-like [KO:K09228]
105099671  ZNF597; zinc finger protein 597 isoform X1 [KO:K09228]
105099679  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
105101625  ZNF26; zinc finger protein 26 isoform X1 [KO:K09228]
105101627  ZNF891; zinc finger protein 891 [KO:K09228]
105101628  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
105097406  zinc finger protein 33B-like [KO:K09228]
105097400  ZNF25; zinc finger protein 25 [KO:K09228]
105104972  zinc finger protein 252-like [KO:K09228]
105104974  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
105105017  ZNF517; LOW QUALITY PROTEIN: zinc finger protein 517 [KO:K09228]
105103907  ZFP92; zinc finger protein 92 homolog isoform X1 [KO:K09228]
105106303  ZNF275; zinc finger protein 275 [KO:K09228]
105084713  zinc finger protein 510 isoform X1 [KO:K09228]
105096829  zinc finger protein 850-like [KO:K09228]
105096815  zinc finger protein 256-like [KO:K09228]
105096947  LOW QUALITY PROTEIN: zinc finger protein 793 [KO:K09228]
105093390  LOW QUALITY PROTEIN: zinc finger protein 780A [KO:K09228]
105104705  ZNF229; LOW QUALITY PROTEIN: zinc finger protein 229 [KO:K09228]
105104714  zinc finger protein 658 [KO:K09228]
116147069  ZNF782; zinc finger protein 782 [KO:K09228]
105084680  ZNF510; LOW QUALITY PROTEIN: zinc finger protein 510 [KO:K09228]
105106073  ZNF175; zinc finger protein 175 [KO:K09228]
116154643  zinc finger protein 432-like isoform X1 [KO:K09228]
105092024  zinc finger protein 84-like isoform X1 [KO:K09228]
105092011  ZNF577; zinc finger protein 577 isoform X1 [KO:K09228]
105092004  zinc finger protein 160-like [KO:K09228]
105092023  LOW QUALITY PROTEIN: zinc finger protein 613-like [KO:K09228]
116154644  ZNF614; zinc finger protein 614 [KO:K09228]
105091274  zinc finger protein OZF-like [KO:K09228]
105092022  zinc finger protein 350-like [KO:K09228]
105091286  zinc finger protein 665-like [KO:K09228]
105091263  ZNF331; LOW QUALITY PROTEIN: zinc finger protein 331 [KO:K09228]
116154645  zinc finger protein 613-like [KO:K09228]
116154646  zinc finger protein 347-like [KO:K09228]
105092003  LOW QUALITY PROTEIN: zinc finger protein 677 [KO:K09228]
105104272  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
105105400  zinc finger protein 177 [KO:K09228]
105105403  zinc finger protein 135-like [KO:K09228]
105104074  zinc finger protein 709-like isoform X1 [KO:K09228]
105104073  zinc finger protein 709-like [KO:K09228]
105104072  zinc finger protein 791-like isoform X1 [KO:K09228]
105096453  ZFP37; zinc finger protein 37 homolog [KO:K09228]
105096463  zinc finger protein 300 [KO:K09228]
116154106  ZNF786; LOW QUALITY PROTEIN: zinc finger protein 786 [KO:K09228]
105085199  ZNF425; LOW QUALITY PROTEIN: zinc finger protein 425 [KO:K09228]
105085217  ZNF282; LOW QUALITY PROTEIN: zinc finger protein 282 [KO:K09228]
105085200  ZNF398; zinc finger protein 398 [KO:K09228]
105085203  ZNF777; zinc finger protein 777 [KO:K09228]
105085219  ZNF783; protein ZNF783 isoform X1 [KO:K09228]
105085220  ZNF746; LOW QUALITY PROTEIN: zinc finger protein 746 [KO:K09228]
105106312  zinc finger protein 256-like isoform X1 [KO:K09228]
105104382  zinc finger protein 814-like [KO:K09228]
105098769  ZFP28; zinc finger protein 28 homolog isoform X1 [KO:K09228]
105084470  zinc finger protein 543-like isoform X1 [KO:K09228]
105103796  ZNF641; zinc finger protein 641 isoform X1 [KO:K09228]
105088411  ZFP90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
116154987  zinc finger protein 160-like [KO:K09228]
105091275  zinc finger protein 160-like [KO:K09228]
105105045  zinc finger protein 154-like [KO:K09228]
105105050  zinc finger protein 211-like [KO:K09228]
105105042  LOW QUALITY PROTEIN: uncharacterized protein LOC105105042 [KO:K09228]
105105037  zinc finger protein OZF-like isoform X1 [KO:K09228]
116147091  zinc finger protein 773-like [KO:K09228]
105105049  zinc finger protein 530-like [KO:K09228]
105105035  ZNF550; zinc finger protein 550 [KO:K09228]
105104379  zinc finger protein 154-like isoform X1 [KO:K09228]
105104378  zinc finger protein 211-like [KO:K09228]
105105032  zinc finger protein 773-like [KO:K09228]
105096729  ZNF599; zinc finger protein 599 [KO:K09228]
105105036  zinc finger protein 211-like [KO:K09228]
105084475  ZNF304; zinc finger protein 304 [KO:K09228]
105098764  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
105084471  zinc finger protein 805-like isoform X1 [KO:K09228]
105098765  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
105085074  ZNF624; zinc finger protein 624 isoform X1 [KO:K09228]
105105031  zinc finger protein 548-like [KO:K09228]
116154670  zinc finger protein 549-like isoform X1 [KO:K09228]
105084625  ZNF621; zinc finger protein 621 [KO:K09228]
105084652  ZNF620; zinc finger protein 620 [KO:K09228]
116149546  zinc finger protein 501-like isoform X1 [KO:K09228]
105092915  ZNF2; zinc finger protein 2 [KO:K09228]
105094539  zinc finger protein 345-like isoform X1 [KO:K09228]
105102844  zinc finger protein 182 [KO:K09228]
105102732  ZNF689; zinc finger protein 689 [KO:K09228]
116148417  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
116148418  zinc finger protein 791-like isoform X1 [KO:K09228]
105099756  ZSCAN32; LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32 [KO:K09228]
105088088  ZNF30; LOW QUALITY PROTEIN: zinc finger protein 30 [KO:K09228]
116154617  ZNF793; zinc finger protein 793 [KO:K09228]
116147049  ZNF684; zinc finger protein 684 [KO:K09228]
105096816  zinc finger protein 345-like isoform X1 [KO:K09228]
116154734  ZNF382; zinc finger protein 382 [KO:K09228]
105090271  ZNF235; zinc finger protein 235 [KO:K09228]
105090248  ZNF404; zinc finger protein 404 [KO:K09228]
105094852  zinc finger protein 37A-like [KO:K09228]
105105046  zinc finger protein 599-like isoform X2 [KO:K09228]
105091309  ZNF502; zinc finger protein 502 isoform X1 [KO:K09228]
105091270  zinc finger protein 813-like isoform X1 [KO:K09228]
105091271  zinc finger protein 347 isoform X1 [KO:K09228]
105101623  zinc finger protein 268 [KO:K09228]
116152185  zinc finger protein 548-like [KO:K09228]
105093234  ZNF80; zinc finger protein 80 [KO:K09228]
105101191  paternally-expressed gene 3 protein [KO:K09228]
105096956  LOW QUALITY PROTEIN: zinc finger protein 729 [KO:K09228]
105096825  zinc finger protein 497-like [KO:K09228]
105105684  zinc finger protein 184-like [KO:K09228]
116151441  zinc finger protein 773-like [KO:K09228]
105101902  BST2; bone marrow stromal antigen 2 [KO:K06731]
105101111  IFNG; interferon gamma [KO:K04687]
105092040  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
105089867  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
105101970  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105101430  DAXX; death domain-associated protein 6 [KO:K02308]
105093764  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
105087276  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105101403  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105101406  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105101385  TAPBP; tapasin [KO:K08058]
105101715  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105100758  CALR; calreticulin [KO:K08057]
105087509  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
105087478  patr class I histocompatibility antigen, B-1 alpha chain isoform X1 [KO:K06751]
105087511  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
116147754  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
105104206  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
116152169  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
105106736  beta-2-microglobulin [KO:K08055]
105101700  beta-2-microglobulin [KO:K08055]
105101697  beta-2-microglobulin-like [KO:K08055]
105101397  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
105101401  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
105101402  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105101408  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105101409  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
105101412  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
105101414  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
105101433  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
105101434  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105101437  HLA class II histocompatibility antigen, DRB1-1 beta chain-like isoform X2 [KO:K06752]
105101410  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
116147669  LOW QUALITY PROTEIN: boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
105101411  boLa class II histocompatibility antigen, DQB*0101 beta chain [KO:K06752]
116147670  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
105101413  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
105098481  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105085191  TSC1; hamartin isoform X1 [KO:K07206]
105099714  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105098696  RHEB; GTP-binding protein Rheb [KO:K07208]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105089940  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105101342  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
105097799  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
105092175  SRSF2; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 2 [KO:K12891]
116152339  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 2-like [KO:K12891]
105101332  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
105087126  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
105086152  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
105090396  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
105103649  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105101994  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
105091509  NXF1; nuclear RNA export factor 1 [KO:K14284]
105106390  ALYREF; LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
105092770  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105102832  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105088459  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105104389  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105101376  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105100821  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105097442  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
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MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
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Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
PMID:21146386
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Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
PMID:25798530
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
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Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
cdk03040  Spliceosome
cdk03050  Proteasome
cdk04115  p53 signaling pathway
cdk04151  PI3K-Akt signaling pathway
cdk04210  Apoptosis
cdk04610  Complement and coagulation cascades
cdk04612  Antigen processing and presentation
cdk04620  Toll-like receptor signaling pathway
cdk04622  RIG-I-like receptor signaling pathway
cdk04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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