KEGG   PATHWAY: cjc04015
Entry
cjc04015                    Pathway                                
Name
Rap1 signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04015  Rap1 signaling pathway
cjc04015

Other DBs
GO: 0007264
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100393183  RAP1A; ras-related protein Rap-1A [KO:K04353]
100411763  ras-related protein Rap-1b-like [KO:K07836]
100413220  RAP1B; ras-related protein Rap-1b [KO:K07836]
100390332  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
100394511  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
100406117  DOCK4; dedicator of cytokinesis protein 4 isoform X2 [KO:K17697]
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100390180  CALM1; calmodulin-1 [KO:K02183]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100406081  CALM3; calmodulin-3 [KO:K02183]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  calmodulin-1-like [KO:K02183]
100400356  F2R; proteinase-activated receptor 1 [KO:K03914]
100396997  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100391898  P2RY1; P2Y purinoceptor 1 [KO:K04270]
100414340  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100391457  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100392576  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100395819  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100413340  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100395031  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
100388327  ADORA2B; adenosine receptor A2b [KO:K04267]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
103787209  neuroendocrine secretory protein 55 [KO:K04632]
100394265  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100385658  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100415165  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100415141  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100412782  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100406617  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100404620  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100404484  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100405403  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100399583  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X3 [KO:K08014]
100401754  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X5 [KO:K04351]
100403006  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100404102  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100896269  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100392014  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118152209  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100398595  fibroblast growth factor 6-like [KO:K04358]
100405886  FGF7; fibroblast growth factor 7 [KO:K04358]
100409540  FGF4; fibroblast growth factor 4 [KO:K04358]
100401797  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100410253  FGF3; fibroblast growth factor 3 [KO:K04358]
100385862  FGF20; fibroblast growth factor 20 [KO:K04358]
100386978  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100402660  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100387695  FGF10; fibroblast growth factor 10 [KO:K04358]
100414371  FGF22; fibroblast growth factor 22 isoform X3 [KO:K04358]
100392792  FGF9; fibroblast growth factor 9 [KO:K04358]
100390531  FGF6; fibroblast growth factor 6 [KO:K04358]
100388550  FGF16; fibroblast growth factor 16 [KO:K04358]
128929061  FGF19; fibroblast growth factor 19 [KO:K22603]
100389889  FGF21; fibroblast growth factor 21 [KO:K22429]
100392707  FGF23; fibroblast growth factor 23 [KO:K22428]
100391837  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100393089  INS; insulin [KO:K04526]
100394985  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100412906  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100388628  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100393010  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100398033  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100386071  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100410844  KITLG; kit ligand isoform X1 [KO:K05461]
103790554  kit ligand-like [KO:K05461]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100400081  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100386568  PGF; placenta growth factor isoform X1 [KO:K16859]
100395294  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100407908  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100385966  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100413870  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100404686  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100397495  ANGPT4; angiopoietin-4 [KO:K05467]
100394813  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100395416  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100395773  EFNA1; ephrin-A1 [KO:K05462]
100396146  EFNA2; ephrin-A2 [KO:K05462]
100388282  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100390192  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100393573  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
100409938  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100414348  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100392306  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
100403400  INSR; insulin receptor isoform X4 [KO:K04527] [EC:2.7.10.1]
100408399  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100406047  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100411615  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100413680  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100388404  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100407045  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100408551  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103793489  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100412970  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
100390206  CRKL; crk-like protein [KO:K04438]
100399916  CRK; adapter molecule crk isoform X1 [KO:K04438]
100402777  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
100391559  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X7 [KO:K05726]
100398679  CDH1; cadherin-1 [KO:K05689]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100403010  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100393799  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100408297  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
100388886  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X19 [KO:K08018]
100386485  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X12 [KO:K08020]
100409044  T cell receptor alpha variable 8-6 [KO:K10784]
100896987  T cell receptor beta variable 7-2 [KO:K10785]
100896470  T cell receptor beta variable 7-9 [KO:K10785]
100414442  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
100411367  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
100396491  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
100396765  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100412986  PRKD1; serine/threonine-protein kinase D1 isoform X3 [KO:K06070] [EC:2.7.11.13]
100397078  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
108587662  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100400797  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100393865  CNR1; cannabinoid receptor 1 [KO:K04277]
100404474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100405745  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
100388113  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100389396  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100402248  RAP1GAP; rap1 GTPase-activating protein 1 isoform X4 [KO:K17700]
100386794  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
100385492  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
100398089  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X3 [KO:K17702]
100386741  SIPA1L3; LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
100412122  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100409316  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
100398374  RALA; ras-related protein Ral-A [KO:K07834]
100409022  RALB; ras-related protein Ral-B [KO:K07835]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100400756  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100392937  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
100392824  TLN2; talin-2 isoform X2 [KO:K06271]
100408584  TLN1; talin-1 isoform X2 [KO:K06271]
100408748  ITGA2B; integrin alpha-IIb [KO:K06476]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100386114  PFN4; profilin-4 [KO:K05759]
100413264  PFN3; profilin-3 [KO:K05759]
100404606  PFN2; profilin-2 isoform X1 [KO:K05759]
100395089  PFN1; profilin-1 [KO:K05759]
100407817  vasodilator-stimulated phosphoprotein [KO:K06274]
100399553  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100410899  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100408931  EVL; ena/VASP-like protein isoform X2 [KO:K23487]
100398645  actin, cytoplasmic 2-like [KO:K05692]
100404409  actin, cytoplasmic 1-like [KO:K05692]
100406907  actin, cytoplasmic 2-like [KO:K05692]
100410882  actin, cytoplasmic 2-like [KO:K05692]
100412618  actin, cytoplasmic 1 [KO:K05692]
100409006  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100388094  actin, cytoplasmic 2 [KO:K05692]
100406296  ACTB; actin, cytoplasmic 1 [KO:K05692]
100401391  actin, cytoplasmic 2-like [KO:K05692]
118150586  actin, cytoplasmic 2-like [KO:K05692]
100387074  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100386165  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100395694  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2 [KO:K06082]
100404291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100406408  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100388432  VAV1; proto-oncogene vav [KO:K05730]
100390165  VAV3; guanine nucleotide exchange factor VAV3 isoform X4 [KO:K05730]
100390844  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100393064  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100403482  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100388182  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
100391194  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
100394749  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
100399514  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100398334  AFDN; afadin isoform X5 [KO:K05702]
100388734  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
100388944  KRIT1; krev interaction trapped protein 1 isoform X2 [KO:K17705]
100404112  RGS14; LOW QUALITY PROTEIN: regulator of G-protein signaling 14 [KO:K17706]
100415559  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100390790  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100389341  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100402685  ITGB2; integrin beta-2 isoform X2 [KO:K06464]
100394145  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100385383  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100413772  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
cjc04010  MAPK signaling pathway
cjc04014  Ras signaling pathway
cjc04020  Calcium signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04510  Focal adhesion
cjc04520  Adherens junction
cjc04660  T cell receptor signaling pathway
cjc04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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