KEGG   PATHWAY: llv05202
Entry
llv05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Lutra lutra (Eurasian river otter)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
llv05202  Transcriptional misregulation in cancer
llv05202

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125094779  runt-related transcription factor 1 isoform X1 [KO:K08367]
125100440  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125088054  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
125100468  granulocyte-macrophage colony-stimulating factor-like isoform X1 [KO:K05427]
125097712  protein CBFA2T1 isoform X1 [KO:K10053]
125102513  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
125080019  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
125098208  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
125106802  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
125104617  paired amphipathic helix protein Sin3a [KO:K11644]
125088135  nuclear receptor corepressor 1 isoform X1 [KO:K04650]
125089775  CCAAT/enhancer-binding protein alpha [KO:K09055]
125095411  period circadian protein homolog 2-like isoform X1 [KO:K02633]
125078757  transcription factor PU.1 isoform X1 [KO:K09438]
125100878  monocyte differentiation antigen CD14-like [KO:K04391]
125091026  integrin alpha-M-like isoform X1 [KO:K06461]
125099196  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498]
125087544  junction plakoglobin [KO:K10056]
125082256  LOW QUALITY PROTEIN: junction plakoglobin-like [KO:K10056]
125103723  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
125087842  retinoic acid receptor alpha isoform X1 [KO:K08527]
125084483  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
125093344  cyclin-A2 isoform X1 [KO:K06627]
125095240  cyclin-A1 [KO:K06627]
125104874  CCAAT/enhancer-binding protein epsilon [KO:K10051]
125105668  bcl-2-related protein A1-like [KO:K02162]
125078696  zinc finger and BTB domain-containing protein 16 [KO:K10055]
125098611  myc proto-oncogene protein [KO:K04377]
125107286  dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125088838  transcription factor E2-alpha-like isoform X1 [KO:K09063]
125085427  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
125080356  protein Wnt-16 [KO:K01558]
125107837  transcription factor ETV6 isoform X1 [KO:K03211]
125103037  transcription factor ETV7-like isoform X1 [KO:K03211]
125087398  neutrophil elastase-like [KO:K01327] [EC:3.4.21.37]
125104493  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
125104667  granzyme B-like [KO:K01353] [EC:3.4.21.79]
125080181  histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
125093144  AF4/FMR2 family member 1-like isoform X1 [KO:K15184]
125083358  cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
125095941  cyclin-T2 isoform X1 [KO:K15188]
125106492  cyclin-T1 isoform X1 [KO:K15188]
125083667  protein AF-9 [KO:K15187]
125088189  protein ENL isoform X1 [KO:K15187]
125088548  histone-lysine N-methyltransferase, H3 lysine-79 specific-like isoform X1 [KO:K11427] [EC:2.1.1.360]
125079484  rhombotin-2 [KO:K15612]
125083424  pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
125102232  runt-related transcription factor 2 isoform X1 [KO:K09278]
125093004  mothers against decapentaplegic homolog 1 [KO:K04676]
125093633  Krueppel-like factor 3 [KO:K15605]
125100113  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
125080632  homeobox protein Hox-A9 [KO:K21950]
125080629  homeobox protein Hox-A10 [KO:K17443]
125084348  probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
125107486  high mobility group protein HMGI-C isoform X1 [KO:K09283]
125091351  lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
125092595  lysine-specific demethylase 6A-like isoform X1 [KO:K11447] [EC:1.14.11.68]
125102233  transcription initiation protein SPT3 homolog [KO:K11313]
125093563  prominin-1-like [KO:K06532]
125096240  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125093897  BMP-2-inducible protein kinase-like isoform X1 [KO:K08854] [EC:2.7.11.1]
125105350  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125106593  cyclin-dependent kinase inhibitor 1B [KO:K06624]
125080593  cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
125109262  homeobox protein Meis1 isoform X1 [KO:K15613]
125080631  homeobox protein Hox-A11 [KO:K21951]
125105119  homeobox protein SIX1 [KO:K15614]
125105418  homeobox protein SIX4 isoform X1 [KO:K15615]
125098630  eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
125098666  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
125092919  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
125092047  glutamate receptor 3 isoform X1 [KO:K05199]
125104213  alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
125100112  T-cell leukemia homeobox protein 3 [KO:K15607]
125084788  T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
125105249  B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
125084643  LIM domain-binding protein 1 isoform X1 [KO:K15617]
125083935  protein lyl-1 [KO:K15604]
125085009  hematopoietically-expressed homeobox protein HHEX [KO:K08024]
125102113  pre T-cell antigen receptor alpha-like [KO:K06056]
125109573  proto-oncogene c-Rel-like isoform X1 [KO:K09254]
125105988  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
125079331  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
125079332  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125083470  TNF receptor-associated factor 1 [KO:K03172]
125108270  bcl-2-like protein 1 [KO:K04570]
125103669  T-lymphocyte activation antigen CD86-like isoform X1 [KO:K05413]
125109530  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
125101963  B-cell lymphoma 6 protein [KO:K15618]
125089114  transcription factor Maf isoform X1 [KO:K09035]
125107565  integrin beta-7 isoform X1 [KO:K06590]
125093459  histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
125100949  histone H3.1-like [KO:K11253]
125102038  histone H3.1 [KO:K11253]
125102039  histone H3.1 [KO:K11253]
125102040  histone H3.1 [KO:K11253]
125085909  histone H3.3A [KO:K11253]
125102594  histone H3.3-like [KO:K11253]
125087183  histone H3.3A [KO:K11253]
125097602  histone H3 [KO:K11253]
125083929  paired box protein Pax-5 isoform X1 [KO:K09383]
125108592  paired box protein Pax-8 isoform X1 [KO:K09293]
125108518  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
125083110  retinoic acid receptor RXR-alpha [KO:K08524]
125102136  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
125085901  retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
125085739  proline-rich protein PRCC [KO:K13105]
125091975  transcription factor E3 [KO:K09105]
125102743  cyclin-dependent kinase inhibitor 1 [KO:K06625]
125094004  transmembrane protease serine 2-like [KO:K09633] [EC:3.4.21.122]
125094243  transcriptional regulator ERG isoform X1 [KO:K09435]
125084356  urokinase-type plasminogen activator-like [KO:K01348] [EC:3.4.21.73]
125092797  tissue-type plasminogen activator-like [KO:K01343] [EC:3.4.21.68]
125078732  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
125078733  stromelysin-2-like [KO:K01394] [EC:3.4.24.17]
125109962  matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
125108004  zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
125109725  interleukin-1 receptor type 2-like isoform X1 [KO:K04387]
125105284  kunitz-type protease inhibitor 1-like [KO:K15619]
125081092  ETS translocation variant 1 isoform X1 [KO:K09431]
125087904  ETS translocation variant 4 isoform X1 [KO:K15592]
125101811  ETS translocation variant 5 [KO:K15593]
125085950  solute carrier family 45 member 3 [KO:K15379]
125085812  ETS domain-containing protein Elk-4-like [KO:K04376]
125088057  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
125096919  LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
125109745  N-myc proto-oncogene protein [KO:K09109]
125104744  protein max isoform X1 [KO:K04453]
125107551  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125097541  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125087037  cellular tumor antigen p53 isoform X1 [KO:K04451]
125106729  polycomb complex protein BMI-1 [KO:K11459]
125106436  transcription factor Sp1 [KO:K04684]
125096718  zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
125085737  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125087886  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125078650  menin isoform X1 [KO:K14970]
125091611  RNA-binding protein EWS-like [KO:K13209]
125108543  RNA-binding protein EWS-like [KO:K13209]
125103085  RNA-binding protein EWS [KO:K13209]
125081303  RNA-binding protein EWS-like [KO:K13209]
125097492  RNA-binding protein EWS-like [KO:K13209]
125110244  Friend leukemia integration 1 transcription factor [KO:K09436]
125106739  insulin-like growth factor I isoform X1 [KO:K05459]
125109522  DNA-binding protein inhibitor ID-2 [KO:K17693]
125105441  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125081186  insulin-like growth factor-binding protein 3 [KO:K10138]
125095250  protein FEV [KO:K09437]
125106664  cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
125104040  aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
125078433  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125109834  microphthalmia-associated transcription factor isoform X1 [KO:K09455]
125079622  Wilms tumor protein [KO:K09234]
125090848  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125107622  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
125090212  BAI1-associated protein 3 isoform X1 [KO:K15621]
125092049  tetraspanin-7 [KO:K06571]
125093186  tetraspanin-7-like [KO:K06571]
125099496  myeloid leukemia factor 1 isoform X1 [KO:K15622]
125083847  nuclear receptor subfamily 4 group A member 3 [KO:K08559]
125087193  TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
125090619  RNA-binding protein FUS isoform X1 [KO:K13098]
125106097  DNA damage-inducible transcript 3 protein [KO:K04452]
125109637  CCAAT/enhancer-binding protein beta [KO:K10048]
125081177  interleukin-6 [KO:K05405]
125096529  NF-kappa-B inhibitor zeta [KO:K14242]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125094403  interleukin-8 [KO:K10030]
125096264  paired box protein Pax-3 isoform X1 [KO:K09381]
125099135  paired box protein Pax-7 isoform X1 [KO:K09381]
125096352  forkhead box protein O1 isoform X1 [KO:K07201]
125096245  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125082065  protein SSXT isoform X1 [KO:K15623]
125092034  putative protein SSX6 [KO:K15624]
125091064  nuclear protein 1-like [KO:K15626]
125086619  tether containing UBX domain for GLUT4-like isoform X1 [KO:K15627]
125080939  hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125084011  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125087160  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
125098822  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125086017  apoptosis regulator BAX-like [KO:K02159]
125089829  apoptosis regulator BAX [KO:K02159]
125102734  bcl-2 homologous antagonist/killer [KO:K14021]
125078755  DNA damage-binding protein 2 isoform X1 [KO:K10140]
125099728  DNA polymerase kappa-like [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
PMID:20974671
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
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Haematologica 94:78-86 (2009)
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Leuk Lymphoma 34:25-33 (1999)
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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J Biol Chem 282:12503-16 (2007)
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Oncogene 22:1-9 (2003)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Cancer Res 69:7140-50 (2009)
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Oncogene 22:41-9 (2003)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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Expression of MET in alveolar soft part sarcoma.
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
llv04115  p53 signaling pathway
llv05211  Renal cell carcinoma
llv05215  Prostate cancer
llv05216  Thyroid cancer
llv05221  Acute myeloid leukemia
KO pathway
ko05202   
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