KEGG   PATHWAY: myb04810
Entry
myb04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Myotis brandtii (Brandt's bat)
Class
Cellular Processes; Cell motility
Pathway map
myb04810  Regulation of actin cytoskeleton
myb04810

Other DBs
GO: 0030036
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102258769  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102246865  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102246973  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102250139  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102247013  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102263583  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102252492  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
102249171  F2R; coagulation factor II thrombin receptor [KO:K03914]
102254396  insulin [KO:K04526]
102264252  EGF; epidermal growth factor [KO:K04357]
102256157  FGF1; fibroblast growth factor 1 [KO:K18496]
102246008  FGF2; fibroblast growth factor 2 [KO:K18497]
102250520  FGF3; fibroblast growth factor 3 [KO:K04358]
102260092  FGF17; fibroblast growth factor 17 [KO:K04358]
102254187  FGF22; fibroblast growth factor 22 [KO:K04358]
102255119  FGF6; fibroblast growth factor 6 [KO:K04358]
102251158  FGF16; fibroblast growth factor 16 [KO:K04358]
102250238  FGF10; fibroblast growth factor 10 [KO:K04358]
102259056  FGF8; fibroblast growth factor 8 [KO:K04358]
102262222  FGF18; fibroblast growth factor 18 [KO:K04358]
102261041  FGF9; fibroblast growth factor 9 [KO:K04358]
102260244  FGF5; fibroblast growth factor 5 [KO:K04358]
102259580  FGF20; fibroblast growth factor 20 [KO:K04358]
102261751  FGF7; fibroblast growth factor 7 [KO:K04358]
102249614  FGF19; fibroblast growth factor 19 [KO:K22603]
102260667  FGF21; fibroblast growth factor 21 [KO:K22429]
102240867  FGF23; fibroblast growth factor 23 [KO:K22428]
102253551  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102239511  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102248385  PDGFC; platelet derived growth factor C [KO:K05450]
102240259  PDGFD; platelet derived growth factor D [KO:K05450]
102248233  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
102257758  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102253832  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102254053  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102258015  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102255326  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102241145  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102244892  FN1; fibronectin 1 [KO:K05717]
102244635  ITGA1; integrin subunit alpha 1 [KO:K06480]
102244336  ITGA2; integrin subunit alpha 2 [KO:K06481]
102252761  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102245715  ITGA3; integrin subunit alpha 3 [KO:K06482]
102259547  ITGA4; integrin subunit alpha 4 [KO:K06483]
102255900  ITGA5; integrin subunit alpha 5 [KO:K06484]
102261916  ITGA6; integrin subunit alpha 6 [KO:K06485]
102249761  ITGA7; integrin subunit alpha 7 [KO:K06583]
102253526  ITGA8; integrin subunit alpha 8 [KO:K06584]
102248306  integrin alpha-9 [KO:K06585]
102260193  ITGA10; integrin subunit alpha 10 [KO:K06586]
102242832  ITGA11; integrin subunit alpha 11 [KO:K06587]
102260401  ITGAV; integrin subunit alpha V [KO:K06487]
102245292  ITGAL; integrin subunit alpha L [KO:K05718]
102257478  ITGAM; integrin subunit alpha M [KO:K06461]
102242521  ITGAX; integrin subunit alpha X [KO:K06462]
102242831  ITGAD; integrin alpha-D [KO:K06594]
102240236  ITGAE; integrin subunit alpha E [KO:K06524]
102260978  ITGB1; integrin subunit beta 1 [KO:K05719]
102248879  ITGB2; integrin subunit beta 2 [KO:K06464]
102242014  ITGB3; integrin subunit beta 3 [KO:K06493]
102260390  ITGB4; integrin subunit beta 4 [KO:K06525]
102262191  ITGB5; integrin subunit beta 5 [KO:K06588]
102249275  ITGB6; integrin subunit beta 6 [KO:K06589]
102258333  integrin beta-7 [KO:K06590]
102258028  integrin beta-7-like [KO:K06590]
102246659  ITGB8; integrin subunit beta 8 [KO:K06591]
102242693  KNG1; kininogen 1 [KO:K03898]
102247581  kininogen-1 [KO:K03898]
102246781  kininogen-1 [KO:K03898]
106723545  BDKRB1; bradykinin receptor B1 [KO:K03915]
102249334  BDKRB2; bradykinin receptor B2 [KO:K03916]
102238610  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102244198  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102258675  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102248536  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
102238762  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102238719  C5; complement C5 [KO:K03994]
102250460  C6; complement C6 [KO:K03995]
102249954  C7; complement C7 [KO:K03996]
102263928  complement component C8 alpha chain [KO:K03997]
106726695  C8A; complement C8 alpha chain [KO:K03997]
102263623  C8B; complement C8 beta chain [KO:K03998]
102259233  complement component C8 gamma chain [KO:K03999]
102263877  C8G; complement C8 gamma chain [KO:K03999]
102255708  C9; complement C9 [KO:K04000]
102260289  GNA12; G protein subunit alpha 12 [KO:K04346]
102252423  GNA13; G protein subunit alpha 13 [KO:K04639]
102242875  GNG12; G protein subunit gamma 12 [KO:K04347]
102240295  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102247323  FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
102252167  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
102245460  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102256265  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102248665  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102252934  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102253195  adapter molecule crk [KO:K04438]
102248014  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
102247553  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102252301  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102259408  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102257602  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102261560  MRAS; muscle RAS oncogene homolog [KO:K07831]
102256281  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102242321  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102253658  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102263523  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102241454  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102260644  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102262287  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102257250  RGCC; regulator of cell cycle [KO:K26108]
102242342  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
102243603  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102245860  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
102244315  RHOA; ras homolog family member A [KO:K04513]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102249503  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102257260  CDC42; cell division cycle 42 [KO:K04393]
102239987  cell division control protein 42 homolog [KO:K04393]
102240321  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102250137  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102250915  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102258522  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102240345  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102251863  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102239994  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
102256933  GIT1; GIT ArfGAP 1 [KO:K05737]
102252747  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102254781  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102259949  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
102262704  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102244214  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102253559  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102248545  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102239740  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102251394  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
102263913  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
102245599  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102258260  MYL2; myosin light chain 2 [KO:K10351]
102256586  MYL5; myosin light chain 5 [KO:K12753]
102247805  MYL7; myosin light chain 7 [KO:K12754]
102251806  myosin regulatory light polypeptide 9 [KO:K12755]
102253999  MYL9; myosin light chain 9 [KO:K12755]
102243369  myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755]
102250776  MYL10; myosin light chain 10 [KO:K12756]
102257812  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102258119  myosin regulatory light polypeptide 9 [KO:K12757]
102242829  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
102245277  MYH14; myosin heavy chain 14 [KO:K10352]
102245570  MYH10; myosin heavy chain 10 [KO:K10352]
102245984  MYH9; myosin heavy chain 9 [KO:K10352]
102238906  MYH11; myosin heavy chain 11 [KO:K10352]
102251278  DIAPH1; diaphanous related formin 1 [KO:K05740]
102249631  DIAPH2; diaphanous related formin 2 [KO:K05741]
102260344  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102250383  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
102261636  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
102256140  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
102247540  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
102243799  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
102250086  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
102241986  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
102246788  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102240139  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
102260421  DIAPH3; diaphanous related formin 3 [KO:K05745]
102240894  BAIAP2; BAI1 associated protein 2 [KO:K05627]
102241745  ENAH; enabled homolog (Drosophila) [KO:K05746]
102251680  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
102257954  WASF2; WAS protein family member 2 [KO:K05748]
102243192  cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102245924  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
102258650  NCKAP1; NCK associated protein 1 [KO:K05750]
102239702  NCKAP1L; NCK associated protein 1 like [KO:K05750]
102256613  ABI2; abl interactor 2 [KO:K05751]
102263320  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
102249211  WASF1; WAS protein family member 1 [KO:K05753]
102252768  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102246974  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
102244688  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102243291  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102243567  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102247342  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102261906  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102240747  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
102255354  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102255042  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
102263592  ACTG1; actin gamma 1 [KO:K05692]
102251030  actin, cytoplasmic 1 [KO:K05692]
102256245  ACTB; actin beta [KO:K05692]
102254975  PFN3; profilin 3 [KO:K05759]
102244910  PFN4; profilin family member 4 [KO:K05759]
102248499  PFN1; profilin 1 [KO:K05759]
102240210  PFN2; profilin 2 [KO:K05759]
102253973  PXN; paxillin [KO:K05760]
102262098  EZR; ezrin [KO:K08007]
102248215  RDX; radixin [KO:K05762]
102260738  MSN; moesin [KO:K05763]
102238686  thymosin beta-4 [KO:K05764]
102243622  thymosin beta-4 [KO:K05764]
102258778  TMSB4X; thymosin beta-4 [KO:K05764]
106725993  thymosin beta-4-like [KO:K05764]
102247446  CFL2; cofilin 2 [KO:K05765]
102256765  cofilin-1 [KO:K05765]
102257903  CFL1; cofilin 1 [KO:K05765]
102243917  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102246339  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102256626  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102248413  VCL; vinculin [KO:K05700]
102263858  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
102243841  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
102239639  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
102244911  SCIN; scinderin [KO:K05768]
102262219  GSN; gelsolin [KO:K05768]
102250785  ACTN4; actinin alpha 4 [KO:K05699]
102247194  ACTN1; actinin alpha 1 [KO:K05699]
102246124  APC; APC, WNT signaling pathway regulator [KO:K02085]
102243742  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102242545  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
102238983  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
myb04010  MAPK signaling pathway
myb04510  Focal adhesion
myb04520  Adherens junction
KO pathway
ko04810   
LinkDB

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