KEGG   PATHWAY: ncar04936
Entry
ncar04936                   Pathway                                
Name
Alcoholic liver disease - Sciurus carolinensis (gray squirrel)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
ncar04936  Alcoholic liver disease
ncar04936

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124992781  complement C1q subcomponent subunit A-like [KO:K03986]
124981820  complement C1q subcomponent subunit B-like isoform X1 [KO:K03987]
124991547  complement C1q subcomponent subunit C-like [KO:K03988]
124989526  complement C2 [KO:K01332] [EC:3.4.21.43]
124988769  complement C4-A [KO:K03989]
124968300  complement C3 [KO:K03990]
124983569  C3a anaphylatoxin chemotactic receptor-like [KO:K04009]
124964350  complement C5 isoform X1 [KO:K03994]
124967614  C5a anaphylatoxin chemotactic receptor 1-like [KO:K04010]
124977816  lipopolysaccharide-binding protein-like isoform X1 [KO:K05399]
124986944  monocyte differentiation antigen CD14-like [KO:K04391]
124983154  lymphocyte antigen 96-like [KO:K05400]
124964909  toll-like receptor 4 [KO:K10160]
124960254  toll/interleukin-1 receptor domain-containing adapter protein-like [KO:K05403]
124968831  myeloid differentiation primary response protein MyD88 [KO:K04729]
124983710  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
124972468  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
124959952  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
124983359  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
124988761  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
124988810  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
124985256  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124983354  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124971778  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124978214  NF-kappa-B inhibitor alpha [KO:K04734]
124960546  transcription factor p65 [KO:K04735]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124988890  tumor necrosis factor [KO:K03156]
124990183  interleukin-6-like [KO:K05405]
124993138  interleukin-12 subunit alpha-like [KO:K05406]
124987404  interleukin-12 subunit beta-like [KO:K05425]
124994380  C-X-C motif chemokine 15-like [KO:K10030]
124994632  interleukin-8 [KO:K10030]
124969552  TIR domain-containing adapter molecule 1-like [KO:K05842]
124976672  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
124962122  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
124983333  LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
124967322  interferon regulatory factor 3-like isoform X1 [KO:K05411]
124964632  interferon alpha-13-like [KO:K05414]
124964656  interferon alpha-5-like [KO:K05414]
124964659  interferon alpha-5-like [KO:K05414]
124964665  interferon alpha-5-like [KO:K05414]
124964666  interferon alpha-5-like [KO:K05414]
124964667  interferon alpha-5-like [KO:K05414]
124964668  interferon alpha-5-like [KO:K05414]
124964675  interferon alpha-5-like [KO:K05414]
124964679  interferon alpha-5-like [KO:K05414]
124964683  interferon alpha-5-like [KO:K05414]
124964869  interferon alpha-5-like [KO:K05414]
124963924  interferon beta-like [KO:K05415]
124963958  interferon beta-like [KO:K05415]
124964114  interferon beta-like [KO:K05415]
124964969  interferon beta-like [KO:K05415]
124965019  interferon beta-like [KO:K05415]
124988033  interleukin-17A-like [KO:K05489]
124983755  interleukin-17 receptor A-like [KO:K05164]
124971001  interleukin-17 receptor C-like isoform X1 [KO:K05166]
124994036  growth-regulated protein homolog gamma-like [KO:K05505]
124994608  growth-regulated protein homolog gamma-like [KO:K05505]
124962014  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
124984583  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
124960510  FAS-associated death domain protein-like [KO:K02373]
124984003  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
124966312  tumor necrosis factor receptor type 1-associated DEATH domain protein-like isoform X1 [KO:K03171]
124980441  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124989445  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
124972381  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
124980543  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
124979686  fatty acid synthase-like isoform X1 [KO:K00665] [EC:2.3.1.85]
124980304  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
124994604  stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
124984655  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
124984908  acyl-CoA desaturase 3-like [KO:K00507] [EC:1.14.19.1]
124985066  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
124985309  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
124977632  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
124963013  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
124965194  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
124985129  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
124992713  transformer-2 protein homolog beta isoform X1 [KO:K12897]
124990724  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
124992968  adiponectin [KO:K07296]
124962190  adiponectin receptor protein 1 [KO:K07297]
124981003  adiponectin receptor protein 1-like [KO:K07297]
124982885  adiponectin receptor protein 2 [KO:K07297]
124976120  LOW QUALITY PROTEIN: adiponectin receptor protein 1-like [KO:K07297]
124990307  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
124987007  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
124983683  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
124990233  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
124960770  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
124990239  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
124980693  5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
124983681  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
124985154  forkhead box protein O1 [KO:K07201]
124989730  forkhead box protein O3 [KO:K09408]
124994408  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
124981928  peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
124958962  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
124981031  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
124988574  medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
124994493  peroxisomal acyl-coenzyme A oxidase 3-like isoform X1 [KO:K00232] [EC:1.3.3.6]
124980496  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
124963714  fatty acid-binding protein, liver [KO:K08750]
124994496  all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
124994588  alcohol dehydrogenase E chain isoform X1 [KO:K13951] [EC:1.1.1.1]
124994994  all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
124994960  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
124990710  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
124979617  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
124964431  aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
124986798  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
124962313  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
124974930  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
124990202  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
124967129  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
124983218  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
124967617  carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
124958702  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124992642  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124969493  catenin beta-1 [KO:K02105]
124986637  transcription factor 7 isoform X1 [KO:K02620]
124963199  transcription factor 7-like 1 isoform X1 [KO:K04490]
124984748  transcription factor 7-like 2 isoform X1 [KO:K04491]
124994528  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
124958520  G1/S-specific cyclin-D1 [KO:K04503]
124988565  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124980435  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
124968601  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124980599  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
124981341  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
124988515  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124989076  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124978202  mitogen-activated protein kinase 14-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124982485  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124982486  LOW QUALITY PROTEIN: mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124980247  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
ncar00061  Fatty acid biosynthesis
ncar00071  Fatty acid degradation
ncar01040  Biosynthesis of unsaturated fatty acids
ncar03040  Spliceosome
ncar04010  MAPK signaling pathway
ncar04064  NF-kappa B signaling pathway
ncar04152  AMPK signaling pathway
ncar04210  Apoptosis
ncar04310  Wnt signaling pathway
ncar04610  Complement and coagulation cascades
ncar04620  Toll-like receptor signaling pathway
ncar04657  IL-17 signaling pathway
ncar04668  TNF signaling pathway
ncar04920  Adipocytokine signaling pathway
ncar05034  Alcoholism
ncar05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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